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The map label for this gene is mhpF

Identifier: 119898264

GI number: 119898264

Start: 2169628

End: 2170548

Strand: Reverse

Name: mhpF

Synonym: azo1973

Alternate gene names: 119898264

Gene position: 2170548-2169628 (Counterclockwise)

Preceding gene: 119898265

Following gene: 119898263

Centisome position: 49.6

GC content: 65.47

Gene sequence:

>921_bases
ATGAACAAGATCAAATGCGCCTTGATTGGTCCGGGCAACATCGGCACCGATCTGCTCTACAAACTCAAGCGCAGCCCGGT
GCTGGAGCCGGTGTGGATGGTGGGCATCGACGCCGCCTCCGAAGGCCTGGCGCGCGCCCGCGAACTCGGCCTGAAAACCA
CCGCCGACGGCGTCGATGGCCTGCTGCCGCATGTGAAGGCCGATGGCGTGCAGATCGCCTTCGACGCCACGTCCGCCTAT
GTCCATGCCGAGAACAGCCGCAAGTTGAATGAACTCGGCGTGCTGATGATCGACTTGACGCCCGCGGCCATCGGCCCCTT
CTGCGTGCCGCCCGTCAATCTCAAGGACCACGTCGGCCGCGGCGAAATGAACGTGAACATGGTCACCTGCGGCGGCCAGG
CCACGATCCCGATGGTCGCGGCGGTGAGCCGCGTGCAGCCGGTGAAGTACGGCGAGATCGTCGCCACCGTGTCGAGCAAG
TCGGCCGGCCCCGGCACCCGCAAGAACATCGACGAATTCACCCGCACCACCGCCGGCGCGGTCGAGAAGGTGGGCGGCGC
CAAGGTCGGCAAGGCCATCATCATCCTCAACCCCGCCGAGCCGCCGCTGATCATGCGCGACACCGTGCATTGCCTCACCG
AAACCGAGCCCGACCAGCAGAAGATCACCGAGTCCATCCACGCGATGATCCGCGAGGTCCAGAAGTACGTGCCGGGCTAC
AAGCTGGTCAATGGCCCGGTCTTCGATGGCAACCGCGTCTCGATCTACCTCGAAGTCGAAGGCCTCGGCGACTACCTGCC
GAAGTACGCCGGCAACCTCGACATCATGACCGCGGCCGGTGCCCGCACCGCCGAGATGTTCGCCGAGGAAATCCTCGCCG
GCCGCCTCACCCTCGAATCCAACCGCGCCGTGCTGGCTTGA

Upstream 100 bases:

>100_bases
GACTGGGCCACGTCGAGGCCTGCTTCGAATGACCCCCGGGGCCGGGAGACGCAGACCTCCCGTCCGCCCCTGTACGACCC
CAACCCCAGTGAGTGCAAGC

Downstream 100 bases:

>100_bases
ATCAGGAGAAAACCATGGACCTTCGCGGCACACGCATCACCGTTCACGACATGACCCTGCGCGACGGCATGCACCCCAAG
CGCCACCTGATGACGCTCGA

Product: acetaldehyde dehydrogenase

Products: NA

Alternate protein names: Acetaldehyde dehydrogenase [acetylating] 2/3

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MNKIKCALIGPGNIGTDLLYKLKRSPVLEPVWMVGIDAASEGLARARELGLKTTADGVDGLLPHVKADGVQIAFDATSAY
VHAENSRKLNELGVLMIDLTPAAIGPFCVPPVNLKDHVGRGEMNVNMVTCGGQATIPMVAAVSRVQPVKYGEIVATVSSK
SAGPGTRKNIDEFTRTTAGAVEKVGGAKVGKAIIILNPAEPPLIMRDTVHCLTETEPDQQKITESIHAMIREVQKYVPGY
KLVNGPVFDGNRVSIYLEVEGLGDYLPKYAGNLDIMTAAGARTAEMFAEEILAGRLTLESNRAVLA

Sequences:

>Translated_306_residues
MNKIKCALIGPGNIGTDLLYKLKRSPVLEPVWMVGIDAASEGLARARELGLKTTADGVDGLLPHVKADGVQIAFDATSAY
VHAENSRKLNELGVLMIDLTPAAIGPFCVPPVNLKDHVGRGEMNVNMVTCGGQATIPMVAAVSRVQPVKYGEIVATVSSK
SAGPGTRKNIDEFTRTTAGAVEKVGGAKVGKAIIILNPAEPPLIMRDTVHCLTETEPDQQKITESIHAMIREVQKYVPGY
KLVNGPVFDGNRVSIYLEVEGLGDYLPKYAGNLDIMTAAGARTAEMFAEEILAGRLTLESNRAVLA
>Mature_306_residues
MNKIKCALIGPGNIGTDLLYKLKRSPVLEPVWMVGIDAASEGLARARELGLKTTADGVDGLLPHVKADGVQIAFDATSAY
VHAENSRKLNELGVLMIDLTPAAIGPFCVPPVNLKDHVGRGEMNVNMVTCGGQATIPMVAAVSRVQPVKYGEIVATVSSK
SAGPGTRKNIDEFTRTTAGAVEKVGGAKVGKAIIILNPAEPPLIMRDTVHCLTETEPDQQKITESIHAMIREVQKYVPGY
KLVNGPVFDGNRVSIYLEVEGLGDYLPKYAGNLDIMTAAGARTAEMFAEEILAGRLTLESNRAVLA

Specific function: Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds

COG id: COG4569

COG function: function code Q; Acetaldehyde dehydrogenase (acetylating)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetaldehyde dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1786547, Length=311, Percent_Identity=55.6270096463022, Blast_Score=310, Evalue=7e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACDH2_AZOSB (A1K6Y5)

Other databases:

- EMBL:   AM406670
- EMBL:   AM406670
- RefSeq:   YP_933477.1
- RefSeq:   YP_933936.1
- STRING:   A1K6Y5
- GeneID:   4609221
- GeneID:   4609322
- GenomeReviews:   AM406670_GR
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo1973
- KEGG:   azo:azo2432
- eggNOG:   COG4569
- HOGENOM:   HBG300125
- OMA:   IGGAQRG
- ProtClustDB:   PRK08300
- BioCyc:   ASP62928:AZO1973-MONOMER
- BioCyc:   ASP62928:AZO2432-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01657
- InterPro:   IPR003361
- InterPro:   IPR015426
- InterPro:   IPR016040
- InterPro:   IPR000534
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR21123
- PIRSF:   PIRSF015689
- SMART:   SM00859
- TIGRFAMs:   TIGR03215

Pfam domain/function: PF09290 AcetDehyd-dimer; PF01118 Semialdhyde_dh

EC number: =1.2.1.10

Molecular weight: Translated: 32572; Mature: 32572

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: BINDING 272-272

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKIKCALIGPGNIGTDLLYKLKRSPVLEPVWMVGIDAASEGLARARELGLKTTADGVDG
CCCEEEEEECCCCCCHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHCCCCCCCCCHHH
LLPHVKADGVQIAFDATSAYVHAENSRKLNELGVLMIDLTPAAIGPFCVPPVNLKDHVGR
HCCCCCCCCEEEEEECCEEEEEECCCCCHHHCCEEEEEECHHHCCCCCCCCCCHHHCCCC
GEMNVNMVTCGGQATIPMVAAVSRVQPVKYGEIVATVSSKSAGPGTRKNIDEFTRTTAGA
CCEEEEEEEECCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHH
VEKVGGAKVGKAIIILNPAEPPLIMRDTVHCLTETEPDQQKITESIHAMIREVQKYVPGY
HHHCCCCCCCCEEEEECCCCCCEEEHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCC
KLVNGPVFDGNRVSIYLEVEGLGDYLPKYAGNLDIMTAAGARTAEMFAEEILAGRLTLES
EEECCCEECCCEEEEEEEECCCHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHCEEEEEC
NRAVLA
CCEECC
>Mature Secondary Structure
MNKIKCALIGPGNIGTDLLYKLKRSPVLEPVWMVGIDAASEGLARARELGLKTTADGVDG
CCCEEEEEECCCCCCHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHCCCCCCCCCHHH
LLPHVKADGVQIAFDATSAYVHAENSRKLNELGVLMIDLTPAAIGPFCVPPVNLKDHVGR
HCCCCCCCCEEEEEECCEEEEEECCCCCHHHCCEEEEEECHHHCCCCCCCCCCHHHCCCC
GEMNVNMVTCGGQATIPMVAAVSRVQPVKYGEIVATVSSKSAGPGTRKNIDEFTRTTAGA
CCEEEEEEEECCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHH
VEKVGGAKVGKAIIILNPAEPPLIMRDTVHCLTETEPDQQKITESIHAMIREVQKYVPGY
HHHCCCCCCCCEEEEECCCCCCEEEHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCC
KLVNGPVFDGNRVSIYLEVEGLGDYLPKYAGNLDIMTAAGARTAEMFAEEILAGRLTLES
EEECCCEECCCEEEEEEEECCCHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHCEEEEEC
NRAVLA
CCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA