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The map label for this gene is hemN [H]

Identifier: 119897643

GI number: 119897643

Start: 1469756

End: 1471147

Strand: Direct

Name: hemN [H]

Synonym: azo1352

Alternate gene names: 119897643

Gene position: 1469756-1471147 (Clockwise)

Preceding gene: 119897641

Following gene: 119897644

Centisome position: 33.59

GC content: 60.63

Gene sequence:

>1392_bases
ATGAACGCCCAGCCAGATCTCATCTTCGATCCGCAACTCATCCGTCGCTTCGATGTGAACGGTCCCCGTTACACATCGTA
CCCCACGGCAGACCGATTCGTTGAGGCATTCGACGCCAACGCATTGCAGGATTGGCTTGCCAAGCGCGCCGTCGGCGGGG
TGAGTCGGCCGCTGTCATTATACTTCCACATCCCGTTCTGCAATACGATCTGCTACTACTGCGCCTGCAACAAGATCATC
ACCAAGGATCATGGGCGCTCCGCCAAGTATCTGAAATACCTTGAGAAAGAGATCGAGATGCAGGTTGCTGCACTCGGAGG
AAGCCGGCAGGTCACGCAGCTTCACCTTGGCGGCGGAACGCCCACCTTCCTGTCGCATGAGGAAATGCATCAGTTGATGG
ACGCGGTGCGGCGCTTCTTCAACCTGGCCCCGAACGGCGAGTATTCGATCGAGGTCGATCCGCGCAAGGTCGATTTCGAT
ACGGTGGAAATGCTCGCCAATCTCGGTTTCAACCGGATGAGCGTCGGGGTGCAGGATTTCTCCGATGATGTGCAGCGCGC
GGTGAACCGCGTGCAGAGCGTCGAGGAGACCCGGTTGGTGATCGACGCGGCGCGCGCCACCGGCTTCAAGTCGGTCAGCC
TCGATCTGATCTACGGCCTGCCCAAGCAAAACGTCATCAGCTTCAATCGCACGCTGGAGCAGGTCCTCGACATTTCGCCG
GACCGCATCTCGCTGTACAGCTACGCGCACTTGCCCGGATTGTTCAAACCGCAGCGCCGCATCCTGCAAAGCGACATGCC
GACGCCGGAAGCCAAGCTGCAGATTCTGCAACTGGCGATTCGCCGCCTCACCGAAGCCGGTTACGTGTACATCGGCATGG
ATCATTTCGCCAAGCCGGACGACGAACTGACGGTGGCCCAGCGGCAAGGGCGTCTGCACCGCAACTTCCAGGGCTACTCC
ACGCAGGCCGAATGCGATCTGCTGGCGTTCGGTGTCTCGGCGATCGGCAAGGTTGGCGCGGCTTACGCGCAGAACGTGAA
GACGCTCGACGAATACTACGACGCGCTCGATCGCGACCAGTTGCCGGTGCTGCGCGGCGTGGAGCTGACCGCCGACGATC
TGTTGCGGCGTTCGGTAATCCAGGCCCTGATGTGCCACTTCGAGTTGTCGATGCAGTCGATCGAGATCGCCCACCTCATC
GACTTCCGCGACTACTTTGCGGCTGAACTCGCCGACCTTGCGGAAATGCAGGCGGCGGGCCTTCTGGAGATCGACGGTGA
CTGGATTACCGTGCTCCCCGCCGGCCGGATGCTGGTTCGCGGTATCGCAATGGTGTTCGACCGCTATCTACGCGCCGACC
GTGAGCGGGCACGCTACTCGAAGGTGATCTGA

Upstream 100 bases:

>100_bases
ACTTGCTCCGAATCCGCAGGAGATTGGCCGCGTTGATCCATGTCAACCACATCGAGCCGGCTTTCTGCGATCGTTTGGTA
CGCCCAGCAACAGCACACCC

Downstream 100 bases:

>100_bases
GCTTCTGGTGGGTGAAGCGGGGGCGTAAGATGCAGGGTTTCAATCTTCGGCAGTGCCGTCCCGGCAACGCGGCGGTCCGT
GTCCAGCATGCCTGAGTCCG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MNAQPDLIFDPQLIRRFDVNGPRYTSYPTADRFVEAFDANALQDWLAKRAVGGVSRPLSLYFHIPFCNTICYYCACNKII
TKDHGRSAKYLKYLEKEIEMQVAALGGSRQVTQLHLGGGTPTFLSHEEMHQLMDAVRRFFNLAPNGEYSIEVDPRKVDFD
TVEMLANLGFNRMSVGVQDFSDDVQRAVNRVQSVEETRLVIDAARATGFKSVSLDLIYGLPKQNVISFNRTLEQVLDISP
DRISLYSYAHLPGLFKPQRRILQSDMPTPEAKLQILQLAIRRLTEAGYVYIGMDHFAKPDDELTVAQRQGRLHRNFQGYS
TQAECDLLAFGVSAIGKVGAAYAQNVKTLDEYYDALDRDQLPVLRGVELTADDLLRRSVIQALMCHFELSMQSIEIAHLI
DFRDYFAAELADLAEMQAAGLLEIDGDWITVLPAGRMLVRGIAMVFDRYLRADRERARYSKVI

Sequences:

>Translated_463_residues
MNAQPDLIFDPQLIRRFDVNGPRYTSYPTADRFVEAFDANALQDWLAKRAVGGVSRPLSLYFHIPFCNTICYYCACNKII
TKDHGRSAKYLKYLEKEIEMQVAALGGSRQVTQLHLGGGTPTFLSHEEMHQLMDAVRRFFNLAPNGEYSIEVDPRKVDFD
TVEMLANLGFNRMSVGVQDFSDDVQRAVNRVQSVEETRLVIDAARATGFKSVSLDLIYGLPKQNVISFNRTLEQVLDISP
DRISLYSYAHLPGLFKPQRRILQSDMPTPEAKLQILQLAIRRLTEAGYVYIGMDHFAKPDDELTVAQRQGRLHRNFQGYS
TQAECDLLAFGVSAIGKVGAAYAQNVKTLDEYYDALDRDQLPVLRGVELTADDLLRRSVIQALMCHFELSMQSIEIAHLI
DFRDYFAAELADLAEMQAAGLLEIDGDWITVLPAGRMLVRGIAMVFDRYLRADRERARYSKVI
>Mature_463_residues
MNAQPDLIFDPQLIRRFDVNGPRYTSYPTADRFVEAFDANALQDWLAKRAVGGVSRPLSLYFHIPFCNTICYYCACNKII
TKDHGRSAKYLKYLEKEIEMQVAALGGSRQVTQLHLGGGTPTFLSHEEMHQLMDAVRRFFNLAPNGEYSIEVDPRKVDFD
TVEMLANLGFNRMSVGVQDFSDDVQRAVNRVQSVEETRLVIDAARATGFKSVSLDLIYGLPKQNVISFNRTLEQVLDISP
DRISLYSYAHLPGLFKPQRRILQSDMPTPEAKLQILQLAIRRLTEAGYVYIGMDHFAKPDDELTVAQRQGRLHRNFQGYS
TQAECDLLAFGVSAIGKVGAAYAQNVKTLDEYYDALDRDQLPVLRGVELTADDLLRRSVIQALMCHFELSMQSIEIAHLI
DFRDYFAAELADLAEMQAAGLLEIDGDWITVLPAGRMLVRGIAMVFDRYLRADRERARYSKVI

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=248, Percent_Identity=29.8387096774194, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI87082341, Length=455, Percent_Identity=48.7912087912088, Blast_Score=447, Evalue=1e-127,
Organism=Escherichia coli, GI1789325, Length=283, Percent_Identity=31.4487632508834, Blast_Score=133, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 52457; Mature: 52457

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAQPDLIFDPQLIRRFDVNGPRYTSYPTADRFVEAFDANALQDWLAKRAVGGVSRPLSL
CCCCCCCEECHHHHHHHCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHCCCCCCEEE
YFHIPFCNTICYYCACNKIITKDHGRSAKYLKYLEKEIEMQVAALGGSRQVTQLHLGGGT
EEECCHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCC
PTFLSHEEMHQLMDAVRRFFNLAPNGEYSIEVDPRKVDFDTVEMLANLGFNRMSVGVQDF
CCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCEECCHHHH
SDDVQRAVNRVQSVEETRLVIDAARATGFKSVSLDLIYGLPKQNVISFNRTLEQVLDISP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCC
DRISLYSYAHLPGLFKPQRRILQSDMPTPEAKLQILQLAIRRLTEAGYVYIGMDHFAKPD
CCEEEEEHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCEEEEECHHCCCCC
DELTVAQRQGRLHRNFQGYSTQAECDLLAFGVSAIGKVGAAYAQNVKTLDEYYDALDRDQ
CHHHHHHHHCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LPVLRGVELTADDLLRRSVIQALMCHFELSMQSIEIAHLIDFRDYFAAELADLAEMQAAG
CCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LLEIDGDWITVLPAGRMLVRGIAMVFDRYLRADRERARYSKVI
EEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNAQPDLIFDPQLIRRFDVNGPRYTSYPTADRFVEAFDANALQDWLAKRAVGGVSRPLSL
CCCCCCCEECHHHHHHHCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHCCCCCCEEE
YFHIPFCNTICYYCACNKIITKDHGRSAKYLKYLEKEIEMQVAALGGSRQVTQLHLGGGT
EEECCHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCC
PTFLSHEEMHQLMDAVRRFFNLAPNGEYSIEVDPRKVDFDTVEMLANLGFNRMSVGVQDF
CCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCEECCHHHH
SDDVQRAVNRVQSVEETRLVIDAARATGFKSVSLDLIYGLPKQNVISFNRTLEQVLDISP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCC
DRISLYSYAHLPGLFKPQRRILQSDMPTPEAKLQILQLAIRRLTEAGYVYIGMDHFAKPD
CCEEEEEHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCEEEEECHHCCCCC
DELTVAQRQGRLHRNFQGYSTQAECDLLAFGVSAIGKVGAAYAQNVKTLDEYYDALDRDQ
CHHHHHHHHCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LPVLRGVELTADDLLRRSVIQALMCHFELSMQSIEIAHLIDFRDYFAAELADLAEMQAAG
CCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LLEIDGDWITVLPAGRMLVRGIAMVFDRYLRADRERARYSKVI
EEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9396835 [H]