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The map label for this gene is strD [H]

Identifier: 119899179

GI number: 119899179

Start: 3171570

End: 3172298

Strand: Direct

Name: strD [H]

Synonym: azo2889

Alternate gene names: 119899179

Gene position: 3171570-3172298 (Clockwise)

Preceding gene: 119899178

Following gene: 119899180

Centisome position: 72.48

GC content: 72.43

Gene sequence:

>729_bases
ATGCGCGCGATGATCTTCGCCGCCGGCCGCGGCGAACGCATGCGGCCGCTGACCGACACCTGTCCCAAGCCGCTGCTCGC
GGTCGGCGGCAAGCCGCTGATCGCGTGGCAGATCGAGGCGCTGGCGCGCGCCGGCATCGCCGACATCGTCATCAACCACG
CCTGGCTGGGCGAGCAGATCGAAGCCACCCTCGGCGACGGCGGCCGCTTCGGCGTGCGCCTGCATTACTCGGCTGAGGGC
GCGGCGCTGGAAACCGCCGGCGGCATCGCCCAGGCGCTGCCGCTGCTCCGTGACCGGCCGGACGCCGCAGGCGAGGTCTT
CCTCGCCGTCTCCGGCGACATCTACTGCGACTACGACTACCGCCGCCTGCTGCCGCGCGCCGCAGCGATGGCGACCAGCC
CGGCGCCGCTGATGCACCTGGTGATGGTACCGAACCCGCCCTTCCATCCCGGGGGCGACTTCGCGCTCGGCGCAGACGGC
CGCCTCGCGCTCGACGGCCCCGCGCGCCTCACCTTCGGCAACATCGGCCTCTACGACACCCGGCTCTTCGCCGACATCCG
CGTCGGCGACAAAGTGGCGATGACACCCTACTACCGCGCCGCCATCGCGGCCGGCCACGCCAGCGGCGAACGCTTCGACG
GCCGCTGGGAAAACGTCGGCACCCCCGCCCAGTTGGCCGCACTCGACCGCAGCCTCGCGGTCGAACAGGCTCCCCCGGCC
ATGAGATAA

Upstream 100 bases:

>100_bases
GGCGAACTCGGGCCGCTGCTGAAGCTGCTCGACCGCCTCGACCCGGAGCAGGTCGAGTTCGGCTACACCTTCTGACCCAC
CCTCGCACCAGGACGACCCG

Downstream 100 bases:

>100_bases
TTCCGCCATGAACGCGCCCACCGCTTCCAGCCTGCTCGACATCACGCCCTTCGCCGCCCGCCGCCAGCGCCTGCTCACGC
GCATGGCCGAAGCCGGCGGC

Product: nucleotidyltransferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MRAMIFAAGRGERMRPLTDTCPKPLLAVGGKPLIAWQIEALARAGIADIVINHAWLGEQIEATLGDGGRFGVRLHYSAEG
AALETAGGIAQALPLLRDRPDAAGEVFLAVSGDIYCDYDYRRLLPRAAAMATSPAPLMHLVMVPNPPFHPGGDFALGADG
RLALDGPARLTFGNIGLYDTRLFADIRVGDKVAMTPYYRAAIAAGHASGERFDGRWENVGTPAQLAALDRSLAVEQAPPA
MR

Sequences:

>Translated_242_residues
MRAMIFAAGRGERMRPLTDTCPKPLLAVGGKPLIAWQIEALARAGIADIVINHAWLGEQIEATLGDGGRFGVRLHYSAEG
AALETAGGIAQALPLLRDRPDAAGEVFLAVSGDIYCDYDYRRLLPRAAAMATSPAPLMHLVMVPNPPFHPGGDFALGADG
RLALDGPARLTFGNIGLYDTRLFADIRVGDKVAMTPYYRAAIAAGHASGERFDGRWENVGTPAQLAALDRSLAVEQAPPA
MR
>Mature_242_residues
MRAMIFAAGRGERMRPLTDTCPKPLLAVGGKPLIAWQIEALARAGIADIVINHAWLGEQIEATLGDGGRFGVRLHYSAEG
AALETAGGIAQALPLLRDRPDAAGEVFLAVSGDIYCDYDYRRLLPRAAAMATSPAPLMHLVMVPNPPFHPGGDFALGADG
RLALDGPARLTFGNIGLYDTRLFADIRVGDKVAMTPYYRAAIAAGHASGERFDGRWENVGTPAQLAALDRSLAVEQAPPA
MR

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=125, Percent_Identity=33.6, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI11761619, Length=125, Percent_Identity=33.6, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI133931050, Length=126, Percent_Identity=36.5079365079365, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320148, Length=124, Percent_Identity=37.9032258064516, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21355443, Length=124, Percent_Identity=36.2903225806452, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24644084, Length=124, Percent_Identity=36.2903225806452, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 25742; Mature: 25742

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAMIFAAGRGERMRPLTDTCPKPLLAVGGKPLIAWQIEALARAGIADIVINHAWLGEQI
CCEEEEECCCCCCCCCCHHHCCCCHHHHCCCEEEEEEHHHHHHCCHHHHHEECCCCCCEE
EATLGDGGRFGVRLHYSAEGAALETAGGIAQALPLLRDRPDAAGEVFLAVSGDIYCDYDY
EEEECCCCEEEEEEEECCCCCEEECCCCHHHHHHHHHCCCCCCCEEEEEECCCEEECCHH
RRLLPRAAAMATSPAPLMHLVMVPNPPFHPGGDFALGADGRLALDGPARLTFGNIGLYDT
HHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEECCCCEEEECCCCEEEECCCCEEEE
RLFADIRVGDKVAMTPYYRAAIAAGHASGERFDGRWENVGTPAQLAALDRSLAVEQAPPA
EEEEEEEECCEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
MR
CC
>Mature Secondary Structure
MRAMIFAAGRGERMRPLTDTCPKPLLAVGGKPLIAWQIEALARAGIADIVINHAWLGEQI
CCEEEEECCCCCCCCCCHHHCCCCHHHHCCCEEEEEEHHHHHHCCHHHHHEECCCCCCEE
EATLGDGGRFGVRLHYSAEGAALETAGGIAQALPLLRDRPDAAGEVFLAVSGDIYCDYDY
EEEECCCCEEEEEEEECCCCCEEECCCCHHHHHHHHHCCCCCCCEEEEEECCCEEECCHH
RRLLPRAAAMATSPAPLMHLVMVPNPPFHPGGDFALGADGRLALDGPARLTFGNIGLYDT
HHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEECCCCEEEECCCCEEEECCCCEEEE
RLFADIRVGDKVAMTPYYRAAIAAGHASGERFDGRWENVGTPAQLAALDRSLAVEQAPPA
EEEEEEEECCEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
MR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]