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The map label for this gene is envZ2 [H]

Identifier: 119899036

GI number: 119899036

Start: 3026732

End: 3028066

Strand: Direct

Name: envZ2 [H]

Synonym: azo2746

Alternate gene names: 119899036

Gene position: 3026732-3028066 (Clockwise)

Preceding gene: 119899035

Following gene: 119899038

Centisome position: 69.17

GC content: 71.99

Gene sequence:

>1335_bases
GTGAAGCTCCTGCCCCGGAGCCTGTTCGCGCGCCTGATGCTGATCTGGCTGGTCGGCATCGCCGCGGTGCTGACCGTGAG
CGTGCTGCTGTTCGTCGGCGAGCGCGACCGCGTGGGACGTGACGCGCTATTCGAAGGCATCGCGCAGGAGATTGCCGCCG
CGGTCGACGTGCTCGACCGCCTGGCGCCCGACGAGCGCGCGCGCTGGATCGACGAATTCGGCCGCCGCCGCCTGCGCCCC
AGCCTGCGCCCGCTTCCGGACGAGGCACGCAACCTGCCGGACGATCATCCGCTGCTGGTCGCGCTGCGCCAGGCCCTGCC
GGGGCGCGCGGTCACGCTGCACGCCTTCCATCGCCACGAAGGCGGCCACGCGATCCTGCTCGCAGCCATCACGCTGGGTG
ACGGCACGCCGCTGACCGTGCGCCTGCCGGGCGTCGCGCCGGTGCCGCATCCGCCGCCTCCGCCACCCGGCAGACTGCTG
GCGGCCCTGAGCGCGTTGGTGGTCGGCATCACCTTGCTCACCTGGCTCGCCGTGCGCCTTGCGACCCGGCCGCTGTCGCG
CATGGCGGCCGCGGCGCGCGCGCTCGGCGAGGACCCCGACCGCGCGCCGATGGAAACCCGCGGGCCGACTGAAGTCGCCC
AGGCCGCGGCGGCGTTCAACCAGATGCAGCAACGCATCCGCGAGCACGTGAGCGAGCGCACCCGCATCCTGGCCGCGATC
TCGCACGATCTGCAAACCCCGATCACCCGGCTGCGCCTGCGCGCCGAAATGGTGGATGACGACACCCTGCGGGGGCGCAT
CCAGTCCGACCTGGATGCGATGCAGGCGCTGGTGAAGGAAGGACTGGCCTACGCCCGCAGCATGGACACCGACACGCCCG
CTCAGCCGATCGACCTCAATGGCTTGCTCGCTGCGCTGCACGACGATGCGGCCGACCTCGGCTGGTCGGTGTCGGTCGAG
GGCCACGCCGCCAGCCCCAGTCTTGGCCGCCCCACGGCCTTGCGGCGCGCGCTATGGAATCTGATCGAGAACGGGGTGAA
GTTCGGCGAACGGGTCGAGCTGAGCCTGACGGAATATCCGGACCGCCATGAAATCCGCGTCCGCGACCACGGCCCCGGAC
TCGACGCCGCCGAGCTGGAGAAGGTGTTCGAACCCTTCTACCGTACCGAAGCATCGCGCAATCGCGAAACCGGCGGCACA
GGGCTGGGGCTGGCAATCGCGCGCAACCTGCTGCGCACCCAGCGCGGCGAGGTCGCGCTGCGCAACCTGCCGGGCGGCGG
GCTGGAAGCGCGGGTGACGCTGCCGCGTGCCCCGACCCATGCGCGCCGGGCCTGA

Upstream 100 bases:

>100_bases
TGGGGGATAACGCGCGCGAACCCGCCATCATCAAGACCGTGCGCAACGAGGGCTATGTGCTCAGCGCCGAGGTCGTTGCC
GGCGACGGGAGCCTGAGCCA

Downstream 100 bases:

>100_bases
AAATGATGAAGCCCGCACACGGCAAAACAGCCGTGGCGGGACTTCGGTGTAAAAAGGCCCCCGGACAAGCCGGGGGCAAG
CGACAAAACCCGGCCCTCCC

Product: putative sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MKLLPRSLFARLMLIWLVGIAAVLTVSVLLFVGERDRVGRDALFEGIAQEIAAAVDVLDRLAPDERARWIDEFGRRRLRP
SLRPLPDEARNLPDDHPLLVALRQALPGRAVTLHAFHRHEGGHAILLAAITLGDGTPLTVRLPGVAPVPHPPPPPPGRLL
AALSALVVGITLLTWLAVRLATRPLSRMAAAARALGEDPDRAPMETRGPTEVAQAAAAFNQMQQRIREHVSERTRILAAI
SHDLQTPITRLRLRAEMVDDDTLRGRIQSDLDAMQALVKEGLAYARSMDTDTPAQPIDLNGLLAALHDDAADLGWSVSVE
GHAASPSLGRPTALRRALWNLIENGVKFGERVELSLTEYPDRHEIRVRDHGPGLDAAELEKVFEPFYRTEASRNRETGGT
GLGLAIARNLLRTQRGEVALRNLPGGGLEARVTLPRAPTHARRA

Sequences:

>Translated_444_residues
MKLLPRSLFARLMLIWLVGIAAVLTVSVLLFVGERDRVGRDALFEGIAQEIAAAVDVLDRLAPDERARWIDEFGRRRLRP
SLRPLPDEARNLPDDHPLLVALRQALPGRAVTLHAFHRHEGGHAILLAAITLGDGTPLTVRLPGVAPVPHPPPPPPGRLL
AALSALVVGITLLTWLAVRLATRPLSRMAAAARALGEDPDRAPMETRGPTEVAQAAAAFNQMQQRIREHVSERTRILAAI
SHDLQTPITRLRLRAEMVDDDTLRGRIQSDLDAMQALVKEGLAYARSMDTDTPAQPIDLNGLLAALHDDAADLGWSVSVE
GHAASPSLGRPTALRRALWNLIENGVKFGERVELSLTEYPDRHEIRVRDHGPGLDAAELEKVFEPFYRTEASRNRETGGT
GLGLAIARNLLRTQRGEVALRNLPGGGLEARVTLPRAPTHARRA
>Mature_444_residues
MKLLPRSLFARLMLIWLVGIAAVLTVSVLLFVGERDRVGRDALFEGIAQEIAAAVDVLDRLAPDERARWIDEFGRRRLRP
SLRPLPDEARNLPDDHPLLVALRQALPGRAVTLHAFHRHEGGHAILLAAITLGDGTPLTVRLPGVAPVPHPPPPPPGRLL
AALSALVVGITLLTWLAVRLATRPLSRMAAAARALGEDPDRAPMETRGPTEVAQAAAAFNQMQQRIREHVSERTRILAAI
SHDLQTPITRLRLRAEMVDDDTLRGRIQSDLDAMQALVKEGLAYARSMDTDTPAQPIDLNGLLAALHDDAADLGWSVSVE
GHAASPSLGRPTALRRALWNLIENGVKFGERVELSLTEYPDRHEIRVRDHGPGLDAAELEKVFEPFYRTEASRNRETGGT
GLGLAIARNLLRTQRGEVALRNLPGGGLEARVTLPRAPTHARRA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=274, Percent_Identity=31.3868613138686, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1790346, Length=239, Percent_Identity=33.0543933054393, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1787894, Length=335, Percent_Identity=28.0597014925373, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1788393, Length=240, Percent_Identity=29.1666666666667, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1786783, Length=298, Percent_Identity=24.8322147651007, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786600, Length=277, Percent_Identity=24.9097472924188, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI145693157, Length=238, Percent_Identity=26.4705882352941, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI48994928, Length=237, Percent_Identity=27.0042194092827, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1789149, Length=264, Percent_Identity=23.8636363636364, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082128, Length=286, Percent_Identity=24.8251748251748, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788549, Length=219, Percent_Identity=23.2876712328767, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1789403, Length=299, Percent_Identity=28.0936454849498, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790861, Length=294, Percent_Identity=26.1904761904762, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788713, Length=226, Percent_Identity=24.3362831858407, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790551, Length=277, Percent_Identity=25.9927797833935, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87081816, Length=335, Percent_Identity=22.6865671641791, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48514; Mature: 48514

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLPRSLFARLMLIWLVGIAAVLTVSVLLFVGERDRVGRDALFEGIAQEIAAAVDVLDR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LAPDERARWIDEFGRRRLRPSLRPLPDEARNLPDDHPLLVALRQALPGRAVTLHAFHRHE
HCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHHHHCCCCEEEEEEHHHCC
GGHAILLAAITLGDGTPLTVRLPGVAPVPHPPPPPPGRLLAALSALVVGITLLTWLAVRL
CCCEEEEEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ATRPLSRMAAAARALGEDPDRAPMETRGPTEVAQAAAAFNQMQQRIREHVSERTRILAAI
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHDLQTPITRLRLRAEMVDDDTLRGRIQSDLDAMQALVKEGLAYARSMDTDTPAQPIDLN
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
GLLAALHDDAADLGWSVSVEGHAASPSLGRPTALRRALWNLIENGVKFGERVELSLTEYP
HHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCC
DRHEIRVRDHGPGLDAAELEKVFEPFYRTEASRNRETGGTGLGLAIARNLLRTQRGEVAL
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEE
RNLPGGGLEARVTLPRAPTHARRA
ECCCCCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure
MKLLPRSLFARLMLIWLVGIAAVLTVSVLLFVGERDRVGRDALFEGIAQEIAAAVDVLDR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LAPDERARWIDEFGRRRLRPSLRPLPDEARNLPDDHPLLVALRQALPGRAVTLHAFHRHE
HCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHHHHCCCCEEEEEEHHHCC
GGHAILLAAITLGDGTPLTVRLPGVAPVPHPPPPPPGRLLAALSALVVGITLLTWLAVRL
CCCEEEEEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ATRPLSRMAAAARALGEDPDRAPMETRGPTEVAQAAAAFNQMQQRIREHVSERTRILAAI
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHDLQTPITRLRLRAEMVDDDTLRGRIQSDLDAMQALVKEGLAYARSMDTDTPAQPIDLN
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
GLLAALHDDAADLGWSVSVEGHAASPSLGRPTALRRALWNLIENGVKFGERVELSLTEYP
HHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCC
DRHEIRVRDHGPGLDAAELEKVFEPFYRTEASRNRETGGTGLGLAIARNLLRTQRGEVAL
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEE
RNLPGGGLEARVTLPRAPTHARRA
ECCCCCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]