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The map label for this gene is fabH

Identifier: 119897914

GI number: 119897914

Start: 1785850

End: 1786815

Strand: Direct

Name: fabH

Synonym: azo1623

Alternate gene names: 119897914

Gene position: 1785850-1786815 (Clockwise)

Preceding gene: 119897913

Following gene: 119897915

Centisome position: 40.81

GC content: 65.84

Gene sequence:

>966_bases
ATGATCCACGCACGTATCGCCGGGACAGGCAGTTATCTCCCCGGCAATCCGGTGAGCAACGACGATCTCGTCGCCCGTGG
CATCGACACCTCCGACGATTGGGTGGTATCGAGAACCGGCATCCGCACCCGCTATCTCGCGCCGCCCGACGTGGGCTCCA
GCGATCTCGCGCTCGTCGCGGCGCAGCGCGCAATTGAAGCGGCGGGCTGTGCGGCCAACGACATCGACCTCATCATCGTG
GCGACCTCGACGCCCGATTACATCTTTCCCAGCACCGCCACGCTGCTGCAGTCCAAGCTGGGCATCGGCAACAACGGTGC
GGCATTCGATGTGCAGGCGGTGTGCAGCGGCTTTGTCTACGCACTGAGCATCGCTGAGAAATTCATCCGTTCGGGCAGTC
ACAAGCGCGCGCTCGTCGTCGGGGCGGAAGTTTTTTCCCGCATTCTCGACTGGACCGATCGCGCTACCTGCGTGCTGTTC
GGAGATGGCGCCGGCGCGGTGGTGCTCGAAGCCTCGGAGCGGCCCGGCGTGCTGACGACCGCGCTCCACGCCGATGGTAG
CCACCATCCAATTCTCTGTGTTCCCGGCAACGTGGCTACCGGGCAGGTGGTAGGCGACCCCTTTCTGCGCATGGACGGTC
AGGCGGTGTTCAAGTTTGCCGTGAAGGTGCTCGGCGACGTCGCGCACGAGGTGCTCGACGCGGCCGGCGTGGCGGCGGAC
AGCGTGGACTGGCTGATTCCCCACCAGGCGAACATCCGCATCATCCAGGCCACGGCGAAGCGCCTGGGCCTGTCGATGGA
GAAGGTCGTGGCCACGGTGGATCGCCATGGCAACACCTCGGCGGCATCGATTCCGCTTGCACTCGATCTCGCGGTGCGGG
ATGGCCGTATCCGCCCCGGGCAGCGCGTCGTGGTCGAGGGTGTAGGCGGCGGGTTCACCTGGGGCGCAGCCCTGATCGAC
TTCTGA

Upstream 100 bases:

>100_bases
TCGCCTTCGAGCAGGCGCTCGGCCGTGCTGCCGATGCAGCCGCGAACCGTTTGATCGAACGTATCGAGGAGAGGATGTCC
GCGATGAGCCAGGAGGCCGC

Downstream 100 bases:

>100_bases
TTTCTTCCGATAGACCTTGGAGAGATGATGGCTTTTGCGCTGGTTTTTCCAGGCCAGGGTTCGCAGTCCGTCGCGATGAT
GGACGCGTATGGCGAATCCG

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MIHARIAGTGSYLPGNPVSNDDLVARGIDTSDDWVVSRTGIRTRYLAPPDVGSSDLALVAAQRAIEAAGCAANDIDLIIV
ATSTPDYIFPSTATLLQSKLGIGNNGAAFDVQAVCSGFVYALSIAEKFIRSGSHKRALVVGAEVFSRILDWTDRATCVLF
GDGAGAVVLEASERPGVLTTALHADGSHHPILCVPGNVATGQVVGDPFLRMDGQAVFKFAVKVLGDVAHEVLDAAGVAAD
SVDWLIPHQANIRIIQATAKRLGLSMEKVVATVDRHGNTSAASIPLALDLAVRDGRIRPGQRVVVEGVGGGFTWGAALID
F

Sequences:

>Translated_321_residues
MIHARIAGTGSYLPGNPVSNDDLVARGIDTSDDWVVSRTGIRTRYLAPPDVGSSDLALVAAQRAIEAAGCAANDIDLIIV
ATSTPDYIFPSTATLLQSKLGIGNNGAAFDVQAVCSGFVYALSIAEKFIRSGSHKRALVVGAEVFSRILDWTDRATCVLF
GDGAGAVVLEASERPGVLTTALHADGSHHPILCVPGNVATGQVVGDPFLRMDGQAVFKFAVKVLGDVAHEVLDAAGVAAD
SVDWLIPHQANIRIIQATAKRLGLSMEKVVATVDRHGNTSAASIPLALDLAVRDGRIRPGQRVVVEGVGGGFTWGAALID
F
>Mature_321_residues
MIHARIAGTGSYLPGNPVSNDDLVARGIDTSDDWVVSRTGIRTRYLAPPDVGSSDLALVAAQRAIEAAGCAANDIDLIIV
ATSTPDYIFPSTATLLQSKLGIGNNGAAFDVQAVCSGFVYALSIAEKFIRSGSHKRALVVGAEVFSRILDWTDRATCVLF
GDGAGAVVLEASERPGVLTTALHADGSHHPILCVPGNVATGQVVGDPFLRMDGQAVFKFAVKVLGDVAHEVLDAAGVAAD
SVDWLIPHQANIRIIQATAKRLGLSMEKVVATVDRHGNTSAASIPLALDLAVRDGRIRPGQRVVVEGVGGGFTWGAALID
F

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=320, Percent_Identity=53.4375, Blast_Score=332, Evalue=2e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_AZOSB (A1K5Y5)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_933127.1
- ProteinModelPortal:   A1K5Y5
- SMR:   A1K5Y5
- STRING:   A1K5Y5
- GeneID:   4609585
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo1623
- eggNOG:   COG0332
- HOGENOM:   HBG649927
- OMA:   ATTTPDM
- PhylomeDB:   A1K5Y5
- ProtClustDB:   PRK09352
- BioCyc:   ASP62928:AZO1623-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.41

Molecular weight: Translated: 33455; Mature: 33455

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: ACT_SITE 115-115 ACT_SITE 248-248 ACT_SITE 278-278

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHARIAGTGSYLPGNPVSNDDLVARGIDTSDDWVVSRTGIRTRYLAPPDVGSSDLALVA
CEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCEEEEECCCEEEEECCCCCCCCCHHHHH
AQRAIEAAGCAANDIDLIIVATSTPDYIFPSTATLLQSKLGIGNNGAAFDVQAVCSGFVY
HHHHHHHCCCCCCCCEEEEEEECCCCEECCCHHHHHHHHCCCCCCCCEEEHHHHHHHHHH
ALSIAEKFIRSGSHKRALVVGAEVFSRILDWTDRATCVLFGDGAGAVVLEASERPGVLTT
HHHHHHHHHHCCCCCEEEEEEHHHHHHHHCCCCCEEEEEEECCCCEEEEECCCCCCEEEE
ALHADGSHHPILCVPGNVATGQVVGDPFLRMDGQAVFKFAVKVLGDVAHEVLDAAGVAAD
EEECCCCCCCEEEECCCCCCCCEECCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
SVDWLIPHQANIRIIQATAKRLGLSMEKVVATVDRHGNTSAASIPLALDLAVRDGRIRPG
CCEEECCCCCCEEEEEEEHHHHCCCHHHHHHHHHCCCCCCCEECEEEEEEEEECCCCCCC
QRVVVEGVGGGFTWGAALIDF
CEEEEEECCCCEEHHHHEECC
>Mature Secondary Structure
MIHARIAGTGSYLPGNPVSNDDLVARGIDTSDDWVVSRTGIRTRYLAPPDVGSSDLALVA
CEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCEEEEECCCEEEEECCCCCCCCCHHHHH
AQRAIEAAGCAANDIDLIIVATSTPDYIFPSTATLLQSKLGIGNNGAAFDVQAVCSGFVY
HHHHHHHCCCCCCCCEEEEEEECCCCEECCCHHHHHHHHCCCCCCCCEEEHHHHHHHHHH
ALSIAEKFIRSGSHKRALVVGAEVFSRILDWTDRATCVLFGDGAGAVVLEASERPGVLTT
HHHHHHHHHHCCCCCEEEEEEHHHHHHHHCCCCCEEEEEEECCCCEEEEECCCCCCEEEE
ALHADGSHHPILCVPGNVATGQVVGDPFLRMDGQAVFKFAVKVLGDVAHEVLDAAGVAAD
EEECCCCCCCEEEECCCCCCCCEECCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
SVDWLIPHQANIRIIQATAKRLGLSMEKVVATVDRHGNTSAASIPLALDLAVRDGRIRPG
CCEEECCCCCCEEEEEEEHHHHCCCHHHHHHHHHCCCCCCCEECEEEEEEEEECCCCCCC
QRVVVEGVGGGFTWGAALIDF
CEEEEEECCCCEEHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA