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The map label for this gene is tmk [H]

Identifier: 119897886

GI number: 119897886

Start: 1751590

End: 1752210

Strand: Direct

Name: tmk [H]

Synonym: azo1595

Alternate gene names: 119897886

Gene position: 1751590-1752210 (Clockwise)

Preceding gene: 119897885

Following gene: 119897887

Centisome position: 40.03

GC content: 68.28

Gene sequence:

>621_bases
ATGCAGCACGGGCGTTTCATCACTTTCGAGGGCATCGACGGCGCCGGCAAGAGCAGCCAGATCGCAGCCGTCGTAGACAT
CCTGCGCGCGCGCGGTTGCACGGTGGAGCAATCGCGCGAGCCCGGCGGCACGCCGCTCGGCGAGCGTCTGCGCGAATTGC
TGTTGCATGAGCCGATGAACCTGGAAACCGAAGCCTTGCTGATGTTCGCCGCGCGCCGCGAACATCTCGCCGCGCGCATC
GTGCCCGCGCTGCAGGCCGGAAACTGGGTGGTGTGCGACCGCTTTTCCGACGCCACCTATGCCTATCAGGTCGGCGGGCG
CGGGCTCGCGCGGGAGAAGTTCGACGCGCTCGAAGCCTGGGTCCATCCCGGCCTTCAACCCGATCTGACGCTGGTTTTCG
ACTTGCCGCCGGAGATCGCCGCCGCGCGCGTGGTGTCGAGCGGCGCGCAGCCGGACCGCTTCGAACGCGAACAGCGCGAC
TTCTTCGAGCGCGTGCGCAACGCCTATCTCGAGCGCGCGCAGGCAGCGCCCCAGCGCATCCGCGTGATCGACGCCAACCG
CCCGCCGGAAGTGATCCGCGCCGAGATCGAGCAACTCGTGGTGGAGCGCTGGTTCGCATGA

Upstream 100 bases:

>100_bases
TCTCGCGCGGCGATGGCACCAGCGTCTTCTCGCGCACGCTCGAAGACCACAATCGCGCGGTCGATCGTTACCAGCGCAAC
GGCAAAGGAAGCTGAACGAC

Downstream 100 bases:

>100_bases
TCCATCCGTGGCTGCAGCCGGTCTGGTCGCGTCTGGTCGCGCTCGAAGGGCGCTTGCCGCACGCGCTGCTGTTCATCGGC
CCGGCCGGCCTGGGCAAGCG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MQHGRFITFEGIDGAGKSSQIAAVVDILRARGCTVEQSREPGGTPLGERLRELLLHEPMNLETEALLMFAARREHLAARI
VPALQAGNWVVCDRFSDATYAYQVGGRGLAREKFDALEAWVHPGLQPDLTLVFDLPPEIAAARVVSSGAQPDRFEREQRD
FFERVRNAYLERAQAAPQRIRVIDANRPPEVIRAEIEQLVVERWFA

Sequences:

>Translated_206_residues
MQHGRFITFEGIDGAGKSSQIAAVVDILRARGCTVEQSREPGGTPLGERLRELLLHEPMNLETEALLMFAARREHLAARI
VPALQAGNWVVCDRFSDATYAYQVGGRGLAREKFDALEAWVHPGLQPDLTLVFDLPPEIAAARVVSSGAQPDRFEREQRD
FFERVRNAYLERAQAAPQRIRVIDANRPPEVIRAEIEQLVVERWFA
>Mature_206_residues
MQHGRFITFEGIDGAGKSSQIAAVVDILRARGCTVEQSREPGGTPLGERLRELLLHEPMNLETEALLMFAARREHLAARI
VPALQAGNWVVCDRFSDATYAYQVGGRGLAREKFDALEAWVHPGLQPDLTLVFDLPPEIAAARVVSSGAQPDRFEREQRD
FFERVRNAYLERAQAAPQRIRVIDANRPPEVIRAEIEQLVVERWFA

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=207, Percent_Identity=39.1304347826087, Blast_Score=128, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 23171; Mature: 23171

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHGRFITFEGIDGAGKSSQIAAVVDILRARGCTVEQSREPGGTPLGERLRELLLHEPMN
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCC
LETEALLMFAARREHLAARIVPALQAGNWVVCDRFSDATYAYQVGGRGLAREKFDALEAW
CCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHHH
VHPGLQPDLTLVFDLPPEIAAARVVSSGAQPDRFEREQRDFFERVRNAYLERAQAAPQRI
HCCCCCCCEEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHE
RVIDANRPPEVIRAEIEQLVVERWFA
EEEECCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQHGRFITFEGIDGAGKSSQIAAVVDILRARGCTVEQSREPGGTPLGERLRELLLHEPMN
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCC
LETEALLMFAARREHLAARIVPALQAGNWVVCDRFSDATYAYQVGGRGLAREKFDALEAW
CCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHHH
VHPGLQPDLTLVFDLPPEIAAARVVSSGAQPDRFEREQRDFFERVRNAYLERAQAAPQRI
HCCCCCCCEEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHE
RVIDANRPPEVIRAEIEQLVVERWFA
EEEECCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA