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The map label for this gene is rnc [H]

Identifier: 119897933

GI number: 119897933

Start: 1802535

End: 1803206

Strand: Direct

Name: rnc [H]

Synonym: azo1642

Alternate gene names: 119897933

Gene position: 1802535-1803206 (Clockwise)

Preceding gene: 119897932

Following gene: 119897934

Centisome position: 41.19

GC content: 64.14

Gene sequence:

>672_bases
ATGTCGGTCGAACACCTGCAGCGTGCGCTCGGTCATCAATTTGCCCAGCCCGAACTGCTGCAGCAGGCACTGACCCACCG
CAGTTTCGGTCAACCCAACAACGAACGCCTCGAATTCCTCGGCGACAGCATTCTCAACTGCGTCACCTCCATCGCGCTCT
ACGAACGCTTCGGCGGCCTGCGCGAGGGTGAGTTGTCGCGTTTGCGGGCAGGCCTGGTATGCCAGGACGCCTTGCACCGG
ATTGCGGTGCAACTGAAGCTGGGCGATTGCCTGCGATTGGGCGAGGGCGAGCTGAAATCCGGCGGTTTCCGCCGTCCCTC
CATCCTCGCCGACGCGCTCGAGGCGATTTTCGCCGCGGTCTTCCTCGATTCCGACTTTGCCGGCGCGAAGGCCGTCATCG
ACCGCCTCTATGCGCCCTTGCTGGCGGAGGTGGAGCCGGGCGCTCCCGCCAAGGATCCCAAGACGGCGTTGCAGGAGTGG
TTGCAGGGGCGCAAGTCGCCGTTGCCCACCTATGTCATGGTCCAGGTCACCGGTGAAGCGCATGCACAGGAATTCGAAGT
GGCGTGCGAAGTCGAAAAGCACAAGGTGCGCACCGTGGGGCGCGGTACCAGCCGCCGGATTGCCGAGCAGCGCGCCGCCG
AACTCGCGCTTGCCCAGTTGAGGAAGAAATGA

Upstream 100 bases:

>100_bases
GCAAGACGCTGATCGAGGCGGAGTATTCGCGCAAGATCCCGGTGGTGGCGAACGTGAGCCTGCTGGTCGATTTCCACGCC
TCGAGCGCGGATTGAGCGGG

Downstream 100 bases:

>100_bases
ACATCGAAGAAGCGGTCCCTTCCGCAAAGCCGGGCTTCAGGACCGGTTTTGTGGCCATCGTCGGACGGCCCAACGTCGGC
AAGTCGACGCTGCTCAACCG

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 223; Mature: 222

Protein sequence:

>223_residues
MSVEHLQRALGHQFAQPELLQQALTHRSFGQPNNERLEFLGDSILNCVTSIALYERFGGLREGELSRLRAGLVCQDALHR
IAVQLKLGDCLRLGEGELKSGGFRRPSILADALEAIFAAVFLDSDFAGAKAVIDRLYAPLLAEVEPGAPAKDPKTALQEW
LQGRKSPLPTYVMVQVTGEAHAQEFEVACEVEKHKVRTVGRGTSRRIAEQRAAELALAQLRKK

Sequences:

>Translated_223_residues
MSVEHLQRALGHQFAQPELLQQALTHRSFGQPNNERLEFLGDSILNCVTSIALYERFGGLREGELSRLRAGLVCQDALHR
IAVQLKLGDCLRLGEGELKSGGFRRPSILADALEAIFAAVFLDSDFAGAKAVIDRLYAPLLAEVEPGAPAKDPKTALQEW
LQGRKSPLPTYVMVQVTGEAHAQEFEVACEVEKHKVRTVGRGTSRRIAEQRAAELALAQLRKK
>Mature_222_residues
SVEHLQRALGHQFAQPELLQQALTHRSFGQPNNERLEFLGDSILNCVTSIALYERFGGLREGELSRLRAGLVCQDALHRI
AVQLKLGDCLRLGEGELKSGGFRRPSILADALEAIFAAVFLDSDFAGAKAVIDRLYAPLLAEVEPGAPAKDPKTALQEWL
QGRKSPLPTYVMVQVTGEAHAQEFEVACEVEKHKVRTVGRGTSRRIAEQRAAELALAQLRKK

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=224, Percent_Identity=29.9107142857143, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI155030236, Length=224, Percent_Identity=29.9107142857143, Blast_Score=88, Evalue=5e-18,
Organism=Escherichia coli, GI1788920, Length=206, Percent_Identity=56.3106796116505, Blast_Score=226, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17506883, Length=232, Percent_Identity=30.1724137931034, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI193202651, Length=232, Percent_Identity=30.1724137931034, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17137682, Length=236, Percent_Identity=28.3898305084746, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 24563; Mature: 24431

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVEHLQRALGHQFAQPELLQQALTHRSFGQPNNERLEFLGDSILNCVTSIALYERFGGL
CCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
REGELSRLRAGLVCQDALHRIAVQLKLGDCLRLGEGELKSGGFRRPSILADALEAIFAAV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FLDSDFAGAKAVIDRLYAPLLAEVEPGAPAKDPKTALQEWLQGRKSPLPTYVMVQVTGEA
HHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCH
HAQEFEVACEVEKHKVRTVGRGTSRRIAEQRAAELALAQLRKK
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVEHLQRALGHQFAQPELLQQALTHRSFGQPNNERLEFLGDSILNCVTSIALYERFGGL
CHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
REGELSRLRAGLVCQDALHRIAVQLKLGDCLRLGEGELKSGGFRRPSILADALEAIFAAV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FLDSDFAGAKAVIDRLYAPLLAEVEPGAPAKDPKTALQEWLQGRKSPLPTYVMVQVTGEA
HHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCH
HAQEFEVACEVEKHKVRTVGRGTSRRIAEQRAAELALAQLRKK
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA