Click here to switch to the map view.

The map label for this gene is pyrD

Identifier: 119898501

GI number: 119898501

Start: 2420577

End: 2421593

Strand: Direct

Name: pyrD

Synonym: azo2210

Alternate gene names: 119898501

Gene position: 2420577-2421593 (Clockwise)

Preceding gene: 119898500

Following gene: 119898502

Centisome position: 55.31

GC content: 67.65

Gene sequence:

>1017_bases
ATGCTCTACGACATCGCCCGCCCCTTCCTGTTTTCGCTCGACGCGGAAACCGCCCACGAGTTCACCCTCGCCGCCCTCAA
CCTCGCCGGCCGCACGCTGCCCGCCGGCAAACCGGAAGCCGCTGACGCGGTGCGCGTGATGGGAATCGACTTTCCCAACC
GCATCGGACTCGCCGCCGGCCTCGACAAGAACGGTGAGGCCATCGACGGTCTCGCCCGGCTGGGCTTCGGTTTCATCGAA
ATCGGCACCATCACCCCGCGCCCGCAGCCGGGCAACCCGCGCCCGCGGCTGTTCCGCCTGCCGGAAGTGCGCGGCATCAT
CAACCGCATGGGCTTCAACAACCACGGCGTCGACACGCTGGTGGCCAACGTCAAGGCAGCGCGCTTCAAGGGCGTGCTCG
GCATCAACATCGGCAAGAACTTCGACACGCCGATCGAGAACGCCGCCGACGACTACCTCGCCTGCCTCGACAAGGTTTAT
CCGCTGGCAAGCTACGTCACGGTCAATATCTCCTCGCCCAACACCAAGAACCTGCGCCAGTTGCAGGGCGAATCCGAACT
CGACGACCTGCTCGGCCGCCTCAAGTCGGCCCAGCAACGCCTCGCCGATCAGCACGGCCGCTACGTGCCGCTTACCCTGA
AGATCGCCCCCGATCTGGAAGCAGCGCAGATCACCAATATCGCCGACGCGCTGCGCCGTCACCGGATCGACGCCGTGATC
GCCACCAACACGACGATTTCGCGCGACAAGGTGCAGGGCGTGCGCTTCGCGGAACAGCAGGGCGGCCTGTCCGGCGCCCC
GGTGTTCGAGGCCTCGACCGCCGTCGTCGCGCAGCTGGCGACGGCGCTGGGCGGCGAACTGCCGATCATCGCCGCAGGCG
GCGTCATGGACACCCGCAGCGCGCGCGCCAAGCTCGAAGCCGGCGCGAGTCTGGTGCAGCTGTACAGCGGCCTCATCTAC
CGCGGTCCCTGCCTGGTGCGGGAGTGCGTGCGCGCCACCGCGGACTTCCCGCGTTAA

Upstream 100 bases:

>100_bases
GAACCGCAAATCGCACCGCCCGACGCCTGACGCGACGCCCGCGCGGTTTTCCGCCGGTCCCGCCTTCGACCACGCGGGGT
CGAAACGCTACAATCCCGCG

Downstream 100 bases:

>100_bases
GACGTTCCGCGCCTGCCGGCATATTCCGCGGTGGGGGCACCGCAGATGGTTTTTGCCGGCGGGCCCCAAGGCCGTGCATC
CGCGCCGGCCCGCGCACCAA

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MLYDIARPFLFSLDAETAHEFTLAALNLAGRTLPAGKPEAADAVRVMGIDFPNRIGLAAGLDKNGEAIDGLARLGFGFIE
IGTITPRPQPGNPRPRLFRLPEVRGIINRMGFNNHGVDTLVANVKAARFKGVLGINIGKNFDTPIENAADDYLACLDKVY
PLASYVTVNISSPNTKNLRQLQGESELDDLLGRLKSAQQRLADQHGRYVPLTLKIAPDLEAAQITNIADALRRHRIDAVI
ATNTTISRDKVQGVRFAEQQGGLSGAPVFEASTAVVAQLATALGGELPIIAAGGVMDTRSARAKLEAGASLVQLYSGLIY
RGPCLVRECVRATADFPR

Sequences:

>Translated_338_residues
MLYDIARPFLFSLDAETAHEFTLAALNLAGRTLPAGKPEAADAVRVMGIDFPNRIGLAAGLDKNGEAIDGLARLGFGFIE
IGTITPRPQPGNPRPRLFRLPEVRGIINRMGFNNHGVDTLVANVKAARFKGVLGINIGKNFDTPIENAADDYLACLDKVY
PLASYVTVNISSPNTKNLRQLQGESELDDLLGRLKSAQQRLADQHGRYVPLTLKIAPDLEAAQITNIADALRRHRIDAVI
ATNTTISRDKVQGVRFAEQQGGLSGAPVFEASTAVVAQLATALGGELPIIAAGGVMDTRSARAKLEAGASLVQLYSGLIY
RGPCLVRECVRATADFPR
>Mature_338_residues
MLYDIARPFLFSLDAETAHEFTLAALNLAGRTLPAGKPEAADAVRVMGIDFPNRIGLAAGLDKNGEAIDGLARLGFGFIE
IGTITPRPQPGNPRPRLFRLPEVRGIINRMGFNNHGVDTLVANVKAARFKGVLGINIGKNFDTPIENAADDYLACLDKVY
PLASYVTVNISSPNTKNLRQLQGESELDDLLGRLKSAQQRLADQHGRYVPLTLKIAPDLEAAQITNIADALRRHRIDAVI
ATNTTISRDKVQGVRFAEQQGGLSGAPVFEASTAVVAQLATALGGELPIIAAGGVMDTRSARAKLEAGASLVQLYSGLIY
RGPCLVRECVRATADFPR

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=330, Percent_Identity=43.6363636363636, Blast_Score=243, Evalue=2e-64,
Organism=Escherichia coli, GI1787177, Length=333, Percent_Identity=54.6546546546547, Blast_Score=358, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17509475, Length=339, Percent_Identity=40.4129793510324, Blast_Score=217, Evalue=7e-57,
Organism=Drosophila melanogaster, GI281361352, Length=332, Percent_Identity=40.9638554216867, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI17137316, Length=332, Percent_Identity=40.9638554216867, Blast_Score=243, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_AZOSB (A1K7M2)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_933714.1
- ProteinModelPortal:   A1K7M2
- SMR:   A1K7M2
- STRING:   A1K7M2
- GeneID:   4608363
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo2210
- eggNOG:   COG0167
- HOGENOM:   HBG351027
- OMA:   SYVTVNI
- PhylomeDB:   A1K7M2
- ProtClustDB:   PRK05286
- BioCyc:   ASP62928:AZO2210-MONOMER
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 36234; Mature: 36234

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 172-172

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYDIARPFLFSLDAETAHEFTLAALNLAGRTLPAGKPEAADAVRVMGIDFPNRIGLAAG
CCCHHCCHHHEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHCCEEEEECCCCCCCCCCCC
LDKNGEAIDGLARLGFGFIEIGTITPRPQPGNPRPRLFRLPEVRGIINRMGFNNHGVDTL
CCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCEEECHHHHHHHHHCCCCCCCHHHH
VANVKAARFKGVLGINIGKNFDTPIENAADDYLACLDKVYPLASYVTVNISSPNTKNLRQ
HHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCHHHHH
LQGESELDDLLGRLKSAQQRLADQHGRYVPLTLKIAPDLEAAQITNIADALRRHRIDAVI
HCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHCCEEE
ATNTTISRDKVQGVRFAEQQGGLSGAPVFEASTAVVAQLATALGGELPIIAAGGVMDTRS
ECCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHH
ARAKLEAGASLVQLYSGLIYRGPCLVRECVRATADFPR
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLYDIARPFLFSLDAETAHEFTLAALNLAGRTLPAGKPEAADAVRVMGIDFPNRIGLAAG
CCCHHCCHHHEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHCCEEEEECCCCCCCCCCCC
LDKNGEAIDGLARLGFGFIEIGTITPRPQPGNPRPRLFRLPEVRGIINRMGFNNHGVDTL
CCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCEEECHHHHHHHHHCCCCCCCHHHH
VANVKAARFKGVLGINIGKNFDTPIENAADDYLACLDKVYPLASYVTVNISSPNTKNLRQ
HHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCHHHHH
LQGESELDDLLGRLKSAQQRLADQHGRYVPLTLKIAPDLEAAQITNIADALRRHRIDAVI
HCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHCCEEE
ATNTTISRDKVQGVRFAEQQGGLSGAPVFEASTAVVAQLATALGGELPIIAAGGVMDTRS
ECCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHH
ARAKLEAGASLVQLYSGLIYRGPCLVRECVRATADFPR
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA