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The map label for this gene is kdpD2 [H]

Identifier: 119899384

GI number: 119899384

Start: 3400910

End: 3402439

Strand: Reverse

Name: kdpD2 [H]

Synonym: azo3094

Alternate gene names: 119899384

Gene position: 3402439-3400910 (Counterclockwise)

Preceding gene: 119899389

Following gene: 119899383

Centisome position: 77.75

GC content: 73.79

Gene sequence:

>1530_bases
ATGGGGGTTGGGAGGCTGGCGGGGCTGTCGGTGCCGGTGCGTCATCTGGTGGCCGCCACGCTGTGCGCGCTGGCCGCGGC
GGCCGTCTATCCGCTGCGCCAGCTGCTCGAACCCGCCAACGTCGTCATGCTGCTCCTGCTGGTGGTGGCCTTCAATGCCG
CGTGGCTGGGGCGGGGGCCGGCGGTGCTCGGCACGGTGGTCAGCGTCGCGCTGTTCGACTTCCTGTTCGTGCCGCCGCAG
CTCTCGTTCGCGGTCAGCGACGTCAAGTACCTGATCACCTTCGCGGTGATGCTGCTGGTGTCGCTGCTGATCGGCCAGCT
CACCGTCAGTCTGCGCGCCAGCGCCGACGAGGCCGCGCTGCGCGAGCGCCGCTCGCATGCGCTGTACGCGCTGGCCCGAT
CTCTGGCGGGGGCGATGCTGCCGGCGCAGGTGATGGAGCAGGTGGCTGCGTTCGTGCGCACCGAGGCGGGCGCCGAGGTG
CATTTCCACCTGCCGGACGAGGACGACGGCGCCCTGCATCCGCAGCCGGCCGGCGTGCCGGCGCCCGGCGTGGCCGAGAC
CACCGCCGCGGCCGGCATCTTTTTCACGCCGGCGGAAGGGCAGGCCGGCTGCGTGGCCGTGGCCGGGGTCGGCCTGATGC
TGCCGCTGCACGGCGCCACCCGCTGCCGCGGCGTGATGGTGGTGCAGCCGGGCGCCGCCGCAGCGCCGCTGGAGTCGCTG
CGGCCGCTGCTGGAGGCGGTCGCCTCGCTCGCCGCGATCGCACTCGAACGCCTGCACTTCGTCGCGGTGGCGCAGGCCAG
CCAGTTCGAGGCCGAGGCTGAGCGCCTGCGCAACTCCATCCTGGCGTCGATCTCGCACGACATCCGCACCCCGCTCACGG
TGCTGTTCGGCCTGGCCGATGCGCTGGCGCTGTCCGAAGGCCGTCTGGGCAGCGAGGAGCGCGAGGCGGCGCACGCGATC
CGCGACCAGGCCGGGCGGCTGCACGACATGGTCGACAAGCTGCTCGACATGGCGCGGCTGCAGGCCGGCACGGTGCGCCT
GCGCAAGGAGTGGCAGCCGCTCGACGAGATCCTCGGCGCGGCGATCGCGCTGCTCGGCGACGCGCTGCGTGCGCATCCGG
TGACGCTGGTGCAGGCCGCGGAAACGCCGCTGGTGGCGGTGGATGCGGTGCTGCTGGAGCGGGTGTTCTGCAACCTGCTC
GACAACGCGGCCAGGTGTTCGCCGGCCGGAACGCCGATCACCGTGGATCTGGCGCGCGAGGGCGACATGCTGGTGGTGGG
CGTGCGCGACCATGGCCCCGGCTTCCCAGCGGGCGGCGAGCGCGCGTTCGAACTCTTCGAGCGCGGCCGCGCGTCCGGGG
TGGCGGGCGTGGGCCTCGGGCTGGCGATCTGCCGCGCGGTGGTCGAAGCCCACGGCGGCTGGATCCGCGCCGGCAACGCG
GCCGACGGCGGGGCCTGCGTGCGGTTTGCGCTGCCCTGCGGCGAGGCGCCCGTCATCGAGCCTGAAGCGGGCGTGGAGGC
ACAGGCATGA

Upstream 100 bases:

