Click here to switch to the map view.

The map label for this gene is nadB [H]

Identifier: 119897920

GI number: 119897920

Start: 1790655

End: 1792244

Strand: Reverse

Name: nadB [H]

Synonym: azo1629

Alternate gene names: 119897920

Gene position: 1792244-1790655 (Counterclockwise)

Preceding gene: 119897927

Following gene: 119897910

Centisome position: 40.96

GC content: 65.47

Gene sequence:

>1590_bases
TTGTTAAATCAATACGATGTTCTCATTCTCGGCAGTGGCACCGCCGGGCAATCCCTCGCACTCCGCCTCGCCGACAAGCT
CAAGGTCGCGCTGGTCACGAAACGGGAACTGAGCGACAGCGCAAGTGCCTGGGCGCAAGGCGGAATCGCCGCGGTGCTGG
ACACCGCCGACAGCATCGAAGCACACATCCAGGACACCTTCACCGCCGGCGCCTACCTGTGCGACCCGGTCGCCACCCGT
TTCGTGGTGGAAAACGGCCGCCGTGCGATCGAGTGGCTGATTGGCCGCGGCGTGCCTTTCACACGCGAAGACCAGTCCGA
GCTCGGCTACCACCTCACCCGCGAAGGCGGCCATTCCCACCGCCGCATCATCCATGCCGCCGACGCGACCGGCGCCGCCG
TGCAAGCCACGCTCAGCGAGGAGGTCCGGCGCCATCCGAACATCCACATCTTCGAGCACCACATCGCGGTCGACCTGATC
ATCGGCGACAAGGTCGGGCGTCCCGGAGAGGGCTGCCTCGGCGCCTACGTGCTGGACATCAAGGCCGACCGAGTAGTCAC
CTTCGGCGCCCCCAACACCGTGCTGGCCACCGGCGGAACCGGCAAGGTCTATCTGTACACGACCAATCCCGACGTGGCGA
CCGGCGACGGCATCGCGATGGCCTGGCGCGCGGGCTGCCGCGTCGCCAACATGGAATTCATCCAGTTCCACCCCACCTGC
CTCTATCACCCACAGGCCAAGTCCTTCCTGATTTCGGAAGCGGTTCGTGGCGAGGGCGGATTGCTCAAGCTGCCGGATGG
CACACGCTTCATGCCGGAACACGACGAGCGCGCCGAACTCGCGCCGCGCGACGTCGTTGCCCGGGCGATCGACTTCGAGA
TGAAGAAGCACGGCGTGGACTGCGTCTATCTCGACATCAGCCACAAGCCGGCCGACTGGCTGCGCGGACACTTCCCCAAC
ATCCACGCGCGCTGCCTGGAACTGGGAATCGACATCACCCGCCAGCCGATTCCGGTCGTCCCTGCGGCGCACTACACCTG
CGGCGGCATCGTGACCGACCTGTCCGCGCGAACCGATGTTGCGGGCCTGTACGCGGTCGGCGAATCCGCCTGCAGCGGCC
TGCACGGCGCGAACCGGCTGGCGAGCAACTCACTGCTCGAATGCCTGGTGTTCGGCGAGGCCGCAGCCCAGGACATCCTG
GCGAAAACGGCCACGGCACCGCTCACCCTCCCGGACTGGGATGAAAGCCGCGTTACGGACGCCGACGAAGAAGTGGTGAT
TTCCCACAACTGGGCGGAATTGCGGCGCGCAATGTGGGACTACGTGGGCATCGTGCGCACCACCAAGCGGCTGCAGCGTG
CCCAGCACCGGATCCGCCTGCTGACCAACGAAATCAACGAGTTCTACTCGAACTTCCGCGTCTCGAACAATCTGATCGAA
CTGCGCAATCTCGTCGTCACCGCCGACCTGATCGTTCGCTGCGCGCTGAAGCGCAAGGAAAGCCGCGGCCTTCATTACTC
GCGCGACTATCCGGACACCGCCGACCGCATCCGCAGCACCGTGCTGCGCCCTCCCCGCTTCAAGGGCTGA

Upstream 100 bases:

>100_bases
CCAACAGGGACTTTCCGCCCGCGGCGGCAGACCGCGCTGCGGACGGAGGCGCCAACGTCATGCTATATTCCGCCCCTTCC
CCTCGCGCCAGACCGACATC

Downstream 100 bases:

>100_bases
GCACGCCCACCGCAGCACGGTGTTTCAACCACAACCGGAATAGCCGCCACTGCCCCGGCGCCAGGTTGGCGGGCACCAGC
ATCAGGCGCATTCCACCGGC

Product: L-aspartate oxidase

Products: NA

Alternate protein names: LASPO 1; Quinolinate synthase B 1 [H]

Number of amino acids: Translated: 529; Mature: 529

Protein sequence:

>529_residues
MLNQYDVLILGSGTAGQSLALRLADKLKVALVTKRELSDSASAWAQGGIAAVLDTADSIEAHIQDTFTAGAYLCDPVATR
FVVENGRRAIEWLIGRGVPFTREDQSELGYHLTREGGHSHRRIIHAADATGAAVQATLSEEVRRHPNIHIFEHHIAVDLI
IGDKVGRPGEGCLGAYVLDIKADRVVTFGAPNTVLATGGTGKVYLYTTNPDVATGDGIAMAWRAGCRVANMEFIQFHPTC
LYHPQAKSFLISEAVRGEGGLLKLPDGTRFMPEHDERAELAPRDVVARAIDFEMKKHGVDCVYLDISHKPADWLRGHFPN
IHARCLELGIDITRQPIPVVPAAHYTCGGIVTDLSARTDVAGLYAVGESACSGLHGANRLASNSLLECLVFGEAAAQDIL
AKTATAPLTLPDWDESRVTDADEEVVISHNWAELRRAMWDYVGIVRTTKRLQRAQHRIRLLTNEINEFYSNFRVSNNLIE
LRNLVVTADLIVRCALKRKESRGLHYSRDYPDTADRIRSTVLRPPRFKG

Sequences:

>Translated_529_residues
MLNQYDVLILGSGTAGQSLALRLADKLKVALVTKRELSDSASAWAQGGIAAVLDTADSIEAHIQDTFTAGAYLCDPVATR
FVVENGRRAIEWLIGRGVPFTREDQSELGYHLTREGGHSHRRIIHAADATGAAVQATLSEEVRRHPNIHIFEHHIAVDLI
IGDKVGRPGEGCLGAYVLDIKADRVVTFGAPNTVLATGGTGKVYLYTTNPDVATGDGIAMAWRAGCRVANMEFIQFHPTC
LYHPQAKSFLISEAVRGEGGLLKLPDGTRFMPEHDERAELAPRDVVARAIDFEMKKHGVDCVYLDISHKPADWLRGHFPN
IHARCLELGIDITRQPIPVVPAAHYTCGGIVTDLSARTDVAGLYAVGESACSGLHGANRLASNSLLECLVFGEAAAQDIL
AKTATAPLTLPDWDESRVTDADEEVVISHNWAELRRAMWDYVGIVRTTKRLQRAQHRIRLLTNEINEFYSNFRVSNNLIE
LRNLVVTADLIVRCALKRKESRGLHYSRDYPDTADRIRSTVLRPPRFKG
>Mature_529_residues
MLNQYDVLILGSGTAGQSLALRLADKLKVALVTKRELSDSASAWAQGGIAAVLDTADSIEAHIQDTFTAGAYLCDPVATR
FVVENGRRAIEWLIGRGVPFTREDQSELGYHLTREGGHSHRRIIHAADATGAAVQATLSEEVRRHPNIHIFEHHIAVDLI
IGDKVGRPGEGCLGAYVLDIKADRVVTFGAPNTVLATGGTGKVYLYTTNPDVATGDGIAMAWRAGCRVANMEFIQFHPTC
LYHPQAKSFLISEAVRGEGGLLKLPDGTRFMPEHDERAELAPRDVVARAIDFEMKKHGVDCVYLDISHKPADWLRGHFPN
IHARCLELGIDITRQPIPVVPAAHYTCGGIVTDLSARTDVAGLYAVGESACSGLHGANRLASNSLLECLVFGEAAAQDIL
AKTATAPLTLPDWDESRVTDADEEVVISHNWAELRRAMWDYVGIVRTTKRLQRAQHRIRLLTNEINEFYSNFRVSNNLIE
LRNLVVTADLIVRCALKRKESRGLHYSRDYPDTADRIRSTVLRPPRFKG

Specific function: Catalyzes the oxidation of L-aspartate to iminoaspartate [H]

COG id: COG0029

COG function: function code H; Aspartate oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=525, Percent_Identity=34.0952380952381, Blast_Score=233, Evalue=3e-61,
Organism=Escherichia coli, GI1788928, Length=524, Percent_Identity=61.4503816793893, Blast_Score=657, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=521, Percent_Identity=32.8214971209213, Blast_Score=242, Evalue=4e-65,
Organism=Escherichia coli, GI1786942, Length=564, Percent_Identity=33.6879432624113, Blast_Score=208, Evalue=8e-55,
Organism=Caenorhabditis elegans, GI17550100, Length=535, Percent_Identity=34.018691588785, Blast_Score=244, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17505833, Length=537, Percent_Identity=33.8919925512104, Blast_Score=235, Evalue=5e-62,
Organism=Saccharomyces cerevisiae, GI6322701, Length=556, Percent_Identity=33.6330935251799, Blast_Score=228, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6322416, Length=560, Percent_Identity=33.2142857142857, Blast_Score=223, Evalue=7e-59,
Organism=Drosophila melanogaster, GI24663005, Length=559, Percent_Identity=32.0214669051878, Blast_Score=234, Evalue=2e-61,
Organism=Drosophila melanogaster, GI17137288, Length=536, Percent_Identity=33.5820895522388, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24655642, Length=536, Percent_Identity=33.5820895522388, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24655647, Length=536, Percent_Identity=33.5820895522388, Blast_Score=233, Evalue=3e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005288 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.4.3.16 [H]

Molecular weight: Translated: 58185; Mature: 58185

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNQYDVLILGSGTAGQSLALRLADKLKVALVTKRELSDSASAWAQGGIAAVLDTADSIE
CCCCEEEEEEECCCCCCHHHHHHHHHHEEEEEEHHHHCCHHHHHHCCCEEEEECCHHHHH
AHIQDTFTAGAYLCDPVATRFVVENGRRAIEWLIGRGVPFTREDQSELGYHLTREGGHSH
HHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHCCEEEECCCCCCC
RRIIHAADATGAAVQATLSEEVRRHPNIHIFEHHIAVDLIIGDKVGRPGEGCLGAYVLDI
EEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEEEEEEEEEECCCCCCCCCCEEEEEEEE
KADRVVTFGAPNTVLATGGTGKVYLYTTNPDVATGDGIAMAWRAGCRVANMEFIQFHPTC
ECCEEEEECCCCEEEEECCCCEEEEEECCCCCCCCCCEEEHHHCCCEEECEEEEEECCEE
LYHPQAKSFLISEAVRGEGGLLKLPDGTRFMPEHDERAELAPRDVVARAIDFEMKKHGVD
EECCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
CVYLDISHKPADWLRGHFPNIHARCLELGIDITRQPIPVVPAAHYTCGGIVTDLSARTDV
EEEEEECCCCHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCC
AGLYAVGESACSGLHGANRLASNSLLECLVFGEAAAQDILAKTATAPLTLPDWDESRVTD
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
ADEEVVISHNWAELRRAMWDYVGIVRTTKRLQRAQHRIRLLTNEINEFYSNFRVSNNLIE
CCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LRNLVVTADLIVRCALKRKESRGLHYSRDYPDTADRIRSTVLRPPRFKG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLNQYDVLILGSGTAGQSLALRLADKLKVALVTKRELSDSASAWAQGGIAAVLDTADSIE
CCCCEEEEEEECCCCCCHHHHHHHHHHEEEEEEHHHHCCHHHHHHCCCEEEEECCHHHHH
AHIQDTFTAGAYLCDPVATRFVVENGRRAIEWLIGRGVPFTREDQSELGYHLTREGGHSH
HHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHCCEEEECCCCCCC
RRIIHAADATGAAVQATLSEEVRRHPNIHIFEHHIAVDLIIGDKVGRPGEGCLGAYVLDI
EEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEEEEEEEEEECCCCCCCCCCEEEEEEEE
KADRVVTFGAPNTVLATGGTGKVYLYTTNPDVATGDGIAMAWRAGCRVANMEFIQFHPTC
ECCEEEEECCCCEEEEECCCCEEEEEECCCCCCCCCCEEEHHHCCCEEECEEEEEECCEE
LYHPQAKSFLISEAVRGEGGLLKLPDGTRFMPEHDERAELAPRDVVARAIDFEMKKHGVD
EECCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
CVYLDISHKPADWLRGHFPNIHARCLELGIDITRQPIPVVPAAHYTCGGIVTDLSARTDV
EEEEEECCCCHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCC
AGLYAVGESACSGLHGANRLASNSLLECLVFGEAAAQDILAKTATAPLTLPDWDESRVTD
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
ADEEVVISHNWAELRRAMWDYVGIVRTTKRLQRAQHRIRLLTNEINEFYSNFRVSNNLIE
CCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LRNLVVTADLIVRCALKRKESRGLHYSRDYPDTADRIRSTVLRPPRFKG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]