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The map label for this gene is lysS

Identifier: 119897778

GI number: 119897778

Start: 1624335

End: 1625837

Strand: Reverse

Name: lysS

Synonym: azo1487

Alternate gene names: 119897778

Gene position: 1625837-1624335 (Counterclockwise)

Preceding gene: 119897780

Following gene: 119897777

Centisome position: 37.15

GC content: 64.6

Gene sequence:

>1503_bases
ATGTCCGACCATAACGCCACCCCTGCCGCCCAGGACGAAAACCACATCATCGCGGAGCGCCGCGAAAAACTCGCCCAATG
GCGCCAGGCAGGCCGGGCCTTCCCCAACGACTTCTCGCGCGAGAACACCGCCGGCAAGCTCGACGAGGTGTATGGCGACA
AAGAGCCGGAAGCGCTGGAAGCCAGCCCGGTGGAAGTCCGCGTAGCGGGCCGCGTGATGCTCAAGCGCGTGATGGGCAAG
GCCAGCTTCATCACCATCCAGGACCTCTCCGGCCGCATCCAGCTGTACGTGCAGCGCGACGGCGTCGGCGAAGACGTCTA
TGCCGACTTCAAGCACTGGGACATCGGCGACATCGTGGGCTGCGTCGGCACGCTGTTCAAGACCAAGACCGGCGAACTCA
CGGTCAAGGCGAGCGAAATCCGCCTGCTCACCAAGAGCCTGCGCCCGCTGCCGGACAAGTTCCACGGCCTCACCGACGTC
GAGCAGAAGTACCGCCAGCGCTACCTCGACCTGATCATGAGCGAGCAGACCCGCTTCACCTTCGTGGCCCGCAGCCGCAT
GGTGCAGTCGATCCGCAACTACATGATCAACCACGGCTTCCTCGAAGTCGAAACGCCGATGATGCACCCCATCCCCGGCG
GCGCCGCGGCCAAGCCCTTCGTCACCCACCACAACGCGCTCGACATGGAACTCTTCCTGCGCATCGCGCCGGAGCTGTAC
CTCAAGCGCCTGGTGGTCGGCGGGCTGGAGAAGGTGTTCGAGGTGAACCGCAACTTCCGCAACGAAGGCCTCTCGCCGCG
CCACAACCCCGAATTCACGATGATGGAGTTCTATGAGGCCTACGCGGACTACCGCAGCCTGATGAACTTCACCGAAGGCC
TCATCCGCCAGGCCGCACGCGAAGCGCTCGGCGCCGAAAGCTTCGTCTACCAGGGCCGCGAACTCGATCTCTCCAAGCCC
TTCCACCGCCTCACCATCGTGCAGGCCATCCGCAAGTACCACCCGGGCTTCTCCGAAGCCCAGCTGGCCGACGCGGAATG
GGTCAAGGAAAAGATCCAGGCCTTCGGCGAGAAGGTGAAGCCGGGCGGCCTCGGCAGCCTGCAGCTGCAACTCTTCGAAG
CCTGCGCCGAAGCCGAGCTGTGGGAACCGACCTTCATCATCGACTACCCGGTTGAAGTCTCGCCGCTCGCCCGCGCCTCC
GACAGCAACCCGGAAATCACCGAACGCTTCGAACTCTTCATCGTCGGCCGCGAGATCGCCAACGGCTTTTCCGAGCTCAA
CGACCCCGAAGACCAGGCCGCGCGCTTCCTCGCCCAGGCCCAGGCCAAGGAAGCCGGCGACGAAGAAGCGATGTACTACG
ACGCCGACTACATCCGCGCGCTCGAATTCGGCCTGCCGCCCACCGGCGGCTGCGGCATCGGCATCGACCGTCTGGTGATG
CTGCTGACCGACAGCGCCTCGATCCGCGACGTGATCCTGTTCCCGCAGATGCGTCCGGAATAA

Upstream 100 bases:

>100_bases
GCAAAAATGGCGGATTTACGCGTGATTTCATGCAACGCCGATTTGCTCGACGGTGGCGCGCCTGCGACAATTGCGGCCTT
GATCACAGTGCCGATGAATC

Downstream 100 bases:

>100_bases
GCGCAGCGCGCCCCGGTCGCGCACGCCGCCTCGCAAGCCCGCCTGGCTCCCGCCAGCGCGGGCTTTTTTGTTCGGGCCGC
TACCCGGCCGCGCGTAACGG

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MSDHNATPAAQDENHIIAERREKLAQWRQAGRAFPNDFSRENTAGKLDEVYGDKEPEALEASPVEVRVAGRVMLKRVMGK
ASFITIQDLSGRIQLYVQRDGVGEDVYADFKHWDIGDIVGCVGTLFKTKTGELTVKASEIRLLTKSLRPLPDKFHGLTDV
EQKYRQRYLDLIMSEQTRFTFVARSRMVQSIRNYMINHGFLEVETPMMHPIPGGAAAKPFVTHHNALDMELFLRIAPELY
LKRLVVGGLEKVFEVNRNFRNEGLSPRHNPEFTMMEFYEAYADYRSLMNFTEGLIRQAAREALGAESFVYQGRELDLSKP
FHRLTIVQAIRKYHPGFSEAQLADAEWVKEKIQAFGEKVKPGGLGSLQLQLFEACAEAELWEPTFIIDYPVEVSPLARAS
DSNPEITERFELFIVGREIANGFSELNDPEDQAARFLAQAQAKEAGDEEAMYYDADYIRALEFGLPPTGGCGIGIDRLVM
LLTDSASIRDVILFPQMRPE

Sequences:

>Translated_500_residues
MSDHNATPAAQDENHIIAERREKLAQWRQAGRAFPNDFSRENTAGKLDEVYGDKEPEALEASPVEVRVAGRVMLKRVMGK
ASFITIQDLSGRIQLYVQRDGVGEDVYADFKHWDIGDIVGCVGTLFKTKTGELTVKASEIRLLTKSLRPLPDKFHGLTDV
EQKYRQRYLDLIMSEQTRFTFVARSRMVQSIRNYMINHGFLEVETPMMHPIPGGAAAKPFVTHHNALDMELFLRIAPELY
LKRLVVGGLEKVFEVNRNFRNEGLSPRHNPEFTMMEFYEAYADYRSLMNFTEGLIRQAAREALGAESFVYQGRELDLSKP
FHRLTIVQAIRKYHPGFSEAQLADAEWVKEKIQAFGEKVKPGGLGSLQLQLFEACAEAELWEPTFIIDYPVEVSPLARAS
DSNPEITERFELFIVGREIANGFSELNDPEDQAARFLAQAQAKEAGDEEAMYYDADYIRALEFGLPPTGGCGIGIDRLVM
LLTDSASIRDVILFPQMRPE
>Mature_499_residues
SDHNATPAAQDENHIIAERREKLAQWRQAGRAFPNDFSRENTAGKLDEVYGDKEPEALEASPVEVRVAGRVMLKRVMGKA
SFITIQDLSGRIQLYVQRDGVGEDVYADFKHWDIGDIVGCVGTLFKTKTGELTVKASEIRLLTKSLRPLPDKFHGLTDVE
QKYRQRYLDLIMSEQTRFTFVARSRMVQSIRNYMINHGFLEVETPMMHPIPGGAAAKPFVTHHNALDMELFLRIAPELYL
KRLVVGGLEKVFEVNRNFRNEGLSPRHNPEFTMMEFYEAYADYRSLMNFTEGLIRQAAREALGAESFVYQGRELDLSKPF
HRLTIVQAIRKYHPGFSEAQLADAEWVKEKIQAFGEKVKPGGLGSLQLQLFEACAEAELWEPTFIIDYPVEVSPLARASD
SNPEITERFELFIVGREIANGFSELNDPEDQAARFLAQAQAKEAGDEEAMYYDADYIRALEFGLPPTGGCGIGIDRLVML
LTDSASIRDVILFPQMRPE