>100_bases
TCGCGCGGCTCTCAGCGCGCGTTTACGCCGTTTTTACTTTGCGGGTAGCAGAATCGGCGCCGTTACCGGCCGTGGGCCGC
GGCAAGGAGATGGGGCGATC

Downstream 100 bases:

>100_bases
ACGCGCCGTCCGCACGCATCCTGCTGGTGGAGGACGAGCTGCAGATCCGCCGCCTTGTGCGGCAGGTGCTGGAGCGCGCC
GGCTACCGGGTGGACGAGGC

Product: sensor for high-affinity potassium transport system

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MGVGRLAGLSVPVRHLVAATLCALAAAAVYPLRQLLEPANVVMLLLLVVAFNAAWLGRGPAVLGTVVSVALFDFLFVPPQ
LSFAVSDVKYLITFAVMLLVSLLIGQLTVSLRASADEAALRERRSHALYALARSLAGAMLPAQVMEQVAAFVRTEAGAEV
HFHLPDEDDGALHPQPAGVPAPGVAETTAAAGIFFTPAEGQAGCVAVAGVGLMLPLHGATRCRGVMVVQPGAAAAPLESL
RPLLEAVASLAAIALERLHFVAVAQASQFEAEAERLRNSILASISHDIRTPLTVLFGLADALALSEGRLGSEEREAAHAI
RDQAGRLHDMVDKLLDMARLQAGTVRLRKEWQPLDEILGAAIALLGDALRAHPVTLVQAAETPLVAVDAVLLERVFCNLL
DNAARCSPAGTPITVDLAREGDMLVVGVRDHGPGFPAGGERAFELFERGRASGVAGVGLGLAICRAVVEAHGGWIRAGNA
ADGGACVRFALPCGEAPVIEPEAGVEAQA

Sequences:

>Translated_509_residues
MGVGRLAGLSVPVRHLVAATLCALAAAAVYPLRQLLEPANVVMLLLLVVAFNAAWLGRGPAVLGTVVSVALFDFLFVPPQ
LSFAVSDVKYLITFAVMLLVSLLIGQLTVSLRASADEAALRERRSHALYALARSLAGAMLPAQVMEQVAAFVRTEAGAEV
HFHLPDEDDGALHPQPAGVPAPGVAETTAAAGIFFTPAEGQAGCVAVAGVGLMLPLHGATRCRGVMVVQPGAAAAPLESL
RPLLEAVASLAAIALERLHFVAVAQASQFEAEAERLRNSILASISHDIRTPLTVLFGLADALALSEGRLGSEEREAAHAI
RDQAGRLHDMVDKLLDMARLQAGTVRLRKEWQPLDEILGAAIALLGDALRAHPVTLVQAAETPLVAVDAVLLERVFCNLL
DNAARCSPAGTPITVDLAREGDMLVVGVRDHGPGFPAGGERAFELFERGRASGVAGVGLGLAICRAVVEAHGGWIRAGNA
ADGGACVRFALPCGEAPVIEPEAGVEAQA
>Mature_508_residues
GVGRLAGLSVPVRHLVAATLCALAAAAVYPLRQLLEPANVVMLLLLVVAFNAAWLGRGPAVLGTVVSVALFDFLFVPPQL
SFAVSDVKYLITFAVMLLVSLLIGQLTVSLRASADEAALRERRSHALYALARSLAGAMLPAQVMEQVAAFVRTEAGAEVH
FHLPDEDDGALHPQPAGVPAPGVAETTAAAGIFFTPAEGQAGCVAVAGVGLMLPLHGATRCRGVMVVQPGAAAAPLESLR
PLLEAVASLAAIALERLHFVAVAQASQFEAEAERLRNSILASISHDIRTPLTVLFGLADALALSEGRLGSEEREAAHAIR
DQAGRLHDMVDKLLDMARLQAGTVRLRKEWQPLDEILGAAIALLGDALRAHPVTLVQAAETPLVAVDAVLLERVFCNLLD
NAARCSPAGTPITVDLAREGDMLVVGVRDHGPGFPAGGERAFELFERGRASGVAGVGLGLAICRAVVEAHGGWIRAGNAA
DGGACVRFALPCGEAPVIEPEAGVEAQA

Specific function: Member of the two-component regulatory system kdpD/kdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates kdpE in response to environmental signals [H]

COG id: COG2205

COG function: function code T; Osmosensitive K+ channel histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786912, Length=494, Percent_Identity=41.0931174089069, Blast_Score=311, Evalue=4e-86,
Organism=Escherichia coli, GI1786600, Length=244, Percent_Identity=29.5081967213115, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1789149, Length=279, Percent_Identity=26.8817204301075, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1790346, Length=224, Percent_Identity=32.1428571428571, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788393, Length=231, Percent_Identity=29.004329004329, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1786783, Length=217, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87081816, Length=248, Percent_Identity=29.8387096774194, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI48994928, Length=231, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1789808, Length=219, Percent_Identity=27.8538812785388, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1787894, Length=438, Percent_Identity=25.1141552511416, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788713, Length=245, Percent_Identity=24.8979591836735, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI145693157, Length=256, Percent_Identity=27.34375, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1789403, Length=284, Percent_Identity=29.5774647887324, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790436, Length=215, Percent_Identity=26.5116279069767, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR003852
- InterPro:   IPR006016 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF02702 KdpD; PF00582 Usp [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52867; Mature: 52736

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVGRLAGLSVPVRHLVAATLCALAAAAVYPLRQLLEPANVVMLLLLVVAFNAAWLGRGP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCHHHCCCCH
AVLGTVVSVALFDFLFVPPQLSFAVSDVKYLITFAVMLLVSLLIGQLTVSLRASADEAAL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
RERRSHALYALARSLAGAMLPAQVMEQVAAFVRTEAGAEVHFHLPDEDDGALHPQPAGVP
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCC
APGVAETTAAAGIFFTPAEGQAGCVAVAGVGLMLPLHGATRCRGVMVVQPGAAAAPLESL
CCCCHHHHHHCCEEEECCCCCCCEEHHHCHHHHEECCCCHHHCEEEEECCCCCCCCHHHH
RPLLEAVASLAAIALERLHFVAVAQASQFEAEAERLRNSILASISHDIRTPLTVLFGLAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALALSEGRLGSEEREAAHAIRDQAGRLHDMVDKLLDMARLQAGTVRLRKEWQPLDEILGA
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AIALLGDALRAHPVTLVQAAETPLVAVDAVLLERVFCNLLDNAARCSPAGTPITVDLARE
HHHHHHHHHHHCCHHEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC
GDMLVVGVRDHGPGFPAGGERAFELFERGRASGVAGVGLGLAICRAVVEAHGGWIRAGNA
CCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCC
ADGGACVRFALPCGEAPVIEPEAGVEAQA
CCCCCEEEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GVGRLAGLSVPVRHLVAATLCALAAAAVYPLRQLLEPANVVMLLLLVVAFNAAWLGRGP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCHHHCCCCH
AVLGTVVSVALFDFLFVPPQLSFAVSDVKYLITFAVMLLVSLLIGQLTVSLRASADEAAL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
RERRSHALYALARSLAGAMLPAQVMEQVAAFVRTEAGAEVHFHLPDEDDGALHPQPAGVP
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCC
APGVAETTAAAGIFFTPAEGQAGCVAVAGVGLMLPLHGATRCRGVMVVQPGAAAAPLESL
CCCCHHHHHHCCEEEECCCCCCCEEHHHCHHHHEECCCCHHHCEEEEECCCCCCCCHHHH
RPLLEAVASLAAIALERLHFVAVAQASQFEAEAERLRNSILASISHDIRTPLTVLFGLAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALALSEGRLGSEEREAAHAIRDQAGRLHDMVDKLLDMARLQAGTVRLRKEWQPLDEILGA
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AIALLGDALRAHPVTLVQAAETPLVAVDAVLLERVFCNLLDNAARCSPAGTPITVDLARE
HHHHHHHHHHHCCHHEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC
GDMLVVGVRDHGPGFPAGGERAFELFERGRASGVAGVGLGLAICRAVVEAHGGWIRAGNA
CCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCC
ADGGACVRFALPCGEAPVIEPEAGVEAQA
CCCCCEEEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1532388; 8905232; 9278503; 7499326 [H]