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The map label for this gene is acoB1 [H]

Identifier: 119897831

GI number: 119897831

Start: 1687671

End: 1688627

Strand: Direct

Name: acoB1 [H]

Synonym: azo1540

Alternate gene names: 119897831

Gene position: 1687671-1688627 (Clockwise)

Preceding gene: 119897830

Following gene: 119897832

Centisome position: 38.57

GC content: 70.43

Gene sequence:

>957_bases
ATGGCCCGGATTACCGTGCAGGAAGCAATCGAACAGGCCCTGGCCGAGGAAATGAGCCTGGACGCCAACGTGCTGCTGAT
GGGCGAGGGTGTCGCCACCAAACGGCCGGGGCTGGTACAGGCCTTCGGCGGCGAGCGCGTGCGCAACACCCCGCTGGCCG
AGGGCATCATCGCCGGCACCGCCGCGGGGGCGGCCGCGATGGGGCTGCGGCCGGTCATCGACCTGCTGTTCGCCCCCTTC
CTGTGTTACGCGATGGACGAACTGGTGAACAGCGCCGGCAAGCTGCGCTACCTCTCCGGCGGGCAGTTCGAATTTCCGCT
GGTGGCACTGGCGATGACCGGTGCCGGTTGGGGGGTGGGCGCGCAGCACAACCACAACGTCGAAGCCTGGTTTGCCCATG
CGCCGGGGCTGAAGATGGTGATGCCCTCCACGGTGGCCGACTTCAAGGGGCTGCTGAAGAGCGCGATCCGGGATCCGAAC
CCGGTGCTGTTCTTCGTCGACATCGCGCTTGCCTATGCAGCCGGCGAGGTGCCGGAGGGGGAGGTGCTGGTGCCGATCGG
CCGCGCCGCGACGCGCCGCGAGGGCGAGGACCTCACGCTGATCGGCTATGCGAAGACGGTCGACACCTGCCTGCGCGCCG
CGGAGACGCTGGCCGGGGAGGGCATCTCGGCGGAGGTCATCGACCTGCGCTCGATCAAGCCGCTGGACGAGGCCGCGATC
CTGGCCTCGGTGCGCAAGACCGGGCGCGCGATCGTCGTCCACGAAGCCAGCCGCACATGCGGCGTGGGCGCGGAAGTGGC
GGCGCTGGTGGCCGAGCATGCGTTCGACGCCTTGAAAGCGCCGGTGCTGCGCCTGACCGGGCCCGACGCGCCGACGCCCG
CCAGCTATCCGTTGGAGCAGGCCTTTGTGCCGCAGGCCGAGGCCGTGGTTGCGGCGGCGCGCCGCCTGGTGCGCTGA

Upstream 100 bases:

>100_bases
GTCGCGGCGCAGGTCGCCGCCGCCCACGCCTTCGCCATCGACTCGCCCTATCCGGCGCTCGAAGAACTCACCACCGATGT
TTACGCCTGAGGAACCCGTC

Downstream 100 bases:

>100_bases
GCGAGACGCGGCCTGCCGCGCATCGAACGGAACGGAGCTTGCTTCGCGGGGTGGCGGGCGCACTTTGTGTGCGCTTTGCG
ACACCCCAGCCATCCCGCGG

Product: acetoin dehydrogenase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MARITVQEAIEQALAEEMSLDANVLLMGEGVATKRPGLVQAFGGERVRNTPLAEGIIAGTAAGAAAMGLRPVIDLLFAPF
LCYAMDELVNSAGKLRYLSGGQFEFPLVALAMTGAGWGVGAQHNHNVEAWFAHAPGLKMVMPSTVADFKGLLKSAIRDPN
PVLFFVDIALAYAAGEVPEGEVLVPIGRAATRREGEDLTLIGYAKTVDTCLRAAETLAGEGISAEVIDLRSIKPLDEAAI
LASVRKTGRAIVVHEASRTCGVGAEVAALVAEHAFDALKAPVLRLTGPDAPTPASYPLEQAFVPQAEAVVAAARRLVR

Sequences:

