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The map label for this gene is nagL1 [H]

Identifier: 119898714

GI number: 119898714

Start: 2676985

End: 2677626

Strand: Direct

Name: nagL1 [H]

Synonym: azo2423

Alternate gene names: 119898714

Gene position: 2676985-2677626 (Clockwise)

Preceding gene: 119898713

Following gene: 119898715

Centisome position: 61.17

GC content: 67.91

Gene sequence:

>642_bases
ATGAAGCTGTACAACTTCTTTCGCAGCGGCACCTCGCACCGCCTGCGCATCGCCCTCAACCTGAAGGGCATCCAATACGA
CTACGTGCCGGTCGATCTGCGCACCGAGGAACACCTCGGCGCCGCCTTCAAGGCGGTCAATCCGCAGCAGCTGGTGCCGG
CGCTGGTCGATGGCGACCTGACGCTGATCCAGTCGCCCGCGATCATCGAATGGCTGGAGGAGCGCCACCCCAACCCGCCG
CTGCTGCCGTCAGACCCGGACGATCGCGCCCATGTGCGCGCGATGGCGGCCATCGTCGGCTGCGACATCCACCCGATCAA
TAACCGCCGCATCCTCGAATACCTGCGCAAGCAGCTCGGGCAGGACGAAAAGGCGGTGCTCGCGTGGTGCGCCAACTGGA
TCGACGCCGGCTTTGCGGCACTGGAGGCGCTGCTCGCTGCCGATACCCGCCGCGGCCGCTTCTGCTTCGGCGATGCGCCG
GGGCTGGCCGAGGTCTATCTGATCCCGCAGGTGGAAAGCGCACGGCGCTTCAACGTGGATCTCACGCCCTATCCCAACAT
CCTCGCCATCGACGCGGCCTGCGCCGAACTCGACGCCTTCCGCCGCGCCGCGCCCGCGCGCCAGCCCGACGCACCCGCCT
GA

Upstream 100 bases:

>100_bases
CTTCCACGCGGCCGCCGCCGGCGCTCCGACCTGAAAAGGCCGGGGCGCCGGCGCGTCGGCATTGCGCGCCGCCCTTCATG
ACAACGGAGTTCGCCCCACG

Downstream 100 bases:

>100_bases
GCCGGGCCGGCAGCCCCGATTTCCAACAAGCATGCGCCGCATGCAAAAACCTCACATCCAGGAGGAGATACGATGAGAAA
GAGCCTGATCACCACCCTCA

Product: maleylpyruvate isomerase

Products: NA

Alternate protein names: MAAI [H]

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MKLYNFFRSGTSHRLRIALNLKGIQYDYVPVDLRTEEHLGAAFKAVNPQQLVPALVDGDLTLIQSPAIIEWLEERHPNPP
LLPSDPDDRAHVRAMAAIVGCDIHPINNRRILEYLRKQLGQDEKAVLAWCANWIDAGFAALEALLAADTRRGRFCFGDAP
GLAEVYLIPQVESARRFNVDLTPYPNILAIDAACAELDAFRRAAPARQPDAPA

Sequences:

>Translated_213_residues
MKLYNFFRSGTSHRLRIALNLKGIQYDYVPVDLRTEEHLGAAFKAVNPQQLVPALVDGDLTLIQSPAIIEWLEERHPNPP
LLPSDPDDRAHVRAMAAIVGCDIHPINNRRILEYLRKQLGQDEKAVLAWCANWIDAGFAALEALLAADTRRGRFCFGDAP
GLAEVYLIPQVESARRFNVDLTPYPNILAIDAACAELDAFRRAAPARQPDAPA
>Mature_213_residues
MKLYNFFRSGTSHRLRIALNLKGIQYDYVPVDLRTEEHLGAAFKAVNPQQLVPALVDGDLTLIQSPAIIEWLEERHPNPP
LLPSDPDDRAHVRAMAAIVGCDIHPINNRRILEYLRKQLGQDEKAVLAWCANWIDAGFAALEALLAADTRRGRFCFGDAP
GLAEVYLIPQVESARRFNVDLTPYPNILAIDAACAELDAFRRAAPARQPDAPA

Specific function: Forms An Equimolar Complex With The RNA Polymerase Holoenzyme (Rnap) But Not With The Core Enzyme. It Is Synthesized Predominantly When Cells Are Exposed To Amino Acid Starvation, At Which Time It Accounts For Over 50% Of The Total Protein Synthesized. It

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GST N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI22202624, Length=213, Percent_Identity=44.6009389671362, Blast_Score=174, Evalue=4e-44,
Organism=Homo sapiens, GI22202622, Length=162, Percent_Identity=43.8271604938272, Blast_Score=131, Evalue=4e-31,
Organism=Homo sapiens, GI194440732, Length=213, Percent_Identity=35.2112676056338, Blast_Score=114, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17551302, Length=213, Percent_Identity=39.906103286385, Blast_Score=149, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17510461, Length=212, Percent_Identity=39.622641509434, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17556142, Length=212, Percent_Identity=41.5094339622642, Blast_Score=136, Evalue=7e-33,
Organism=Drosophila melanogaster, GI21355857, Length=214, Percent_Identity=40.6542056074766, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24645375, Length=214, Percent_Identity=44.392523364486, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI45553325, Length=214, Percent_Identity=44.392523364486, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI21355859, Length=214, Percent_Identity=44.392523364486, Blast_Score=159, Evalue=2e-39,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1982 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010987
- InterPro:   IPR004045
- InterPro:   IPR017933
- InterPro:   IPR004046
- InterPro:   IPR005955
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00043 GST_C; PF02798 GST_N [H]

EC number: =5.2.1.2 [H]

Molecular weight: Translated: 23687; Mature: 23687

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLYNFFRSGTSHRLRIALNLKGIQYDYVPVDLRTEEHLGAAFKAVNPQQLVPALVDGDL
CCHHHHHHCCCCCEEEEEEEECCEEEEEEEEECCCHHHHHHHHHCCCHHHHHHHHHCCCE
TLIQSPAIIEWLEERHPNPPLLPSDPDDRAHVRAMAAIVGCDIHPINNRRILEYLRKQLG
EEECCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHC
QDEKAVLAWCANWIDAGFAALEALLAADTRRGRFCFGDAPGLAEVYLIPQVESARRFNVD
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEEECCCCCCCEECCC
LTPYPNILAIDAACAELDAFRRAAPARQPDAPA
CCCCCCEEEEHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKLYNFFRSGTSHRLRIALNLKGIQYDYVPVDLRTEEHLGAAFKAVNPQQLVPALVDGDL
CCHHHHHHCCCCCEEEEEEEECCEEEEEEEEECCCHHHHHHHHHCCCHHHHHHHHHCCCE
TLIQSPAIIEWLEERHPNPPLLPSDPDDRAHVRAMAAIVGCDIHPINNRRILEYLRKQLG
EEECCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHC
QDEKAVLAWCANWIDAGFAALEALLAADTRRGRFCFGDAPGLAEVYLIPQVESARRFNVD
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEEECCCCCCCEECCC
LTPYPNILAIDAACAELDAFRRAAPARQPDAPA
CCCCCCEEEEHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]