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The map label for this gene is yakC [H]

Identifier: 119898826

GI number: 119898826

Start: 2802611

End: 2803606

Strand: Reverse

Name: yakC [H]

Synonym: azo2535

Alternate gene names: 119898826

Gene position: 2803606-2802611 (Counterclockwise)

Preceding gene: 119898827

Following gene: 119898825

Centisome position: 64.07

GC content: 70.18

Gene sequence:

>996_bases
ATGCACCACCGCACTCTCGGCCCCTTCCAGGTCGGCGCCATCGGCCTGGGCTGCATGAATCTCTCGCACGCCTACGGCGT
CCCGCCGTCGCCCGAGCAGGCGGAGGCGGTGTTGCTGCGGGCGCTCGATCTTGGCGTCACCCATTTCGACACCGCCGCGC
TGTACGGCTTCGGTGCCAACGAAACCCTCGTCGGCCGCGTGCTCTCCCCGTATCGCTCCCGCTTCACGCTGGCGAGCAAG
TGCGGCATGACTGGCGTGGATGGCAAGCGCGTCATCGACGGCCGCCCCGAAACCCTCAAGCGCACCTGCGAAGAGGCGCT
CGCCCGCCTGCACACCGACGTCATCGACCTCTACTACCTGCACCGCTGGGACAAGCAGGTGCCGGTGGAGGACAGCGTGG
GCGCGCTCGCCGACCTGGTGCGCGAAGGCAAGATCCGCGCGATCGGCCTCTCGGAAGTGTCCGCCGACACCCTGCGCCGC
GCCCACGCGGTGCACCCGATTGCCGCGCTGCAGACCGAATACTCGCTGTGGACCCGTAACGCCGAGATCGCGGCGCTGGA
TGCCTGCCGCGAACTGGGGGTGAGCTTCGTTGCCTTCAGCCCGGTGGGGCGCGGCTTCCTGGCCGCGGCGCTGTCGTCGC
CGGCCGACGTCGCCGCGTTCGACGCCAAGGACATCCGCCGCGCGATGCCGCGCTTCCAGGGCGACAACTTCGTCGCCAAC
CTGCGCCTGCTCGAGGGCTACAAGGCGCTGGCGGCGGAAGCCGGGTGCACACCGGCGCAGCTCGCGCTGGCATGGCTGCT
GGCCAAGGGCGGGCACGTGCTGCCGATCCCGGGTACCACCCGCGTCGCCCACCTGGAAGAGAACCTCGCCGCCGCCGAGA
TCCGCCTGAGCGCCGGGCTGATCGAGCAGGTGGAGACGCTGATCAACCAGGCCACCGTTGCCGGCCCGCGCTACAACGCG
GCGACGCAGACCGAGATCGACACCGAGGAATTCTGA

Upstream 100 bases:

>100_bases
CCGTGGTTGTAATGTGGATTGCATGCGGGGGCCAAGGCTCAGCAGCGATAGCCTCTGCGGCACATTGATTGTTGTCCGAA
TGTCCATAACAGGAGCCCCC

Downstream 100 bases:

>100_bases
TTTCCTTCCGCGCGGCGGCGCTGCGCACTGCGCAGGCCGCCGCTTCCGGGCCGCGCCGCGCCTTCGGGCGGGGCGCGGCC
TGTTTTTCGAGGAGCGTGTC

Product: aldo-keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MHHRTLGPFQVGAIGLGCMNLSHAYGVPPSPEQAEAVLLRALDLGVTHFDTAALYGFGANETLVGRVLSPYRSRFTLASK
CGMTGVDGKRVIDGRPETLKRTCEEALARLHTDVIDLYYLHRWDKQVPVEDSVGALADLVREGKIRAIGLSEVSADTLRR
AHAVHPIAALQTEYSLWTRNAEIAALDACRELGVSFVAFSPVGRGFLAAALSSPADVAAFDAKDIRRAMPRFQGDNFVAN
LRLLEGYKALAAEAGCTPAQLALAWLLAKGGHVLPIPGTTRVAHLEENLAAAEIRLSAGLIEQVETLINQATVAGPRYNA
ATQTEIDTEEF

Sequences:

>Translated_331_residues
MHHRTLGPFQVGAIGLGCMNLSHAYGVPPSPEQAEAVLLRALDLGVTHFDTAALYGFGANETLVGRVLSPYRSRFTLASK
CGMTGVDGKRVIDGRPETLKRTCEEALARLHTDVIDLYYLHRWDKQVPVEDSVGALADLVREGKIRAIGLSEVSADTLRR
AHAVHPIAALQTEYSLWTRNAEIAALDACRELGVSFVAFSPVGRGFLAAALSSPADVAAFDAKDIRRAMPRFQGDNFVAN
LRLLEGYKALAAEAGCTPAQLALAWLLAKGGHVLPIPGTTRVAHLEENLAAAEIRLSAGLIEQVETLINQATVAGPRYNA
ATQTEIDTEEF
>Mature_331_residues
MHHRTLGPFQVGAIGLGCMNLSHAYGVPPSPEQAEAVLLRALDLGVTHFDTAALYGFGANETLVGRVLSPYRSRFTLASK
CGMTGVDGKRVIDGRPETLKRTCEEALARLHTDVIDLYYLHRWDKQVPVEDSVGALADLVREGKIRAIGLSEVSADTLRR
AHAVHPIAALQTEYSLWTRNAEIAALDACRELGVSFVAFSPVGRGFLAAALSSPADVAAFDAKDIRRAMPRFQGDNFVAN
LRLLEGYKALAAEAGCTPAQLALAWLLAKGGHVLPIPGTTRVAHLEENLAAAEIRLSAGLIEQVETLINQATVAGPRYNA
ATQTEIDTEEF

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436969, Length=345, Percent_Identity=24.6376811594203, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI4504825, Length=343, Percent_Identity=24.4897959183673, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI27436966, Length=342, Percent_Identity=23.9766081871345, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI27436964, Length=342, Percent_Identity=23.6842105263158, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI223718702, Length=306, Percent_Identity=29.0849673202614, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI27436962, Length=342, Percent_Identity=23.6842105263158, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI41152114, Length=307, Percent_Identity=28.6644951140065, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI41327764, Length=282, Percent_Identity=28.3687943262411, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI27436971, Length=314, Percent_Identity=25.4777070063694, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI87081735, Length=336, Percent_Identity=31.8452380952381, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1787674, Length=310, Percent_Identity=31.9354838709677, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1788070, Length=275, Percent_Identity=30.9090909090909, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1789375, Length=309, Percent_Identity=30.0970873786408, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1788081, Length=296, Percent_Identity=28.3783783783784, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1789199, Length=346, Percent_Identity=26.3005780346821, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI48994888, Length=289, Percent_Identity=25.2595155709343, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6325384, Length=228, Percent_Identity=27.1929824561404, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6323998, Length=297, Percent_Identity=22.8956228956229, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6319958, Length=297, Percent_Identity=22.8956228956229, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6325169, Length=338, Percent_Identity=23.9644970414201, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322615, Length=220, Percent_Identity=23.6363636363636, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319951, Length=220, Percent_Identity=21.8181818181818, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45553081, Length=326, Percent_Identity=26.0736196319018, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24644950, Length=309, Percent_Identity=26.8608414239482, Blast_Score=85, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 35604; Mature: 35604

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHHRTLGPFQVGAIGLGCMNLSHAYGVPPSPEQAEAVLLRALDLGVTHFDTAALYGFGAN
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHEECCCC
ETLVGRVLSPYRSRFTLASKCGMTGVDGKRVIDGRPETLKRTCEEALARLHTDVIDLYYL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
HRWDKQVPVEDSVGALADLVREGKIRAIGLSEVSADTLRRAHAVHPIAALQTEYSLWTRN
HHCCCCCCCCCHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
AEIAALDACRELGVSFVAFSPVGRGFLAAALSSPADVAAFDAKDIRRAMPRFQGDNFVAN
CHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCCHHCCHHHHHHHHHCCCCCCEEEE
LRLLEGYKALAAEAGCTPAQLALAWLLAKGGHVLPIPGTTRVAHLEENLAAAEIRLSAGL
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHH
IEQVETLINQATVAGPRYNAATQTEIDTEEF
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHHRTLGPFQVGAIGLGCMNLSHAYGVPPSPEQAEAVLLRALDLGVTHFDTAALYGFGAN
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHEECCCC
ETLVGRVLSPYRSRFTLASKCGMTGVDGKRVIDGRPETLKRTCEEALARLHTDVIDLYYL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
HRWDKQVPVEDSVGALADLVREGKIRAIGLSEVSADTLRRAHAVHPIAALQTEYSLWTRN
HHCCCCCCCCCHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
AEIAALDACRELGVSFVAFSPVGRGFLAAALSSPADVAAFDAKDIRRAMPRFQGDNFVAN
CHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCCHHCCHHHHHHHHHCCCCCCEEEE
LRLLEGYKALAAEAGCTPAQLALAWLLAKGGHVLPIPGTTRVAHLEENLAAAEIRLSAGL
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHH
IEQVETLINQATVAGPRYNAATQTEIDTEEF
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9274031; 9384377; 9106203 [H]