>Translated_318_residues
MARITVQEAIEQALAEEMSLDANVLLMGEGVATKRPGLVQAFGGERVRNTPLAEGIIAGTAAGAAAMGLRPVIDLLFAPF
LCYAMDELVNSAGKLRYLSGGQFEFPLVALAMTGAGWGVGAQHNHNVEAWFAHAPGLKMVMPSTVADFKGLLKSAIRDPN
PVLFFVDIALAYAAGEVPEGEVLVPIGRAATRREGEDLTLIGYAKTVDTCLRAAETLAGEGISAEVIDLRSIKPLDEAAI
LASVRKTGRAIVVHEASRTCGVGAEVAALVAEHAFDALKAPVLRLTGPDAPTPASYPLEQAFVPQAEAVVAAARRLVR
>Mature_317_residues
ARITVQEAIEQALAEEMSLDANVLLMGEGVATKRPGLVQAFGGERVRNTPLAEGIIAGTAAGAAAMGLRPVIDLLFAPFL
CYAMDELVNSAGKLRYLSGGQFEFPLVALAMTGAGWGVGAQHNHNVEAWFAHAPGLKMVMPSTVADFKGLLKSAIRDPNP
VLFFVDIALAYAAGEVPEGEVLVPIGRAATRREGEDLTLIGYAKTVDTCLRAAETLAGEGISAEVIDLRSIKPLDEAAIL
ASVRKTGRAIVVHEASRTCGVGAEVAALVAEHAFDALKAPVLRLTGPDAPTPASYPLEQAFVPQAEAVVAAARRLVR

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156564403, Length=324, Percent_Identity=39.5061728395062, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI291084858, Length=324, Percent_Identity=37.6543209876543, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI4557353, Length=325, Percent_Identity=35.6923076923077, Blast_Score=184, Evalue=6e-47,
Organism=Homo sapiens, GI34101272, Length=325, Percent_Identity=35.6923076923077, Blast_Score=184, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17538422, Length=323, Percent_Identity=43.0340557275542, Blast_Score=244, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI17506935, Length=326, Percent_Identity=39.5705521472393, Blast_Score=199, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6319698, Length=326, Percent_Identity=41.7177914110429, Blast_Score=238, Evalue=1e-63,
Organism=Drosophila melanogaster, GI21358145, Length=327, Percent_Identity=42.8134556574924, Blast_Score=241, Evalue=4e-64,
Organism=Drosophila melanogaster, GI24650940, Length=327, Percent_Identity=42.8134556574924, Blast_Score=241, Evalue=4e-64,
Organism=Drosophila melanogaster, GI160714828, Length=326, Percent_Identity=38.3435582822086, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI160714832, Length=324, Percent_Identity=37.6543209876543, Blast_Score=190, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR000089
- InterPro:   IPR011053
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF00364 Biotin_lipoyl; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 33300; Mature: 33169

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARITVQEAIEQALAEEMSLDANVLLMGEGVATKRPGLVQAFGGERVRNTPLAEGIIAGT
CCEEEHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCCCCCCCCCHHHHHHHHH
AAGAAAMGLRPVIDLLFAPFLCYAMDELVNSAGKLRYLSGGQFEFPLVALAMTGAGWGVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEEECCCCCCC
AQHNHNVEAWFAHAPGLKMVMPSTVADFKGLLKSAIRDPNPVLFFVDIALAYAAGEVPEG
CCCCCCCEEEEEECCCCEEECCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCCC
EVLVPIGRAATRREGEDLTLIGYAKTVDTCLRAAETLAGEGISAEVIDLRSIKPLDEAAI
CEEEECCCCHHCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHH
LASVRKTGRAIVVHEASRTCGVGAEVAALVAEHAFDALKAPVLRLTGPDAPTPASYPLEQ
HHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCHHH
AFVPQAEAVVAAARRLVR
HHCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
ARITVQEAIEQALAEEMSLDANVLLMGEGVATKRPGLVQAFGGERVRNTPLAEGIIAGT
CEEEHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCCCCCCCCCHHHHHHHHH
AAGAAAMGLRPVIDLLFAPFLCYAMDELVNSAGKLRYLSGGQFEFPLVALAMTGAGWGVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEEECCCCCCC
AQHNHNVEAWFAHAPGLKMVMPSTVADFKGLLKSAIRDPNPVLFFVDIALAYAAGEVPEG
CCCCCCCEEEEEECCCCEEECCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCCC
EVLVPIGRAATRREGEDLTLIGYAKTVDTCLRAAETLAGEGISAEVIDLRSIKPLDEAAI
CEEEECCCCHHCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHH
LASVRKTGRAIVVHEASRTCGVGAEVAALVAEHAFDALKAPVLRLTGPDAPTPASYPLEQ
HHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCHHH
AFVPQAEAVVAAARRLVR
HHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]