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The map label for this gene is gcdH2 [H]

Identifier: 119898221

GI number: 119898221

Start: 2117761

End: 2118942

Strand: Reverse

Name: gcdH2 [H]

Synonym: azo1930

Alternate gene names: 119898221

Gene position: 2118942-2117761 (Counterclockwise)

Preceding gene: 119898222

Following gene: 119898220

Centisome position: 48.42

GC content: 65.57

Gene sequence:

>1182_bases
ATGAGCAAAGTCCAATTCAACTGGGAAGACCCCCTCCACCTCGACAGCCAGCTGACCGACGTGGAGCGCATGGTGCGTGA
CACCGCGCGCGCCTACTGCCAGGAAAAGCTGCTGCCGCGCGTGCAGGAAGCCTTCCGCCATGAGCGCACCGACCGCGAGA
TCTTCAACGAGATGGGCGAACTCGGCCTGCTCGGTCCGACGATTCCCGAGCAGTACGGCGGCGCCGGCATGAACTACATC
AGCTACGGCCTGATCGCCCGCGAAGTCGAGCGGGTGGACTCCGGCTACCGCTCGATGATGAGCGTGCAGTCCTCGCTGGT
CATGGTGCCGATCAACGAATTCGGCACCGAAGCGCAGAAGCAGAAATACCTGCCCAAGCTCGCCACCGGCGAATGGGTGG
GCTGCTTCGGCCTCACCGAACCGAACCACGGCTCCGACCCCGGCAGCATGATCACCCGCGCCAAGAAGGTGCCCGGCGGC
TACAGCATTTCCGGCGCCAAGATGTGGATCACCAACAGCCCGATCGCCGACGTGTTCGTGGTGTGGGCCAAGGACGACGA
AGGCGACATCCGCGGCTTCGTGCTGGAGAAGGGCTGGAAGGGCCTGTCGGCCCCGGCGATCCACGGCAAGGTCGGCCTGC
GTGCGTCGATCACCGGCGAGATCGTCATGGACGAAGTCTTCTGCCCGGAAGAGAACGCCTTCCCGACGGTGCGTGGCCTG
AAGGGTCCCTTCACCTGCCTGAACTCCGCCCGCTACGGCATCGCCTGGGGCGCGCTCGGCGCGGCCGAAGCCTGCTACGA
AACGGCCCGCCAATACACCATGGACCGCAAGCAGTTCGGCCGTCCGCTCGCGGCCAACCAGCTGGTGCAGAAGAAGCTCG
CCGACATGCTCACCGAGATCACGCTCGGGCTGCAGGCCTGCCTGCAGGTCGGCCGCCTGAAGGACGCCGGCAACGCGCCG
GTGGAGATCACCTCCATCATCAAGCGCAACTCCTGCGGCAAGGCGCTCGACATCGCCCGCACCGCGCGCGACATGCTCGG
CGGCAACGGCATCTCGGACGAGTTCTGCGTGGCGCGTCACCTCGTGAATCTGGAAGTGGTGAACACCTACGAGGGTACGC
ACGACATCCATGCGCTGATCCTCGGCCGCGCCATCACCGGCATCGCCGCTTTCAGCAACTGA

Upstream 100 bases:

>100_bases
GAAGGCGCGACAGAAGTGCAGAAGCTGATCGTCGCCCGCGAACTGTTGAAGTAAGCCTACCCCCAGCCCCGACCCCAACC
CCTACGGAGCCGAACAGAGC

Downstream 100 bases:

>100_bases
GCAAGGAGCCCGTCGTGACCCAGCACCCCGATTCCGATACGGCTCGCGAAGCGGCGCGTTTCGTCGTCGAGCGCCGCGTG
CGCTTCGAGGACTGCGACCC

Product: glutaryl-CoA dehydrogenase

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MSKVQFNWEDPLHLDSQLTDVERMVRDTARAYCQEKLLPRVQEAFRHERTDREIFNEMGELGLLGPTIPEQYGGAGMNYI
SYGLIAREVERVDSGYRSMMSVQSSLVMVPINEFGTEAQKQKYLPKLATGEWVGCFGLTEPNHGSDPGSMITRAKKVPGG
YSISGAKMWITNSPIADVFVVWAKDDEGDIRGFVLEKGWKGLSAPAIHGKVGLRASITGEIVMDEVFCPEENAFPTVRGL
KGPFTCLNSARYGIAWGALGAAEACYETARQYTMDRKQFGRPLAANQLVQKKLADMLTEITLGLQACLQVGRLKDAGNAP
VEITSIIKRNSCGKALDIARTARDMLGGNGISDEFCVARHLVNLEVVNTYEGTHDIHALILGRAITGIAAFSN

Sequences:

>Translated_393_residues
MSKVQFNWEDPLHLDSQLTDVERMVRDTARAYCQEKLLPRVQEAFRHERTDREIFNEMGELGLLGPTIPEQYGGAGMNYI
SYGLIAREVERVDSGYRSMMSVQSSLVMVPINEFGTEAQKQKYLPKLATGEWVGCFGLTEPNHGSDPGSMITRAKKVPGG
YSISGAKMWITNSPIADVFVVWAKDDEGDIRGFVLEKGWKGLSAPAIHGKVGLRASITGEIVMDEVFCPEENAFPTVRGL
KGPFTCLNSARYGIAWGALGAAEACYETARQYTMDRKQFGRPLAANQLVQKKLADMLTEITLGLQACLQVGRLKDAGNAP
VEITSIIKRNSCGKALDIARTARDMLGGNGISDEFCVARHLVNLEVVNTYEGTHDIHALILGRAITGIAAFSN
>Mature_392_residues
SKVQFNWEDPLHLDSQLTDVERMVRDTARAYCQEKLLPRVQEAFRHERTDREIFNEMGELGLLGPTIPEQYGGAGMNYIS
YGLIAREVERVDSGYRSMMSVQSSLVMVPINEFGTEAQKQKYLPKLATGEWVGCFGLTEPNHGSDPGSMITRAKKVPGGY
SISGAKMWITNSPIADVFVVWAKDDEGDIRGFVLEKGWKGLSAPAIHGKVGLRASITGEIVMDEVFCPEENAFPTVRGLK
GPFTCLNSARYGIAWGALGAAEACYETARQYTMDRKQFGRPLAANQLVQKKLADMLTEITLGLQACLQVGRLKDAGNAPV
EITSIIKRNSCGKALDIARTARDMLGGNGISDEFCVARHLVNLEVVNTYEGTHDIHALILGRAITGIAAFSN

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=393, Percent_Identity=67.4300254452926, Blast_Score=542, Evalue=1e-154,
Organism=Homo sapiens, GI7669494, Length=372, Percent_Identity=66.1290322580645, Blast_Score=503, Evalue=1e-142,
Organism=Homo sapiens, GI226958412, Length=378, Percent_Identity=33.0687830687831, Blast_Score=204, Evalue=8e-53,
Organism=Homo sapiens, GI226958414, Length=346, Percent_Identity=32.9479768786127, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI4557233, Length=377, Percent_Identity=30.2387267904509, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI4501859, Length=373, Percent_Identity=29.4906166219839, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI76496475, Length=384, Percent_Identity=31.25, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI4557235, Length=384, Percent_Identity=31.25, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI187960098, Length=390, Percent_Identity=28.7179487179487, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI4557231, Length=390, Percent_Identity=28.7179487179487, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI21361497, Length=349, Percent_Identity=30.945558739255, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI4501857, Length=378, Percent_Identity=28.8359788359788, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI7656849, Length=373, Percent_Identity=27.0777479892761, Blast_Score=135, Evalue=6e-32,
Organism=Escherichia coli, GI1786223, Length=336, Percent_Identity=25.5952380952381, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI87081958, Length=340, Percent_Identity=25.5882352941176, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17534353, Length=389, Percent_Identity=63.4961439588689, Blast_Score=510, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17538396, Length=376, Percent_Identity=32.9787234042553, Blast_Score=188, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17508101, Length=366, Percent_Identity=32.2404371584699, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17506239, Length=380, Percent_Identity=30, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71985184, Length=368, Percent_Identity=30.7065217391304, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17569725, Length=383, Percent_Identity=28.4595300261097, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI71990804, Length=269, Percent_Identity=35.3159851301115, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI71985192, Length=280, Percent_Identity=33.2142857142857, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17534899, Length=381, Percent_Identity=28.0839895013123, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17570075, Length=380, Percent_Identity=27.6315789473684, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71982178, Length=272, Percent_Identity=31.25, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=33.3333333333333, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17533517, Length=373, Percent_Identity=24.3967828418231, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17551932, Length=265, Percent_Identity=26.4150943396226, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17505929, Length=244, Percent_Identity=26.2295081967213, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI19920834, Length=393, Percent_Identity=63.6132315521629, Blast_Score=510, Evalue=1e-145,
Organism=Drosophila melanogaster, GI21356377, Length=376, Percent_Identity=30.8510638297872, Blast_Score=193, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24646207, Length=373, Percent_Identity=32.171581769437, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24666513, Length=373, Percent_Identity=31.9034852546917, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI21355753, Length=379, Percent_Identity=31.9261213720317, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI281363737, Length=370, Percent_Identity=30.2702702702703, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=30.6878306878307, Blast_Score=158, Evalue=5e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 43113; Mature: 42982

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVQFNWEDPLHLDSQLTDVERMVRDTARAYCQEKLLPRVQEAFRHERTDREIFNEMGE
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHC
LGLLGPTIPEQYGGAGMNYISYGLIAREVERVDSGYRSMMSVQSSLVMVPINEFGTEAQK
CCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECHHHCCHHHH
QKYLPKLATGEWVGCFGLTEPNHGSDPGSMITRAKKVPGGYSISGAKMWITNSPIADVFV
HHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCCEECCCEEEEECCCCCCEEE
VWAKDDEGDIRGFVLEKGWKGLSAPAIHGKVGLRASITGEIVMDEVFCPEENAFPTVRGL
EEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCEEECCCHHHHHHHCCCCCCCCCCHHCC
KGPFTCLNSARYGIAWGALGAAEACYETARQYTMDRKQFGRPLAANQLVQKKLADMLTEI
CCCHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
TLGLQACLQVGRLKDAGNAPVEITSIIKRNSCGKALDIARTARDMLGGNGISDEFCVARH
HHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
LVNLEVVNTYEGTHDIHALILGRAITGIAAFSN
HHCEEEEECCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKVQFNWEDPLHLDSQLTDVERMVRDTARAYCQEKLLPRVQEAFRHERTDREIFNEMGE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHC
LGLLGPTIPEQYGGAGMNYISYGLIAREVERVDSGYRSMMSVQSSLVMVPINEFGTEAQK
CCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECHHHCCHHHH
QKYLPKLATGEWVGCFGLTEPNHGSDPGSMITRAKKVPGGYSISGAKMWITNSPIADVFV
HHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCCEECCCEEEEECCCCCCEEE
VWAKDDEGDIRGFVLEKGWKGLSAPAIHGKVGLRASITGEIVMDEVFCPEENAFPTVRGL
EEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCEEECCCHHHHHHHCCCCCCCCCCHHCC
KGPFTCLNSARYGIAWGALGAAEACYETARQYTMDRKQFGRPLAANQLVQKKLADMLTEI
CCCHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
TLGLQACLQVGRLKDAGNAPVEITSIIKRNSCGKALDIARTARDMLGGNGISDEFCVARH
HHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
LVNLEVVNTYEGTHDIHALILGRAITGIAAFSN
HHCEEEEECCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]