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The map label for this gene is moeA2 [H]

Identifier: 119899115

GI number: 119899115

Start: 3103351

End: 3104595

Strand: Direct

Name: moeA2 [H]

Synonym: azo2825

Alternate gene names: 119899115

Gene position: 3103351-3104595 (Clockwise)

Preceding gene: 119899113

Following gene: 119899116

Centisome position: 70.92

GC content: 69.16

Gene sequence:

>1245_bases
ATGCCCTCTTCCAACGGCAGTGGCGAAGTCCGCAACCATCTCACGGTCGCCGAAGCGCGTGCCGCCATCCTCGACACCCT
CACTCCTGTCACCGGCTGGGAGCGCGTAGCCGTGCGCGCGGCGCTGGGCCGCGTACTGGCGGAGGACGTGGTCGCGCCCT
ACAACGTGCCCGCCCACGACAACTCCGCGATGGATGGCTATGCGGTACGCGCGGCCGACCTTGCGGCCGGCGAAGTGACG
CTCGCGGTGGTGGGCACCGCTTACGCAGGACATCCGTTCTCGGGCGCTGTCGGTGCAGGCCAGGCGGTCCGCATCATGAC
CGGCGCCGCCATCCCCGCGGGCGCCGACACTATCGTGGTGCAGGAGGTGACCCAGCGCGACGGCGACCAGGTCCGCATCC
CGCCCGGGCAGCGCGCGGGACAGAACCTGCGCCGGGCCGGGGAAGACCTGGCCGCAGGAGGCGTGGCGCTTGCCTGCGGC
ACGCTGTGCGGACCGGCGGAGCTGGGGCTGATTGCCTCGCTCGGCATCGCCGAAGTGGCTGTGCGGCGCCGTCTGCGGGT
CGCCTTCTTTTCCACCGGCGACGAGATCGCCTCTATCGGTCGCCCGCTGTCGCCGGGCGAGGTCTACGACAGCAACCGCT
ACACCTTGTATAGCGCACTGACGCGACTGGGCTGCGAACTGCTCGACATGGGCGTGATCGAGGACCAGCCGGAGGCGCTC
GAAGCCGCCTTCCGCGCAGCCTCGCAGGCCGCCGACGTGGTGATCACCAGCGGCGGCGTTTCGGTCGGCGAGGCGGATTT
CATCCGCCAGATGATGGATCGGCTGGGCGAAGTCGCCTTCTGGAAGCTCGCAATCAAGCCGGGCCGGCCGATGGCCTACG
GCCGCATCGGCAACGCGTGTCTGTTCGGCCTTCCGGGTAATCCGGTGGCGGTGATGGTGACCTACTACCAGTTTGTTCGC
GACGCCCTGCTGGCGCTGATGGGCGTCAGCCCGTTGCCCGAGAACCTGATGTTCGAAGCCCGCAGCACGGCCGCGCTTCG
CAAGCAGCCGGGACGCCGGGAATTCCTGCGCGGCACCCTGCAACGGCAGGCCGACGGACTTACGGTGACACCAGCGGGCG
CCCAGGGCTCGGGCATCCTGCGGTCGATGTCCGAGGCCAACTGCTTCATCGTGCTGCCGGAAGACAATGCGGGCGTCGCT
GCCGGCGATCTCGTTCTGGTGCAGCCTTTCGACGGTCTCGTCTGA

Upstream 100 bases:

>100_bases
CTGGCGAGTGTACCGGACCACGCCGGCGGCGAACGCTGCACGGCGCGGAGCATTGCGGGATAATGCCGATCGTCCGCCCG
ACCCTCTACCGGAACCTCAG

Downstream 100 bases:

>100_bases
CCGGCCACCGCACACACCTCTCGTATGCCACTTTTCCGAGCGAACACATGACCCAGGACGAACTCAAGAAAGCCGCCGCC
CTCGCCGCACTCGACTATGT

Product: molybdopterin biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MPSSNGSGEVRNHLTVAEARAAILDTLTPVTGWERVAVRAALGRVLAEDVVAPYNVPAHDNSAMDGYAVRAADLAAGEVT
LAVVGTAYAGHPFSGAVGAGQAVRIMTGAAIPAGADTIVVQEVTQRDGDQVRIPPGQRAGQNLRRAGEDLAAGGVALACG
TLCGPAELGLIASLGIAEVAVRRRLRVAFFSTGDEIASIGRPLSPGEVYDSNRYTLYSALTRLGCELLDMGVIEDQPEAL
EAAFRAASQAADVVITSGGVSVGEADFIRQMMDRLGEVAFWKLAIKPGRPMAYGRIGNACLFGLPGNPVAVMVTYYQFVR
DALLALMGVSPLPENLMFEARSTAALRKQPGRREFLRGTLQRQADGLTVTPAGAQGSGILRSMSEANCFIVLPEDNAGVA
AGDLVLVQPFDGLV

Sequences:

>Translated_414_residues
MPSSNGSGEVRNHLTVAEARAAILDTLTPVTGWERVAVRAALGRVLAEDVVAPYNVPAHDNSAMDGYAVRAADLAAGEVT
LAVVGTAYAGHPFSGAVGAGQAVRIMTGAAIPAGADTIVVQEVTQRDGDQVRIPPGQRAGQNLRRAGEDLAAGGVALACG
TLCGPAELGLIASLGIAEVAVRRRLRVAFFSTGDEIASIGRPLSPGEVYDSNRYTLYSALTRLGCELLDMGVIEDQPEAL
EAAFRAASQAADVVITSGGVSVGEADFIRQMMDRLGEVAFWKLAIKPGRPMAYGRIGNACLFGLPGNPVAVMVTYYQFVR
DALLALMGVSPLPENLMFEARSTAALRKQPGRREFLRGTLQRQADGLTVTPAGAQGSGILRSMSEANCFIVLPEDNAGVA
AGDLVLVQPFDGLV
>Mature_413_residues
PSSNGSGEVRNHLTVAEARAAILDTLTPVTGWERVAVRAALGRVLAEDVVAPYNVPAHDNSAMDGYAVRAADLAAGEVTL
AVVGTAYAGHPFSGAVGAGQAVRIMTGAAIPAGADTIVVQEVTQRDGDQVRIPPGQRAGQNLRRAGEDLAAGGVALACGT
LCGPAELGLIASLGIAEVAVRRRLRVAFFSTGDEIASIGRPLSPGEVYDSNRYTLYSALTRLGCELLDMGVIEDQPEALE
AAFRAASQAADVVITSGGVSVGEADFIRQMMDRLGEVAFWKLAIKPGRPMAYGRIGNACLFGLPGNPVAVMVTYYQFVRD
ALLALMGVSPLPENLMFEARSTAALRKQPGRREFLRGTLQRQADGLTVTPAGAQGSGILRSMSEANCFIVLPEDNAGVAA
GDLVLVQPFDGLV

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=383, Percent_Identity=37.8590078328982, Blast_Score=221, Evalue=7e-58,
Organism=Homo sapiens, GI10880983, Length=383, Percent_Identity=37.8590078328982, Blast_Score=221, Evalue=9e-58,
Organism=Escherichia coli, GI1787049, Length=403, Percent_Identity=50.1240694789082, Blast_Score=377, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI25147659, Length=294, Percent_Identity=32.312925170068, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17562606, Length=377, Percent_Identity=26.525198938992, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI17136978, Length=370, Percent_Identity=29.1891891891892, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24638841, Length=370, Percent_Identity=29.1891891891892, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43157; Mature: 43026

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSSNGSGEVRNHLTVAEARAAILDTLTPVTGWERVAVRAALGRVLAEDVVAPYNVPAHD
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
NSAMDGYAVRAADLAAGEVTLAVVGTAYAGHPFSGAVGAGQAVRIMTGAAIPAGADTIVV
CCCCCCEEEEEHHCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHEE
QEVTQRDGDQVRIPPGQRAGQNLRRAGEDLAAGGVALACGTLCGPAELGLIASLGIAEVA
EHHHHCCCCEEECCCCHHHHHHHHHCCHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHH
VRRRLRVAFFSTGDEIASIGRPLSPGEVYDSNRYTLYSALTRLGCELLDMGVIEDQPEAL
HHHHHEEEEECCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHHCCCCCCCHHHH
EAAFRAASQAADVVITSGGVSVGEADFIRQMMDRLGEVAFWKLAIKPGRPMAYGRIGNAC
HHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHCCEEEEEEEECCCCCEECCCCCCEE
LFGLPGNPVAVMVTYYQFVRDALLALMGVSPLPENLMFEARSTAALRKQPGRREFLRGTL
EECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
QRQADGLTVTPAGAQGSGILRSMSEANCFIVLPEDNAGVAAGDLVLVQPFDGLV
HHHCCCCEEECCCCCCCHHHHHHCCCCEEEEEECCCCCCEECCEEEECCCCCCC
>Mature Secondary Structure 
PSSNGSGEVRNHLTVAEARAAILDTLTPVTGWERVAVRAALGRVLAEDVVAPYNVPAHD
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
NSAMDGYAVRAADLAAGEVTLAVVGTAYAGHPFSGAVGAGQAVRIMTGAAIPAGADTIVV
CCCCCCEEEEEHHCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHEE
QEVTQRDGDQVRIPPGQRAGQNLRRAGEDLAAGGVALACGTLCGPAELGLIASLGIAEVA
EHHHHCCCCEEECCCCHHHHHHHHHCCHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHH
VRRRLRVAFFSTGDEIASIGRPLSPGEVYDSNRYTLYSALTRLGCELLDMGVIEDQPEAL
HHHHHEEEEECCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHHCCCCCCCHHHH
EAAFRAASQAADVVITSGGVSVGEADFIRQMMDRLGEVAFWKLAIKPGRPMAYGRIGNAC
HHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHCCEEEEEEEECCCCCEECCCCCCEE
LFGLPGNPVAVMVTYYQFVRDALLALMGVSPLPENLMFEARSTAALRKQPGRREFLRGTL
EECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
QRQADGLTVTPAGAQGSGILRSMSEANCFIVLPEDNAGVAAGDLVLVQPFDGLV
HHHCCCCEEECCCCCCCHHHHHHCCCCEEEEEECCCCCCEECCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]