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The map label for this gene is nqo1 [C]

Identifier: 119897874

GI number: 119897874

Start: 1741067

End: 1741870

Strand: Direct

Name: nqo1 [C]

Synonym: azo1583

Alternate gene names: 119897874

Gene position: 1741067-1741870 (Clockwise)

Preceding gene: 119897872

Following gene: 119897879

Centisome position: 39.79

GC content: 64.18

Gene sequence:

>804_bases
ATGAATGTTCTGATCGTCTATGCCCACCCTGAACCGCAATCCCTGAACGGTTCACTGAAGGATTTTTCTGTTCACCGCCT
CCAGCAGGGCGGTCACTCAGTCCAGGTCTCGGACCTCTATGCCATGCGATGGAAGCCGGCACTGGATGCGAGCGACAACA
CGGTGGGTGCCGCCGGTGCGCGCTTCGAGGCGTCCGCGGATTCACGGCGGGCGTTCGAACGCGGCACGCAGAGCGCCGAT
ATCGCGGGCGAGCAGGACAAGCTGCGTTGGGCCGATGCCGTCATCCTGCAATTTCCGCTGTGGTGGTTCTCGATGCCCGC
GATTCTCAAGGGCTGGGTCGACCGTGTGTACGCCTGCGGTTTTGCCTATGGCGTCGGTGAGCATTCCGACGTCCGCTGGG
GACAACGCTATGGCGAAGGCACGCTGGCGGGAAAGCGGGCGATGCTGGTGGTGACGACCGGCGGCTGGGCATCGCACTAC
GGACCGCGGGGCATCAACGGGCCGATCGACGATCTGCTGTTCCCTATCCAGCACGGCGTGCTGTTCTATCCCGGTTTCGA
TGTGCTGCCGCCGCATGTGATCCATCGCACCGGCAAGATCGATGACGCGGCATTCGAACGCGTTTGCGAGGCGCTCGGCC
GCCGACTCGATACCTTGGCGACGACTGCGCCGATTCCGTTCCGTCGCCAGAACGGCGGCGACTACCGCATTCCGGAGCTA
ACGCTACAGCCAGAACTCGCGCCAGGCGCTTCGGGCTTCGGCATCCACCTGTCGTCCGCAGAGGCAGGCGTGCCGGCCGT
GTAG

Upstream 100 bases:

>100_bases
GCAAGGAATTATCCAAGGCAATACCAGAGATTCCGGAAATTCATTTCAACTATATCTCACGCAACCCTATCCTGCGGCGG
TCTATTACGGAGCCTCCGCC

Downstream 100 bases:

>100_bases
TCAGCCGGCTGCGGCGGCGTCAGTCGAACGCGGTGCTGCAGCGGGATGCGGGGGCCGGCAGCGTGAAGCGGAAGACGGCC
CCGTCCCCGGGTGTCGCTTC

Product: NAD(P)H dehydrogenase, quinone 1

Products: NAD(P); reduced acceptor [C]

Alternate protein names: NA

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MNVLIVYAHPEPQSLNGSLKDFSVHRLQQGGHSVQVSDLYAMRWKPALDASDNTVGAAGARFEASADSRRAFERGTQSAD
IAGEQDKLRWADAVILQFPLWWFSMPAILKGWVDRVYACGFAYGVGEHSDVRWGQRYGEGTLAGKRAMLVVTTGGWASHY
GPRGINGPIDDLLFPIQHGVLFYPGFDVLPPHVIHRTGKIDDAAFERVCEALGRRLDTLATTAPIPFRRQNGGDYRIPEL
TLQPELAPGASGFGIHLSSAEAGVPAV

Sequences:

>Translated_267_residues
MNVLIVYAHPEPQSLNGSLKDFSVHRLQQGGHSVQVSDLYAMRWKPALDASDNTVGAAGARFEASADSRRAFERGTQSAD
IAGEQDKLRWADAVILQFPLWWFSMPAILKGWVDRVYACGFAYGVGEHSDVRWGQRYGEGTLAGKRAMLVVTTGGWASHY
GPRGINGPIDDLLFPIQHGVLFYPGFDVLPPHVIHRTGKIDDAAFERVCEALGRRLDTLATTAPIPFRRQNGGDYRIPEL
TLQPELAPGASGFGIHLSSAEAGVPAV
>Mature_267_residues
MNVLIVYAHPEPQSLNGSLKDFSVHRLQQGGHSVQVSDLYAMRWKPALDASDNTVGAAGARFEASADSRRAFERGTQSAD
IAGEQDKLRWADAVILQFPLWWFSMPAILKGWVDRVYACGFAYGVGEHSDVRWGQRYGEGTLAGKRAMLVVTTGGWASHY
GPRGINGPIDDLLFPIQHGVLFYPGFDVLPPHVIHRTGKIDDAAFERVCEALGRRLDTLATTAPIPFRRQNGGDYRIPEL
TLQPELAPGASGFGIHLSSAEAGVPAV

Specific function: Unknown

COG id: COG2249

COG function: function code R; Putative NADPH-quinone reductase (modulator of drug activity B)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD(P)H dehydrogenase (quinone) family [H]

Homologues:

Organism=Homo sapiens, GI156564357, Length=226, Percent_Identity=42.4778761061947, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI4505415, Length=225, Percent_Identity=39.1111111111111, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI70995396, Length=225, Percent_Identity=32.4444444444444, Blast_Score=99, Evalue=5e-21,
Organism=Escherichia coli, GI1786231, Length=214, Percent_Identity=29.4392523364486, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1787129, Length=134, Percent_Identity=30.5970149253731, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003680 [H]

Pfam domain/function: PF02525 Flavodoxin_2 [H]

EC number: 1.6.99.- [C]

Molecular weight: Translated: 29108; Mature: 29108

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVLIVYAHPEPQSLNGSLKDFSVHRLQQGGHSVQVSDLYAMRWKPALDASDNTVGAAGA
CCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCC
RFEASADSRRAFERGTQSADIAGEQDKLRWADAVILQFPLWWFSMPAILKGWVDRVYACG
EEECCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAYGVGEHSDVRWGQRYGEGTLAGKRAMLVVTTGGWASHYGPRGINGPIDDLLFPIQHGV
HHHCCCCCCCCCHHHHCCCCCCCCCEEEEEEEECCHHHHCCCCCCCCCHHHHHHHHHCCE
LFYPGFDVLPPHVIHRTGKIDDAAFERVCEALGRRLDTLATTAPIPFRRQNGGDYRIPEL
EEECCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCEECCEE
TLQPELAPGASGFGIHLSSAEAGVPAV
EECCCCCCCCCCCEEEECCCCCCCCCC
>Mature Secondary Structure
MNVLIVYAHPEPQSLNGSLKDFSVHRLQQGGHSVQVSDLYAMRWKPALDASDNTVGAAGA
CCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCC
RFEASADSRRAFERGTQSADIAGEQDKLRWADAVILQFPLWWFSMPAILKGWVDRVYACG
EEECCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAYGVGEHSDVRWGQRYGEGTLAGKRAMLVVTTGGWASHYGPRGINGPIDDLLFPIQHGV
HHHCCCCCCCCCHHHHCCCCCCCCCEEEEEEEECCHHHHCCCCCCCCCHHHHHHHHHCCE
LFYPGFDVLPPHVIHRTGKIDDAAFERVCEALGRRLDTLATTAPIPFRRQNGGDYRIPEL
EEECCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCEECCEE
TLQPELAPGASGFGIHLSSAEAGVPAV
EECCCCCCCCCCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NAD(P)H2; acceptor [C]

Specific reaction: NAD(P)H2 + acceptor = NAD(P) + reduced acceptor [C]

General reaction: Oxidoreductases; Acting on NADH or NADPH; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]