Click here to switch to the map view.

The map label for this gene is lhgO [H]

Identifier: 119898210

GI number: 119898210

Start: 2106499

End: 2107608

Strand: Direct

Name: lhgO [H]

Synonym: azo1919

Alternate gene names: 119898210

Gene position: 2106499-2107608 (Clockwise)

Preceding gene: 119898204

Following gene: 119898216

Centisome position: 48.14

GC content: 71.89

Gene sequence:

>1110_bases
ATGGAGACAGTCGATTGCGTGGTCGTCGGGGCGGGCGTGGTGGGGCTGGCCTGTGCCCGGGCGATTGCGGCGAGCGGCCG
CGAGGTGTTGATCCTGGAGCGCGAACGCGCGTTCGGCACCGGCATCAGCTCGCGCAACAGCGAGGTCATCCATGCCGGGC
TGTACTACCCGCCGGGTTCGCTCAAGGCGCGTCTCAGCGTTGCCGGCGGCCGCATGCTCTACGCCTATTGCGAGTCGCGC
GGCGTCGCCCACCGGCGCTGCGGCAAGCTGGTGGTGGCGGCGCAGCGCGAGGCGCTGCCGGCGCTTGCGCGCATCCGGGC
GCGAGCGCTCGCCAACGGCGTGGAGGAATTGCTGTGGCTGGAGCCGGGCGCGGTGAAGGAGATCGAACCCGCGCTCGACA
GCTGCGGGGCGCTGTTCTCGCCCGCCACCGGCATCGTGGACAGCCATGGGCTGATGCTTGCGCTGCTCGGCGACGCTGAG
CGCCATGGCGCGACGCTGGTGCTGGACACGCCGGTGCTCGGCGGTCGGGCCGAGGCTGGCGGCATCGTGCTGCAGACGGG
CGGCGAGGCACCGATGACCTTGCAGGCGCGCTGCGTCGTGAACGCGGCGGGGCTCGACGCGGTCCGCCTTGCCGGCCAAC
TGCCGGCGTCGTCACGCGGTCTGCCGCAGGCGCATTTTGCCCGTGGCGTGTATTTCAGCTACGCGGGCCGGGTGCCGTTC
TCGCACCTGATCTATCCGGTGCCCGAGCCCGGCGGCCTGGGCATCCATCTCACGCTCGACATGGGCGGCCAGCCCCGCTT
CGGCCCGGACGTGGAGTGGATCGACACGCCCGATTACACGGTGGACCCGGCGCGGGCGGAGCGTTTCGCCGCGGCGATCC
GCAAATGGTGGCCGGGCCTGGAGCCGGAACGGCTGCAGCCCGCGTATGCCGGCGTGCGACCCAAGATCGTCGGCCCCGGC
GAGGCGGACGCCGATTTCCAGATCGATGGCCCCGCCGAGCATCGCGTGCCTGGGCTCATCAACCTGCTGGGCATCGAATC
GCCGGGGCTTACCGCGGCGCTCGCAATCGGCGAGGAAGTGGCGCGGCGGATTGCCGCGCCGCAAGGCTGA

Upstream 100 bases:

>100_bases
GCTCCGGTGTGGGTGCGGAACCATATCCGCCGTCCGCGCAATCTGATAAAACGGCGGTCCCGCGGCGAAGGCGAGGCTGC
GGCGGAGCGAGGAGGTGGCG

Downstream 100 bases:

>100_bases
GGGGCGCGCCCCTCAGCGGATGCCGCCGAGGCAAAGGTATTTGATCTCGACGTAGTCCTCGATGCCGTACTTCGACCCCT
CGCGCCCGATGCCGGACTCC

Product: oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
METVDCVVVGAGVVGLACARAIAASGREVLILERERAFGTGISSRNSEVIHAGLYYPPGSLKARLSVAGGRMLYAYCESR
GVAHRRCGKLVVAAQREALPALARIRARALANGVEELLWLEPGAVKEIEPALDSCGALFSPATGIVDSHGLMLALLGDAE
RHGATLVLDTPVLGGRAEAGGIVLQTGGEAPMTLQARCVVNAAGLDAVRLAGQLPASSRGLPQAHFARGVYFSYAGRVPF
SHLIYPVPEPGGLGIHLTLDMGGQPRFGPDVEWIDTPDYTVDPARAERFAAAIRKWWPGLEPERLQPAYAGVRPKIVGPG
EADADFQIDGPAEHRVPGLINLLGIESPGLTAALAIGEEVARRIAAPQG

Sequences:

>Translated_369_residues
METVDCVVVGAGVVGLACARAIAASGREVLILERERAFGTGISSRNSEVIHAGLYYPPGSLKARLSVAGGRMLYAYCESR
GVAHRRCGKLVVAAQREALPALARIRARALANGVEELLWLEPGAVKEIEPALDSCGALFSPATGIVDSHGLMLALLGDAE
RHGATLVLDTPVLGGRAEAGGIVLQTGGEAPMTLQARCVVNAAGLDAVRLAGQLPASSRGLPQAHFARGVYFSYAGRVPF
SHLIYPVPEPGGLGIHLTLDMGGQPRFGPDVEWIDTPDYTVDPARAERFAAAIRKWWPGLEPERLQPAYAGVRPKIVGPG
EADADFQIDGPAEHRVPGLINLLGIESPGLTAALAIGEEVARRIAAPQG
>Mature_369_residues
METVDCVVVGAGVVGLACARAIAASGREVLILERERAFGTGISSRNSEVIHAGLYYPPGSLKARLSVAGGRMLYAYCESR
GVAHRRCGKLVVAAQREALPALARIRARALANGVEELLWLEPGAVKEIEPALDSCGALFSPATGIVDSHGLMLALLGDAE
RHGATLVLDTPVLGGRAEAGGIVLQTGGEAPMTLQARCVVNAAGLDAVRLAGQLPASSRGLPQAHFARGVYFSYAGRVPF
SHLIYPVPEPGGLGIHLTLDMGGQPRFGPDVEWIDTPDYTVDPARAERFAAAIRKWWPGLEPERLQPAYAGVRPKIVGPG
EADADFQIDGPAEHRVPGLINLLGIESPGLTAALAIGEEVARRIAAPQG

Specific function: Oxidizes L-2-hydroxyglutarate, probably to recover alpha-ketoglutarate mistakenly reduced by other enzymes or formed during growth on propionate [H]

COG id: COG0579

COG function: function code R; Predicted dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the L2HGDH family [H]

Homologues:

Organism=Homo sapiens, GI13376331, Length=259, Percent_Identity=32.4324324324324, Blast_Score=118, Evalue=1e-26,
Organism=Escherichia coli, GI87082148, Length=377, Percent_Identity=29.4429708222812, Blast_Score=135, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17565764, Length=400, Percent_Identity=28.25, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24585081, Length=403, Percent_Identity=30.272952853598, Blast_Score=125, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015657
- InterPro:   IPR006076 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: =1.1.3.15 [H]

Molecular weight: Translated: 38668; Mature: 38668

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METVDCVVVGAGVVGLACARAIAASGREVLILERERAFGTGISSRNSEVIHAGLYYPPGS
CCCEEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCC
LKARLSVAGGRMLYAYCESRGVAHRRCGKLVVAAQREALPALARIRARALANGVEELLWL
CEEEEEECCCEEEEEEECCCCHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHC
EPGAVKEIEPALDSCGALFSPATGIVDSHGLMLALLGDAERHGATLVLDTPVLGGRAEAG
CCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCC
GIVLQTGGEAPMTLQARCVVNAAGLDAVRLAGQLPASSRGLPQAHFARGVYFSYAGRVPF
CEEEEECCCCCEEEEEEEEEEECCCHHHHHHCCCCCCCCCCCHHHHHCCEEEEEECCCCH
SHLIYPVPEPGGLGIHLTLDMGGQPRFGPDVEWIDTPDYTVDPARAERFAAAIRKWWPGL
HHCEEECCCCCCCEEEEEEECCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHCCCC
EPERLQPAYAGVRPKIVGPGEADADFQIDGPAEHRVPGLINLLGIESPGLTAALAIGEEV
CHHHCCHHHCCCCCEEECCCCCCCCEEECCCCCCCCCCEEEEEECCCCCCEEHHHHHHHH
ARRIAAPQG
HHHHCCCCC
>Mature Secondary Structure
METVDCVVVGAGVVGLACARAIAASGREVLILERERAFGTGISSRNSEVIHAGLYYPPGS
CCCEEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCC
LKARLSVAGGRMLYAYCESRGVAHRRCGKLVVAAQREALPALARIRARALANGVEELLWL
CEEEEEECCCEEEEEEECCCCHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHC
EPGAVKEIEPALDSCGALFSPATGIVDSHGLMLALLGDAERHGATLVLDTPVLGGRAEAG
CCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCC
GIVLQTGGEAPMTLQARCVVNAAGLDAVRLAGQLPASSRGLPQAHFARGVYFSYAGRVPF
CEEEEECCCCCEEEEEEEEEEECCCHHHHHHCCCCCCCCCCCHHHHHCCEEEEEECCCCH
SHLIYPVPEPGGLGIHLTLDMGGQPRFGPDVEWIDTPDYTVDPARAERFAAAIRKWWPGL
HHCEEECCCCCCCEEEEEEECCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHCCCC
EPERLQPAYAGVRPKIVGPGEADADFQIDGPAEHRVPGLINLLGIESPGLTAALAIGEEV
CHHHCCHHHCCCCCEEECCCCCCCCEEECCCCCCCCCCEEEEEECCCCCCEEHHHHHHHH
ARRIAAPQG
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 8297211; 7984428 [H]