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The map label for this gene is guaA

Identifier: 119897872

GI number: 119897872

Start: 1738436

End: 1740001

Strand: Direct

Name: guaA

Synonym: azo1581

Alternate gene names: 119897872

Gene position: 1738436-1740001 (Clockwise)

Preceding gene: 119897871

Following gene: 119897874

Centisome position: 39.73

GC content: 63.98

Gene sequence:

>1566_bases
ATGTCCCACCAGAAAATCCTCATTCTCGATTTCGGCTCCCAGGTTTCGCAGCTGATTGCACGGCGCGTGCGCGAACAACA
CGTGTATTGCGAACTGCACCCCTACGACGTGTCCGAAGCCTTCATCCGGGACTTCAAGCCGCAGGGCATCATCCTTTCCG
GTGGTCCGAATTCGGTGTACGAGGCGGTGGACTGGCGTGCGCCGCAGGTGGTCTTCGAACTCGGCGTGCCGGTGCTCGGT
ATCTGCTACGGCATGCAGACCATGGCCGAGCAACTCGGCGGCAAGGTCGAAAGCTCCGCCAAGCGCGAGTTCGGCTATGC
AGAACTGCGCGCCCGTGGCCATTCCAAGCTGTTCCAGGGCATCGAGGACCGGACCAACGCCGAAGGCCACGGCCTGCTCG
ACGTGTGGATGAGCCACGGCGACAAGGTCACTGAGCTGCCCGCCGGCTTCAAGGTGATCGGCAGCAACGAATCCTGCCCG
GTGGCGGCGATGGCGGACGAGGAGCGCGGCTTCTACGGCGTGCAGTTCCACCCGGAAGTCACCCACACGATCAAGGGCAA
GGAAATGCTCGCCCGCTTCGTGCACGAGATCTGCGGCTGCGGCAATGACTGGAACATGCCGGACTACATTTCGGAAGCGG
TCGAGAAGATCCGCGCCCAGGTTGGCGACGAGGAAGTCATCCTCGGCCTGTCGGGCGGGGTCGATTCCTCGGTGGCGGCG
GCGCTGATCCACCGTGCCATTGGCGACCAGCTCACCTGCGTGTTCGTCGACAACGGCTTGCTGCGCCTCAACGAAGGCGC
GCAGGTGATGGAAACCTTCAACCGCTCGCTCGGCGTCAAGGTCATCCACGTCGATGCCACCGAGCAGTTCATGGGCCATC
TGAAAGGCGTTTCGGACCCCGAGCAGAAACGCAAGATCATCGGCCGCGAATTCGTCGAGGTGTTCCAGGCCGAAGCGGCC
AAGCTGCCCAAGGCGCGCTGGCTGGCGCAGGGCACGATCTACCCGGACGTGATCGAGTCCGCTGGCGCCAAGACCGGCAA
GGCGCACGCGATCAAGAGCCACCACAACGTGGGCGGCCTGCCCGAAACGCTCAACCTCAAGCTGCTTGAGCCGCTGCGCG
ACCTCTTCAAGGACGAAGTGCGCGAACTCGGCGTCGCCCTCGGCCTGCCGCACGACATGGTCTATCGCCATCCCTTCCCC
GGCCCCGGCCTGGGCGTGCGCATCCTCGGCGAGGTCAAGAAGGAATTCGCCGACCTGCTGCGTCGCGCCGATGCGATCTT
CATCGACGAACTGCGCGCCGCGGACTGGTACGACAAGACCAGTCAGGCTTTTGCGGTCTTCCTGCCGGTAAAGAGCGTGG
GCGTAATGGGCGACGGCCGCACCTACGAATACGTGGTGGCGCTGCGCGCCGTGCAGACCCAGGACTTCATGACGGCGCAC
TGGGCGGAGCTGCCCCACAGCCTGCTGGGCAAGGTGAGTAACCGCATCATCAACGAAGTCCGCGGCATCAACCGGGTGGT
GTACGACATCTCGGGCAAACCGCCAGCGACAATCGAGTGGGAGTGA

Upstream 100 bases:

>100_bases
GCCCAACTACCACGTCGATTAACGCTGCATCGTCGTAGCGTCACCTACAGGCGGTCGTCGGGTTGTACCGACGCCGCCTT
TCCTGTTTGTTGAGACGGAC

Downstream 100 bases:

>100_bases
CCGATAAAGCCTGACGCCTGAAAACGTCAGGCTTTTTTGTTGGTGCTCACGCGCTCGCCGTGTGGCAGACGGGGCCGGCT
GATTTCAGACGGCGCCGGCA

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 521; Mature: 520

Protein sequence:

>521_residues
MSHQKILILDFGSQVSQLIARRVREQHVYCELHPYDVSEAFIRDFKPQGIILSGGPNSVYEAVDWRAPQVVFELGVPVLG
ICYGMQTMAEQLGGKVESSAKREFGYAELRARGHSKLFQGIEDRTNAEGHGLLDVWMSHGDKVTELPAGFKVIGSNESCP
VAAMADEERGFYGVQFHPEVTHTIKGKEMLARFVHEICGCGNDWNMPDYISEAVEKIRAQVGDEEVILGLSGGVDSSVAA
ALIHRAIGDQLTCVFVDNGLLRLNEGAQVMETFNRSLGVKVIHVDATEQFMGHLKGVSDPEQKRKIIGREFVEVFQAEAA
KLPKARWLAQGTIYPDVIESAGAKTGKAHAIKSHHNVGGLPETLNLKLLEPLRDLFKDEVRELGVALGLPHDMVYRHPFP
GPGLGVRILGEVKKEFADLLRRADAIFIDELRAADWYDKTSQAFAVFLPVKSVGVMGDGRTYEYVVALRAVQTQDFMTAH
WAELPHSLLGKVSNRIINEVRGINRVVYDISGKPPATIEWE

Sequences:

>Translated_521_residues
MSHQKILILDFGSQVSQLIARRVREQHVYCELHPYDVSEAFIRDFKPQGIILSGGPNSVYEAVDWRAPQVVFELGVPVLG
ICYGMQTMAEQLGGKVESSAKREFGYAELRARGHSKLFQGIEDRTNAEGHGLLDVWMSHGDKVTELPAGFKVIGSNESCP
VAAMADEERGFYGVQFHPEVTHTIKGKEMLARFVHEICGCGNDWNMPDYISEAVEKIRAQVGDEEVILGLSGGVDSSVAA
ALIHRAIGDQLTCVFVDNGLLRLNEGAQVMETFNRSLGVKVIHVDATEQFMGHLKGVSDPEQKRKIIGREFVEVFQAEAA
KLPKARWLAQGTIYPDVIESAGAKTGKAHAIKSHHNVGGLPETLNLKLLEPLRDLFKDEVRELGVALGLPHDMVYRHPFP
GPGLGVRILGEVKKEFADLLRRADAIFIDELRAADWYDKTSQAFAVFLPVKSVGVMGDGRTYEYVVALRAVQTQDFMTAH
WAELPHSLLGKVSNRIINEVRGINRVVYDISGKPPATIEWE
>Mature_520_residues
SHQKILILDFGSQVSQLIARRVREQHVYCELHPYDVSEAFIRDFKPQGIILSGGPNSVYEAVDWRAPQVVFELGVPVLGI
CYGMQTMAEQLGGKVESSAKREFGYAELRARGHSKLFQGIEDRTNAEGHGLLDVWMSHGDKVTELPAGFKVIGSNESCPV
AAMADEERGFYGVQFHPEVTHTIKGKEMLARFVHEICGCGNDWNMPDYISEAVEKIRAQVGDEEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDNGLLRLNEGAQVMETFNRSLGVKVIHVDATEQFMGHLKGVSDPEQKRKIIGREFVEVFQAEAAK
LPKARWLAQGTIYPDVIESAGAKTGKAHAIKSHHNVGGLPETLNLKLLEPLRDLFKDEVRELGVALGLPHDMVYRHPFPG
PGLGVRILGEVKKEFADLLRRADAIFIDELRAADWYDKTSQAFAVFLPVKSVGVMGDGRTYEYVVALRAVQTQDFMTAHW
AELPHSLLGKVSNRIINEVRGINRVVYDISGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=562, Percent_Identity=36.4768683274021, Blast_Score=306, Evalue=2e-83,
Organism=Escherichia coli, GI1788854, Length=518, Percent_Identity=68.9189189189189, Blast_Score=741, Evalue=0.0,
Organism=Escherichia coli, GI1789760, Length=159, Percent_Identity=30.188679245283, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71992717, Length=581, Percent_Identity=35.9724612736661, Blast_Score=296, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI71992710, Length=581, Percent_Identity=35.9724612736661, Blast_Score=296, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI133901714, Length=581, Percent_Identity=35.9724612736661, Blast_Score=296, Evalue=2e-80,
Organism=Saccharomyces cerevisiae, GI6323873, Length=525, Percent_Identity=52.1904761904762, Blast_Score=543, Evalue=1e-155,
Organism=Drosophila melanogaster, GI281365319, Length=566, Percent_Identity=37.4558303886926, Blast_Score=310, Evalue=2e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_AZOSB (A1K5U3)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_933085.1
- ProteinModelPortal:   A1K5U3
- SMR:   A1K5U3
- STRING:   A1K5U3
- GeneID:   4608962
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo1581
- eggNOG:   COG0519
- HOGENOM:   HBG391775
- OMA:   MKLVEPL
- PhylomeDB:   A1K5U3
- ProtClustDB:   PRK00074
- BioCyc:   ASP62928:AZO1581-MONOMER
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 57673; Mature: 57542

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 82-82 ACT_SITE 177-177 ACT_SITE 179-179

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHQKILILDFGSQVSQLIARRVREQHVYCELHPYDVSEAFIRDFKPQGIILSGGPNSVY
CCCCEEEEEECCHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHCCCCCEEEEECCCCHHH
EAVDWRAPQVVFELGVPVLGICYGMQTMAEQLGGKVESSAKREFGYAELRARGHSKLFQG
HHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHCCHHHHHHH
IEDRTNAEGHGLLDVWMSHGDKVTELPAGFKVIGSNESCPVAAMADEERGFYGVQFHPEV
HHHHCCCCCCCHHHHHHHCCCEEEECCCCEEEECCCCCCCEEEEECCCCCEEEEEECCCH
THTIKGKEMLARFVHEICGCGNDWNMPDYISEAVEKIRAQVGDEEVILGLSGGVDSSVAA
HHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHH
ALIHRAIGDQLTCVFVDNGLLRLNEGAQVMETFNRSLGVKVIHVDATEQFMGHLKGVSDP
HHHHHHHCCCEEEEEECCCEEEECCCHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCCH
EQKRKIIGREFVEVFQAEAAKLPKARWLAQGTIYPDVIESAGAKTGKAHAIKSHHNVGGL
HHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHCCCCCCCHHHHHCCCCCCCC
PETLNLKLLEPLRDLFKDEVRELGVALGLPHDMVYRHPFPGPGLGVRILGEVKKEFADLL
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
RRADAIFIDELRAADWYDKTSQAFAVFLPVKSVGVMGDGRTYEYVVALRAVQTQDFMTAH
HHCCHHHHHHHHHCCCCCCCCCEEEEEEEHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHH
WAELPHSLLGKVSNRIINEVRGINRVVYDISGKPPATIEWE
HHHCHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCEECC
>Mature Secondary Structure 
SHQKILILDFGSQVSQLIARRVREQHVYCELHPYDVSEAFIRDFKPQGIILSGGPNSVY
CCCEEEEEECCHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHCCCCCEEEEECCCCHHH
EAVDWRAPQVVFELGVPVLGICYGMQTMAEQLGGKVESSAKREFGYAELRARGHSKLFQG
HHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHCCHHHHHHH
IEDRTNAEGHGLLDVWMSHGDKVTELPAGFKVIGSNESCPVAAMADEERGFYGVQFHPEV
HHHHCCCCCCCHHHHHHHCCCEEEECCCCEEEECCCCCCCEEEEECCCCCEEEEEECCCH
THTIKGKEMLARFVHEICGCGNDWNMPDYISEAVEKIRAQVGDEEVILGLSGGVDSSVAA
HHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHH
ALIHRAIGDQLTCVFVDNGLLRLNEGAQVMETFNRSLGVKVIHVDATEQFMGHLKGVSDP
HHHHHHHCCCEEEEEECCCEEEECCCHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCCH
EQKRKIIGREFVEVFQAEAAKLPKARWLAQGTIYPDVIESAGAKTGKAHAIKSHHNVGGL
HHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHCCCCCCCHHHHHCCCCCCCC
PETLNLKLLEPLRDLFKDEVRELGVALGLPHDMVYRHPFPGPGLGVRILGEVKKEFADLL
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
RRADAIFIDELRAADWYDKTSQAFAVFLPVKSVGVMGDGRTYEYVVALRAVQTQDFMTAH
HHCCHHHHHHHHHCCCCCCCCCEEEEEEEHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHH
WAELPHSLLGKVSNRIINEVRGINRVVYDISGKPPATIEWE
HHHCHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA