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The map label for this gene is paaG5 [C]

Identifier: 119899359

GI number: 119899359

Start: 3379877

End: 3380665

Strand: Reverse

Name: paaG5 [C]

Synonym: azo3069

Alternate gene names: 119899359

Gene position: 3380665-3379877 (Counterclockwise)

Preceding gene: 119899360

Following gene: 119899358

Centisome position: 77.25

GC content: 70.85

Gene sequence:

>789_bases
ATGTACGAAACCCTGGAAATCCTGCGCGACGGCGGCGTCGCCACCGTGTGGATGAACCGCCCCGAGGTGCACAACGCCTT
CAACGCGCAGCTCATCGCCGACCTCACCGCCGCCTTCCGCGCGCTGGACGCCGACGACGGCGTGCGCGTGGTGGTACTGG
CCGGGCGTGGCAAAAGCTTTTCCGCCGGCGCCGACCTCAACTGGATGAAGGCGGCCGGCGCGGCCAGCGTGGTAGACAAC
CTCGCCGACGCGCGCAAGCTCGCCGGCATGCTGCGGGTGATCGCCGAAATGACCAAGCCGACCATCGCCCGCGTGCATGG
CGCGGCGCTGGGCGGCGGCATGGGGCTGGCATCGGCCTGCGACATCTGCGTGGCGGGTGACAAGGCGGTGTTTGCGACCT
CGGAAGTGCGCTTCGGGATCATCCCCTCGGCGATCAGTCCCTATGTGCTCCGCGCCATCGGCGAACGCCAGGCGTATCGC
TACTTCCAGACCGCGGAGCGGATTTCCGCTGCGCGCGCGGTGGAACTGGGGCTGGCGCACGAGCTGGCCGAGGGCGACGC
GCTGGATGCCAAGGTGGCGGAGATCGTTGGCGCGCTGCTGCAGGGCGGGCCGAAGTCGCAGGCCGCGGCGAAGGCGCTGA
TCCGCGCGGTGGCGAACCGGCCGGTGGCGGATGCGGTGGTGGAGGACACGGCGCGGCGGATCGCGGAGTTGAGAGCGACG
CCGGAGGCGCGGGAAGGGCTGGATGCGTTTTTGGGCAAGCGGCCGGCGGGGTGGGTGCCGGGGGGTTGA

Upstream 100 bases:

>100_bases
CGCAGACGCGCCGCATCCTCGGCTTGAGCCTGTCCGCGGCCTTGAACGCGCCCATCCAGCCGACCAGGTTCGGCGTGTTC
CGGATGTAAGGGGAGGCGAC

Downstream 100 bases:

>100_bases
GAGCGACAGCGCAGCCGGTTGAGCGCGCGCGACGCGGGTTAGAAGGTCCCTTCCCTTTCAAGGGGAAGGACAGGATGGGG
ATGGGGTTGGGTTGAGCGCC

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: 3-hydroxypropionyl-CoA dehydratase [H]

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MYETLEILRDGGVATVWMNRPEVHNAFNAQLIADLTAAFRALDADDGVRVVVLAGRGKSFSAGADLNWMKAAGAASVVDN
LADARKLAGMLRVIAEMTKPTIARVHGAALGGGMGLASACDICVAGDKAVFATSEVRFGIIPSAISPYVLRAIGERQAYR
YFQTAERISAARAVELGLAHELAEGDALDAKVAEIVGALLQGGPKSQAAAKALIRAVANRPVADAVVEDTARRIAELRAT
PEAREGLDAFLGKRPAGWVPGG

Sequences:

>Translated_262_residues
MYETLEILRDGGVATVWMNRPEVHNAFNAQLIADLTAAFRALDADDGVRVVVLAGRGKSFSAGADLNWMKAAGAASVVDN
LADARKLAGMLRVIAEMTKPTIARVHGAALGGGMGLASACDICVAGDKAVFATSEVRFGIIPSAISPYVLRAIGERQAYR
YFQTAERISAARAVELGLAHELAEGDALDAKVAEIVGALLQGGPKSQAAAKALIRAVANRPVADAVVEDTARRIAELRAT
PEAREGLDAFLGKRPAGWVPGG
>Mature_262_residues
MYETLEILRDGGVATVWMNRPEVHNAFNAQLIADLTAAFRALDADDGVRVVVLAGRGKSFSAGADLNWMKAAGAASVVDN
LADARKLAGMLRVIAEMTKPTIARVHGAALGGGMGLASACDICVAGDKAVFATSEVRFGIIPSAISPYVLRAIGERQAYR
YFQTAERISAARAVELGLAHELAEGDALDAKVAEIVGALLQGGPKSQAAAKALIRAVANRPVADAVVEDTARRIAELRAT
PEAREGLDAFLGKRPAGWVPGG

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the reversible dehydration of 3-hydroxypropionyl-CoA to form acryloyl- CoA, and the reversible dehydration of (S)-3-hydroxybutyryl-CoA to form crot

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=259, Percent_Identity=31.6602316602317, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI45643119, Length=219, Percent_Identity=26.4840182648402, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI260275230, Length=219, Percent_Identity=26.4840182648402, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI260274832, Length=219, Percent_Identity=26.4840182648402, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI70995211, Length=148, Percent_Identity=34.4594594594595, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI157694516, Length=219, Percent_Identity=26.4840182648402, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI213417737, Length=219, Percent_Identity=26.4840182648402, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI20127408, Length=180, Percent_Identity=30.5555555555556, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI31542718, Length=249, Percent_Identity=25.7028112449799, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI37594469, Length=181, Percent_Identity=24.3093922651934, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI37594471, Length=181, Percent_Identity=24.3093922651934, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787659, Length=253, Percent_Identity=31.6205533596838, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI221142681, Length=265, Percent_Identity=30.188679245283, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788597, Length=246, Percent_Identity=26.4227642276423, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI87082183, Length=265, Percent_Identity=24.9056603773585, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787660, Length=252, Percent_Identity=29.7619047619048, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788682, Length=190, Percent_Identity=29.4736842105263, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17554946, Length=255, Percent_Identity=31.7647058823529, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI25145438, Length=268, Percent_Identity=30.2238805970149, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17540306, Length=253, Percent_Identity=26.8774703557312, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17535521, Length=254, Percent_Identity=25.9842519685039, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17540714, Length=211, Percent_Identity=31.2796208530806, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17549921, Length=210, Percent_Identity=29.0476190476191, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI25144276, Length=148, Percent_Identity=33.1081081081081, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17508951, Length=148, Percent_Identity=33.1081081081081, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17508953, Length=148, Percent_Identity=33.1081081081081, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17534483, Length=153, Percent_Identity=32.0261437908497, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17558304, Length=183, Percent_Identity=30.6010928961749, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17536985, Length=143, Percent_Identity=30.7692307692308, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17560910, Length=199, Percent_Identity=28.1407035175879, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI20129971, Length=270, Percent_Identity=29.6296296296296, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24653477, Length=270, Percent_Identity=29.6296296296296, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24653139, Length=250, Percent_Identity=30.4, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24654903, Length=253, Percent_Identity=22.1343873517787, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24650670, Length=187, Percent_Identity=29.4117647058824, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI19921018, Length=216, Percent_Identity=28.2407407407407, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19920382, Length=138, Percent_Identity=32.6086956521739, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24583165, Length=251, Percent_Identity=23.9043824701195, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.116 [H]

Molecular weight: Translated: 27330; Mature: 27330

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYETLEILRDGGVATVWMNRPEVHNAFNAQLIADLTAAFRALDADDGVRVVVLAGRGKSF
CCHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCC
SAGADLNWMKAAGAASVVDNLADARKLAGMLRVIAEMTKPTIARVHGAALGGGMGLASAC
CCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCHHHHC
DICVAGDKAVFATSEVRFGIIPSAISPYVLRAIGERQAYRYFQTAERISAARAVELGLAH
CEEECCCCEEEEECCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELAEGDALDAKVAEIVGALLQGGPKSQAAAKALIRAVANRPVADAVVEDTARRIAELRAT
HHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
PEAREGLDAFLGKRPAGWVPGG
CHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MYETLEILRDGGVATVWMNRPEVHNAFNAQLIADLTAAFRALDADDGVRVVVLAGRGKSF
CCHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCC
SAGADLNWMKAAGAASVVDNLADARKLAGMLRVIAEMTKPTIARVHGAALGGGMGLASAC
CCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCHHHHC
DICVAGDKAVFATSEVRFGIIPSAISPYVLRAIGERQAYRYFQTAERISAARAVELGLAH
CEEECCCCEEEEECCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELAEGDALDAKVAEIVGALLQGGPKSQAAAKALIRAVANRPVADAVVEDTARRIAELRAT
HHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
PEAREGLDAFLGKRPAGWVPGG
CHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA