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The map label for this gene is relA [H]

Identifier: 119897979

GI number: 119897979

Start: 1853847

End: 1856048

Strand: Direct

Name: relA [H]

Synonym: azo1688

Alternate gene names: 119897979

Gene position: 1853847-1856048 (Clockwise)

Preceding gene: 119897974

Following gene: 119897981

Centisome position: 42.36

GC content: 65.94

Gene sequence:

>2202_bases
ATGGTTTCCGTCTCCCACGCGATCTCCCAGGACGCCGCCGTTCCGCCGGTCGAACTGCTTTCCGCCGGTCTGTGCGCCAA
CGAAAAAGCGCTGATCCAGAAGGCGCTCGACCTTGCCGCCGACATCTACGAGGGCCACGTCCTCGGCACCGGCGAATCGG
TCTGGACCCATGCCATGGGCACCGCGCTGATCGCCGCGTCGCTCAGGCTGGACGCCGATACGCGGATCGCCGCACTGTTG
TTTTCAGCCAACGAATATCTGGACGATGCACCGACGCTGATTGAAGAGCGCTTCGGCGGCAGCGTCGCGCGCCTGGTCGA
AGGCTTGCGCAAGCTGAACGGCCTGCGCGTCGTCACCCGCATGACCGCCACCGCCTCCGCACCTGAAATCCGCGCGCAGA
CCGAAGTGCTGCGCAAGATGCTGCTGGCGATGGTGGAGGACATCCGGGTGGTGTTGATCCGTCTCGCCTCGCGCACCCAG
ACGCTGCGCTACTACGCCGATACCAAGTCCGAGAACCGGCAGGACATCGCGCGCGAAAGCCTGGATATCTACGCGCCGCT
GGCGAATCGGCTGGGTGTGTGGCAGCTCAAGTGGGAGCTGGAAGACCTCTCCTTCCGCTTTCTGGAGCCGGACACCTACA
AGCGCATCGCCAAGATGCTCGACGAGCGTCGGGTGGAGCGCGAGGAATTCATCCGCAACGCGATCGAACGGCTGCGCAGC
GAAATCGCGGCGGTGGGCATCAAGGCCGAGATCCAGGGGCGGCCCAAGCACATCTACAGCATCTACAACAAGATGCGCGC
CAAGCGCCTCGACTTCTCCCAGGTGTACGACATCCGCGCGCTGCGGGTGCTGGTGGACGAGGTGAAGGACTGCTACACGG
TGCTCGGGCTTGTGCACCAGATCTGGCAGCCGATCAACAAGGAATTCGACGACTACATCACCAAGCCCAAGGGCAACAAC
TACCAGTCGCTGCACACCGCGGTCCTGGCGGGTGACGGCCGAGCGCTCGAGGTGCAGATCCGCACCCACGACATGCACCG
CCACGCCGAGCTGGGTGTGGCGGCGCACTGGCGCTACAAGGAGGGCAGCGGCCACGGGGGCGACTACGACGACAAGATCG
CGCTGCTGCGCAACCTGCTGTCGTGGCGCGACGAGGTGGCCGATTCGGCCCGCTGGGTGGAGCAGTTCAAGCGCGCGTCG
CTGGACGACACGCTGTACGTGCTGACGCCCCAGGGGCGTGTGGTGGATCTGCCGCAGGGCGCGACGCCGGTGGATTTTGC
CTACCGGGTGCATACCGATCTCGGCCACCGCTGCCGCGGCGCCAAGGTCGACGGTCATCTGGTGCCGCTCAACACCCCGC
TGCAAAGCGGGCAGACGGTGGAGATCACCGCGGCGAAGGAGGGCGGCCCCTCGCGCGACTGGCTGGATTCGCGCCAGGGC
TATGTCGCGACCTCGCGTGCGCGGACCAAGATCAAGCAGTACTTCAGCCAGCTCGAAGAGGAAGAACTGCTGGCGCGCGG
GCGCACCTCGATCACGCGCGAGATGCAGCGCGACGGGCATGGCCAGGCAAATATCGAAGGCCTGGCCGAACGGCTCGGTT
TCAAGTCGGCCGATGCGCTCTATCTGGCCGCGGGCCGCGGCGAAATCGGTCCGCGCGCAGTGCAGATGGCCTTGCGCGAG
GCGGACGCGGTGGTCGATGCGCCGGCCGAACCCGAGATCGTCGTTGGCCGCAGCCGCTCCGGCGACAACTCCGACAAGAT
CCTGATCGTCGGCGTCGGCAAGCTGCTGACTTCGCTGTCGCGCTGCTGCAAGCCGGCCCCGCCCGATGCAATCGAAGGCT
TCGTCACGCGCGGTCGCGGCATTTCCATTCACCGCGTGGATTGCCACGATTTCCAGCTGCTGGCCCGACGCCACCCGGAG
CGGGTCATCTCGGCGGAGTGGGGCGACCAGGCCTACAACAACGCGCAGGCGGTCTACCCGGTCGATATCGCGGTGCAGGC
CAACGATCGCCAGGGTTTGCTGCGCGATATCTCCGAGGTGCTGTCGCGCGAAAAGCTCAACGTCACGGCAGTCAACACGC
TCACGAAGAAGGGCACCGCCTTCATGCGTTTCACGATGGAGGTGGGCGGGGTGACGCAGTTGCAGCGCGCGATCACGCTG
ATCCGCGAGGTGCCGGGCGTGATCGACGCCCAGCGAAAATGA

Upstream 100 bases:

>100_bases
CCGTGTGCGAGGCGGGGATGCTGCTGGAATGCGGGCGGCGAGGTGACTTCGGCGCGTGATCTTAGCACCTCGCGTTGGGC
GATATGGGATAATCCGCGCC

Downstream 100 bases:

>100_bases
AGCTGCGGGCGCCGCTGCTGCGGCGCCCGCGGTGTATCAGCCGGCGTTGCCGAGTTCGGCGAGCAGGATGAGCTGCGCGG
CGCGGCGCGTGCCGCGCGGG

Product: GTP diphosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 733; Mature: 733

Protein sequence:

>733_residues
MVSVSHAISQDAAVPPVELLSAGLCANEKALIQKALDLAADIYEGHVLGTGESVWTHAMGTALIAASLRLDADTRIAALL
FSANEYLDDAPTLIEERFGGSVARLVEGLRKLNGLRVVTRMTATASAPEIRAQTEVLRKMLLAMVEDIRVVLIRLASRTQ
TLRYYADTKSENRQDIARESLDIYAPLANRLGVWQLKWELEDLSFRFLEPDTYKRIAKMLDERRVEREEFIRNAIERLRS
EIAAVGIKAEIQGRPKHIYSIYNKMRAKRLDFSQVYDIRALRVLVDEVKDCYTVLGLVHQIWQPINKEFDDYITKPKGNN
YQSLHTAVLAGDGRALEVQIRTHDMHRHAELGVAAHWRYKEGSGHGGDYDDKIALLRNLLSWRDEVADSARWVEQFKRAS
LDDTLYVLTPQGRVVDLPQGATPVDFAYRVHTDLGHRCRGAKVDGHLVPLNTPLQSGQTVEITAAKEGGPSRDWLDSRQG
YVATSRARTKIKQYFSQLEEEELLARGRTSITREMQRDGHGQANIEGLAERLGFKSADALYLAAGRGEIGPRAVQMALRE
ADAVVDAPAEPEIVVGRSRSGDNSDKILIVGVGKLLTSLSRCCKPAPPDAIEGFVTRGRGISIHRVDCHDFQLLARRHPE
RVISAEWGDQAYNNAQAVYPVDIAVQANDRQGLLRDISEVLSREKLNVTAVNTLTKKGTAFMRFTMEVGGVTQLQRAITL
IREVPGVIDAQRK

Sequences:

>Translated_733_residues
MVSVSHAISQDAAVPPVELLSAGLCANEKALIQKALDLAADIYEGHVLGTGESVWTHAMGTALIAASLRLDADTRIAALL
FSANEYLDDAPTLIEERFGGSVARLVEGLRKLNGLRVVTRMTATASAPEIRAQTEVLRKMLLAMVEDIRVVLIRLASRTQ
TLRYYADTKSENRQDIARESLDIYAPLANRLGVWQLKWELEDLSFRFLEPDTYKRIAKMLDERRVEREEFIRNAIERLRS
EIAAVGIKAEIQGRPKHIYSIYNKMRAKRLDFSQVYDIRALRVLVDEVKDCYTVLGLVHQIWQPINKEFDDYITKPKGNN
YQSLHTAVLAGDGRALEVQIRTHDMHRHAELGVAAHWRYKEGSGHGGDYDDKIALLRNLLSWRDEVADSARWVEQFKRAS
LDDTLYVLTPQGRVVDLPQGATPVDFAYRVHTDLGHRCRGAKVDGHLVPLNTPLQSGQTVEITAAKEGGPSRDWLDSRQG
YVATSRARTKIKQYFSQLEEEELLARGRTSITREMQRDGHGQANIEGLAERLGFKSADALYLAAGRGEIGPRAVQMALRE
ADAVVDAPAEPEIVVGRSRSGDNSDKILIVGVGKLLTSLSRCCKPAPPDAIEGFVTRGRGISIHRVDCHDFQLLARRHPE
RVISAEWGDQAYNNAQAVYPVDIAVQANDRQGLLRDISEVLSREKLNVTAVNTLTKKGTAFMRFTMEVGGVTQLQRAITL
IREVPGVIDAQRK
>Mature_733_residues
MVSVSHAISQDAAVPPVELLSAGLCANEKALIQKALDLAADIYEGHVLGTGESVWTHAMGTALIAASLRLDADTRIAALL
FSANEYLDDAPTLIEERFGGSVARLVEGLRKLNGLRVVTRMTATASAPEIRAQTEVLRKMLLAMVEDIRVVLIRLASRTQ
TLRYYADTKSENRQDIARESLDIYAPLANRLGVWQLKWELEDLSFRFLEPDTYKRIAKMLDERRVEREEFIRNAIERLRS
EIAAVGIKAEIQGRPKHIYSIYNKMRAKRLDFSQVYDIRALRVLVDEVKDCYTVLGLVHQIWQPINKEFDDYITKPKGNN
YQSLHTAVLAGDGRALEVQIRTHDMHRHAELGVAAHWRYKEGSGHGGDYDDKIALLRNLLSWRDEVADSARWVEQFKRAS
LDDTLYVLTPQGRVVDLPQGATPVDFAYRVHTDLGHRCRGAKVDGHLVPLNTPLQSGQTVEITAAKEGGPSRDWLDSRQG
YVATSRARTKIKQYFSQLEEEELLARGRTSITREMQRDGHGQANIEGLAERLGFKSADALYLAAGRGEIGPRAVQMALRE
ADAVVDAPAEPEIVVGRSRSGDNSDKILIVGVGKLLTSLSRCCKPAPPDAIEGFVTRGRGISIHRVDCHDFQLLARRHPE
RVISAEWGDQAYNNAQAVYPVDIAVQANDRQGLLRDISEVLSREKLNVTAVNTLTKKGTAFMRFTMEVGGVTQLQRAITL
IREVPGVIDAQRK

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=690, Percent_Identity=43.3333333333333, Blast_Score=560, Evalue=1e-160,
Organism=Escherichia coli, GI1790082, Length=726, Percent_Identity=35.5371900826446, Blast_Score=433, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 81798; Mature: 81798

