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The map label for this gene is holA [H]

Identifier: 119899506

GI number: 119899506

Start: 3548093

End: 3549103

Strand: Direct

Name: holA [H]

Synonym: azo3217

Alternate gene names: 119899506

Gene position: 3548093-3549103 (Clockwise)

Preceding gene: 119899505

Following gene: 119899507

Centisome position: 81.08

GC content: 68.74

Gene sequence:

>1011_bases
GTGAATTTGCGCCCCGACCAGCTCGCGGCCCAGCTCGACAAGCCGCTCGCACCGCTCTGGGTGCTGCACGGCAACGAGCC
GCTGCTGGTGCTCGAAGCCGCCGACGCAATCCGCGCGGCGGCGCGCCGCCAGGGTTACTCGGAACGAGAAACGCTGGTGG
TGGGCCAGGGCTTCCGCTGGGATTCGTTGACACTCGCCGCCGGCAACATGTCCTTGTTTGGCGGCGCCAAGCTCATCGAT
CTGCGCATTCCCACCGGCAAGCCGGGGCGCGATGGCGGCGACGCGTTGCAGCGCTATGTCGCGCAACTGCCCGCTGCCAC
GCTCACCCTGGTGACGCTGCCGGAACTCGACTGGCAGGCACGCAAAACCAGCTGGTTCAAGGCATTGGGCGACGCCGGCA
CGGTCATCGAGCTAAACGCGCCGGAACGCGAACGCCTTCCTCAGTGGCTGGCGCAGCGGCTGGCCGCGCAACACCTCACC
GCCCCGGCGGAAGCGCTGGCTTTCATTGCCGACCACGTGGAAGGCAACCTGCTCGCGGCACATCAGGAGATCCTCAAGCT
CGGGCTGTTGTTTCCGCACGGCGCGCAACTGACCCTTGATGACGTCCAGCAAGCCGTACTCAACGTCGCGCGCTACGACA
TCGATACGCTTCGACAGGCCGTACTGGAAGGCGACCCGGCGCGCTGCGCCCGTCTGCTCGAAGGCCTGCACGGCGAGGGC
GCGGCGCCTCCGCTGGTGCTGTGGGCGCTGGCCAACGAAACCCGCAGCCTCGCGCTGCTGCGCGCCGGACAGGACGCCGG
CCAGCCACTCGCCGCGCTGTTCAAGGCCGAACGCGTCTTCGACGAACGGCGCAAGCAACTCCTTACCCGCGCCCTTGCCC
GCCTTGGCGGTGGGCGCCTGCGCGCCGCGCTGATGCACGCGGCCCGCATCGACCGGATGATCAAGGGGCTGGCGGACGGC
GACGTGTGGGACGAATTCCTGCAGCTTGCGCTGCGGCTCTGCCGTCACTGA

Upstream 100 bases:

>100_bases
TCCTGGGTAAGGAACAGGAGGAAAACCTGCTGTTCCGCGACATGCAGAGCGACCTCGTGCAACAGTTGATGCGTCGCCTC
GCGGTGGTCCGCCGCCCGCA

Downstream 100 bases:

>100_bases
CCCCTTCCGCGGCGGATGTAGCGTGTGACCCACGGGCGCCGCGATCAGTGCTTTAATCCCTTTTTGGCTTTTCCGCCTGT
GACTATGATGGATATCCAGC

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MNLRPDQLAAQLDKPLAPLWVLHGNEPLLVLEAADAIRAAARRQGYSERETLVVGQGFRWDSLTLAAGNMSLFGGAKLID
LRIPTGKPGRDGGDALQRYVAQLPAATLTLVTLPELDWQARKTSWFKALGDAGTVIELNAPERERLPQWLAQRLAAQHLT
APAEALAFIADHVEGNLLAAHQEILKLGLLFPHGAQLTLDDVQQAVLNVARYDIDTLRQAVLEGDPARCARLLEGLHGEG
AAPPLVLWALANETRSLALLRAGQDAGQPLAALFKAERVFDERRKQLLTRALARLGGGRLRAALMHAARIDRMIKGLADG
DVWDEFLQLALRLCRH

Sequences:

>Translated_336_residues
MNLRPDQLAAQLDKPLAPLWVLHGNEPLLVLEAADAIRAAARRQGYSERETLVVGQGFRWDSLTLAAGNMSLFGGAKLID
LRIPTGKPGRDGGDALQRYVAQLPAATLTLVTLPELDWQARKTSWFKALGDAGTVIELNAPERERLPQWLAQRLAAQHLT
APAEALAFIADHVEGNLLAAHQEILKLGLLFPHGAQLTLDDVQQAVLNVARYDIDTLRQAVLEGDPARCARLLEGLHGEG
AAPPLVLWALANETRSLALLRAGQDAGQPLAALFKAERVFDERRKQLLTRALARLGGGRLRAALMHAARIDRMIKGLADG
DVWDEFLQLALRLCRH
>Mature_336_residues
MNLRPDQLAAQLDKPLAPLWVLHGNEPLLVLEAADAIRAAARRQGYSERETLVVGQGFRWDSLTLAAGNMSLFGGAKLID
LRIPTGKPGRDGGDALQRYVAQLPAATLTLVTLPELDWQARKTSWFKALGDAGTVIELNAPERERLPQWLAQRLAAQHLT
APAEALAFIADHVEGNLLAAHQEILKLGLLFPHGAQLTLDDVQQAVLNVARYDIDTLRQAVLEGDPARCARLLEGLHGEG
AAPPLVLWALANETRSLALLRAGQDAGQPLAALFKAERVFDERRKQLLTRALARLGGGRLRAALMHAARIDRMIKGLADG
DVWDEFLQLALRLCRH

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=334, Percent_Identity=32.9341317365269, Blast_Score=128, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 36721; Mature: 36721

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLRPDQLAAQLDKPLAPLWVLHGNEPLLVLEAADAIRAAARRQGYSERETLVVGQGFRW
CCCCHHHHHHHHCCCCCCEEEEECCCCEEEEEHHHHHHHHHHHCCCCCCCEEEEECCCCC
DSLTLAAGNMSLFGGAKLIDLRIPTGKPGRDGGDALQRYVAQLPAATLTLVTLPELDWQA
CCEEEEECCEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHHCCHHHEEEEECCCCCCHH
RKTSWFKALGDAGTVIELNAPERERLPQWLAQRLAAQHLTAPAEALAFIADHVEGNLLAA
HHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHH
HQEILKLGLLFPHGAQLTLDDVQQAVLNVARYDIDTLRQAVLEGDPARCARLLEGLHGEG
HHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHCHHHHHHHHHCCCHHHHHHHHHCCCCCC
AAPPLVLWALANETRSLALLRAGQDAGQPLAALFKAERVFDERRKQLLTRALARLGGGRL
CCCCEEEEEHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
RAALMHAARIDRMIKGLADGDVWDEFLQLALRLCRH
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLRPDQLAAQLDKPLAPLWVLHGNEPLLVLEAADAIRAAARRQGYSERETLVVGQGFRW
CCCCHHHHHHHHCCCCCCEEEEECCCCEEEEEHHHHHHHHHHHCCCCCCCEEEEECCCCC
DSLTLAAGNMSLFGGAKLIDLRIPTGKPGRDGGDALQRYVAQLPAATLTLVTLPELDWQA
CCEEEEECCEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHHCCHHHEEEEECCCCCCHH
RKTSWFKALGDAGTVIELNAPERERLPQWLAQRLAAQHLTAPAEALAFIADHVEGNLLAA
HHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHH
HQEILKLGLLFPHGAQLTLDDVQQAVLNVARYDIDTLRQAVLEGDPARCARLLEGLHGEG
HHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHCHHHHHHHHHCCCHHHHHHHHHCCCCCC
AAPPLVLWALANETRSLALLRAGQDAGQPLAALFKAERVFDERRKQLLTRALARLGGGRL
CCCCEEEEEHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
RAALMHAARIDRMIKGLADGDVWDEFLQLALRLCRH
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]