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The map label for this gene is thrC [H]

Identifier: 119898371

GI number: 119898371

Start: 2285402

End: 2286865

Strand: Reverse

Name: thrC [H]

Synonym: azo2080

Alternate gene names: 119898371

Gene position: 2286865-2285402 (Counterclockwise)

Preceding gene: 119898372

Following gene: 119898363

Centisome position: 52.26

GC content: 65.1

Gene sequence:

>1464_bases
GTGAAGTACATCTCCACCCGCGGCCACGCCGGCCAGCCCGCCAATCCCGAATTCTGCGACATCCTGCTCGGCGGCCTGGC
GCCCGACGGCGGCCTCTACCTGCCGGAAACCTATCCGCAGGTGACCCGCGCCGAACTCGACGCCTGGCGCAAGCTCTCCT
ACGCCGACCTGGCCTTCGCCATCCTGTCGAAGTTCATCACCGACATTCCCGCCGCCGACCTCAAGGCGATCTGCGACAAG
ACCTACACCGCCGATGTCTACCGCCACGTGCGCGCCGGCGACAACCCCGCCGACATCACCCCGGTGCACTGGCTGGAGAA
GGATGCCGCGGGCAAGGGCAGCTTTGGCCTGCTTGAGCTTTCCAATGGCCCGACGCTCGCCTTCAAGGACATGGCGATGC
AGTTGCTCGGCAACCTGTTCGAGTACGTGCTGGCCAAGCGCAGCGAGACCATCAACATCCTCGGCGCCACCTCGGGCGAC
ACCGGCTCCGCCGCGGAGTACGCGATGCGTGGCAAGCACGGCGTGCGCGTGTTCATGCTGTCGCCGCACGGCAAGATGAG
CGCCTTCCAGCGTGCCCAGATGTACTCGCTGCAGGACGGCAACATCTTCAACATCGCCGTCACCGGCATGTTCGACGATG
CCCAGGACATCGTGAAGGCGGTCTCCAACGACCACGCCTTCAAGGCGAAGTACAAGATCGGCGCGGTCAACTCGATCAAC
TGGGCGCGGGTCGCGGCGCAGATCGTCTATTACTTCAAGGGCTATTTCGCCGCCACCGAGAGCAATGACCAGCAGGTCGC
GTTCTGCGTGCCCTCGGGCAACTTCGGCAACATCTGCGCCGGCCATATCGCTCGCCAGATGGGTCTTCCGGTCGCCAAGC
TGATCCTCGCCACCAACGAAAACGACGTGCTCGACGAGTTCTTCCGCACCGGCGTCTATCGCCCGCGCAAGGCGGCGGAA
ACCCATGTCACCTCCAGCCCGTCGATGGATATCTCCAAGGCGTCCAACTTCGAGCGTTTCGTGTTCGACCTCGTCGGCCG
CGATCCGCAGAAGGTGGCCGCGCTGTGGAAGCAGGTCGACGGCGGTGCCGCTTTCGATCTGACCGCGTCCGGCGAGTTCT
CCCGCATCGGCGGCTTCGGCTTCGCCTCCGGCAGCAGTTCGCACGCCGACCGCCTCGCGACCATCCGCAAGGTGTTCGAC
AAGTACGGCGTGATGATCGACACCCACACCGCGGACGGCGTAAAGGTGGCTTGGGAGAAGGCGGACACAGTGCCCGCCGG
CGTGCCGGTGCTGGTGCTGGAAACCGCGCTGCCGGTGAAGTTTGCGGAAACCATCCAGGAAGCGCTCGGCCGTGAGCCCG
AGCGTCCTGCAGACCTCGAAGGCATCGAAGCGCTGCCGCAGCGCGTGGAAGTGATGGCGCCGGATGTCGAGGCCGTGAAG
CGCTTCATCACTACCCGGGTCTGA

Upstream 100 bases:

>100_bases
ACAAAGCCGCGAAGCCCCGGCCTGCTTTCGCTAAACTCTCGCCTTTGCGTTCGCTCCGCCCGGCGCGCTGCGCACATCCG
CTGATCCCGAGGACTGTTCC

Downstream 100 bases:

>100_bases
CCCCGTTGTGGTGCTTCGGCCGCGTCCGTTGACGTGGCCGAGGCGGCTTCGGATCGCCGGGGGGGCCTCGGCGGGGCTCC
AGTCTTGGTTCCGCGCCGCG

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MKYISTRGHAGQPANPEFCDILLGGLAPDGGLYLPETYPQVTRAELDAWRKLSYADLAFAILSKFITDIPAADLKAICDK
TYTADVYRHVRAGDNPADITPVHWLEKDAAGKGSFGLLELSNGPTLAFKDMAMQLLGNLFEYVLAKRSETINILGATSGD
TGSAAEYAMRGKHGVRVFMLSPHGKMSAFQRAQMYSLQDGNIFNIAVTGMFDDAQDIVKAVSNDHAFKAKYKIGAVNSIN
WARVAAQIVYYFKGYFAATESNDQQVAFCVPSGNFGNICAGHIARQMGLPVAKLILATNENDVLDEFFRTGVYRPRKAAE
THVTSSPSMDISKASNFERFVFDLVGRDPQKVAALWKQVDGGAAFDLTASGEFSRIGGFGFASGSSSHADRLATIRKVFD
KYGVMIDTHTADGVKVAWEKADTVPAGVPVLVLETALPVKFAETIQEALGREPERPADLEGIEALPQRVEVMAPDVEAVK
RFITTRV

Sequences:

>Translated_487_residues
MKYISTRGHAGQPANPEFCDILLGGLAPDGGLYLPETYPQVTRAELDAWRKLSYADLAFAILSKFITDIPAADLKAICDK
TYTADVYRHVRAGDNPADITPVHWLEKDAAGKGSFGLLELSNGPTLAFKDMAMQLLGNLFEYVLAKRSETINILGATSGD
TGSAAEYAMRGKHGVRVFMLSPHGKMSAFQRAQMYSLQDGNIFNIAVTGMFDDAQDIVKAVSNDHAFKAKYKIGAVNSIN
WARVAAQIVYYFKGYFAATESNDQQVAFCVPSGNFGNICAGHIARQMGLPVAKLILATNENDVLDEFFRTGVYRPRKAAE
THVTSSPSMDISKASNFERFVFDLVGRDPQKVAALWKQVDGGAAFDLTASGEFSRIGGFGFASGSSSHADRLATIRKVFD
KYGVMIDTHTADGVKVAWEKADTVPAGVPVLVLETALPVKFAETIQEALGREPERPADLEGIEALPQRVEVMAPDVEAVK
RFITTRV
>Mature_487_residues
MKYISTRGHAGQPANPEFCDILLGGLAPDGGLYLPETYPQVTRAELDAWRKLSYADLAFAILSKFITDIPAADLKAICDK
TYTADVYRHVRAGDNPADITPVHWLEKDAAGKGSFGLLELSNGPTLAFKDMAMQLLGNLFEYVLAKRSETINILGATSGD
TGSAAEYAMRGKHGVRVFMLSPHGKMSAFQRAQMYSLQDGNIFNIAVTGMFDDAQDIVKAVSNDHAFKAKYKIGAVNSIN
WARVAAQIVYYFKGYFAATESNDQQVAFCVPSGNFGNICAGHIARQMGLPVAKLILATNENDVLDEFFRTGVYRPRKAAE
THVTSSPSMDISKASNFERFVFDLVGRDPQKVAALWKQVDGGAAFDLTASGEFSRIGGFGFASGSSSHADRLATIRKVFD
KYGVMIDTHTADGVKVAWEKADTVPAGVPVLVLETALPVKFAETIQEALGREPERPADLEGIEALPQRVEVMAPDVEAVK
RFITTRV

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=478, Percent_Identity=31.1715481171548, Blast_Score=221, Evalue=9e-58,
Organism=Homo sapiens, GI153792148, Length=454, Percent_Identity=32.8193832599119, Blast_Score=200, Evalue=3e-51,
Organism=Escherichia coli, GI1786185, Length=487, Percent_Identity=29.7741273100616, Blast_Score=188, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6319901, Length=480, Percent_Identity=41.25, Blast_Score=323, Evalue=4e-89,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 52943; Mature: 52943

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYISTRGHAGQPANPEFCDILLGGLAPDGGLYLPETYPQVTRAELDAWRKLSYADLAFA
CCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHHCHHHHHHHH
ILSKFITDIPAADLKAICDKTYTADVYRHVRAGDNPADITPVHWLEKDAAGKGSFGLLEL
HHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCEEEEEE
SNGPTLAFKDMAMQLLGNLFEYVLAKRSETINILGATSGDTGSAAEYAMRGKHGVRVFML
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHCCCCCEEEEEE
SPHGKMSAFQRAQMYSLQDGNIFNIAVTGMFDDAQDIVKAVSNDHAFKAKYKIGAVNSIN
CCCCHHHHHHHHHHEECCCCCEEEEEEEECCCCHHHHHHHHCCCCEEEEEEEECCCCCCH
WARVAAQIVYYFKGYFAATESNDQQVAFCVPSGNFGNICAGHIARQMGLPVAKLILATNE
HHHHHHHHHHHHHHEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHHEEECCC
NDVLDEFFRTGVYRPRKAAETHVTSSPSMDISKASNFERFVFDLVGRDPQKVAALWKQVD
CHHHHHHHHCCCCCCCHHHHHCCCCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHCC
GGAAFDLTASGEFSRIGGFGFASGSSSHADRLATIRKVFDKYGVMIDTHTADGVKVAWEK
CCCEEEEECCCCCHHCCCCEECCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCEEEEEEC
ADTVPAGVPVLVLETALPVKFAETIQEALGREPERPADLEGIEALPQRVEVMAPDVEAVK
CCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHH
RFITTRV
HHHHCCC
>Mature Secondary Structure
MKYISTRGHAGQPANPEFCDILLGGLAPDGGLYLPETYPQVTRAELDAWRKLSYADLAFA
CCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHHCHHHHHHHH
ILSKFITDIPAADLKAICDKTYTADVYRHVRAGDNPADITPVHWLEKDAAGKGSFGLLEL
HHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCEEEEEE
SNGPTLAFKDMAMQLLGNLFEYVLAKRSETINILGATSGDTGSAAEYAMRGKHGVRVFML
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHCCCCCEEEEEE
SPHGKMSAFQRAQMYSLQDGNIFNIAVTGMFDDAQDIVKAVSNDHAFKAKYKIGAVNSIN
CCCCHHHHHHHHHHEECCCCCEEEEEEEECCCCHHHHHHHHCCCCEEEEEEEECCCCCCH
WARVAAQIVYYFKGYFAATESNDQQVAFCVPSGNFGNICAGHIARQMGLPVAKLILATNE
HHHHHHHHHHHHHHEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHHEEECCC
NDVLDEFFRTGVYRPRKAAETHVTSSPSMDISKASNFERFVFDLVGRDPQKVAALWKQVD
CHHHHHHHHCCCCCCCHHHHHCCCCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHCC
GGAAFDLTASGEFSRIGGFGFASGSSSHADRLATIRKVFDKYGVMIDTHTADGVKVAWEK
CCCEEEEECCCCCHHCCCCEECCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCEEEEEEC
ADTVPAGVPVLVLETALPVKFAETIQEALGREPERPADLEGIEALPQRVEVMAPDVEAVK
CCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHH
RFITTRV
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8117070 [H]