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSVSHAISQDAAVPPVELLSAGLCANEKALIQKALDLAADIYEGHVLGTGESVWTHAMG
CCCCHHHHCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHH
TALIAASLRLDADTRIAALLFSANEYLDDAPTLIEERFGGSVARLVEGLRKLNGLRVVTR
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCEEEHH
MTATASAPEIRAQTEVLRKMLLAMVEDIRVVLIRLASRTQTLRYYADTKSENRQDIARES
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHH
LDIYAPLANRLGVWQLKWELEDLSFRFLEPDTYKRIAKMLDERRVEREEFIRNAIERLRS
HHHHHHHHHCCCEEEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIAAVGIKAEIQGRPKHIYSIYNKMRAKRLDFSQVYDIRALRVLVDEVKDCYTVLGLVHQ
HHHHHCCEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IWQPINKEFDDYITKPKGNNYQSLHTAVLAGDGRALEVQIRTHDMHRHAELGVAAHWRYK
HHHHHHHHHHHHHCCCCCCCHHHHHHEEEECCCCEEEEEEEECCHHHHHHCCEEEEEEEC
EGSGHGGDYDDKIALLRNLLSWRDEVADSARWVEQFKRASLDDTLYVLTPQGRVVDLPQG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCC
ATPVDFAYRVHTDLGHRCRGAKVDGHLVPLNTPLQSGQTVEITAAKEGGPSRDWLDSRQG
CCCCHHEEEEECCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEEECCCCCCCHHHHCCCC
YVATSRARTKIKQYFSQLEEEELLARGRTSITREMQRDGHGQANIEGLAERLGFKSADAL
CEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCEE
YLAAGRGEIGPRAVQMALREADAVVDAPAEPEIVVGRSRSGDNSDKILIVGVGKLLTSLS
EEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCEEEEEEHHHHHHHHH
RCCKPAPPDAIEGFVTRGRGISIHRVDCHDFQLLARRHPERVISAEWGDQAYNNAQAVYP
HHCCCCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHCCCHHHHCCCCCCHHHCCCCEEEE
VDIAVQANDRQGLLRDISEVLSREKLNVTAVNTLTKKGTAFMRFTMEVGGVTQLQRAITL
EEEEEECCCCCHHHHHHHHHHHHCCCCEEEEHHHHHCCCEEEEEEEHHCCHHHHHHHHHH
IREVPGVIDAQRK
HHHCCCCCCCCCC
>Mature Secondary Structure
MVSVSHAISQDAAVPPVELLSAGLCANEKALIQKALDLAADIYEGHVLGTGESVWTHAMG
CCCCHHHHCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHH
TALIAASLRLDADTRIAALLFSANEYLDDAPTLIEERFGGSVARLVEGLRKLNGLRVVTR
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCEEEHH
MTATASAPEIRAQTEVLRKMLLAMVEDIRVVLIRLASRTQTLRYYADTKSENRQDIARES
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHH
LDIYAPLANRLGVWQLKWELEDLSFRFLEPDTYKRIAKMLDERRVEREEFIRNAIERLRS
HHHHHHHHHCCCEEEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIAAVGIKAEIQGRPKHIYSIYNKMRAKRLDFSQVYDIRALRVLVDEVKDCYTVLGLVHQ
HHHHHCCEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IWQPINKEFDDYITKPKGNNYQSLHTAVLAGDGRALEVQIRTHDMHRHAELGVAAHWRYK
HHHHHHHHHHHHHCCCCCCCHHHHHHEEEECCCCEEEEEEEECCHHHHHHCCEEEEEEEC
EGSGHGGDYDDKIALLRNLLSWRDEVADSARWVEQFKRASLDDTLYVLTPQGRVVDLPQG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCC
ATPVDFAYRVHTDLGHRCRGAKVDGHLVPLNTPLQSGQTVEITAAKEGGPSRDWLDSRQG
CCCCHHEEEEECCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEEECCCCCCCHHHHCCCC
YVATSRARTKIKQYFSQLEEEELLARGRTSITREMQRDGHGQANIEGLAERLGFKSADAL
CEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCEE
YLAAGRGEIGPRAVQMALREADAVVDAPAEPEIVVGRSRSGDNSDKILIVGVGKLLTSLS
EEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCEEEEEEHHHHHHHHH
RCCKPAPPDAIEGFVTRGRGISIHRVDCHDFQLLARRHPERVISAEWGDQAYNNAQAVYP
HHCCCCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHCCCHHHHCCCCCCHHHCCCCEEEE
VDIAVQANDRQGLLRDISEVLSREKLNVTAVNTLTKKGTAFMRFTMEVGGVTQLQRAITL
EEEEEECCCCCHHHHHHHHHHHHCCCCEEEEHHHHHCCCEEEEEEEHHCCHHHHHHHHHH
IREVPGVIDAQRK
HHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]