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The map label for this gene is serA [H]

Identifier: 119899389

GI number: 119899389

Start: 3407478

End: 3408710

Strand: Reverse

Name: serA [H]

Synonym: azo3099

Alternate gene names: 119899389

Gene position: 3408710-3407478 (Counterclockwise)

Preceding gene: 119899390

Following gene: 119899384

Centisome position: 77.89

GC content: 69.75

Gene sequence:

>1233_bases
ATGAATCAGCGCCTTTCGGTGCAGAAGGACAAGCTCAACGTGGTGCTGTTCGAAGGCATCCACGCCTCCGCGGTGGAAGC
CTTCCGCGCCGATGGCTACGGCAGCGTCACCGCCGTCGCCAAGGCGCTGGCGGGTGAGGAGCTGGCGCAGGCGCTGGCCC
ACGCCCACTTCGTCGGCATCCGCTCGCGCACCCGCCTCACCGCCGAGGTGCTGGCGCAGGCGCCCAAGCTGGTCGCCGTC
GGCTGCTTCTGCATCGGCACCAACCAGGTGGACCTGGGCGCCGCCGCGGCGCGCGGCGTGCCGGTGTTCAACGCGCCTTT
CTCCAACACCCGCAGCGTGGCCGAGCTGGTGATCGCCGAAACCATCATGCTGATGCGCGGCATCCCGGCGCGCAACGCGC
TGCAGCACCGCGGCGGCTGGATGAAGAGCGCCGCCAACGCCTGGGAGGTGCGCGGCAAGACGCTGGGTATCGTCGGCTAC
GGCCACATCGGCACCCAGGTGGGCGTGCTCGCCGAACAGCTCGGCATGAGCGTGGTGTTCCACGACATCGAGACCCGGCT
GCCGCTCGGCAACGCCCGCCAGCTCGGCTCGCTCGACGCGCTGCTGGCGGTGGCCGACGTGGTGAGCCTGCACGTGCCGG
AAACCCCGGCGACGATGAACATGATCGCCGCGCCGCAGCTGGCCGCGATGAAGGCCGGCAGCTTCCTCATCAACGCCTCG
CGCGGCACCGTGGTGGACATCGACGCGCTCGCCCAGGCGCTGGAGGCCGGCCACCTGCTCGGCGCCGCGATCGACGTCTT
CCCGGTGGAGCCGGAAGGCAACGACGACCCCTTCGTGTCGCCGCTCACCCGCTTCGACAACGTCATCCTGACGCCCCACA
TCGGCGGCTCCACCGCCGAAGCGCAGGCCAACATCGGCCGCGAGGTCGCCGCCAAGCTGATCCGCTACAGCAACAACGGC
TCCACCGTCACCGCGGTGAATTTCCCCGAGGTGTCGCTGCCCGAGCACGCCGGCAAGTGCCGCGTGCTGCACATCCACCG
CAACGTGCCCGGCATGCTCGCGCGCATCAACGAGCGCTTCTCGCGGGCCGGCATCAACATCGCCGGCCAGTACCTGCAGA
CCACGCCCGACCTCGGCTACGTGGTGATCGACGTGGATGCCGCTGCCAGCCAGGTGGCCTTCGACGAGCTGTGCTCGATC
GAAGGCACCATCCGCTGCCGGGTGCTGTACTAG

Upstream 100 bases:

>100_bases
ACCGTGACGGACACCGCCAACGCCGGCGTCCGCGTCAGCGAGACCGCCAGGTTCTGGATGCCCTAGCCGCGGCGAGCAAC
GCAGCAAGGAGGACGGCCCG

Downstream 100 bases:

>100_bases
CGGCGGGCATCGCTCCCGCCGCGCCCTCAGTCCAGGCTGGCGCGCAGGCGGGCCAGGTCCGGAATGCGGATCGTGCGCCC
GGCGACCTCGATCAGCCCGG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MNQRLSVQKDKLNVVLFEGIHASAVEAFRADGYGSVTAVAKALAGEELAQALAHAHFVGIRSRTRLTAEVLAQAPKLVAV
GCFCIGTNQVDLGAAAARGVPVFNAPFSNTRSVAELVIAETIMLMRGIPARNALQHRGGWMKSAANAWEVRGKTLGIVGY
GHIGTQVGVLAEQLGMSVVFHDIETRLPLGNARQLGSLDALLAVADVVSLHVPETPATMNMIAAPQLAAMKAGSFLINAS
RGTVVDIDALAQALEAGHLLGAAIDVFPVEPEGNDDPFVSPLTRFDNVILTPHIGGSTAEAQANIGREVAAKLIRYSNNG
STVTAVNFPEVSLPEHAGKCRVLHIHRNVPGMLARINERFSRAGINIAGQYLQTTPDLGYVVIDVDAAASQVAFDELCSI
EGTIRCRVLY

Sequences:

>Translated_410_residues
MNQRLSVQKDKLNVVLFEGIHASAVEAFRADGYGSVTAVAKALAGEELAQALAHAHFVGIRSRTRLTAEVLAQAPKLVAV
GCFCIGTNQVDLGAAAARGVPVFNAPFSNTRSVAELVIAETIMLMRGIPARNALQHRGGWMKSAANAWEVRGKTLGIVGY
GHIGTQVGVLAEQLGMSVVFHDIETRLPLGNARQLGSLDALLAVADVVSLHVPETPATMNMIAAPQLAAMKAGSFLINAS
RGTVVDIDALAQALEAGHLLGAAIDVFPVEPEGNDDPFVSPLTRFDNVILTPHIGGSTAEAQANIGREVAAKLIRYSNNG
STVTAVNFPEVSLPEHAGKCRVLHIHRNVPGMLARINERFSRAGINIAGQYLQTTPDLGYVVIDVDAAASQVAFDELCSI
EGTIRCRVLY
>Mature_410_residues
MNQRLSVQKDKLNVVLFEGIHASAVEAFRADGYGSVTAVAKALAGEELAQALAHAHFVGIRSRTRLTAEVLAQAPKLVAV
GCFCIGTNQVDLGAAAARGVPVFNAPFSNTRSVAELVIAETIMLMRGIPARNALQHRGGWMKSAANAWEVRGKTLGIVGY
GHIGTQVGVLAEQLGMSVVFHDIETRLPLGNARQLGSLDALLAVADVVSLHVPETPATMNMIAAPQLAAMKAGSFLINAS
RGTVVDIDALAQALEAGHLLGAAIDVFPVEPEGNDDPFVSPLTRFDNVILTPHIGGSTAEAQANIGREVAAKLIRYSNNG
STVTAVNFPEVSLPEHAGKCRVLHIHRNVPGMLARINERFSRAGINIAGQYLQTTPDLGYVVIDVDAAASQVAFDELCSI
EGTIRCRVLY

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=287, Percent_Identity=35.191637630662, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI145580578, Length=272, Percent_Identity=34.5588235294118, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI4557499, Length=272, Percent_Identity=34.5588235294118, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI145580575, Length=272, Percent_Identity=34.5588235294118, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI61743967, Length=267, Percent_Identity=31.8352059925094, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI4557497, Length=267, Percent_Identity=31.8352059925094, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI6912396, Length=266, Percent_Identity=27.0676691729323, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1789279, Length=409, Percent_Identity=61.3691931540342, Blast_Score=515, Evalue=1e-147,
Organism=Escherichia coli, GI87082289, Length=251, Percent_Identity=34.2629482071713, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1787645, Length=243, Percent_Identity=29.2181069958848, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1788660, Length=305, Percent_Identity=30.4918032786885, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081824, Length=162, Percent_Identity=32.0987654320988, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=322, Percent_Identity=35.0931677018634, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI25147481, Length=268, Percent_Identity=30.9701492537313, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320925, Length=414, Percent_Identity=49.2753623188406, Blast_Score=392, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6322116, Length=414, Percent_Identity=49.0338164251208, Blast_Score=391, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6324964, Length=358, Percent_Identity=26.8156424581006, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324055, Length=254, Percent_Identity=25.1968503937008, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6325144, Length=158, Percent_Identity=32.9113924050633, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI19921140, Length=320, Percent_Identity=33.75, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI28574286, Length=273, Percent_Identity=29.6703296703297, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24646446, Length=278, Percent_Identity=32.0143884892086, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24646448, Length=278, Percent_Identity=32.0143884892086, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24646452, Length=278, Percent_Identity=32.0143884892086, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24646450, Length=278, Percent_Identity=32.0143884892086, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI62472511, Length=262, Percent_Identity=32.4427480916031, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI28571528, Length=304, Percent_Identity=27.9605263157895, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI45552429, Length=260, Percent_Identity=27.3076923076923, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI45551003, Length=260, Percent_Identity=27.3076923076923, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24585514, Length=260, Percent_Identity=27.3076923076923, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI28574282, Length=260, Percent_Identity=27.3076923076923, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI28574284, Length=260, Percent_Identity=27.3076923076923, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24585516, Length=294, Percent_Identity=24.4897959183673, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR010771
- InterPro:   IPR016040
- ProDom:   PD147088 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 43343; Mature: 43343

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQRLSVQKDKLNVVLFEGIHASAVEAFRADGYGSVTAVAKALAGEELAQALAHAHFVGI
CCCCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
RSRTRLTAEVLAQAPKLVAVGCFCIGTNQVDLGAAAARGVPVFNAPFSNTRSVAELVIAE
CCCHHHHHHHHHCCCCEEEEEEEEEECCCCCCCHHHHCCCCEECCCCCCHHHHHHHHHHH
TIMLMRGIPARNALQHRGGWMKSAANAWEVRGKTLGIVGYGHIGTQVGVLAEQLGMSVVF
HHHHHCCCCCHHHHHHCCCHHHHCCCHHEECCCEEEEEEECCHHHHHHHHHHHHCCEEEE
HDIETRLPLGNARQLGSLDALLAVADVVSLHVPETPATMNMIAAPQLAAMKAGSFLINAS
EHHHHCCCCCCCHHCCHHHHHHHHHHHHHEECCCCCCCHHECCCCHHHHHCCCCEEEECC
RGTVVDIDALAQALEAGHLLGAAIDVFPVEPEGNDDPFVSPLTRFDNVILTPHIGGSTAE
CCCEEEHHHHHHHHHHCHHHEEEEEEEECCCCCCCCCCCCHHHHCCCEEEECCCCCCCCH
AQANIGREVAAKLIRYSNNGSTVTAVNFPEVSLPEHAGKCRVLHIHRNVPGMLARINERF
HHHHCCHHHHHHHHEECCCCCEEEEEECCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHH
SRAGINIAGQYLQTTPDLGYVVIDVDAAASQVAFDELCSIEGTIRCRVLY
HHCCCCEECHHHHCCCCCCEEEEEECCCHHHHHHHHHHCCCCEEEEEEEC
>Mature Secondary Structure
MNQRLSVQKDKLNVVLFEGIHASAVEAFRADGYGSVTAVAKALAGEELAQALAHAHFVGI
CCCCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
RSRTRLTAEVLAQAPKLVAVGCFCIGTNQVDLGAAAARGVPVFNAPFSNTRSVAELVIAE
CCCHHHHHHHHHCCCCEEEEEEEEEECCCCCCCHHHHCCCCEECCCCCCHHHHHHHHHHH
TIMLMRGIPARNALQHRGGWMKSAANAWEVRGKTLGIVGYGHIGTQVGVLAEQLGMSVVF
HHHHHCCCCCHHHHHHCCCHHHHCCCHHEECCCEEEEEEECCHHHHHHHHHHHHCCEEEE
HDIETRLPLGNARQLGSLDALLAVADVVSLHVPETPATMNMIAAPQLAAMKAGSFLINAS
EHHHHCCCCCCCHHCCHHHHHHHHHHHHHEECCCCCCCHHECCCCHHHHHCCCCEEEECC
RGTVVDIDALAQALEAGHLLGAAIDVFPVEPEGNDDPFVSPLTRFDNVILTPHIGGSTAE
CCCEEEHHHHHHHHHHCHHHEEEEEEEECCCCCCCCCCCCHHHHCCCEEEECCCCCCCCH
AQANIGREVAAKLIRYSNNGSTVTAVNFPEVSLPEHAGKCRVLHIHRNVPGMLARINERF
HHHHCCHHHHHHHHEECCCCCEEEEEECCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHH
SRAGINIAGQYLQTTPDLGYVVIDVDAAASQVAFDELCSIEGTIRCRVLY
HHCCCCEECHHHHCCCCCCEEEEEECCCHHHHHHHHHHCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]