Specific function: Unknown

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI5031815, Length=508, Percent_Identity=40.748031496063, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI194272210, Length=508, Percent_Identity=40.748031496063, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI40789249, Length=270, Percent_Identity=28.1481481481481, Blast_Score=100, Evalue=6e-21,
Organism=Escherichia coli, GI1789256, Length=503, Percent_Identity=60.8349900596421, Blast_Score=623, Evalue=1e-180,
Organism=Escherichia coli, GI1790571, Length=493, Percent_Identity=60.6490872210953, Blast_Score=620, Evalue=1e-179,
Organism=Escherichia coli, GI87082379, Length=328, Percent_Identity=32.3170731707317, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI1788173, Length=279, Percent_Identity=25.089605734767, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17535927, Length=452, Percent_Identity=45.1327433628319, Blast_Score=351, Evalue=6e-97,
Organism=Caenorhabditis elegans, GI17535925, Length=452, Percent_Identity=45.1327433628319, Blast_Score=351, Evalue=6e-97,
Organism=Caenorhabditis elegans, GI71994340, Length=452, Percent_Identity=45.1327433628319, Blast_Score=350, Evalue=1e-96,
Organism=Caenorhabditis elegans, GI32566633, Length=278, Percent_Identity=24.4604316546763, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320242, Length=457, Percent_Identity=42.4507658643326, Blast_Score=353, Evalue=4e-98,
Organism=Saccharomyces cerevisiae, GI6324256, Length=478, Percent_Identity=30.7531380753138, Blast_Score=179, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6323011, Length=336, Percent_Identity=24.702380952381, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24640849, Length=465, Percent_Identity=44.3010752688172, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24640851, Length=465, Percent_Identity=44.3010752688172, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24584738, Length=327, Percent_Identity=25.9938837920489, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI19922416, Length=461, Percent_Identity=22.7765726681128, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: 1200 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYK_AZOSB (A1K5J9)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_932991.1
- ProteinModelPortal:   A1K5J9
- SMR:   A1K5J9
- STRING:   A1K5J9
- GeneID:   4606873
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo1487
- eggNOG:   COG1190
- HOGENOM:   HBG631383
- OMA:   GHPQMMS
- PhylomeDB:   A1K5J9
- ProtClustDB:   PRK00484
- BioCyc:   ASP62928:AZO1487-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00252
- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR22594
- PANTHER:   PTHR22594:SF4
- PRINTS:   PR00982
- TIGRFAMs:   TIGR00499

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti; SSF50249 Nucleic_acid_OB

EC number: =6.1.1.6

Molecular weight: Translated: 56640; Mature: 56509

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDHNATPAAQDENHIIAERREKLAQWRQAGRAFPNDFSRENTAGKLDEVYGDKEPEALE
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCC
ASPVEVRVAGRVMLKRVMGKASFITIQDLSGRIQLYVQRDGVGEDVYADFKHWDIGDIVG
CCCCEEEHHHHHHHHHHHCCCCEEEEEECCCEEEEEEECCCCCCCHHHCCCCCCHHHHHH
CVGTLFKTKTGELTVKASEIRLLTKSLRPLPDKFHGLTDVEQKYRQRYLDLIMSEQTRFT
HHHHHHHCCCCCEEEEHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHHCCCHHHH
FVARSRMVQSIRNYMINHGFLEVETPMMHPIPGGAAAKPFVTHHNALDMELFLRIAPELY
HHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHH
LKRLVVGGLEKVFEVNRNFRNEGLSPRHNPEFTMMEFYEAYADYRSLMNFTEGLIRQAAR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EALGAESFVYQGRELDLSKPFHRLTIVQAIRKYHPGFSEAQLADAEWVKEKIQAFGEKVK
HHHCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCC
PGGLGSLQLQLFEACAEAELWEPTFIIDYPVEVSPLARASDSNPEITERFELFIVGREIA
CCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHCCCCCCCCHHHEEEHEEEEHHHH
NGFSELNDPEDQAARFLAQAQAKEAGDEEAMYYDADYIRALEFGLPPTGGCGIGIDRLVM
HHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHCCCCCCCCCCCHHHHHH
LLTDSASIRDVILFPQMRPE
HHCCCCCCCEEEECCCCCCC
>Mature Secondary Structure 
SDHNATPAAQDENHIIAERREKLAQWRQAGRAFPNDFSRENTAGKLDEVYGDKEPEALE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCC
ASPVEVRVAGRVMLKRVMGKASFITIQDLSGRIQLYVQRDGVGEDVYADFKHWDIGDIVG
CCCCEEEHHHHHHHHHHHCCCCEEEEEECCCEEEEEEECCCCCCCHHHCCCCCCHHHHHH
CVGTLFKTKTGELTVKASEIRLLTKSLRPLPDKFHGLTDVEQKYRQRYLDLIMSEQTRFT
HHHHHHHCCCCCEEEEHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHHCCCHHHH
FVARSRMVQSIRNYMINHGFLEVETPMMHPIPGGAAAKPFVTHHNALDMELFLRIAPELY
HHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHH
LKRLVVGGLEKVFEVNRNFRNEGLSPRHNPEFTMMEFYEAYADYRSLMNFTEGLIRQAAR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EALGAESFVYQGRELDLSKPFHRLTIVQAIRKYHPGFSEAQLADAEWVKEKIQAFGEKVK
HHHCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCC
PGGLGSLQLQLFEACAEAELWEPTFIIDYPVEVSPLARASDSNPEITERFELFIVGREIA
CCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHCCCCCCCCHHHEEEHEEEEHHHH
NGFSELNDPEDQAARFLAQAQAKEAGDEEAMYYDADYIRALEFGLPPTGGCGIGIDRLVM
HHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHCCCCCCCCCCCHHHHHH
LLTDSASIRDVILFPQMRPE
HHCCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA