Click here to switch to the map view.

The map label for this gene is hscB

Identifier: 119898304

GI number: 119898304

Start: 2218661

End: 2219194

Strand: Reverse

Name: hscB

Synonym: azo2013

Alternate gene names: 119898304

Gene position: 2219194-2218661 (Counterclockwise)

Preceding gene: 119898305

Following gene: 119898303

Centisome position: 50.71

GC content: 66.1

Gene sequence:

>534_bases
ATGGCCATCGATCTGCAGCAGGACTACTTCTCGCTGTTCGGGATGCCGCGCCGCTTTCGCATCGACGAGTCGGCGCTGGA
GGCGGCGTGGCACGGCCTGCAGGGCGAGGTCCACCCGGACCGCTTCGCCCACCTGCCGGACGTCGAGAAGCGGCGGTCGA
TGCAGTGGGCCACGCGGGTCAATGAAGGTTTTCGCGTGCTGCGCAAACCGCTGAGCCGCGCGCAGTATCTGCTCGAACTC
GCCGGCGTCGATGCGGCCATCGACACCAACACCGCGATGTCGCCCGAGTTCCTGATGGAGCAGATGGAGTGGCGCGAAGC
GGTGGAGGAAGCTCGCGCGGCCGGCGAGGTGGATGAGCTGGAGCAGCTTCATCTGCGCCTGCGCCAGCATTCGCGCGAGG
TGCACGCCGGACTCGCGGACGCGCTCGATGATGCGGGTGATTACCCCGCTGCCGCCGAAACCGTGCGGCGCCTGATGTTC
ATCGAGAAACTACAACACGAGATCGACGACGCCCTAGAGGCGCTCGAAAACTAG

Upstream 100 bases:

>100_bases
CTGGACTTCGTGCGCGAGGGCCTGAACGAAGGCTTCAAGTTCAACAACCCGAACGTGAAAGACGCCTGCGGTTGCGGCGA
GAGCTTCAACGTCTGAACGC

Downstream 100 bases:

>100_bases
ATGGGCGCGTAAAGCATGGCTCTGCTCCAAATCGCCGAACCAGGCATGTCCGCCGAGCCCCACAAACACCGCCTCGCGGT
GGGGATCGACCTCGGCACGA

Product: co-chaperone HscB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MAIDLQQDYFSLFGMPRRFRIDESALEAAWHGLQGEVHPDRFAHLPDVEKRRSMQWATRVNEGFRVLRKPLSRAQYLLEL
AGVDAAIDTNTAMSPEFLMEQMEWREAVEEARAAGEVDELEQLHLRLRQHSREVHAGLADALDDAGDYPAAAETVRRLMF
IEKLQHEIDDALEALEN

Sequences:

>Translated_177_residues
MAIDLQQDYFSLFGMPRRFRIDESALEAAWHGLQGEVHPDRFAHLPDVEKRRSMQWATRVNEGFRVLRKPLSRAQYLLEL
AGVDAAIDTNTAMSPEFLMEQMEWREAVEEARAAGEVDELEQLHLRLRQHSREVHAGLADALDDAGDYPAAAETVRRLMF
IEKLQHEIDDALEALEN
>Mature_176_residues
AIDLQQDYFSLFGMPRRFRIDESALEAAWHGLQGEVHPDRFAHLPDVEKRRSMQWATRVNEGFRVLRKPLSRAQYLLELA
GVDAAIDTNTAMSPEFLMEQMEWREAVEEARAAGEVDELEQLHLRLRQHSREVHAGLADALDDAGDYPAAAETVRRLMFI
EKLQHEIDDALEALEN

Specific function: Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward hscA

COG id: COG1076

COG function: function code O; DnaJ-domain-containing proteins 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 J domain

Homologues:

Organism=Homo sapiens, GI50301234, Length=167, Percent_Identity=31.7365269461078, Blast_Score=87, Evalue=9e-18,
Organism=Escherichia coli, GI1788876, Length=157, Percent_Identity=38.8535031847134, Blast_Score=112, Evalue=1e-26,
Organism=Drosophila melanogaster, GI161084223, Length=168, Percent_Identity=31.547619047619, Blast_Score=96, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HSCB_AZOSB (A1K725)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_933517.1
- ProteinModelPortal:   A1K725
- SMR:   A1K725
- STRING:   A1K725
- GeneID:   4607176
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo2013
- eggNOG:   COG1076
- HOGENOM:   HBG751004
- OMA:   LNDAYQT
- PhylomeDB:   A1K725
- ProtClustDB:   PRK03578
- BioCyc:   ASP62928:AZO2013-MONOMER
- HAMAP:   MF_00682
- InterPro:   IPR001623
- InterPro:   IPR009073
- InterPro:   IPR004640
- Gene3D:   G3DSA:1.10.287.110
- Gene3D:   G3DSA:1.20.1280.20
- SMART:   SM00271
- TIGRFAMs:   TIGR00714

Pfam domain/function: PF00226 DnaJ; PF07743 HSCB_C; SSF46565 DnaJ_N; SSF47144 HSC20_C

EC number: NA

Molecular weight: Translated: 20339; Mature: 20208

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00636 DNAJ_1; PS50076 DNAJ_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIDLQQDYFSLFGMPRRFRIDESALEAAWHGLQGEVHPDRFAHLPDVEKRRSMQWATRV
CCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHH
NEGFRVLRKPLSRAQYLLELAGVDAAIDTNTAMSPEFLMEQMEWREAVEEARAAGEVDEL
HHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHH
EQLHLRLRQHSREVHAGLADALDDAGDYPAAAETVRRLMFIEKLQHEIDDALEALEN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AIDLQQDYFSLFGMPRRFRIDESALEAAWHGLQGEVHPDRFAHLPDVEKRRSMQWATRV
CCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHH
NEGFRVLRKPLSRAQYLLELAGVDAAIDTNTAMSPEFLMEQMEWREAVEEARAAGEVDEL
HHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHH
EQLHLRLRQHSREVHAGLADALDDAGDYPAAAETVRRLMFIEKLQHEIDDALEALEN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA