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The map label for this gene is ppnK

Identifier: 119898871

GI number: 119898871

Start: 2860012

End: 2860896

Strand: Reverse

Name: ppnK

Synonym: azo2580

Alternate gene names: 119898871

Gene position: 2860896-2860012 (Counterclockwise)

Preceding gene: 119898876

Following gene: 119898870

Centisome position: 65.38

GC content: 65.31

Gene sequence:

>885_bases
ATGAGTGCGCACTTTCGCAGCGTTGCCCTGATCGGAAAATACCAGAGCGCCGATGTCGCAGAATCCGTGTTCGCGATCGC
GAATCACCTGCGGCAGCGGGGGCTCGTTGTGTGGATCGAACAGGGTACGGCAAGTTCCATTGGCGGTGCGGCCGACTTCA
CGGTCGCCAGCTACGAGGAAATCGGCTCACGCGCCGAACTGGCGGTGGTGATCGGCGGCGATGGCACGATGCTCAATGCC
GCGCGGCGGTTGGCAGAACACCAGGTGCCGCTGGTCGGTGTCAATCTCGGCCGGCTCGGCTTCCTCACCGACGTCGCGCG
CAGTGATGCCCTGCAGCGTCTGGAAGAGATCGTGGACGGCCGTTACAGCGAAGAGTCCCGCTTCATGCTCGACGCCGAGG
TGCTGCGCAGCGGCGAGCGCGTATTCCAGACCCTCGCGCTGAACGATGTCGTGGTGAATAAGGGCGACCTTGGCCGCATG
ATCGAGTTCGACCTGTCGATCGACGGCGAATTCGTCTATACGCAGCGCTCGGACGGCATGATCATTTCGACGCCCACCGG
CTCTACCGCCTACGCGCTGTCGGCCAACGGTCCCATCCTTCATCCCGGCGTGGGCGGCATCGCGTTGGTGCCGCTGTGTC
CGCACGCACTGACCGCGCGCCCGGTCACCTTGCCCGACACCTGCCGCATCGAAATCCGGCTGCTGCCGCCTCACGACGCC
AGCATCCACTTCGACGGCCAGGCACGCTTCGACGCACGCGCGGGCGACTGCGTGCGCCTCGGGCGCTCGCCACTCGCGGT
GCGGCTGCTGCATCCCGAGGGTTACAACTACTACGCGATGCTGCGCGAAAAGCTGCACTGGAGCGCTGTTCCCCGCCACA
ACTGA

Upstream 100 bases:

>100_bases
AGTAGGCAAGGATAGTGCCTGATTCTAGGGAAGAGCACAGGCTGCTGCCAAGCGTCAGTGCGCGCCAAGCCGATACATGA
ATGTGGTTTAATCCGCGCCC

Downstream 100 bases:

>100_bases
CCGGCCCCTCGCGCCGGGCTTCTGCCGAATCCATCCTATGCTCCGCCGCCTGACCATCCGCGACTTCGTCATCGTCGACC
GCCTGGAACTCGAATTCGGC

Product: inorganic polyphosphate/ATP-NAD kinase

Products: NA

Alternate protein names: Poly(P)/ATP NAD kinase

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MSAHFRSVALIGKYQSADVAESVFAIANHLRQRGLVVWIEQGTASSIGGAADFTVASYEEIGSRAELAVVIGGDGTMLNA
ARRLAEHQVPLVGVNLGRLGFLTDVARSDALQRLEEIVDGRYSEESRFMLDAEVLRSGERVFQTLALNDVVVNKGDLGRM
IEFDLSIDGEFVYTQRSDGMIISTPTGSTAYALSANGPILHPGVGGIALVPLCPHALTARPVTLPDTCRIEIRLLPPHDA
SIHFDGQARFDARAGDCVRLGRSPLAVRLLHPEGYNYYAMLREKLHWSAVPRHN

Sequences:

>Translated_294_residues
MSAHFRSVALIGKYQSADVAESVFAIANHLRQRGLVVWIEQGTASSIGGAADFTVASYEEIGSRAELAVVIGGDGTMLNA
ARRLAEHQVPLVGVNLGRLGFLTDVARSDALQRLEEIVDGRYSEESRFMLDAEVLRSGERVFQTLALNDVVVNKGDLGRM
IEFDLSIDGEFVYTQRSDGMIISTPTGSTAYALSANGPILHPGVGGIALVPLCPHALTARPVTLPDTCRIEIRLLPPHDA
SIHFDGQARFDARAGDCVRLGRSPLAVRLLHPEGYNYYAMLREKLHWSAVPRHN
>Mature_293_residues
SAHFRSVALIGKYQSADVAESVFAIANHLRQRGLVVWIEQGTASSIGGAADFTVASYEEIGSRAELAVVIGGDGTMLNAA
RRLAEHQVPLVGVNLGRLGFLTDVARSDALQRLEEIVDGRYSEESRFMLDAEVLRSGERVFQTLALNDVVVNKGDLGRMI
EFDLSIDGEFVYTQRSDGMIISTPTGSTAYALSANGPILHPGVGGIALVPLCPHALTARPVTLPDTCRIEIRLLPPHDAS
IHFDGQARFDARAGDCVRLGRSPLAVRLLHPEGYNYYAMLREKLHWSAVPRHN

Specific function: Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus

COG id: COG0061

COG function: function code G; Predicted sugar kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD kinase family

Homologues:

Organism=Homo sapiens, GI55743112, Length=324, Percent_Identity=26.8518518518519, Blast_Score=130, Evalue=1e-30,
Organism=Escherichia coli, GI1788968, Length=289, Percent_Identity=39.4463667820069, Blast_Score=215, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI71999610, Length=171, Percent_Identity=29.2397660818713, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322509, Length=240, Percent_Identity=30.8333333333333, Blast_Score=126, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6320794, Length=240, Percent_Identity=29.5833333333333, Blast_Score=125, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6325068, Length=178, Percent_Identity=34.8314606741573, Blast_Score=118, Evalue=1e-27,
Organism=Drosophila melanogaster, GI28573826, Length=322, Percent_Identity=27.3291925465839, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI28573832, Length=322, Percent_Identity=27.3291925465839, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI28573830, Length=322, Percent_Identity=27.3291925465839, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI28573828, Length=322, Percent_Identity=27.3291925465839, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI161077047, Length=322, Percent_Identity=27.3291925465839, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI20129957, Length=283, Percent_Identity=27.208480565371, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24653422, Length=283, Percent_Identity=27.208480565371, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24653424, Length=283, Percent_Identity=27.208480565371, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI281363323, Length=283, Percent_Identity=27.208480565371, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI281363321, Length=283, Percent_Identity=27.208480565371, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PPNK_AZOSB (A1K8P2)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_934084.1
- ProteinModelPortal:   A1K8P2
- SMR:   A1K8P2
- STRING:   A1K8P2
- GeneID:   4609708
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo2580
- eggNOG:   COG0061
- HOGENOM:   HBG713904
- OMA:   DGTMLNA
- PhylomeDB:   A1K8P2
- ProtClustDB:   CLSK766875
- BioCyc:   ASP62928:AZO2580-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00361
- InterPro:   IPR016064
- InterPro:   IPR017438
- InterPro:   IPR017437
- InterPro:   IPR002504
- Gene3D:   G3DSA:2.60.200.30
- Gene3D:   G3DSA:3.40.50.10330
- PANTHER:   PTHR20275

Pfam domain/function: PF01513 NAD_kinase; SSF111331 ATP-NAD_kinase_PpnK-typ

EC number: =2.7.1.23

Molecular weight: Translated: 31957; Mature: 31826

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAHFRSVALIGKYQSADVAESVFAIANHLRQRGLVVWIEQGTASSIGGAADFTVASYEE
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCEEEECHHH
IGSRAELAVVIGGDGTMLNAARRLAEHQVPLVGVNLGRLGFLTDVARSDALQRLEEIVDG
CCCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCC
RYSEESRFMLDAEVLRSGERVFQTLALNDVVVNKGDLGRMIEFDLSIDGEFVYTQRSDGM
CCCCCCEEEEEHHHHHCHHHHHHHHHHHHEEECCCCCCCEEEEEEEECCEEEEEECCCCE
IISTPTGSTAYALSANGPILHPGVGGIALVPLCPHALTARPVTLPDTCRIEIRLLPPHDA
EEECCCCCEEEEEECCCCEECCCCCCEEEEECCCCHHCCCCCCCCCCCEEEEEEECCCCC
SIHFDGQARFDARAGDCVRLGRSPLAVRLLHPEGYNYYAMLREKLHWSAVPRHN
EEEECCCEEECCCCCCCEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SAHFRSVALIGKYQSADVAESVFAIANHLRQRGLVVWIEQGTASSIGGAADFTVASYEE
CCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCEEEECHHH
IGSRAELAVVIGGDGTMLNAARRLAEHQVPLVGVNLGRLGFLTDVARSDALQRLEEIVDG
CCCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCC
RYSEESRFMLDAEVLRSGERVFQTLALNDVVVNKGDLGRMIEFDLSIDGEFVYTQRSDGM
CCCCCCEEEEEHHHHHCHHHHHHHHHHHHEEECCCCCCCEEEEEEEECCEEEEEECCCCE
IISTPTGSTAYALSANGPILHPGVGGIALVPLCPHALTARPVTLPDTCRIEIRLLPPHDA
EEECCCCCEEEEEECCCCEECCCCCCEEEEECCCCHHCCCCCCCCCCCEEEEEEECCCCC
SIHFDGQARFDARAGDCVRLGRSPLAVRLLHPEGYNYYAMLREKLHWSAVPRHN
EEEECCCEEECCCCCCCEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA