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The map label for this gene is pepP [H]

Identifier: 119899180

GI number: 119899180

Start: 3172306

End: 3173652

Strand: Direct

Name: pepP [H]

Synonym: azo2890

Alternate gene names: 119899180

Gene position: 3172306-3173652 (Clockwise)

Preceding gene: 119899179

Following gene: 119899181

Centisome position: 72.49

GC content: 68.97

Gene sequence:

>1347_bases
ATGAACGCGCCCACCGCTTCCAGCCTGCTCGACATCACGCCCTTCGCCGCCCGCCGCCAGCGCCTGCTCACGCGCATGGC
CGAAGCCGGCGGCGGCGTCGCGATCCTGCCCACCGCGCCGGAAGTCGCGCGCAACCGCGACACCCACTACCCCTACCGCC
ACGACAGCTACTTCTATTACCTCAGCGGTTTCCGCGAGCCGGGCGCGGTACTGGTGCTGGTGGCCGGCGAGACGCCGAAG
CAGATCCTGTTCTGTCGCGAGAAGGACGAGGAACGCGAGATCTGGGACGGTTTCCGCTACGGTCCCGACGCTGCCCGCGA
GGTATTCGGTTTCGACGAAGCCTGGACGCTGGGCGAATTCGACCGCCGGCTGGCCGAACTGCTCGCCAACCAGCCGCTGA
TGTGGTTCAGCCTCGGCCACGACGCCGACTGGGATGCCCGCATCACCCGCGGCCTCAACGCGGTGCGCGCCAATGCCCGC
ACCGGCATCGTGCCGCCGCATTCGGTGCGTGACCTGCGCGCCGAACTCGACGAAATGCGGCTGGTCAAGGACGCCTACGA
GATCGACATCATGCGGCGCGCCGGGCGCATTTCGGCCGAGGCCCACTGCCGCGCGATGCGCGCGACCCGCCCGGGCTGCC
ACGAATACGAGATCGAGGCCGAGCTGCTGCATCATTTCCGCCGCAACGGCAGCCAGTTTCCCGCCTACACCTCCATCGTC
GCCGCCGGCGCCAACGCCTGCATCCTGCACTACGTCGAGAATGACCAGCGGATCGCCGACGGCGATCTGGTGCTGATCGA
CGCCGGCTGCGAACTCGACGGCTACGCCTCCGACATCACCCGCAGCTTCCCGGCAAACGGCCGCTTCAGCGGCCCGCAAC
GCGCGGTGTACGAACTGGTGCTGGCGGCGCAGCACGCGGCGCGCGCAACCATCCGCCCCGGCGCCCACTGGAACGCGCCG
CACGAGGCGGCAGTCAAGGTGCTCGCGCAGGGCATGCTCGACCTCAAGCTGCTCAACGGTTCGCTCGATGCAGTCCTGGA
GAACGGCGACTACCGCCGCTTCTACATGCACCGCACCGGCCACTGGCTGGGCATGGATGTGCACGACGCCGGCGAGTACA
AGCTGGGCGGCGAGTGGCGCCCGCTCGAACCCGGCATGGTGCTCACCGTCGAGCCGGGCTGTTACATCCGCCCCGCCGCC
GACGTGCCGGAAACCTTCTGGAACATCGGCATCCGCATCGAGGACGACGCGCTGGTCACCGCCGACGGCTGCGAATACCT
CACCGAAGGCGTACCGCGCGAGGCGGCGGACATCGAAGCCCTGATGCGCGACGCCCATGCAGCCTGA

Upstream 100 bases:

>100_bases
GACGGCCGCTGGGAAAACGTCGGCACCCCCGCCCAGTTGGCCGCACTCGACCGCAGCCTCGCGGTCGAACAGGCTCCCCC
GGCCATGAGATAATTCCGCC

Downstream 100 bases:

>100_bases
CCGGGTCGACCTGCTGATCGTCGGCGCCGGCCCGGTGGGGCTGGCCCTGGCGCTGGCTCTGCGCGACAGCGGCTTGCGCA
TCGCCCTGGCGGACGCCCGC

Product: Xaa-Pro aminopeptidase

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MNAPTASSLLDITPFAARRQRLLTRMAEAGGGVAILPTAPEVARNRDTHYPYRHDSYFYYLSGFREPGAVLVLVAGETPK
QILFCREKDEEREIWDGFRYGPDAAREVFGFDEAWTLGEFDRRLAELLANQPLMWFSLGHDADWDARITRGLNAVRANAR
TGIVPPHSVRDLRAELDEMRLVKDAYEIDIMRRAGRISAEAHCRAMRATRPGCHEYEIEAELLHHFRRNGSQFPAYTSIV
AAGANACILHYVENDQRIADGDLVLIDAGCELDGYASDITRSFPANGRFSGPQRAVYELVLAAQHAARATIRPGAHWNAP
HEAAVKVLAQGMLDLKLLNGSLDAVLENGDYRRFYMHRTGHWLGMDVHDAGEYKLGGEWRPLEPGMVLTVEPGCYIRPAA
DVPETFWNIGIRIEDDALVTADGCEYLTEGVPREAADIEALMRDAHAA

Sequences:

>Translated_448_residues
MNAPTASSLLDITPFAARRQRLLTRMAEAGGGVAILPTAPEVARNRDTHYPYRHDSYFYYLSGFREPGAVLVLVAGETPK
QILFCREKDEEREIWDGFRYGPDAAREVFGFDEAWTLGEFDRRLAELLANQPLMWFSLGHDADWDARITRGLNAVRANAR
TGIVPPHSVRDLRAELDEMRLVKDAYEIDIMRRAGRISAEAHCRAMRATRPGCHEYEIEAELLHHFRRNGSQFPAYTSIV
AAGANACILHYVENDQRIADGDLVLIDAGCELDGYASDITRSFPANGRFSGPQRAVYELVLAAQHAARATIRPGAHWNAP
HEAAVKVLAQGMLDLKLLNGSLDAVLENGDYRRFYMHRTGHWLGMDVHDAGEYKLGGEWRPLEPGMVLTVEPGCYIRPAA
DVPETFWNIGIRIEDDALVTADGCEYLTEGVPREAADIEALMRDAHAA
>Mature_448_residues
MNAPTASSLLDITPFAARRQRLLTRMAEAGGGVAILPTAPEVARNRDTHYPYRHDSYFYYLSGFREPGAVLVLVAGETPK
QILFCREKDEEREIWDGFRYGPDAAREVFGFDEAWTLGEFDRRLAELLANQPLMWFSLGHDADWDARITRGLNAVRANAR
TGIVPPHSVRDLRAELDEMRLVKDAYEIDIMRRAGRISAEAHCRAMRATRPGCHEYEIEAELLHHFRRNGSQFPAYTSIV
AAGANACILHYVENDQRIADGDLVLIDAGCELDGYASDITRSFPANGRFSGPQRAVYELVLAAQHAARATIRPGAHWNAP
HEAAVKVLAQGMLDLKLLNGSLDAVLENGDYRRFYMHRTGHWLGMDVHDAGEYKLGGEWRPLEPGMVLTVEPGCYIRPAA
DVPETFWNIGIRIEDDALVTADGCEYLTEGVPREAADIEALMRDAHAA

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=448, Percent_Identity=34.375, Blast_Score=262, Evalue=4e-70,
Organism=Homo sapiens, GI149589008, Length=474, Percent_Identity=33.7552742616034, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI260593665, Length=305, Percent_Identity=38.6885245901639, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI260593663, Length=478, Percent_Identity=30.1255230125523, Blast_Score=169, Evalue=4e-42,
Organism=Escherichia coli, GI1789275, Length=430, Percent_Identity=44.8837209302326, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI1788728, Length=255, Percent_Identity=32.156862745098, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1790282, Length=282, Percent_Identity=29.4326241134752, Blast_Score=93, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17508215, Length=476, Percent_Identity=31.9327731092437, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI71989583, Length=369, Percent_Identity=28.9972899728997, Blast_Score=129, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6321118, Length=427, Percent_Identity=34.6604215456674, Blast_Score=214, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6320922, Length=410, Percent_Identity=29.2682926829268, Blast_Score=201, Evalue=2e-52,
Organism=Drosophila melanogaster, GI19920384, Length=456, Percent_Identity=33.9912280701754, Blast_Score=228, Evalue=8e-60,
Organism=Drosophila melanogaster, GI21357079, Length=436, Percent_Identity=34.1743119266055, Blast_Score=213, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 50015; Mature: 50015

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPTASSLLDITPFAARRQRLLTRMAEAGGGVAILPTAPEVARNRDTHYPYRHDSYFYY
CCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHCCCCCCCCCCCCCEEEE
LSGFREPGAVLVLVAGETPKQILFCREKDEEREIWDGFRYGPDAAREVFGFDEAWTLGEF
EECCCCCCEEEEEEECCCCCCEEEECCCCCHHHHHCCCCCCHHHHHHHHCCCCCCCHHHH
DRRLAELLANQPLMWFSLGHDADWDARITRGLNAVRANARTGIVPPHSVRDLRAELDEMR
HHHHHHHHHCCCEEEEECCCCCCCCHHHHHCHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
LVKDAYEIDIMRRAGRISAEAHCRAMRATRPGCHEYEIEAELLHHFRRNGSQFPAYTSIV
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHCCCCCCHHHHHH
AAGANACILHYVENDQRIADGDLVLIDAGCELDGYASDITRSFPANGRFSGPQRAVYELV
HCCCCEEEEEEECCCCEEECCCEEEEECCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHH
LAAQHAARATIRPGAHWNAPHEAAVKVLAQGMLDLKLLNGSLDAVLENGDYRRFYMHRTG
HHHHHHHHCEECCCCCCCCCHHHHHHHHHHHHHEEEEECCCCEEEEECCCEEEEEEEECC
HWLGMDVHDAGEYKLGGEWRPLEPGMVLTVEPGCYIRPAADVPETFWNIGIRIEDDALVT
CEEEEEECCCCCEEECCCCCCCCCCEEEEECCCCEECCCCCCCHHHHHCCEEECCCCEEE
ADGCEYLTEGVPREAADIEALMRDAHAA
ECCHHHHHCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MNAPTASSLLDITPFAARRQRLLTRMAEAGGGVAILPTAPEVARNRDTHYPYRHDSYFYY
CCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHCCCCCCCCCCCCCEEEE
LSGFREPGAVLVLVAGETPKQILFCREKDEEREIWDGFRYGPDAAREVFGFDEAWTLGEF
EECCCCCCEEEEEEECCCCCCEEEECCCCCHHHHHCCCCCCHHHHHHHHCCCCCCCHHHH
DRRLAELLANQPLMWFSLGHDADWDARITRGLNAVRANARTGIVPPHSVRDLRAELDEMR
HHHHHHHHHCCCEEEEECCCCCCCCHHHHHCHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
LVKDAYEIDIMRRAGRISAEAHCRAMRATRPGCHEYEIEAELLHHFRRNGSQFPAYTSIV
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHCCCCCCHHHHHH
AAGANACILHYVENDQRIADGDLVLIDAGCELDGYASDITRSFPANGRFSGPQRAVYELV
HCCCCEEEEEEECCCCEEECCCEEEEECCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHH
LAAQHAARATIRPGAHWNAPHEAAVKVLAQGMLDLKLLNGSLDAVLENGDYRRFYMHRTG
HHHHHHHHCEECCCCCCCCCHHHHHHHHHHHHHEEEEECCCCEEEEECCCEEEEEEEECC
HWLGMDVHDAGEYKLGGEWRPLEPGMVLTVEPGCYIRPAADVPETFWNIGIRIEDDALVT
CEEEEEECCCCCEEECCCCCCCCCCEEEEECCCCEECCCCCCCHHHHHCCEEECCCCEEE
ADGCEYLTEGVPREAADIEALMRDAHAA
ECCHHHHHCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]