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The map label for this gene is lpxD

Identifier: 119898190

GI number: 119898190

Start: 2082110

End: 2083135

Strand: Reverse

Name: lpxD

Synonym: azo1899

Alternate gene names: 119898190

Gene position: 2083135-2082110 (Counterclockwise)

Preceding gene: 119898191

Following gene: 119898189

Centisome position: 47.6

GC content: 68.71

Gene sequence:

>1026_bases
ATGTTTCGCCTCGATGAGCTGGCCGCGCGGCTGGGCGGGGATGTCGTCGGCGATCCGGCGACCACGGTGCGGCGCGTCGC
CACGCTGGAACAGGCAGGGGAGGGCGACCTCTCCTTCCTCGCCAATCCCAAGTACGTCGGCCGGCTGAAGTCCAGCCACG
CCAGCGCCATCATCGTCGCCGACAGCGCGCGCAGCCTGCTCGGTGAAAAGGCCGGCATCGTCACCCGCGACCCCTATCTG
TATTTCGCCCGCGTCGCCCAGCTCTTCAACCCGCCCGAAGCGGTCGCACCCGGCGTTCATCCGCTCGCGGACGTGGCGGT
CGCGGTTCCCGCCAGCGTAGCGGTGGCGGCGGGTGCCAGCATCGGCGCGGGCGTCGAACTGGGCGAAGACGTGGTGATTG
GCGCGGGGAGCAGCATCGGTGCGGGCGTGCGCATCGGCGCCGGCACCCGGCTCGCGCCGCGCGTCGTGATCTACCCCGGC
TGCGTGATCGGCACGAATTGCCTGATCCATGCCGGCGCGGTCATCGGCTCGGACGGCTTCGGTTTCGCGCGCGAGAAGAG
CGGCGCCTGGGTCAAGATTCCGCAGGTCGGCCGCGTGGTGATCGGGGACGACGTCGAGATCGGCGCCAACACCACCATCG
ACCGCGGCGCACTCGATGACACGGTGATCGGCAACGGGGTCAAGATCGACAACCAGATCCAGATCGGACACAACGTGCGG
ATCGGCGACTACACCGCGATCGCCGGCTGCGTCGGCATCGCCGGCAGCACCCAGATCGGCGCCCGCTGCATGATCGGCGG
GCAGGCGGGCATCATCGGCCACCTCACCATCGCCGACGACGTCGTCATCTCGGCGGGCACGCTGGTCACCAAATCCATCC
ACAAACCGGGCGTCTATACGGCCAACCTGCCTGTCCAGCCCCACGCCGACTGGGTGAAAAACTTCGCCCACCTGCGCCAC
CTGGACAGCCTCGCCGCTAGAATACGCGCCCTCGAACAATCGCCGGACCACCCGGAATCAGCCTGA

Upstream 100 bases:

>100_bases
GACGTGATCCTGCAGGAAGCGGTCTACGCCAGCCCGCGCATCGACATCACGGACAAGGTCATCAAGTCCCTGTCCGAAGG
CAAGTAAGCGCTTCGCCCCG

Downstream 100 bases:

>100_bases
TCGCCATGGATATCAACGAAATCGTCCAATACCTCCCACACCGTTACCCCTTCCTGCTGGTGGATCGGGTGCTGGAGCTG
GAAGAGAACAAGCGCATCCT

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MFRLDELAARLGGDVVGDPATTVRRVATLEQAGEGDLSFLANPKYVGRLKSSHASAIIVADSARSLLGEKAGIVTRDPYL
YFARVAQLFNPPEAVAPGVHPLADVAVAVPASVAVAAGASIGAGVELGEDVVIGAGSSIGAGVRIGAGTRLAPRVVIYPG
CVIGTNCLIHAGAVIGSDGFGFAREKSGAWVKIPQVGRVVIGDDVEIGANTTIDRGALDDTVIGNGVKIDNQIQIGHNVR
IGDYTAIAGCVGIAGSTQIGARCMIGGQAGIIGHLTIADDVVISAGTLVTKSIHKPGVYTANLPVQPHADWVKNFAHLRH
LDSLAARIRALEQSPDHPESA

Sequences:

>Translated_341_residues
MFRLDELAARLGGDVVGDPATTVRRVATLEQAGEGDLSFLANPKYVGRLKSSHASAIIVADSARSLLGEKAGIVTRDPYL
YFARVAQLFNPPEAVAPGVHPLADVAVAVPASVAVAAGASIGAGVELGEDVVIGAGSSIGAGVRIGAGTRLAPRVVIYPG
CVIGTNCLIHAGAVIGSDGFGFAREKSGAWVKIPQVGRVVIGDDVEIGANTTIDRGALDDTVIGNGVKIDNQIQIGHNVR
IGDYTAIAGCVGIAGSTQIGARCMIGGQAGIIGHLTIADDVVISAGTLVTKSIHKPGVYTANLPVQPHADWVKNFAHLRH
LDSLAARIRALEQSPDHPESA
>Mature_341_residues
MFRLDELAARLGGDVVGDPATTVRRVATLEQAGEGDLSFLANPKYVGRLKSSHASAIIVADSARSLLGEKAGIVTRDPYL
YFARVAQLFNPPEAVAPGVHPLADVAVAVPASVAVAAGASIGAGVELGEDVVIGAGSSIGAGVRIGAGTRLAPRVVIYPG
CVIGTNCLIHAGAVIGSDGFGFAREKSGAWVKIPQVGRVVIGDDVEIGANTTIDRGALDDTVIGNGVKIDNQIQIGHNVR
IGDYTAIAGCVGIAGSTQIGARCMIGGQAGIIGHLTIADDVVISAGTLVTKSIHKPGVYTANLPVQPHADWVKNFAHLRH
LDSLAARIRALEQSPDHPESA

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=340, Percent_Identity=45.2941176470588, Blast_Score=294, Evalue=6e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_AZOSB (A1K6R1)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_933403.1
- ProteinModelPortal:   A1K6R1
- STRING:   A1K6R1
- GeneID:   4608716
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo1899
- eggNOG:   COG1044
- HOGENOM:   HBG469615
- OMA:   CFVGKNT
- PhylomeDB:   A1K6R1
- ProtClustDB:   PRK00892
- BioCyc:   ASP62928:AZO1899-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 34909; Mature: 34909

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRLDELAARLGGDVVGDPATTVRRVATLEQAGEGDLSFLANPKYVGRLKSSHASAIIVA
CCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCCCEEEEE
DSARSLLGEKAGIVTRDPYLYFARVAQLFNPPEAVAPGVHPLADVAVAVPASVAVAAGAS
CCHHHHHHCCCCCEECCCHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHCCCHHHHHCCCC
IGAGVELGEDVVIGAGSSIGAGVRIGAGTRLAPRVVIYPGCVIGTNCLIHAGAVIGSDGF
CCCCCCCCCEEEEECCCCCCCCEEECCCCCCCCEEEEECCHHHHCCCEEEECEEECCCCC
GFAREKSGAWVKIPQVGRVVIGDDVEIGANTTIDRGALDDTVIGNGVKIDNQIQIGHNVR
CCCCCCCCCEEECCCCCEEEECCCEEECCCCCCCCCCCCCCCCCCCEEECCEEEECCEEE
IGDYTAIAGCVGIAGSTQIGARCMIGGQAGIIGHLTIADDVVISAGTLVTKSIHKPGVYT
ECCHHHHHHHHHCCCCCCCCCEEEECCCCCEEEEEEECCCEEEECCHHEEHHCCCCCCEE
ANLPVQPHADWVKNFAHLRHLDSLAARIRALEQSPDHPESA
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MFRLDELAARLGGDVVGDPATTVRRVATLEQAGEGDLSFLANPKYVGRLKSSHASAIIVA
CCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCCCEEEEE
DSARSLLGEKAGIVTRDPYLYFARVAQLFNPPEAVAPGVHPLADVAVAVPASVAVAAGAS
CCHHHHHHCCCCCEECCCHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHCCCHHHHHCCCC
IGAGVELGEDVVIGAGSSIGAGVRIGAGTRLAPRVVIYPGCVIGTNCLIHAGAVIGSDGF
CCCCCCCCCEEEEECCCCCCCCEEECCCCCCCCEEEEECCHHHHCCCEEEECEEECCCCC
GFAREKSGAWVKIPQVGRVVIGDDVEIGANTTIDRGALDDTVIGNGVKIDNQIQIGHNVR
CCCCCCCCCEEECCCCCEEEECCCEEECCCCCCCCCCCCCCCCCCCEEECCEEEECCEEE
IGDYTAIAGCVGIAGSTQIGARCMIGGQAGIIGHLTIADDVVISAGTLVTKSIHKPGVYT
ECCHHHHHHHHHCCCCCCCCCEEEECCCCCEEEEEEECCCEEEECCHHEEHHCCCCCCEE
ANLPVQPHADWVKNFAHLRHLDSLAARIRALEQSPDHPESA
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA