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The map label for this gene is acoA1 [H]

Identifier: 119897830

GI number: 119897830

Start: 1686698

End: 1687660

Strand: Direct

Name: acoA1 [H]

Synonym: azo1539

Alternate gene names: 119897830

Gene position: 1686698-1687660 (Clockwise)

Preceding gene: 119897829

Following gene: 119897831

Centisome position: 38.54

GC content: 71.55

Gene sequence:

>963_bases
ATGGGAATCAGGCTTTACGACGAGCGGCCCGAAGCCTTGCTGGAGGCCATGCTGCTGATCCGCGCCTACGAGGAAAAGGC
GGCGGCCTTGCAGGCCGAAAGCGGCACGCCCGGCACCTGCACCGCGGTGGGCCAGGAGGCGGCCGCGGTGGGCGTGGTGG
CGGCGCTTGGCGCAGACGAACTCATCCTCACCAACCACCGCAGCGCTGGGCATCTGCTGGCGCGCGGCGCCGACCCGGGA
CGGCTGCTGGCGGAGGTGATGGGGCGGCGCGGCGGCTACTGCAAGGGCAAGAGCGGTTCGCTGCACGTTTCCGCGCGTGA
GCTGGGCGTGGTGCTGACGTCCACCATCGTCGGCGGCGAACTCGCGCTGGCCACCGGGGTGGCGCTGGCGCAGAAGCAGC
TGCGCCGGCCGGGCGCGGTGGTGTGCTTCTTCGGCGATGGCGCAGCCTGCGAGGGCCGCTTCCACGAATCGCTGAACCTC
GCCGCGCTGTGGGGGCTGCCGGTGCTCTATGTGTGCGAGAACAACGAATGGCAGGCCTTCGTGCATCGGCGCGAGACCAT
GCTGGCCGAGGGCATCGCCGGCTGGGCGGGCAACTACGGCATCGACCACGCCACCGTAGACGGCAACGACGTCGAGCAGG
TGCGCGCGGTGGCCGCGGCCGCGCTGGAGTCGGTGCGCGGCCGCGGCCGGCCCTTCCTGCTGGAAGCGCGCACCTACCGC
CTGCGCGGGCATTTCGAACCGGACGACCAGGCCTACGTCGATACGGACGAACTGGCAGCCTGGCGCGCGCGCGATCCGCT
GCCGCGCATGGAGGCGCGCCTGCTTGCCAGCGGACGCTGCGATGCCGGCGCGATCACCGCGATGAAGGCCGCCGTCGCGG
CGCAGGTCGCCGCCGCCCACGCCTTCGCCATCGACTCGCCCTATCCGGCGCTCGAAGAACTCACCACCGATGTTTACGCC
TGA

Upstream 100 bases:

>100_bases
TCCCTAAGGGCACCGGACCGGGCCCGCTGTCTCGCTACAGTGCGACGCCATGCACCGGCTGCGGCCGGCGCGCGAGCGAA
TCGCAACCAGGAGACGGAAC

Downstream 100 bases:

>100_bases
GGAACCCGTCATGGCCCGGATTACCGTGCAGGAAGCAATCGAACAGGCCCTGGCCGAGGAAATGAGCCTGGACGCCAACG
TGCTGCTGATGGGCGAGGGT

Product: putative acetion dehydrogenase subunit alpha

Products: [dihydrolipoyllysine-residue acetyltransferase] ; $S-acetyldihydrolipoyllysine; CO2

Alternate protein names: Acetoin:DCPIP oxidoreductase-alpha; Ao:DCPIP OR; TPP-dependent acetoin dehydrogenase E1 subunit alpha [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MGIRLYDERPEALLEAMLLIRAYEEKAAALQAESGTPGTCTAVGQEAAAVGVVAALGADELILTNHRSAGHLLARGADPG
RLLAEVMGRRGGYCKGKSGSLHVSARELGVVLTSTIVGGELALATGVALAQKQLRRPGAVVCFFGDGAACEGRFHESLNL
AALWGLPVLYVCENNEWQAFVHRRETMLAEGIAGWAGNYGIDHATVDGNDVEQVRAVAAAALESVRGRGRPFLLEARTYR
LRGHFEPDDQAYVDTDELAAWRARDPLPRMEARLLASGRCDAGAITAMKAAVAAQVAAAHAFAIDSPYPALEELTTDVYA

Sequences:

>Translated_320_residues
MGIRLYDERPEALLEAMLLIRAYEEKAAALQAESGTPGTCTAVGQEAAAVGVVAALGADELILTNHRSAGHLLARGADPG
RLLAEVMGRRGGYCKGKSGSLHVSARELGVVLTSTIVGGELALATGVALAQKQLRRPGAVVCFFGDGAACEGRFHESLNL
AALWGLPVLYVCENNEWQAFVHRRETMLAEGIAGWAGNYGIDHATVDGNDVEQVRAVAAAALESVRGRGRPFLLEARTYR
LRGHFEPDDQAYVDTDELAAWRARDPLPRMEARLLASGRCDAGAITAMKAAVAAQVAAAHAFAIDSPYPALEELTTDVYA
>Mature_319_residues
GIRLYDERPEALLEAMLLIRAYEEKAAALQAESGTPGTCTAVGQEAAAVGVVAALGADELILTNHRSAGHLLARGADPGR
LLAEVMGRRGGYCKGKSGSLHVSARELGVVLTSTIVGGELALATGVALAQKQLRRPGAVVCFFGDGAACEGRFHESLNLA
ALWGLPVLYVCENNEWQAFVHRRETMLAEGIAGWAGNYGIDHATVDGNDVEQVRAVAAAALESVRGRGRPFLLEARTYRL
RGHFEPDDQAYVDTDELAAWRARDPLPRMEARLLASGRCDAGAITAMKAAVAAQVAAAHAFAIDSPYPALEELTTDVYA

Specific function: Catalyzes the 2,6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde. The alpha subunit is probably the catalytic subunit of the enzyme [H]

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=307, Percent_Identity=34.2019543973941, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI11386135, Length=317, Percent_Identity=30.9148264984227, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI258645172, Length=317, Percent_Identity=31.2302839116719, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI4505685, Length=307, Percent_Identity=32.5732899022801, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI291084742, Length=307, Percent_Identity=32.5732899022801, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI291084744, Length=314, Percent_Identity=31.5286624203822, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI291084757, Length=307, Percent_Identity=29.6416938110749, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17536047, Length=307, Percent_Identity=33.2247557003257, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI32564172, Length=307, Percent_Identity=33.2247557003257, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI86563357, Length=284, Percent_Identity=33.0985915492958, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI86563355, Length=284, Percent_Identity=33.0985915492958, Blast_Score=128, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6321026, Length=314, Percent_Identity=32.8025477707006, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24639748, Length=324, Percent_Identity=31.7901234567901, Blast_Score=138, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24639740, Length=330, Percent_Identity=31.8181818181818, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24639744, Length=330, Percent_Identity=31.8181818181818, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI28571106, Length=330, Percent_Identity=31.8181818181818, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24639746, Length=316, Percent_Identity=32.9113924050633, Blast_Score=134, Evalue=6e-32,
Organism=Drosophila melanogaster, GI21355903, Length=316, Percent_Identity=30.0632911392405, Blast_Score=129, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: 1.2.4.1

Molecular weight: Translated: 33920; Mature: 33789

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIRLYDERPEALLEAMLLIRAYEEKAAALQAESGTPGTCTAVGQEAAAVGVVAALGADE
CCCEECCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEECCCCHHHHHHHHHHCCCCC
LILTNHRSAGHLLARGADPGRLLAEVMGRRGGYCKGKSGSLHVSARELGVVLTSTIVGGE
EEEECCCCCCCEEECCCCHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHCCCEEHHHCCCH
LALATGVALAQKQLRRPGAVVCFFGDGAACEGRFHESLNLAALWGLPVLYVCENNEWQAF
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHCCCCEEEEECCCEEEEEECCCHHHH
VHRRETMLAEGIAGWAGNYGIDHATVDGNDVEQVRAVAAAALESVRGRGRPFLLEARTYR
HHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEE
LRGHFEPDDQAYVDTDELAAWRARDPLPRMEARLLASGRCDAGAITAMKAAVAAQVAAAH
EECCCCCCCCCEECHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
AFAIDSPYPALEELTTDVYA
HEECCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
GIRLYDERPEALLEAMLLIRAYEEKAAALQAESGTPGTCTAVGQEAAAVGVVAALGADE
CCEECCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEECCCCHHHHHHHHHHCCCCC
LILTNHRSAGHLLARGADPGRLLAEVMGRRGGYCKGKSGSLHVSARELGVVLTSTIVGGE
EEEECCCCCCCEEECCCCHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHCCCEEHHHCCCH
LALATGVALAQKQLRRPGAVVCFFGDGAACEGRFHESLNLAALWGLPVLYVCENNEWQAF
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHCCCCEEEEECCCEEEEEECCCHHHH
VHRRETMLAEGIAGWAGNYGIDHATVDGNDVEQVRAVAAAALESVRGRGRPFLLEARTYR
HHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEE
LRGHFEPDDQAYVDTDELAAWRARDPLPRMEARLLASGRCDAGAITAMKAAVAAQVAAAH
EECCCCCCCCCEECHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
AFAIDSPYPALEELTTDVYA
HEECCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: pyruvate; [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine

Specific reaction: pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S- $acetyldihydrolipoyllysine + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969503; 10368162; 9384377 [H]