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The map label for this gene is cobD1 [H]

Identifier: 119898464

GI number: 119898464

Start: 2381808

End: 2382734

Strand: Reverse

Name: cobD1 [H]

Synonym: azo2173

Alternate gene names: 119898464

Gene position: 2382734-2381808 (Counterclockwise)

Preceding gene: 119898465

Following gene: 119898463

Centisome position: 54.45

GC content: 64.19

Gene sequence:

>927_bases
ATGACCCTCTTTTCGCTGATCTTTGCACTGCTCATCGAGCAGGTCCGCCCGCTTCCGGTCCAGCAGGTGGTCCAGCTGCC
CTTGCGCCGCCTTTCGGCACTGCTTATCGAGCGCTTCAACGACGGTCAGGCCCGTCACGGCAAGGCAGCGTGGTGGCTTA
TCGTGCTGCTCGCCTCGCTGGGCAGCGCGGTGGCTTATTTCCTGTTGTGGCATCTGCATCCGCTGCTCGCCTTCGCATTC
AACGTCGCGGTGCTGTACCTCACGCTGGGGTTCCGGCAGGAAAGCCATTTCTTTACCGATATCCACCTCGCGCTGAGGAT
GGGCGAACTCGACCGCGCGCGCGCGCTGCTGGCGGAGTGGCGCGGCGGGCAGTATCACGAGGCGAGCTCCAGTGAAGTCG
CCCGGCTCGCGATCGAACAGGCACTCGTCGCCGCGCATCGCAATGTCTTCGGGGTCGCGTTCTGGTTCATCGTGCTGCCG
GGGCCGAGCGGCGCGGTCATGTACCGGTTGGCGCGGTTCTTTGCCGACGAGTGGGGGCAACGCGCGGACATCGAGTTCGG
GGATTTCGGCCGCTTTGCCAGTCGGGCCTTCGAGGTCATCGACTGGCTGCCGGCCCGCCTGACGGCTGCTTCATTTTCTG
TCGTCGGCGACTTCGAGGATGCAGTGTATTGTTGGCGCACCCAGGCCATGCTTTGGCCCGACAAGGCGTCGGCTATACTC
ATTGCAAGTGGTGCCGGGGCGCTGGGCGTCAAGCTCGGCATGCCGGTCCACGAATCGGGCGAGATCGTAGAACGGCCCGA
AATGGGCATCGGGGATGAGGCCGATGCCGACTACATGCAAAGCACTGTCGGGCTCGTTTGGCGAGCCCTCGTGGTGTGTC
TGCTGATGCTTGCCTTGCTCGGCGTTGCCGGCTGGGTAGGCCGTTGA

Upstream 100 bases:

>100_bases
AGCGGCGCCCGCTCGGGCGTCGGCACCTTTGTGGTATCTTCGGGGCAATGCTGCCGGGCAGCACCGAATCGTCATCTGCG
CCTCCTCGCCTTCGTTCCGA

Downstream 100 bases:

>100_bases
ATCTCAAGGAGGGAGTGCAGATGGCAAGTCGTGAAGTTGTGGTTTTGAGCGCGGTGCGCTCGGCTGTTGGCGGCTTTGGC
GGTTCGCTCAAGGACATGGA

Product: CobD/CbiB family protein

Products: ADP; phosphate; Adenosyl cobinamide phosphate; Adenosyl cobinamide

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MTLFSLIFALLIEQVRPLPVQQVVQLPLRRLSALLIERFNDGQARHGKAAWWLIVLLASLGSAVAYFLLWHLHPLLAFAF
NVAVLYLTLGFRQESHFFTDIHLALRMGELDRARALLAEWRGGQYHEASSSEVARLAIEQALVAAHRNVFGVAFWFIVLP
GPSGAVMYRLARFFADEWGQRADIEFGDFGRFASRAFEVIDWLPARLTAASFSVVGDFEDAVYCWRTQAMLWPDKASAIL
IASGAGALGVKLGMPVHESGEIVERPEMGIGDEADADYMQSTVGLVWRALVVCLLMLALLGVAGWVGR

Sequences:

>Translated_308_residues
MTLFSLIFALLIEQVRPLPVQQVVQLPLRRLSALLIERFNDGQARHGKAAWWLIVLLASLGSAVAYFLLWHLHPLLAFAF
NVAVLYLTLGFRQESHFFTDIHLALRMGELDRARALLAEWRGGQYHEASSSEVARLAIEQALVAAHRNVFGVAFWFIVLP
GPSGAVMYRLARFFADEWGQRADIEFGDFGRFASRAFEVIDWLPARLTAASFSVVGDFEDAVYCWRTQAMLWPDKASAIL
IASGAGALGVKLGMPVHESGEIVERPEMGIGDEADADYMQSTVGLVWRALVVCLLMLALLGVAGWVGR
>Mature_307_residues
TLFSLIFALLIEQVRPLPVQQVVQLPLRRLSALLIERFNDGQARHGKAAWWLIVLLASLGSAVAYFLLWHLHPLLAFAFN
VAVLYLTLGFRQESHFFTDIHLALRMGELDRARALLAEWRGGQYHEASSSEVARLAIEQALVAAHRNVFGVAFWFIVLPG
PSGAVMYRLARFFADEWGQRADIEFGDFGRFASRAFEVIDWLPARLTAASFSVVGDFEDAVYCWRTQAMLWPDKASAILI
ASGAGALGVKLGMPVHESGEIVERPEMGIGDEADADYMQSTVGLVWRALVVCLLMLALLGVAGWVGR

Specific function: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group [H]

COG id: COG1270

COG function: function code H; Cobalamin biosynthesis protein CobD/CbiB

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobD/CbiB family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004485 [H]

Pfam domain/function: PF03186 CobD_Cbib [H]

EC number: 6.3.1.10

Molecular weight: Translated: 34186; Mature: 34055

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLFSLIFALLIEQVRPLPVQQVVQLPLRRLSALLIERFNDGQARHGKAAWWLIVLLASL
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
GSAVAYFLLWHLHPLLAFAFNVAVLYLTLGFRQESHFFTDIHLALRMGELDRARALLAEW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHH
RGGQYHEASSSEVARLAIEQALVAAHRNVFGVAFWFIVLPGPSGAVMYRLARFFADEWGQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEHHHHEECCCCHHHHHHHHHHHHHHCCC
RADIEFGDFGRFASRAFEVIDWLPARLTAASFSVVGDFEDAVYCWRTQAMLWPDKASAIL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEECCCCCCEEE
IASGAGALGVKLGMPVHESGEIVERPEMGIGDEADADYMQSTVGLVWRALVVCLLMLALL
EECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GVAGWVGR
HHHHHCCC
>Mature Secondary Structure 
TLFSLIFALLIEQVRPLPVQQVVQLPLRRLSALLIERFNDGQARHGKAAWWLIVLLASL
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
GSAVAYFLLWHLHPLLAFAFNVAVLYLTLGFRQESHFFTDIHLALRMGELDRARALLAEW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHH
RGGQYHEASSSEVARLAIEQALVAAHRNVFGVAFWFIVLPGPSGAVMYRLARFFADEWGQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEHHHHEECCCCHHHHHHHHHHHHHHCCC
RADIEFGDFGRFASRAFEVIDWLPARLTAASFSVVGDFEDAVYCWRTQAMLWPDKASAIL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEECCCCCCEEE
IASGAGALGVKLGMPVHESGEIVERPEMGIGDEADADYMQSTVGLVWRALVVCLLMLALL
EECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GVAGWVGR
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyric acid; (R)-1-aminopropan-2-yl phosphate; (R)-1-aminopropan-2-ol

Specific reaction: (1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate; (2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA