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The map label for this gene is accC2 [H]

Identifier: 119899358

GI number: 119899358

Start: 3377487

End: 3379487

Strand: Reverse

Name: accC2 [H]

Synonym: azo3068

Alternate gene names: 119899358

Gene position: 3379487-3377487 (Counterclockwise)

Preceding gene: 119899359

Following gene: 119899357

Centisome position: 77.23

GC content: 68.62

Gene sequence:

>2001_bases
ATGTTCAACAAGATCCTGATCGCCAACCGCGGTGAAATCGCCTGCCGCGTCATCAAGACGGCCCGCCGCATGGGCATCAA
GACGGTGGCGGTGTATTCCGAGGCGGACGCCAACGCCCGCCATGTGCGGCTGGCCGATGAGGCGGTGCTGATCGGGCCGG
CGGCGGCGCGCGAGAGCTATCTCGTCATCGACCGCATCATCGCCGCGGCCAAGGCCACGGGCGCGCAGGCCATCCATCCG
GGCTACGGCTTCCTGTCGGAAAACGAGGATTTCTGCGAAGCCTGCGAGCGCGAGGGCATCGTCTTCATCGGCCCGCCGGT
TTCGGCGATCCGGGCGATGGGCTCCAAGTCCGAGGCCAAGAAGCTGATGGAGGCGGCGCGCGTGCCGCTCACCCCGGGCT
ACCACGGCGACAACCAGGAACCCGCCTTCCTGCACCGGCAGGCCGATGGCATCGGCTACCCGGTGCTGATCAAGGCCGCG
GCGGGCGGCGGCGGCAAGGGCATGCGGCTGGTGGAGAAGAGCGAGGACTTCATCGACGCGCTGGCCTCCTGCAAGCGCGA
GGCGATCTCCAGCTTTGGCGACGACCATGTGCTGGTCGAGAAGTACATCACCCGCCCGCGCCACATCGAGATCCAGGTGT
TCGGCGACAGCCACGGCAACTGCGTCTACCTCTTCGAGCGCGACTGCTCGGTGCAGCGCCGCCACCAGAAGGTGCTGGAA
GAAGCGCCCGCGCCCGGCATGACGGCCGAACGCCGCGCGGCGATGGGCAAGGCGGCGGTGGAGGCGGCGCGGGCGGTCGG
TTACGTCGGCGCCGGCACGGTGGAGTTCATCGCCAACCAGGACGGCAGCTTCTACTTCATGGAGATGAACACCCGGCTGC
AGGTGGAGCATCCGGTCACCGAGATGATCACCGGGCTGGACCTGGTCGAATGGCAGCTGCGCGTGGCCTCCGGCGAAAAG
CTGCCGCTGGCGCAGGAGCAATTGCAGATCCGCGGCCATGCGCTGGAAGCGCGCATCTACGCCGAAGACCCCGCCAAGGG
CTTTTTGCCTTCCACCGGCAAGCTGGTGCATCTGGCGCCGCCGGCCGAAGGCCTGCATGTGCGGGTGGATACCGGCGTGG
AGGAGGGCGACGAGATCAGCCCGCACTACGACCCGATGATCGCCAAGCTCATCGTCTGGGACATCAACCGCGACCGCGCC
TTGGCCCGCATGCTGCAGGCGCTGGCCGATTACCGGGTGGTGGGCGTCGCCAACAACATCGAGTTCCTGTCCCGCCTCAC
CGCCTGCCCCGCCTTCGCCACCGCCGACCTCGACACCGGCCTGATCGAGCGCGAACGCGCCTATCTCTTCCCGGAAGGCG
ACGCGATTCCCGCCGAAGTCTGGCGGGTCGCCGCGCTCGCCGAACTGCTGCGCGACCGCCGCTACGGCGAAGAAAAGGCG
CAGCGCGGCCGCGATCCGCTGTCGCCCTGGCATGCGCGCGACGGCTGGCGGATGAACGCCTCGGCGCGCCGCAACCTGGT
GTTCCGCGCCGGCGAAGCGCAGCAGACGGTGAGCGTGTCCTACCGCGCCAACGGCTTTGCGCTGACGGTGGACGGCAACA
CGGTGTCCGCCCGCGGCGAACTCAACCCACGCGGCCTGCTGCACGTCGATTTCGATGGCGCCCGCATGGATGCAACGGTG
ATCGCCGCCGGCGAAAAGCGCCACATCTTCCTGCACGGCCGCAGCTGGCAGCTGGCGAGTGTCGATCCGCTGCACCACGC
CGGTGAAGGCGGCGGCGCCGAAGGCGGCCTGCTGGCACCGATGCCGGGCAAGGTGATCGCGCTGCTCGCCGAAGCCGGCG
CCAAGGTGGAGAAGGGCGCGCCGCTGCTGATCTTGGAGGCGATGAAGATGGAACACACGATCACCGCGCCGGCGACGGGG
ACGGTGAAGGGGTTCCGGTTTGCGGTGGGGGATCAGGTCGGGGATGGGGCGGAGTTGGTGGAGTTTGAGGTGGCGGGGTA
A

Upstream 100 bases:

>100_bases
TGAGTCGGCAGCGCTCCCCCGAAAAGCTGTCCCTCACGGAAGGGTGAAGAGCCGCCCCCCCGCGCAACACGAAACAAAAG
AACTGGCTGGAGACAAACCA

Downstream 100 bases:

>100_bases
GAGCGGGCGCTCGGCGGCTAGCGGGTTTTGCCTCCTCTCCGTCACGGAGGTGAAACAGGGGGGGGGCGGCAAGCACCTGT
GGCACCGGATGAGTAATGAA

Product: biotin carboxylase subunit of acetyl-CoA carboxylase

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 666; Mature: 666

Protein sequence:

>666_residues
MFNKILIANRGEIACRVIKTARRMGIKTVAVYSEADANARHVRLADEAVLIGPAAARESYLVIDRIIAAAKATGAQAIHP
GYGFLSENEDFCEACEREGIVFIGPPVSAIRAMGSKSEAKKLMEAARVPLTPGYHGDNQEPAFLHRQADGIGYPVLIKAA
AGGGGKGMRLVEKSEDFIDALASCKREAISSFGDDHVLVEKYITRPRHIEIQVFGDSHGNCVYLFERDCSVQRRHQKVLE
EAPAPGMTAERRAAMGKAAVEAARAVGYVGAGTVEFIANQDGSFYFMEMNTRLQVEHPVTEMITGLDLVEWQLRVASGEK
LPLAQEQLQIRGHALEARIYAEDPAKGFLPSTGKLVHLAPPAEGLHVRVDTGVEEGDEISPHYDPMIAKLIVWDINRDRA
LARMLQALADYRVVGVANNIEFLSRLTACPAFATADLDTGLIERERAYLFPEGDAIPAEVWRVAALAELLRDRRYGEEKA
QRGRDPLSPWHARDGWRMNASARRNLVFRAGEAQQTVSVSYRANGFALTVDGNTVSARGELNPRGLLHVDFDGARMDATV
IAAGEKRHIFLHGRSWQLASVDPLHHAGEGGGAEGGLLAPMPGKVIALLAEAGAKVEKGAPLLILEAMKMEHTITAPATG
TVKGFRFAVGDQVGDGAELVEFEVAG

Sequences:

>Translated_666_residues
MFNKILIANRGEIACRVIKTARRMGIKTVAVYSEADANARHVRLADEAVLIGPAAARESYLVIDRIIAAAKATGAQAIHP
GYGFLSENEDFCEACEREGIVFIGPPVSAIRAMGSKSEAKKLMEAARVPLTPGYHGDNQEPAFLHRQADGIGYPVLIKAA
AGGGGKGMRLVEKSEDFIDALASCKREAISSFGDDHVLVEKYITRPRHIEIQVFGDSHGNCVYLFERDCSVQRRHQKVLE
EAPAPGMTAERRAAMGKAAVEAARAVGYVGAGTVEFIANQDGSFYFMEMNTRLQVEHPVTEMITGLDLVEWQLRVASGEK
LPLAQEQLQIRGHALEARIYAEDPAKGFLPSTGKLVHLAPPAEGLHVRVDTGVEEGDEISPHYDPMIAKLIVWDINRDRA
LARMLQALADYRVVGVANNIEFLSRLTACPAFATADLDTGLIERERAYLFPEGDAIPAEVWRVAALAELLRDRRYGEEKA
QRGRDPLSPWHARDGWRMNASARRNLVFRAGEAQQTVSVSYRANGFALTVDGNTVSARGELNPRGLLHVDFDGARMDATV
IAAGEKRHIFLHGRSWQLASVDPLHHAGEGGGAEGGLLAPMPGKVIALLAEAGAKVEKGAPLLILEAMKMEHTITAPATG
TVKGFRFAVGDQVGDGAELVEFEVAG
>Mature_666_residues
MFNKILIANRGEIACRVIKTARRMGIKTVAVYSEADANARHVRLADEAVLIGPAAARESYLVIDRIIAAAKATGAQAIHP
GYGFLSENEDFCEACEREGIVFIGPPVSAIRAMGSKSEAKKLMEAARVPLTPGYHGDNQEPAFLHRQADGIGYPVLIKAA
AGGGGKGMRLVEKSEDFIDALASCKREAISSFGDDHVLVEKYITRPRHIEIQVFGDSHGNCVYLFERDCSVQRRHQKVLE
EAPAPGMTAERRAAMGKAAVEAARAVGYVGAGTVEFIANQDGSFYFMEMNTRLQVEHPVTEMITGLDLVEWQLRVASGEK
LPLAQEQLQIRGHALEARIYAEDPAKGFLPSTGKLVHLAPPAEGLHVRVDTGVEEGDEISPHYDPMIAKLIVWDINRDRA
LARMLQALADYRVVGVANNIEFLSRLTACPAFATADLDTGLIERERAYLFPEGDAIPAEVWRVAALAELLRDRRYGEEKA
QRGRDPLSPWHARDGWRMNASARRNLVFRAGEAQQTVSVSYRANGFALTVDGNTVSARGELNPRGLLHVDFDGARMDATV
IAAGEKRHIFLHGRSWQLASVDPLHHAGEGGGAEGGLLAPMPGKVIALLAEAGAKVEKGAPLLILEAMKMEHTITAPATG
TVKGFRFAVGDQVGDGAELVEFEVAG

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=667, Percent_Identity=49.3253373313343, Blast_Score=661, Evalue=0.0,
Organism=Homo sapiens, GI65506442, Length=677, Percent_Identity=43.7223042836041, Blast_Score=504, Evalue=1e-142,
Organism=Homo sapiens, GI189095269, Length=677, Percent_Identity=43.7223042836041, Blast_Score=503, Evalue=1e-142,
Organism=Homo sapiens, GI295821183, Length=668, Percent_Identity=43.4131736526946, Blast_Score=483, Evalue=1e-136,
Organism=Homo sapiens, GI106049528, Length=454, Percent_Identity=44.273127753304, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI106049295, Length=454, Percent_Identity=44.273127753304, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI106049292, Length=454, Percent_Identity=44.273127753304, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI38679971, Length=710, Percent_Identity=29.0140845070423, Blast_Score=260, Evalue=3e-69,
Organism=Homo sapiens, GI38679960, Length=710, Percent_Identity=29.0140845070423, Blast_Score=260, Evalue=3e-69,
Organism=Homo sapiens, GI38679977, Length=710, Percent_Identity=29.0140845070423, Blast_Score=260, Evalue=3e-69,
Organism=Homo sapiens, GI38679967, Length=710, Percent_Identity=29.0140845070423, Blast_Score=260, Evalue=3e-69,
Organism=Homo sapiens, GI38679974, Length=710, Percent_Identity=29.0140845070423, Blast_Score=259, Evalue=5e-69,
Organism=Homo sapiens, GI134142062, Length=735, Percent_Identity=28.5714285714286, Blast_Score=244, Evalue=2e-64,
Organism=Escherichia coli, GI1789654, Length=446, Percent_Identity=50, Blast_Score=411, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI71987519, Length=669, Percent_Identity=46.1883408071749, Blast_Score=560, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI17567343, Length=682, Percent_Identity=43.841642228739, Blast_Score=508, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17562816, Length=457, Percent_Identity=46.3894967177243, Blast_Score=371, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI133931226, Length=487, Percent_Identity=29.1581108829569, Blast_Score=198, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI71997163, Length=425, Percent_Identity=31.0588235294118, Blast_Score=188, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI71997168, Length=425, Percent_Identity=31.0588235294118, Blast_Score=188, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6319685, Length=444, Percent_Identity=45.4954954954955, Blast_Score=392, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=42.8571428571429, Blast_Score=335, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=43.75, Blast_Score=333, Evalue=5e-92,
Organism=Saccharomyces cerevisiae, GI6323863, Length=689, Percent_Identity=28.3018867924528, Blast_Score=251, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6324343, Length=511, Percent_Identity=31.7025440313112, Blast_Score=240, Evalue=5e-64,
Organism=Drosophila melanogaster, GI24651757, Length=678, Percent_Identity=48.8200589970501, Blast_Score=625, Evalue=1e-179,
Organism=Drosophila melanogaster, GI24651759, Length=639, Percent_Identity=48.0438184663537, Blast_Score=572, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24652212, Length=453, Percent_Identity=45.2538631346578, Blast_Score=347, Evalue=2e-95,
Organism=Drosophila melanogaster, GI24652210, Length=453, Percent_Identity=45.2538631346578, Blast_Score=347, Evalue=2e-95,
Organism=Drosophila melanogaster, GI24652214, Length=453, Percent_Identity=45.2538631346578, Blast_Score=347, Evalue=2e-95,
Organism=Drosophila melanogaster, GI19921944, Length=453, Percent_Identity=45.2538631346578, Blast_Score=347, Evalue=2e-95,
Organism=Drosophila melanogaster, GI24652216, Length=453, Percent_Identity=45.2538631346578, Blast_Score=347, Evalue=2e-95,
Organism=Drosophila melanogaster, GI281363050, Length=453, Percent_Identity=45.2538631346578, Blast_Score=346, Evalue=3e-95,
Organism=Drosophila melanogaster, GI24652224, Length=453, Percent_Identity=45.2538631346578, Blast_Score=346, Evalue=3e-95,
Organism=Drosophila melanogaster, GI24652222, Length=453, Percent_Identity=45.2538631346578, Blast_Score=346, Evalue=3e-95,
Organism=Drosophila melanogaster, GI24652220, Length=453, Percent_Identity=45.2538631346578, Blast_Score=346, Evalue=3e-95,
Organism=Drosophila melanogaster, GI24652218, Length=453, Percent_Identity=45.2538631346578, Blast_Score=346, Evalue=3e-95,
Organism=Drosophila melanogaster, GI161076407, Length=502, Percent_Identity=31.4741035856574, Blast_Score=235, Evalue=9e-62,
Organism=Drosophila melanogaster, GI24586460, Length=502, Percent_Identity=31.4741035856574, Blast_Score=235, Evalue=9e-62,
Organism=Drosophila melanogaster, GI161076409, Length=502, Percent_Identity=31.4741035856574, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24586458, Length=502, Percent_Identity=31.4741035856574, Blast_Score=234, Evalue=1e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 72194; Mature: 72194

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNKILIANRGEIACRVIKTARRMGIKTVAVYSEADANARHVRLADEAVLIGPAAARESY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCEEEECCHHCCCCH
LVIDRIIAAAKATGAQAIHPGYGFLSENEDFCEACEREGIVFIGPPVSAIRAMGSKSEAK
HHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHCCEEEECCCHHHHHHCCCHHHHH
KLMEAARVPLTPGYHGDNQEPAFLHRQADGIGYPVLIKAAAGGGGKGMRLVEKSEDFIDA
HHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEECCCCCCCCEEECCCHHHHHH
LASCKREAISSFGDDHVLVEKYITRPRHIEIQVFGDSHGNCVYLFERDCSVQRRHQKVLE
HHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEEEEECCCCCEEEEEECCCCHHHHHHHHHH
EAPAPGMTAERRAAMGKAAVEAARAVGYVGAGTVEFIANQDGSFYFMEMNTRLQVEHPVT
HCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCEEEECCCHH
EMITGLDLVEWQLRVASGEKLPLAQEQLQIRGHALEARIYAEDPAKGFLPSTGKLVHLAP
HHHHCCCEEEEEEEECCCCCCCCHHHHHHHCCEEEEEEEEECCCCCCCCCCCCCEEEECC
PAEGLHVRVDTGVEEGDEISPHYDPMIAKLIVWDINRDRALARMLQALADYRVVGVANNI
CCCCEEEEEECCCCCCCCCCCCCCHHEEEEEEEECCCCHHHHHHHHHHHCEEEEEEECCH
EFLSRLTACPAFATADLDTGLIERERAYLFPEGDAIPAEVWRVAALAELLRDRRYGEEKA
HHHHHHHCCCCCEECCCCCCHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHH
QRGRDPLSPWHARDGWRMNASARRNLVFRAGEAQQTVSVSYRANGFALTVDGNTVSARGE
HCCCCCCCCCCCCCCCEECCHHHCCEEEECCCCCEEEEEEEECCCEEEEECCCEEEECCC
LNPRGLLHVDFDGARMDATVIAAGEKRHIFLHGRSWQLASVDPLHHAGEGGGAEGGLLAP
CCCCEEEEEECCCCEECEEEEECCCCEEEEEECCCEEECCCCCHHHCCCCCCCCCCEECC
MPGKVIALLAEAGAKVEKGAPLLILEAMKMEHTITAPATGTVKGFRFAVGDQVGDGAELV
CCCHHHHHHHHCCCCCCCCCCEEEEEEHHHCEEEECCCCCCCCCEEEEECCCCCCCCEEE
EFEVAG
EEEECC
>Mature Secondary Structure
MFNKILIANRGEIACRVIKTARRMGIKTVAVYSEADANARHVRLADEAVLIGPAAARESY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCEEEECCHHCCCCH
LVIDRIIAAAKATGAQAIHPGYGFLSENEDFCEACEREGIVFIGPPVSAIRAMGSKSEAK
HHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHCCEEEECCCHHHHHHCCCHHHHH
KLMEAARVPLTPGYHGDNQEPAFLHRQADGIGYPVLIKAAAGGGGKGMRLVEKSEDFIDA
HHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEECCCCCCCCEEECCCHHHHHH
LASCKREAISSFGDDHVLVEKYITRPRHIEIQVFGDSHGNCVYLFERDCSVQRRHQKVLE
HHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEEEEECCCCCEEEEEECCCCHHHHHHHHHH
EAPAPGMTAERRAAMGKAAVEAARAVGYVGAGTVEFIANQDGSFYFMEMNTRLQVEHPVT
HCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCEEEECCCHH
EMITGLDLVEWQLRVASGEKLPLAQEQLQIRGHALEARIYAEDPAKGFLPSTGKLVHLAP
HHHHCCCEEEEEEEECCCCCCCCHHHHHHHCCEEEEEEEEECCCCCCCCCCCCCEEEECC
PAEGLHVRVDTGVEEGDEISPHYDPMIAKLIVWDINRDRALARMLQALADYRVVGVANNI
CCCCEEEEEECCCCCCCCCCCCCCHHEEEEEEEECCCCHHHHHHHHHHHCEEEEEEECCH
EFLSRLTACPAFATADLDTGLIERERAYLFPEGDAIPAEVWRVAALAELLRDRRYGEEKA
HHHHHHHCCCCCEECCCCCCHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHH
QRGRDPLSPWHARDGWRMNASARRNLVFRAGEAQQTVSVSYRANGFALTVDGNTVSARGE
HCCCCCCCCCCCCCCCEECCHHHCCEEEECCCCCEEEEEEEECCCEEEEECCCEEEECCC
LNPRGLLHVDFDGARMDATVIAAGEKRHIFLHGRSWQLASVDPLHHAGEGGGAEGGLLAP
CCCCEEEEEECCCCEECEEEEECCCCEEEEEECCCEEECCCCCHHHCCCCCCCCCCEECC
MPGKVIALLAEAGAKVEKGAPLLILEAMKMEHTITAPATGTVKGFRFAVGDQVGDGAELV
CCCHHHHHHHHCCCCCCCCCCEEEEEEHHHCEEEECCCCCCCCCEEEEECCCCCCCCEEE
EFEVAG
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]