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The map label for this gene is gcdH1 [H]

Identifier: 119898215

GI number: 119898215

Start: 2112858

End: 2114045

Strand: Reverse

Name: gcdH1 [H]

Synonym: azo1924

Alternate gene names: 119898215

Gene position: 2114045-2112858 (Counterclockwise)

Preceding gene: 119898218

Following gene: 119898214

Centisome position: 48.31

GC content: 65.4

Gene sequence:

>1188_bases
ATGGCTTCCAACAAGGCGACCTTCGACTGGGCAGACCCGCTTTTCCTCGACAGCCAACTGACCGACGTGGAGCGCATGGT
GCGCGACACCGCGCGCGCCTACTGCCAGGAAAAGCTGCTGCCGCGCGTGCAGGAAGCCTTCCGCCATGAGCGCACCGATC
GCGAGATCTTCAACGAGATGGGCGAACTCGGCCTGCTCGGCCCGACGATTCCCGAGCAGTACGGCGGCGCCGGCATGAAC
TACATCAGCTACGGCCTGATCGCCCGCGAAGTCGAACGCGTCGATTCCGGCTACCGCTCGATGATGAGCGTGCAGTCCTC
GCTGGTCATGGTGCCGATCAACGAATTCGGCACCGAAGCGCAGAAGCAGAAATACCTGCCCAAGCTCGCCACCGGCGAAT
GGGTGGGCTGCTTCGGCCTCACCGAACCGAACCACGGCTCCGACCCCGGCAGCATGATCACCCGCGCCAAGAAGGTGCCC
GGCGGCTACAGCATTTCCGGCGCCAAGATGTGGATCACCAACAGCCCGATCGCCGACGTGTTCGTGGTGTGGGCCAAGGA
CGACGAAGGCGACATCCGCGGCTTCGTGCTGGAAAAGGGCTGGAAGGGCCTGTCGGCCCCGGCGATCCACGGCAAGGTCG
GCCTGCGCGCGTCGATCACCGGCGAGATCGTCATGGACGAAGTGTTCTGTCCGGAAGAGAACGCCTTCCCGACGGTGCGT
GGCCTCAAGGGCCCCTTCACCTGCCTCAACTCCGCCCGCTACGGCATCGCCTGGGGCGCGCTCGGCGCGGCCGAAGCCTG
CTACGAGACCGCCCGCCAATACACCATGGACCGCAAGCAGTTCGGCCGTCCGCTCGCGGCCAACCAGCTGGTGCAGAAGA
AGCTCGCCGACATGCTCACCGAGATCACGCTGGGGCTGCAGGCCTGCCTGCAGGTCGGCCGGTTGAAGGACGCCGGCAAC
GCGCCGGTGGAGATCACCTCCATCATCAAGCGCAACTCCTGCGGCAAGGCGCTCGACATCGCCCGCACCGCGCGCGACAT
GCTCGGCGGCAACGGCATCTCGGACGAGTTCTGCGTGGCGCGTCACCTCGTGAATCTGGAAGTGGTGAACACCTACGAGG
GTACGCACGACATCCATGCGCTGATTCTGGGGCGGGCGATTACCGGGATTGCGGCGTTCGGTAACTGA

Upstream 100 bases:

>100_bases
TTCCAAATACTCGTTTGCCGGGACGAAGGACGATCCCTAGTATTGGCTCATCCGCGGCCCGAACCAACGGCCGCCCCGAC
ACCGTGAAAAAGGAGACGAC

Downstream 100 bases:

>100_bases
GCGGGATTGTTTTGTTCCTCCCCCTTCAAGGGGGAGGTTAGGAGGGGGATGGGGTTGGGCGCGCCGCAGAGCTTGACCCC
ATCCCCACCCCAGCCCTCCC

Product: glutaryl-CoA dehydrogenase

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MASNKATFDWADPLFLDSQLTDVERMVRDTARAYCQEKLLPRVQEAFRHERTDREIFNEMGELGLLGPTIPEQYGGAGMN
YISYGLIAREVERVDSGYRSMMSVQSSLVMVPINEFGTEAQKQKYLPKLATGEWVGCFGLTEPNHGSDPGSMITRAKKVP
GGYSISGAKMWITNSPIADVFVVWAKDDEGDIRGFVLEKGWKGLSAPAIHGKVGLRASITGEIVMDEVFCPEENAFPTVR
GLKGPFTCLNSARYGIAWGALGAAEACYETARQYTMDRKQFGRPLAANQLVQKKLADMLTEITLGLQACLQVGRLKDAGN
APVEITSIIKRNSCGKALDIARTARDMLGGNGISDEFCVARHLVNLEVVNTYEGTHDIHALILGRAITGIAAFGN

Sequences:

>Translated_395_residues
MASNKATFDWADPLFLDSQLTDVERMVRDTARAYCQEKLLPRVQEAFRHERTDREIFNEMGELGLLGPTIPEQYGGAGMN
YISYGLIAREVERVDSGYRSMMSVQSSLVMVPINEFGTEAQKQKYLPKLATGEWVGCFGLTEPNHGSDPGSMITRAKKVP
GGYSISGAKMWITNSPIADVFVVWAKDDEGDIRGFVLEKGWKGLSAPAIHGKVGLRASITGEIVMDEVFCPEENAFPTVR
GLKGPFTCLNSARYGIAWGALGAAEACYETARQYTMDRKQFGRPLAANQLVQKKLADMLTEITLGLQACLQVGRLKDAGN
APVEITSIIKRNSCGKALDIARTARDMLGGNGISDEFCVARHLVNLEVVNTYEGTHDIHALILGRAITGIAAFGN
>Mature_394_residues
ASNKATFDWADPLFLDSQLTDVERMVRDTARAYCQEKLLPRVQEAFRHERTDREIFNEMGELGLLGPTIPEQYGGAGMNY
ISYGLIAREVERVDSGYRSMMSVQSSLVMVPINEFGTEAQKQKYLPKLATGEWVGCFGLTEPNHGSDPGSMITRAKKVPG
GYSISGAKMWITNSPIADVFVVWAKDDEGDIRGFVLEKGWKGLSAPAIHGKVGLRASITGEIVMDEVFCPEENAFPTVRG
LKGPFTCLNSARYGIAWGALGAAEACYETARQYTMDRKQFGRPLAANQLVQKKLADMLTEITLGLQACLQVGRLKDAGNA
PVEITSIIKRNSCGKALDIARTARDMLGGNGISDEFCVARHLVNLEVVNTYEGTHDIHALILGRAITGIAAFGN

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=393, Percent_Identity=67.6844783715013, Blast_Score=544, Evalue=1e-155,
Organism=Homo sapiens, GI7669494, Length=373, Percent_Identity=66.2198391420911, Blast_Score=504, Evalue=1e-143,
Organism=Homo sapiens, GI226958412, Length=378, Percent_Identity=33.0687830687831, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI226958414, Length=346, Percent_Identity=32.9479768786127, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI4557233, Length=377, Percent_Identity=30.2387267904509, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI4501859, Length=373, Percent_Identity=29.4906166219839, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI4557235, Length=409, Percent_Identity=30.5623471882641, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI76496475, Length=409, Percent_Identity=30.5623471882641, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI21361497, Length=353, Percent_Identity=30.8781869688385, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI187960098, Length=375, Percent_Identity=29.0666666666667, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI4557231, Length=375, Percent_Identity=29.0666666666667, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI4501857, Length=378, Percent_Identity=28.8359788359788, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI7656849, Length=373, Percent_Identity=27.0777479892761, Blast_Score=135, Evalue=6e-32,
Organism=Escherichia coli, GI1786223, Length=336, Percent_Identity=25.5952380952381, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87081958, Length=340, Percent_Identity=25.5882352941176, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17534353, Length=393, Percent_Identity=63.3587786259542, Blast_Score=508, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17538396, Length=376, Percent_Identity=32.9787234042553, Blast_Score=188, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17508101, Length=366, Percent_Identity=32.2404371584699, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17506239, Length=373, Percent_Identity=30.0268096514745, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71985184, Length=368, Percent_Identity=30.7065217391304, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17569725, Length=378, Percent_Identity=28.8359788359788, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI71990804, Length=269, Percent_Identity=35.3159851301115, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI71985192, Length=280, Percent_Identity=33.2142857142857, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17534899, Length=377, Percent_Identity=28.3819628647215, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17570075, Length=380, Percent_Identity=27.6315789473684, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71982178, Length=277, Percent_Identity=31.0469314079422, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=33.3333333333333, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17533517, Length=373, Percent_Identity=24.3967828418231, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17551932, Length=265, Percent_Identity=26.4150943396226, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17505929, Length=244, Percent_Identity=26.2295081967213, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI19920834, Length=392, Percent_Identity=63.5204081632653, Blast_Score=506, Evalue=1e-143,
Organism=Drosophila melanogaster, GI21356377, Length=376, Percent_Identity=30.8510638297872, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24646207, Length=373, Percent_Identity=32.171581769437, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24666513, Length=373, Percent_Identity=31.9034852546917, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI21355753, Length=379, Percent_Identity=31.9261213720317, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI281363737, Length=375, Percent_Identity=30.1333333333333, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=30.6878306878307, Blast_Score=159, Evalue=4e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 43166; Mature: 43035

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASNKATFDWADPLFLDSQLTDVERMVRDTARAYCQEKLLPRVQEAFRHERTDREIFNEM
CCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
GELGLLGPTIPEQYGGAGMNYISYGLIAREVERVDSGYRSMMSVQSSLVMVPINEFGTEA
HCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECHHHCCHH
QKQKYLPKLATGEWVGCFGLTEPNHGSDPGSMITRAKKVPGGYSISGAKMWITNSPIADV
HHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCCEECCCEEEEECCCCCCE
FVVWAKDDEGDIRGFVLEKGWKGLSAPAIHGKVGLRASITGEIVMDEVFCPEENAFPTVR
EEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCEEECCCHHHHHHHCCCCCCCCCCHH
GLKGPFTCLNSARYGIAWGALGAAEACYETARQYTMDRKQFGRPLAANQLVQKKLADMLT
CCCCCHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
EITLGLQACLQVGRLKDAGNAPVEITSIIKRNSCGKALDIARTARDMLGGNGISDEFCVA
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHH
RHLVNLEVVNTYEGTHDIHALILGRAITGIAAFGN
HHHHCEEEEECCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ASNKATFDWADPLFLDSQLTDVERMVRDTARAYCQEKLLPRVQEAFRHERTDREIFNEM
CCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
GELGLLGPTIPEQYGGAGMNYISYGLIAREVERVDSGYRSMMSVQSSLVMVPINEFGTEA
HCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECHHHCCHH
QKQKYLPKLATGEWVGCFGLTEPNHGSDPGSMITRAKKVPGGYSISGAKMWITNSPIADV
HHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCCEECCCEEEEECCCCCCE
FVVWAKDDEGDIRGFVLEKGWKGLSAPAIHGKVGLRASITGEIVMDEVFCPEENAFPTVR
EEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCEEECCCHHHHHHHCCCCCCCCCCHH
GLKGPFTCLNSARYGIAWGALGAAEACYETARQYTMDRKQFGRPLAANQLVQKKLADMLT
CCCCCHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
EITLGLQACLQVGRLKDAGNAPVEITSIIKRNSCGKALDIARTARDMLGGNGISDEFCVA
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHH
RHLVNLEVVNTYEGTHDIHALILGRAITGIAAFGN
HHHHCEEEEECCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]