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The map label for this gene is paaG3 [C]

Identifier: 119898789

GI number: 119898789

Start: 2761584

End: 2762369

Strand: Reverse

Name: paaG3 [C]

Synonym: azo2498

Alternate gene names: 119898789

Gene position: 2762369-2761584 (Counterclockwise)

Preceding gene: 119898790

Following gene: 119898788

Centisome position: 63.12

GC content: 68.58

Gene sequence:

>786_bases
ATGAGCGAACAACTGGTCAAGACTTCGTATGGCGACAGCGAGGCAGGGGACAACATCTACACCATCACCCTGGCGCGCCC
GGAGAAGCGCAACGCGGTGAGCGACCGCCTGCTGGCCGCGCTGGAGGCCGCGCTGATCGCCACGCCGGAAGGCACCCGCG
CGATCATCCTGGCGGGCGAGGGCGAGCACTTCTGCGCCGGGCTGGACCTCGCGGAGCACCAGCACCGCGAGCCCTTCGGC
GTGATGCTGCATTCGCGCGGCTGGCACCGCATCTTCGACCGCATCCAGAACGGTGGCATCCCGGTCATCGCCGCGATGCA
GGGCGCGGTGATCGGCGGCGGGCTGGAACTGGCGACCGCCACCCATGTGCGCGTGTCCGAACCCAACACGATCTACCAGC
TGCCCGAAGGCCGCCACGGCATCTTCGTCGGCGGCGGCGCCTCGGTGCGGGTGGCCAAGATCATCGGCCCCGGCCGCATG
TGCGAAATGATGCTGACCGGCCGCATCCTCGACGCCGACGAAGGCCTGCGCCTCGGCCTCGCGCATTACCTGGTCGGCCC
CGGCGAAGCGCTCGCCAAGGCGCAGCAGCTCGCCCGCCGCATCGCCGAGAACGCGCCGATGGCCAACTGGGCGATGGTCT
CCGCCATTTCCCGCATCGACAACATGGCCACCGACGACGGCTTCTTCGTCGAATCGCTGACCGCCGCACTGACCCAGACC
AGCCCCGAAGTCGCCGAGCGTATCGGCCACTTCCTCACCCGCAAAGGCAAGGGACCGCAAAAATGA

Upstream 100 bases:

>100_bases
ACCGCCGTGCTGACCTGGTCGAGTACCTGTACCAGGACGTGGTGGACAAGACGGTGATCACCGTCCATTCCGCCATCTGA
GCCCCCCGAGGAAAACGAGA

Downstream 100 bases:

>100_bases
GCAATCCGTACTCCGCCTCCGAAGCCGCCGCGCTGACGACGTCCTACGACGACATCTGGCTGGTGGCCGGCCAGCGCACC
CCGTTCGCCGACTACAACGG

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: 3-hydroxypropionyl-CoA dehydratase [H]

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MSEQLVKTSYGDSEAGDNIYTITLARPEKRNAVSDRLLAALEAALIATPEGTRAIILAGEGEHFCAGLDLAEHQHREPFG
VMLHSRGWHRIFDRIQNGGIPVIAAMQGAVIGGGLELATATHVRVSEPNTIYQLPEGRHGIFVGGGASVRVAKIIGPGRM
CEMMLTGRILDADEGLRLGLAHYLVGPGEALAKAQQLARRIAENAPMANWAMVSAISRIDNMATDDGFFVESLTAALTQT
SPEVAERIGHFLTRKGKGPQK

Sequences:

>Translated_261_residues
MSEQLVKTSYGDSEAGDNIYTITLARPEKRNAVSDRLLAALEAALIATPEGTRAIILAGEGEHFCAGLDLAEHQHREPFG
VMLHSRGWHRIFDRIQNGGIPVIAAMQGAVIGGGLELATATHVRVSEPNTIYQLPEGRHGIFVGGGASVRVAKIIGPGRM
CEMMLTGRILDADEGLRLGLAHYLVGPGEALAKAQQLARRIAENAPMANWAMVSAISRIDNMATDDGFFVESLTAALTQT
SPEVAERIGHFLTRKGKGPQK
>Mature_260_residues
SEQLVKTSYGDSEAGDNIYTITLARPEKRNAVSDRLLAALEAALIATPEGTRAIILAGEGEHFCAGLDLAEHQHREPFGV
MLHSRGWHRIFDRIQNGGIPVIAAMQGAVIGGGLELATATHVRVSEPNTIYQLPEGRHGIFVGGGASVRVAKIIGPGRMC
EMMLTGRILDADEGLRLGLAHYLVGPGEALAKAQQLARRIAENAPMANWAMVSAISRIDNMATDDGFFVESLTAALTQTS
PEVAERIGHFLTRKGKGPQK

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the reversible dehydration of 3-hydroxypropionyl-CoA to form acryloyl- CoA, and the reversible dehydration of (S)-3-hydroxybutyryl-CoA to form crot

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI70995211, Length=244, Percent_Identity=27.8688524590164, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI68989263, Length=205, Percent_Identity=28.780487804878, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI194097323, Length=188, Percent_Identity=30.3191489361702, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI31542718, Length=248, Percent_Identity=25.8064516129032, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI20127408, Length=140, Percent_Identity=31.4285714285714, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI221142681, Length=231, Percent_Identity=32.034632034632, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1787659, Length=239, Percent_Identity=28.8702928870293, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788682, Length=196, Percent_Identity=32.6530612244898, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790281, Length=201, Percent_Identity=27.363184079602, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788597, Length=212, Percent_Identity=27.8301886792453, Blast_Score=69, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560910, Length=201, Percent_Identity=32.3383084577114, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17534483, Length=220, Percent_Identity=29.5454545454545, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17540714, Length=193, Percent_Identity=27.979274611399, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17536985, Length=233, Percent_Identity=26.6094420600858, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI25145438, Length=211, Percent_Identity=29.8578199052133, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17554946, Length=219, Percent_Identity=26.9406392694064, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25144276, Length=244, Percent_Identity=27.0491803278689, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17508953, Length=244, Percent_Identity=27.0491803278689, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17508951, Length=244, Percent_Identity=27.0491803278689, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17558304, Length=180, Percent_Identity=26.1111111111111, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24653139, Length=223, Percent_Identity=30.4932735426009, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI20129971, Length=192, Percent_Identity=31.7708333333333, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24653477, Length=192, Percent_Identity=31.7708333333333, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24650670, Length=256, Percent_Identity=28.515625, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19920382, Length=206, Percent_Identity=28.6407766990291, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357171, Length=195, Percent_Identity=29.7435897435897, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19921000, Length=212, Percent_Identity=32.5471698113208, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24583077, Length=212, Percent_Identity=32.5471698113208, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24583079, Length=212, Percent_Identity=32.5471698113208, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.116 [H]

Molecular weight: Translated: 27939; Mature: 27808

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQLVKTSYGDSEAGDNIYTITLARPEKRNAVSDRLLAALEAALIATPEGTRAIILAGE
CCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHEECCCCCEEEEEECC
GEHFCAGLDLAEHQHREPFGVMLHSRGWHRIFDRIQNGGIPVIAAMQGAVIGGGLELATA
CCEEEECCCHHHHCCCCCCEEEEECCCHHHHHHHHHCCCCEEEEEECCEEEECCEEEEEE
THVRVSEPNTIYQLPEGRHGIFVGGGASVRVAKIIGPGRMCEMMLTGRILDADEGLRLGL
EEEEECCCCEEEECCCCCCEEEEECCCCEEEEEEECCHHHHHHHHHCEEECCCCCCHHHH
AHYLVGPGEALAKAQQLARRIAENAPMANWAMVSAISRIDNMATDDGFFVESLTAALTQT
HHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
SPEVAERIGHFLTRKGKGPQK
CHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SEQLVKTSYGDSEAGDNIYTITLARPEKRNAVSDRLLAALEAALIATPEGTRAIILAGE
CCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHEECCCCCEEEEEECC
GEHFCAGLDLAEHQHREPFGVMLHSRGWHRIFDRIQNGGIPVIAAMQGAVIGGGLELATA
CCEEEECCCHHHHCCCCCCEEEEECCCHHHHHHHHHCCCCEEEEEECCEEEECCEEEEEE
THVRVSEPNTIYQLPEGRHGIFVGGGASVRVAKIIGPGRMCEMMLTGRILDADEGLRLGL
EEEEECCCCEEEECCCCCCEEEEECCCCEEEEEEECCHHHHHHHHHCEEECCCCCCHHHH
AHYLVGPGEALAKAQQLARRIAENAPMANWAMVSAISRIDNMATDDGFFVESLTAALTQT
HHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
SPEVAERIGHFLTRKGKGPQK
CHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA