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The map label for this gene is hom [H]

Identifier: 119898372

GI number: 119898372

Start: 2287025

End: 2288332

Strand: Reverse

Name: hom [H]

Synonym: azo2081

Alternate gene names: 119898372

Gene position: 2288332-2287025 (Counterclockwise)

Preceding gene: 119898373

Following gene: 119898371

Centisome position: 52.29

GC content: 65.9

Gene sequence:

>1308_bases
ATGAAACCGATCAACGTTGGCCTGCTGGGCATCGGAACCGTCGGCGGCGGTACCTTCACCGTCCTCAAACGCAACGAAGA
AGAAATCACGCGTCGCGCCGGGCGTCCGATCCGAATTACCGCGGTGGCCGACAAGAACCTCGAGCTCGCCCGCAGCGTCA
CCGGCGGCGGGGTCAAGCTCACCGACGACGCCTTCGCGGTCGTGACCGACCCCGAAGTCGATATCGTCGTCGAACTGATC
GGCGGCTACGGCATCGCCCGCGAACTGGTGCTGAAGGCGATCGAGAACGGCAAGCATGTGGTTACCGCCAACAAGGCGCT
GCTCGCGGTCCACGGCAACGAAATCTTCGCCGCCGCGCAGGCGCGCGGCGTGATGGTCGCCTTCGAGGCGGCGGTGGCCG
GCGGCATTCCCATCATCAAGGCGCTGCGCGAAGGCCTGTCGGCCAACCGCATCCAGTGGCTGGCCGGCATCATCAACGGC
ACCACCAACTTCATCCTGTCGGAAATGCGCGACAAGGGCCTGCCGTTCGCCGACGTGCTGAAGGAAGCCCAGGCGCTCGG
CTATGCCGAAGCCGACCCGACCTTCGACATCGAAGGCATCGATGCCGCCCACAAGGCGACCATCATGAGCGCGATCGCCT
TCGGCATCCCCATGCAGTTCGACAAGGCCTACGTCGAAGGCATCACCAAGCTCGACGCCGCCGACATCCGCTACGCGGAG
CAGCTCGGCTACCGCATCAAGCTGCTCGGCATCGCCCGCCGCCGCGACGAAGGCGTGGAACTGCGCGTGCATCCGACGCT
GATCCCGGAAAAGCGCCTCATCGCCAATGTGGAAGGCGCGATGAACGCGGTGCTGGTGCAGGGCGACGCCGTCGGCGCGA
CGCTGTACTACGGCAAGGGTGCCGGCGCAGAGCCGACCGCCTCGGCCGTCATCGCCGACCTGGTCGACGTCACCCGCCTG
CACACCGCCGATCCGGAACACCGCGTGCCCCACCTGGCCTTCCAGCCGGACCAGGTACAGGACGTGGCGGTTCTGCCGAT
CGAGGAAGTGGTCACCTCCTACTACCTGCGCCTGCGGGTGGATGACAAGCCGGGCGTGCTCGCCGACATCACCCGCATCC
TCGCCGACAGCGACATCTCGATCGACGCGATGATCCAGAAGGAGCCGGGCGAAGGCGAAGCGCAGACCGACATCATCATG
CTGACCCACCAGACGGTGGAGAAGAACGCCAACGCCGCGATCGCCAAGATCGAAGCGCTGCCGGTGGTGGTGGGCAAGGT
CACCAAGCTGCGGCTCGAAAACCTCTGA

Upstream 100 bases:

>100_bases
CCATCGGCCGCGTTGCGCGCTTCCTCGAAGGCTATCGCAAGCGCCACGGCACCTGAACCTCACCGAACCACCTTTCACAC
GACAGAAACGGAAGCACTGA

Downstream 100 bases:

>100_bases
GCGCTGCCGGGTTAAAGCTGAGTCGGCGCTCCGGCGCCGATTCTTCGTTTACCGCCGGCACAAAGCCGCGAAGCCCCGGC
CTGCTTTCGCTAAACTCTCG

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MKPINVGLLGIGTVGGGTFTVLKRNEEEITRRAGRPIRITAVADKNLELARSVTGGGVKLTDDAFAVVTDPEVDIVVELI
GGYGIARELVLKAIENGKHVVTANKALLAVHGNEIFAAAQARGVMVAFEAAVAGGIPIIKALREGLSANRIQWLAGIING
TTNFILSEMRDKGLPFADVLKEAQALGYAEADPTFDIEGIDAAHKATIMSAIAFGIPMQFDKAYVEGITKLDAADIRYAE
QLGYRIKLLGIARRRDEGVELRVHPTLIPEKRLIANVEGAMNAVLVQGDAVGATLYYGKGAGAEPTASAVIADLVDVTRL
HTADPEHRVPHLAFQPDQVQDVAVLPIEEVVTSYYLRLRVDDKPGVLADITRILADSDISIDAMIQKEPGEGEAQTDIIM
LTHQTVEKNANAAIAKIEALPVVVGKVTKLRLENL

Sequences:

>Translated_435_residues
MKPINVGLLGIGTVGGGTFTVLKRNEEEITRRAGRPIRITAVADKNLELARSVTGGGVKLTDDAFAVVTDPEVDIVVELI
GGYGIARELVLKAIENGKHVVTANKALLAVHGNEIFAAAQARGVMVAFEAAVAGGIPIIKALREGLSANRIQWLAGIING
TTNFILSEMRDKGLPFADVLKEAQALGYAEADPTFDIEGIDAAHKATIMSAIAFGIPMQFDKAYVEGITKLDAADIRYAE
QLGYRIKLLGIARRRDEGVELRVHPTLIPEKRLIANVEGAMNAVLVQGDAVGATLYYGKGAGAEPTASAVIADLVDVTRL
HTADPEHRVPHLAFQPDQVQDVAVLPIEEVVTSYYLRLRVDDKPGVLADITRILADSDISIDAMIQKEPGEGEAQTDIIM
LTHQTVEKNANAAIAKIEALPVVVGKVTKLRLENL
>Mature_435_residues
MKPINVGLLGIGTVGGGTFTVLKRNEEEITRRAGRPIRITAVADKNLELARSVTGGGVKLTDDAFAVVTDPEVDIVVELI
GGYGIARELVLKAIENGKHVVTANKALLAVHGNEIFAAAQARGVMVAFEAAVAGGIPIIKALREGLSANRIQWLAGIING
TTNFILSEMRDKGLPFADVLKEAQALGYAEADPTFDIEGIDAAHKATIMSAIAFGIPMQFDKAYVEGITKLDAADIRYAE
QLGYRIKLLGIARRRDEGVELRVHPTLIPEKRLIANVEGAMNAVLVQGDAVGATLYYGKGAGAEPTASAVIADLVDVTRL
HTADPEHRVPHLAFQPDQVQDVAVLPIEEVVTSYYLRLRVDDKPGVLADITRILADSDISIDAMIQKEPGEGEAQTDIIM
LTHQTVEKNANAAIAKIEALPVVVGKVTKLRLENL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=258, Percent_Identity=26.3565891472868, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1790376, Length=244, Percent_Identity=24.5901639344262, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322599, Length=233, Percent_Identity=29.1845493562232, Blast_Score=77, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46502; Mature: 46502

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00318 HMG_COA_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPINVGLLGIGTVGGGTFTVLKRNEEEITRRAGRPIRITAVADKNLELARSVTGGGVKL
CCCEEEEEEEEEECCCCEEEEEECCHHHHHHHCCCCEEEEEEECCCCHHHHHCCCCCEEE
TDDAFAVVTDPEVDIVVELIGGYGIARELVLKAIENGKHVVTANKALLAVHGNEIFAAAQ
ECCCEEEEECCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCEEEEEECCEEEEECC
ARGVMVAFEAAVAGGIPIIKALREGLSANRIQWLAGIINGTTNFILSEMRDKGLPFADVL
CCCEEEEEEHHHHCCCHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHH
KEAQALGYAEADPTFDIEGIDAAHKATIMSAIAFGIPMQFDKAYVEGITKLDAADIRYAE
HHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHH
QLGYRIKLLGIARRRDEGVELRVHPTLIPEKRLIANVEGAMNAVLVQGDAVGATLYYGKG
HCCCEEEEEEEEECCCCCCEEEEECCCCCCHHHHHCCCCCCEEEEEECCCCEEEEEECCC
AGAEPTASAVIADLVDVTRLHTADPEHRVPHLAFQPDQVQDVAVLPIEEVVTSYYLRLRV
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCEEECCHHHHHHEEEEEEEE
DDKPGVLADITRILADSDISIDAMIQKEPGEGEAQTDIIMLTHQTVEKNANAAIAKIEAL
CCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEEEEEHHHHCCCCEEEEEEEHH
PVVVGKVTKLRLENL
HHHHHHHHEEEECCC
>Mature Secondary Structure
MKPINVGLLGIGTVGGGTFTVLKRNEEEITRRAGRPIRITAVADKNLELARSVTGGGVKL
CCCEEEEEEEEEECCCCEEEEEECCHHHHHHHCCCCEEEEEEECCCCHHHHHCCCCCEEE
TDDAFAVVTDPEVDIVVELIGGYGIARELVLKAIENGKHVVTANKALLAVHGNEIFAAAQ
ECCCEEEEECCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCEEEEEECCEEEEECC
ARGVMVAFEAAVAGGIPIIKALREGLSANRIQWLAGIINGTTNFILSEMRDKGLPFADVL
CCCEEEEEEHHHHCCCHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHH
KEAQALGYAEADPTFDIEGIDAAHKATIMSAIAFGIPMQFDKAYVEGITKLDAADIRYAE
HHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHH
QLGYRIKLLGIARRRDEGVELRVHPTLIPEKRLIANVEGAMNAVLVQGDAVGATLYYGKG
HCCCEEEEEEEEECCCCCCEEEEECCCCCCHHHHHCCCCCCEEEEEECCCCEEEEEECCC
AGAEPTASAVIADLVDVTRLHTADPEHRVPHLAFQPDQVQDVAVLPIEEVVTSYYLRLRV
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCEEECCHHHHHHEEEEEEEE
DDKPGVLADITRILADSDISIDAMIQKEPGEGEAQTDIIMLTHQTVEKNANAAIAKIEAL
CCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEEEEEHHHHCCCCEEEEEEEHH
PVVVGKVTKLRLENL
HHHHHHHHEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]