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The map label for this gene is lip2 [H]

Identifier: 119898564

GI number: 119898564

Start: 2490788

End: 2491693

Strand: Reverse

Name: lip2 [H]

Synonym: azo2273

Alternate gene names: 119898564

Gene position: 2491693-2490788 (Counterclockwise)

Preceding gene: 119898565

Following gene: 119898563

Centisome position: 56.94

GC content: 68.21

Gene sequence:

>906_bases
ATGGTGTATCGCGTGGGTGCCCCGCGATTCCATGAACTCTCCGTGGCGCAGGCGCGCCACTCTTTCCAGAAGCTGCAGTA
CGCCTTCCGTCCGGATGTTCCCGCGGTGGCCTCGGTGACTGAGGTGCCGATGGCCCGTGCCGACGGCTCGGCGCTGCTTG
CCCGCTACTACCGCCCGCTGCAGGCGGGCCCGCACGAAGCCTTGCCCTTGCTGCTGTACTTCCACGGCGGTGGCTGGTGC
GTGGGCGATGTCGAAAGCTACGACGTGCTGTGCCGCGAACTGGCAAACGCCGCCGGCTGCGCGGTGCTGTCGGTGGACTA
TCGCCTGGCGCCGGAGCACCCGTTTCCGGCCGCGGTGCACGATGCGCGTTTTGCGGTGGAGTGGGCGCGCGAGCAGGCCG
GGCTGCTGGATATCGACCCCGCCCGCATCGCGCTGGCAGGCGACAGTGCCGGCGGCAACCTCTCCATCGTCACCGCGCTC
GCGATGCGCGACGAAGGCGCTGTCCCCGCGCGCTGCCTTGCGCTGGTCTATCCCAGCACCGAGATCGCCAGCGGCCGGCC
TTCGCGCGAGCGTTATGCCGAGGGTTATTTCCTCGATCGCGAAAGCCTGCAGTGGTTCTTCGAACGCTATCTGCCGGAAG
GCGGCAGCGAAGACTGGCGGGCCTCGCCAATGCGCGCCGACTCGCTTGTCGGCCTGCCGCCGATGCTGCTGGTGAGCGCC
GAGTGCGATCCGCTGGTGGACGATTGCACTGCCTTTGCGGCGCGCGTGCGGGCCGAGGGCGGTACGGTGGATGAGGTCTG
CGTGCCGGGCATGGTCCACGGCTTCCTGACGCTCGGCAAGTACTTCCCGGAAGCCGGTCAGACGGTACGACTTTTGGCTG
AGACCTTGAAGGCGCGTCTGGCATAG

Upstream 100 bases:

>100_bases
AGAATCGCGGCATTCCGACAACCTGTGCCGCAGCGGCCAGCAAGAGCCGCGCGGTTTGCCCGACATGCCCCTGACTCCCC
AGGCCCGGTCGTTGCTCGAC

Downstream 100 bases:

>100_bases
AATGCGCGGCCGTGCGAAAACGCATGGCGCGCCAGCACGCTGTTAAGTGAAGCTGTCAGTATCCCGCAGCGGGACCCGGC
ATCTCTCGCCAGGTCTTTGA

Product: hypothetical protein

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MVYRVGAPRFHELSVAQARHSFQKLQYAFRPDVPAVASVTEVPMARADGSALLARYYRPLQAGPHEALPLLLYFHGGGWC
VGDVESYDVLCRELANAAGCAVLSVDYRLAPEHPFPAAVHDARFAVEWAREQAGLLDIDPARIALAGDSAGGNLSIVTAL
AMRDEGAVPARCLALVYPSTEIASGRPSRERYAEGYFLDRESLQWFFERYLPEGGSEDWRASPMRADSLVGLPPMLLVSA
ECDPLVDDCTAFAARVRAEGGTVDEVCVPGMVHGFLTLGKYFPEAGQTVRLLAETLKARLA

Sequences:

>Translated_301_residues
MVYRVGAPRFHELSVAQARHSFQKLQYAFRPDVPAVASVTEVPMARADGSALLARYYRPLQAGPHEALPLLLYFHGGGWC
VGDVESYDVLCRELANAAGCAVLSVDYRLAPEHPFPAAVHDARFAVEWAREQAGLLDIDPARIALAGDSAGGNLSIVTAL
AMRDEGAVPARCLALVYPSTEIASGRPSRERYAEGYFLDRESLQWFFERYLPEGGSEDWRASPMRADSLVGLPPMLLVSA
ECDPLVDDCTAFAARVRAEGGTVDEVCVPGMVHGFLTLGKYFPEAGQTVRLLAETLKARLA
>Mature_301_residues
MVYRVGAPRFHELSVAQARHSFQKLQYAFRPDVPAVASVTEVPMARADGSALLARYYRPLQAGPHEALPLLLYFHGGGWC
VGDVESYDVLCRELANAAGCAVLSVDYRLAPEHPFPAAVHDARFAVEWAREQAGLLDIDPARIALAGDSAGGNLSIVTAL
AMRDEGAVPARCLALVYPSTEIASGRPSRERYAEGYFLDRESLQWFFERYLPEGGSEDWRASPMRADSLVGLPPMLLVSA
ECDPLVDDCTAFAARVRAEGGTVDEVCVPGMVHGFLTLGKYFPEAGQTVRLLAETLKARLA

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI68299767, Length=363, Percent_Identity=27.5482093663912, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI206597554, Length=270, Percent_Identity=28.5185185185185, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI21328446, Length=147, Percent_Identity=36.0544217687075, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI68051721, Length=276, Percent_Identity=26.0869565217391, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI157041239, Length=152, Percent_Identity=27.6315789473684, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI226423947, Length=284, Percent_Identity=25.3521126760563, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1786682, Length=237, Percent_Identity=31.2236286919831, Blast_Score=103, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17567059, Length=269, Percent_Identity=27.8810408921933, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI72001146, Length=150, Percent_Identity=36, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71996133, Length=147, Percent_Identity=33.3333333333333, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17540028, Length=147, Percent_Identity=29.9319727891156, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115533410, Length=85, Percent_Identity=38.8235294117647, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI115533412, Length=85, Percent_Identity=38.8235294117647, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24656084, Length=125, Percent_Identity=38.4, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24656076, Length=125, Percent_Identity=38.4, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI20130169, Length=125, Percent_Identity=38.4, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 32726; Mature: 32726

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVYRVGAPRFHELSVAQARHSFQKLQYAFRPDVPAVASVTEVPMARADGSALLARYYRPL
CEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHH
QAGPHEALPLLLYFHGGGWCVGDVESYDVLCRELANAAGCAVLSVDYRLAPEHPFPAAVH
CCCCCCCCEEEEEEECCCEEECCCHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCHHH
DARFAVEWAREQAGLLDIDPARIALAGDSAGGNLSIVTALAMRDEGAVPARCLALVYPST
HHHHHHHHHHHHCCCEEECCCEEEEECCCCCCCEEEEEEEECCCCCCCCCEEEEEECCCC
EIASGRPSRERYAEGYFLDRESLQWFFERYLPEGGSEDWRASPMRADSLVGLPPMLLVSA
HHCCCCCCHHHHHCCEEECHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEC
ECDPLVDDCTAFAARVRAEGGTVDEVCVPGMVHGFLTLGKYFPEAGQTVRLLAETLKARL
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
A
C
>Mature Secondary Structure
MVYRVGAPRFHELSVAQARHSFQKLQYAFRPDVPAVASVTEVPMARADGSALLARYYRPL
CEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHH
QAGPHEALPLLLYFHGGGWCVGDVESYDVLCRELANAAGCAVLSVDYRLAPEHPFPAAVH
CCCCCCCCEEEEEEECCCEEECCCHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCHHH
DARFAVEWAREQAGLLDIDPARIALAGDSAGGNLSIVTALAMRDEGAVPARCLALVYPST
HHHHHHHHHHHHCCCEEECCCEEEEECCCCCCCEEEEEEEECCCCCCCCCEEEEEECCCC
EIASGRPSRERYAEGYFLDRESLQWFFERYLPEGGSEDWRASPMRADSLVGLPPMLLVSA
HHCCCCCCHHHHHCCEEECHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEC
ECDPLVDDCTAFAARVRAEGGTVDEVCVPGMVHGFLTLGKYFPEAGQTVRLLAETLKARL
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]