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The map label for this gene is xdhA [H]

Identifier: 119898502

GI number: 119898502

Start: 2421804

End: 2423330

Strand: Direct

Name: xdhA [H]

Synonym: azo2211

Alternate gene names: 119898502

Gene position: 2421804-2423330 (Clockwise)

Preceding gene: 119898501

Following gene: 119898503

Centisome position: 55.34

GC content: 70.99

Gene sequence:

>1527_bases
ATGGGCCGTCAACCCGCCCCGCCGCCCACCGTCTCCCCCGACCACACCGTCCGCTTCCTCCTCGACGGTGAGGAGGTGCA
GTGCAGCGGTTTCGCGCCCACCACCACGCTGCTGACGTGGTTGCGCGAATCGCGCGGCCGCTGCGGCACCAAGGAGGGTT
GCGCCGAGGGCGATTGCGGCGCGTGTACCGTGGTCGTCGCAGAGGCGGTGGAGGGGCGGATCGCCTGGCGTAGCGTCAAT
GCCTGCATCCAGTTGCTCGCCACGCTGCACGGCAAGGCGCTCTACACGGTGGAAAGCCTGCGCGAACCTGACGGCACACT
GCATCCCGCCCAGCAGGCGATGATCGACTGCCATGCCTCGCAGTGCGGTTTCTGCACGCCGGGCTTCGTGATGTCCCTGT
TCGCGCTCTACCGCAACCAGTCCCGTGCGGACAATGACGCCGTGACCGACGCCTTGTCGGGCAACCTGTGCCGCTGCACC
GGCTACCGCCCCATCGTCGATGCGGCGCAGCGGATGTACGCCTTGCCCGCGCCGGCTGAGGATGCCGACCGCAGGGCGCG
GGAAACCGCCCTGTACGCCCGCCTGCAGGCCCTGGAGGGCGAGGCCGACCTGGTGCTGGCCCACGCGCAGGGGCGCTATC
TCGCGCCACGTACGCTGGCCAGCTTCGCAAACTGCTACGCGGACAACCCCGACGCGACCGTGCTCGCCGGCGGCACCGAC
ATCGGGCTGTGGATCACCAAGCACTTTCGCCCCTTGCCGCTGCTGCTGCATCTCGGCCGGGTGCGAGAGCTGGCCGCCAT
CCGCCAGCACGACGGTGCGCTCGAAATCGGCGCGGCGGTCCGGCTCGAGGACGCCTTCCGCGCGCTCGTCGCGCACTATC
CGGATGCCGCCGGGCTTCACCGCCGCTTCGCCTCGCTGCCCATCCGCAACGCCGGCACCCTGTGCGGCAACATCGCCAAC
GGCAGTCCGATCGGCGACAGCATGCCGGCGCTGATCGCGCTCGGGGCCGAAGTCGTGCTGCACCGCGCCGGCCAGCAGCG
CCGGCTGGCGCTCGAAGACCTCTATCTCGGCTATCAGCAGAAGGCGCTGGCGGCCGGCGAGTTCGTCGAGGCGGTCCGCA
TTCCGCTACCCCGTGCCGCCGGCGACGTCCACTTCCGCGCCTGGAAAGTGTCGCGCCGGCACGACCAGGACATCTCCGCG
GTATTTGCCGGCTTTGCGCTGCAGTACGAAGACGGGCGCATCACACGGGTACGGCTCGCCTACGGCGGCATGGCGGCCAC
GCCGCGCCGGGCCTACGCCACCGAGGCGGCGCTGCTCGGGCGTCCCTTCGATGCCGCCGCGCTGGCCGACGCCCGCCGCG
CGCTGCAGCAGGACTTCACCCCGCTCAGCGACGTGCGCGCGTCGGCCGAGTACCGGATGCGGGTCGCGCAGAACCTGCTG
ACGCGCCTGCAACTCGAAACAAGCGGAGGGGCGCGGGCCGCCTCCAGCCTTGCCGACCTGGGAGACGGGGGACATGCATC
CATCTGA

Upstream 100 bases:

>100_bases
AAACATCTTTTCTTTCAGTATCTTGCATAATGTGTATGGTTGACAGCGGCGCGATCGCCTCGCTACATTGATCCGCATCC
CGATCGCCCACGGAGCCCGC

Downstream 100 bases:

>100_bases
GCTGGGAACGGTCGATGCGGCGGCCATCCGCGGCGGGGTCGGCACCGCGCAGACGCACGACTCGGCCCACCTGCACGTGA
CCGGCTGCGCCAGCTACATC

Product: xanthine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MGRQPAPPPTVSPDHTVRFLLDGEEVQCSGFAPTTTLLTWLRESRGRCGTKEGCAEGDCGACTVVVAEAVEGRIAWRSVN
ACIQLLATLHGKALYTVESLREPDGTLHPAQQAMIDCHASQCGFCTPGFVMSLFALYRNQSRADNDAVTDALSGNLCRCT
GYRPIVDAAQRMYALPAPAEDADRRARETALYARLQALEGEADLVLAHAQGRYLAPRTLASFANCYADNPDATVLAGGTD
IGLWITKHFRPLPLLLHLGRVRELAAIRQHDGALEIGAAVRLEDAFRALVAHYPDAAGLHRRFASLPIRNAGTLCGNIAN
GSPIGDSMPALIALGAEVVLHRAGQQRRLALEDLYLGYQQKALAAGEFVEAVRIPLPRAAGDVHFRAWKVSRRHDQDISA
VFAGFALQYEDGRITRVRLAYGGMAATPRRAYATEAALLGRPFDAAALADARRALQQDFTPLSDVRASAEYRMRVAQNLL
TRLQLETSGGARAASSLADLGDGGHASI

Sequences:

>Translated_508_residues
MGRQPAPPPTVSPDHTVRFLLDGEEVQCSGFAPTTTLLTWLRESRGRCGTKEGCAEGDCGACTVVVAEAVEGRIAWRSVN
ACIQLLATLHGKALYTVESLREPDGTLHPAQQAMIDCHASQCGFCTPGFVMSLFALYRNQSRADNDAVTDALSGNLCRCT
GYRPIVDAAQRMYALPAPAEDADRRARETALYARLQALEGEADLVLAHAQGRYLAPRTLASFANCYADNPDATVLAGGTD
IGLWITKHFRPLPLLLHLGRVRELAAIRQHDGALEIGAAVRLEDAFRALVAHYPDAAGLHRRFASLPIRNAGTLCGNIAN
GSPIGDSMPALIALGAEVVLHRAGQQRRLALEDLYLGYQQKALAAGEFVEAVRIPLPRAAGDVHFRAWKVSRRHDQDISA
VFAGFALQYEDGRITRVRLAYGGMAATPRRAYATEAALLGRPFDAAALADARRALQQDFTPLSDVRASAEYRMRVAQNLL
TRLQLETSGGARAASSLADLGDGGHASI
>Mature_507_residues
GRQPAPPPTVSPDHTVRFLLDGEEVQCSGFAPTTTLLTWLRESRGRCGTKEGCAEGDCGACTVVVAEAVEGRIAWRSVNA
CIQLLATLHGKALYTVESLREPDGTLHPAQQAMIDCHASQCGFCTPGFVMSLFALYRNQSRADNDAVTDALSGNLCRCTG
YRPIVDAAQRMYALPAPAEDADRRARETALYARLQALEGEADLVLAHAQGRYLAPRTLASFANCYADNPDATVLAGGTDI
GLWITKHFRPLPLLLHLGRVRELAAIRQHDGALEIGAAVRLEDAFRALVAHYPDAAGLHRRFASLPIRNAGTLCGNIANG
SPIGDSMPALIALGAEVVLHRAGQQRRLALEDLYLGYQQKALAAGEFVEAVRIPLPRAAGDVHFRAWKVSRRHDQDISAV
FAGFALQYEDGRITRVRLAYGGMAATPRRAYATEAALLGRPFDAAALADARRALQQDFTPLSDVRASAEYRMRVAQNLLT
RLQLETSGGARAASSLADLGDGGHASI

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG4630

COG function: function code F; Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=491, Percent_Identity=29.1242362525458, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI71773480, Length=528, Percent_Identity=27.8409090909091, Blast_Score=156, Evalue=4e-38,
Organism=Escherichia coli, GI1789231, Length=279, Percent_Identity=29.0322580645161, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI1786480, Length=151, Percent_Identity=36.4238410596026, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1789232, Length=139, Percent_Identity=40.2877697841727, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17540638, Length=540, Percent_Identity=27.7777777777778, Blast_Score=212, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI32566215, Length=475, Percent_Identity=26.7368421052632, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17539860, Length=411, Percent_Identity=26.7639902676399, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI17737937, Length=475, Percent_Identity=32, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24647199, Length=512, Percent_Identity=28.90625, Blast_Score=168, Evalue=9e-42,
Organism=Drosophila melanogaster, GI24647197, Length=509, Percent_Identity=29.2730844793713, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24647201, Length=524, Percent_Identity=25.763358778626, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24647195, Length=505, Percent_Identity=26.9306930693069, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24647193, Length=514, Percent_Identity=26.6536964980545, Blast_Score=133, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005107
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR002346 [H]

Pfam domain/function: PF03450 CO_deh_flav_C; PF00941 FAD_binding_5 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 54656; Mature: 54524

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRQPAPPPTVSPDHTVRFLLDGEEVQCSGFAPTTTLLTWLRESRGRCGTKEGCAEGDCG
CCCCCCCCCCCCCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
ACTVVVAEAVEGRIAWRSVNACIQLLATLHGKALYTVESLREPDGTLHPAQQAMIDCHAS
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHCCCCCCCCHHHHHHHHHCCC
QCGFCTPGFVMSLFALYRNQSRADNDAVTDALSGNLCRCTGYRPIVDAAQRMYALPAPAE
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHEECCCCCC
DADRRARETALYARLQALEGEADLVLAHAQGRYLAPRTLASFANCYADNPDATVLAGGTD
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEECCCC
IGLWITKHFRPLPLLLHLGRVRELAAIRQHDGALEIGAAVRLEDAFRALVAHYPDAAGLH
EEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEECHHEEHHHHHHHHHHHCCCHHHHH
RRFASLPIRNAGTLCGNIANGSPIGDSMPALIALGAEVVLHRAGQQRRLALEDLYLGYQQ
HHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHH
KALAAGEFVEAVRIPLPRAAGDVHFRAWKVSRRHDQDISAVFAGFALQYEDGRITRVRLA
HHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHEEEECCCCEEEEEEE
YGGMAATPRRAYATEAALLGRPFDAAALADARRALQQDFTPLSDVRASAEYRMRVAQNLL
ECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
TRLQLETSGGARAASSLADLGDGGHASI
HHEEEECCCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
GRQPAPPPTVSPDHTVRFLLDGEEVQCSGFAPTTTLLTWLRESRGRCGTKEGCAEGDCG
CCCCCCCCCCCCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
ACTVVVAEAVEGRIAWRSVNACIQLLATLHGKALYTVESLREPDGTLHPAQQAMIDCHAS
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHCCCCCCCCHHHHHHHHHCCC
QCGFCTPGFVMSLFALYRNQSRADNDAVTDALSGNLCRCTGYRPIVDAAQRMYALPAPAE
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHEECCCCCC
DADRRARETALYARLQALEGEADLVLAHAQGRYLAPRTLASFANCYADNPDATVLAGGTD
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEECCCC
IGLWITKHFRPLPLLLHLGRVRELAAIRQHDGALEIGAAVRLEDAFRALVAHYPDAAGLH
EEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEECHHEEHHHHHHHHHHHCCCHHHHH
RRFASLPIRNAGTLCGNIANGSPIGDSMPALIALGAEVVLHRAGQQRRLALEDLYLGYQQ
HHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHH
KALAAGEFVEAVRIPLPRAAGDVHFRAWKVSRRHDQDISAVFAGFALQYEDGRITRVRLA
HHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHEEEECCCCEEEEEEE
YGGMAATPRRAYATEAALLGRPFDAAALADARRALQQDFTPLSDVRASAEYRMRVAQNLL
ECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
TRLQLETSGGARAASSLADLGDGGHASI
HHEEEECCCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]