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The map label for this gene is rnhA2 [H]

Identifier: 119898346

GI number: 119898346

Start: 2255849

End: 2256307

Strand: Reverse

Name: rnhA2 [H]

Synonym: azo2055

Alternate gene names: 119898346

Gene position: 2256307-2255849 (Counterclockwise)

Preceding gene: 119898347

Following gene: 119898345

Centisome position: 51.56

GC content: 67.32

Gene sequence:

>459_bases
ATGGAAGAAGTCGACATCTATACCGATGGAGCCTGCAGCGGAAATCCCGGCCCCGGCGGCTGGGGCGCGATCCTGCGCTC
CAACGGGCATGAGAAGGAAATCTGGGGCGGTGAGCCGCAGACCACGAACAACCGGATGGAACTGATCGCCGTCATCCGGG
CGCTGGAAGCGCTGAAGCGCCCGGTTGCCGCCCGGGTGCACACCGACAGCCAATACGTGCAGAAGGGCATCTCCGAGTGG
ATCCACGGCTGGAAGGCGCGGGGCTGGAAGACCGCGTCCAAGGAGCCGGTGAAGAACGCCGACCTGTGGCGGACGCTGGA
CGAGGTGGCTGGCCGGCATCAGGTCAAGTGGCTGTGGGTACGCGGCCATGCCGGCCACGTGGAGAACGAGCGGGCCGACG
CCCTCGCGCGCCGTGGCGCCGAGGCCGCCCGCAAACAAGGCACCGTCGTCACCAACTAA

Upstream 100 bases:

>100_bases
GTTATTGACGCCGAACTGGCGCGAGAAGAAAGCAACCGGCAAGCAATTGTCGACGGTCGCGCAGCGGGATTCCGCCGCGG
GCCGAGCAAGGACACAGTGA

Downstream 100 bases:

>100_bases
GGTCAAGTCAGATTCCCATGCGGCAAATCGTTCTGGATACCGAGACCACGGGTCTCGATTGGCGCACCGGTGACCGTGTC
ATCGAAATCGGCTGCGTCGA

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H [H]

Number of amino acids: Translated: 152; Mature: 152

Protein sequence:

>152_residues
MEEVDIYTDGACSGNPGPGGWGAILRSNGHEKEIWGGEPQTTNNRMELIAVIRALEALKRPVAARVHTDSQYVQKGISEW
IHGWKARGWKTASKEPVKNADLWRTLDEVAGRHQVKWLWVRGHAGHVENERADALARRGAEAARKQGTVVTN

Sequences:

>Translated_152_residues
MEEVDIYTDGACSGNPGPGGWGAILRSNGHEKEIWGGEPQTTNNRMELIAVIRALEALKRPVAARVHTDSQYVQKGISEW
IHGWKARGWKTASKEPVKNADLWRTLDEVAGRHQVKWLWVRGHAGHVENERADALARRGAEAARKQGTVVTN
>Mature_152_residues
MEEVDIYTDGACSGNPGPGGWGAILRSNGHEKEIWGGEPQTTNNRMELIAVIRALEALKRPVAARVHTDSQYVQKGISEW
IHGWKARGWKTASKEPVKNADLWRTLDEVAGRHQVKWLWVRGHAGHVENERADALARRGAEAARKQGTVVTN

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids [H]

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain [H]

Homologues:

Organism=Homo sapiens, GI21359816, Length=150, Percent_Identity=35.3333333333333, Blast_Score=82, Evalue=3e-16,
Organism=Escherichia coli, GI1786408, Length=140, Percent_Identity=62.8571428571429, Blast_Score=189, Evalue=9e-50,
Organism=Caenorhabditis elegans, GI115532542, Length=141, Percent_Identity=42.5531914893617, Blast_Score=104, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17505482, Length=133, Percent_Identity=37.593984962406, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45552509, Length=150, Percent_Identity=36, Blast_Score=83, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17137476, Length=150, Percent_Identity=36, Blast_Score=83, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156 [H]

Pfam domain/function: PF00075 RnaseH [H]

EC number: =3.1.26.4 [H]

Molecular weight: Translated: 16881; Mature: 16881

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEVDIYTDGACSGNPGPGGWGAILRSNGHEKEIWGGEPQTTNNRMELIAVIRALEALKR
CCCCCEEECCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
PVAARVHTDSQYVQKGISEWIHGWKARGWKTASKEPVKNADLWRTLDEVAGRHQVKWLWV
CHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEE
RGHAGHVENERADALARRGAEAARKQGTVVTN
ECCCCCCCCHHHHHHHHHCHHHHHHCCCCCCC
>Mature Secondary Structure
MEEVDIYTDGACSGNPGPGGWGAILRSNGHEKEIWGGEPQTTNNRMELIAVIRALEALKR
CCCCCEEECCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
PVAARVHTDSQYVQKGISEWIHGWKARGWKTASKEPVKNADLWRTLDEVAGRHQVKWLWV
CHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEE
RGHAGHVENERADALARRGAEAARKQGTVVTN
ECCCCCCCCHHHHHHHHHCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA