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The map label for this gene is degP [H]

Identifier: 119899153

GI number: 119899153

Start: 3143481

End: 3144263

Strand: Reverse

Name: degP [H]

Synonym: azo2863

Alternate gene names: 119899153

Gene position: 3144263-3143481 (Counterclockwise)

Preceding gene: 119899157

Following gene: 119899152

Centisome position: 71.85

GC content: 71.39

Gene sequence:

>783_bases
GTGGCCACGCTGATTGCGTGCGCGCTGCTGCTCGCGTTCGGGCTCGGCACCTACCACGCGCTGCTGCCGCCCCCGCCGGC
GCTGAGTCCGGCCCAGGTGGAGGCGGTGGTGGACAAGGTCATCGTGCACAAGTCGCTCACCGCCCCGGCGGCGCGCGCCT
TTCGCGCGATCGGTCCGTCGGTGGTGCGGGTGCGCGGCTACGGCCATCCGCACAAGGGCAAGGGCAAGGACAAGGGCGAC
GACGAGGCGCTCAGCATCGGTTCGGGCGTGGTGGTGGTCGACCGCGGCGTGATCCTGACCAGCCTGCATGTGGTGGCGGG
TTCGCCGCGGCTGAAGGTGACCTTTGCCAGCGGACTGGAATCCGAGGCCGAGCTGGTGGGCGCGCGCCCGGACCAGGACC
TGGCGGTGATCCAGGCGGCGCGCATTCCCGACGACCTCGTCGCCGCGACCATGCGTTCCAGCAACGACCTCGCGCTCGGC
CAGCCGGTGGTGGCGGTCGGCTTTCCGTTCGACGTCGGCCTGACCGTGACCGAGGGCGTGGTCTCCGGCCTCGGGCGCGA
ATTCCGCACGCCCGGCGGGCGCATGCCGCTGCGCGACCTCATCCAGTTCGACGCCGCGGTCAATCCCGGCAGCTCCGGCG
GGCCACTGGTCACCATCGACGGCGAGGTGGTCGGCATCGTCACCGGCATCCTCAATCCCACCGACGAGGGCTTCTTCGTC
GGCATCGGCTTTGCAGTGCCCATCGAAAGCGCCGCCGGCGCCGCCGGCATCTCGCCGTTCTAG

Upstream 100 bases:

>100_bases
CGCCCCCGCGGCGGCGCAACCCGGCCTGCCCTTGGCCGCTTCAACGCCTCCGCCTGCGGCGCAAAAGCCGGTCCGCCCGC
CCTGGCGGCGTCATCCCCAT

Downstream 100 bases:

>100_bases
CCGCATCCATCACCGACAGGGGGACGCATGAGCACCAACAACAGGGATAGCGATCACGTGGAAGTGGCGGCCTTGATGGA
GCGGGTGCTCTACGAGGTCA

Product: putative serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MATLIACALLLAFGLGTYHALLPPPPALSPAQVEAVVDKVIVHKSLTAPAARAFRAIGPSVVRVRGYGHPHKGKGKDKGD
DEALSIGSGVVVVDRGVILTSLHVVAGSPRLKVTFASGLESEAELVGARPDQDLAVIQAARIPDDLVAATMRSSNDLALG
QPVVAVGFPFDVGLTVTEGVVSGLGREFRTPGGRMPLRDLIQFDAAVNPGSSGGPLVTIDGEVVGIVTGILNPTDEGFFV
GIGFAVPIESAAGAAGISPF

Sequences:

>Translated_260_residues
MATLIACALLLAFGLGTYHALLPPPPALSPAQVEAVVDKVIVHKSLTAPAARAFRAIGPSVVRVRGYGHPHKGKGKDKGD
DEALSIGSGVVVVDRGVILTSLHVVAGSPRLKVTFASGLESEAELVGARPDQDLAVIQAARIPDDLVAATMRSSNDLALG
QPVVAVGFPFDVGLTVTEGVVSGLGREFRTPGGRMPLRDLIQFDAAVNPGSSGGPLVTIDGEVVGIVTGILNPTDEGFFV
GIGFAVPIESAAGAAGISPF
>Mature_259_residues
ATLIACALLLAFGLGTYHALLPPPPALSPAQVEAVVDKVIVHKSLTAPAARAFRAIGPSVVRVRGYGHPHKGKGKDKGDD
EALSIGSGVVVVDRGVILTSLHVVAGSPRLKVTFASGLESEAELVGARPDQDLAVIQAARIPDDLVAATMRSSNDLALGQ
PVVAVGFPFDVGLTVTEGVVSGLGREFRTPGGRMPLRDLIQFDAAVNPGSSGGPLVTIDGEVVGIVTGILNPTDEGFFVG
IGFAVPIESAAGAAGISPF

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=207, Percent_Identity=38.1642512077295, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI4506141, Length=164, Percent_Identity=40.2439024390244, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI24308541, Length=191, Percent_Identity=36.6492146596859, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI7019477, Length=169, Percent_Identity=37.8698224852071, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1786356, Length=165, Percent_Identity=42.4242424242424, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789629, Length=203, Percent_Identity=37.4384236453202, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1789630, Length=214, Percent_Identity=33.1775700934579, Blast_Score=94, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24646839, Length=168, Percent_Identity=35.1190476190476, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 26465; Mature: 26334

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATLIACALLLAFGLGTYHALLPPPPALSPAQVEAVVDKVIVHKSLTAPAARAFRAIGPS
CHHHHHHHHHHHHHHCHHEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCC
VVRVRGYGHPHKGKGKDKGDDEALSIGSGVVVVDRGVILTSLHVVAGSPRLKVTFASGLE
EEEEECCCCCCCCCCCCCCCCHHEECCCCEEEEECCEEEEEEEEEECCCEEEEEECCCCC
SEAELVGARPDQDLAVIQAARIPDDLVAATMRSSNDLALGQPVVAVGFPFDVGLTVTEGV
CHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCHHHHH
VSGLGREFRTPGGRMPLRDLIQFDAAVNPGSSGGPLVTIDGEVVGIVTGILNPTDEGFFV
HHHCCHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCEEEEEEECCCCCCCCEEE
GIGFAVPIESAAGAAGISPF
EEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
ATLIACALLLAFGLGTYHALLPPPPALSPAQVEAVVDKVIVHKSLTAPAARAFRAIGPS
HHHHHHHHHHHHHHCHHEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCC
VVRVRGYGHPHKGKGKDKGDDEALSIGSGVVVVDRGVILTSLHVVAGSPRLKVTFASGLE
EEEEECCCCCCCCCCCCCCCCHHEECCCCEEEEECCEEEEEEEEEECCCEEEEEECCCCC
SEAELVGARPDQDLAVIQAARIPDDLVAATMRSSNDLALGQPVVAVGFPFDVGLTVTEGV
CHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCHHHHH
VSGLGREFRTPGGRMPLRDLIQFDAAVNPGSSGGPLVTIDGEVVGIVTGILNPTDEGFFV
HHHCCHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCEEEEEEECCCCCCCCEEE
GIGFAVPIESAAGAAGISPF
EEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]