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The map label for this gene is dfp [H]

Identifier: 119897429

GI number: 119897429

Start: 1225220

End: 1226419

Strand: Direct

Name: dfp [H]

Synonym: azo1138

Alternate gene names: 119897429

Gene position: 1225220-1226419 (Clockwise)

Preceding gene: 119897425

Following gene: 119897430

Centisome position: 28.0

GC content: 69.5

Gene sequence:

>1200_bases
ATGACCAGTCTCCAAGGCAAGAGGATAGTGCTGGGTGTTACCGGTGGGGTTGCCGCCTACAAGGCGGCCGAACTGGTACG
TCTGCTGGGCAAGGCCGGTGTGGACGTCCACGTCGTACTGACCGAGGCGGGCGCGCGCTTCGTCGGCGCGGTCACGTTCC
AGGCGCTGTCGGGCAATCCGGTGTGGAGCGACCTGTGGGACCCGCGCATGCCCAACAACATGGCGCACATCGACCTCGGC
CGTGAGGCCGACGCGGTGCTCGTCGCGCCGGCATCGGCGGACTTCATCGCCCGCATCGCGGGCGGCCGGGCCGACGATCT
GCTGACCACCTTGTGCCTTGCGCGCGATTGCCCCTTGCTGGTGGCGCCTGCGATGAACCGCCAGATGTGGGAACACCCTG
CCACCCAGCGCAACGTCGGCCAGGCCGTCGCCGACGGCGTCACGATGCTTGGCCCGGCGGCTGGCGACCAGGCTTGCGGG
GAAACCGGCATGGGGCGCATGGAAGAGCCGGAGGCGCTGCTCGAGGGCCTGGAGGCCTTCTTCGTGGCGAAGACGCTGGC
GGGGCGCCGGGTCGTGTTGACGGCCGGGCCGACCTTCGAGGCCATCGATCCGGTGCGGGGCATCACCAACAGCAGTTCCG
GCAAGATGGGATACGCGCTGGCCCGCGCCTGTGCCCAGGCCGGCGCCGAGGTCGTGCTCGTCAGTGGCCCGGTGGCCTTG
CCGGTGCCGAGGGGTGTTCGCCGCGTCGATGTGCGCAGTGCGCTGGAGATGCGCGGCGCCGTGCTGGACGCCCTGCCGGG
CACTGACGTCTTCATCGCCGTCGCCGCGGTGGCGGACTACCGCCCGGCGCAGACGGCGGAGCACAAGATCAAGAAGTCGG
GCGACACCTTGCACCTTTCCCTGACGCCCAATCCCGACATCCTCGCCGAGGTCGCGGCGCGCCCGGATGCGCCGTTCTGC
GTTGGTTTTGCCGCCGAAAGCCGCGATCTGGATGCCTATGCGGAGGGCAAGCGGCGCAACAAGCGGCTGCCGCTGCTCGT
GGGCAATCTGGTCGGCGACGGCCTCGGGGGCGACGACAACCTCGTCGTGCTGTACGACGATCGCGGCAAGCACCCGTTGC
CACGTGCGCCCAAAACCGAACTCGCCCGACAGATCGTCGACCATCTGGCCGCCCTGCTGCCGCCTTCGAATTCCCGCTGA

Upstream 100 bases:

>100_bases
GTTTTTCTCGCGGGCGTTCGTCTTCGGGCCAGTCGGTGATCGCCATCTTCGCGCCAGTTTTGATTATGCCTTTGTATTTT
TCCAGTTTAACGCGAATGTC

Downstream 100 bases:

>100_bases
CCCATCGGAAACCGCCATGCACCGCATCGACGTCAAGCTGCTCGATCCCCGTCTGAAAACCCATCCGCCCGCTTATGCCA
GTGCCGGCGCTGCGGGGCTG

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MTSLQGKRIVLGVTGGVAAYKAAELVRLLGKAGVDVHVVLTEAGARFVGAVTFQALSGNPVWSDLWDPRMPNNMAHIDLG
READAVLVAPASADFIARIAGGRADDLLTTLCLARDCPLLVAPAMNRQMWEHPATQRNVGQAVADGVTMLGPAAGDQACG
ETGMGRMEEPEALLEGLEAFFVAKTLAGRRVVLTAGPTFEAIDPVRGITNSSSGKMGYALARACAQAGAEVVLVSGPVAL
PVPRGVRRVDVRSALEMRGAVLDALPGTDVFIAVAAVADYRPAQTAEHKIKKSGDTLHLSLTPNPDILAEVAARPDAPFC
VGFAAESRDLDAYAEGKRRNKRLPLLVGNLVGDGLGGDDNLVVLYDDRGKHPLPRAPKTELARQIVDHLAALLPPSNSR

Sequences:

>Translated_399_residues
MTSLQGKRIVLGVTGGVAAYKAAELVRLLGKAGVDVHVVLTEAGARFVGAVTFQALSGNPVWSDLWDPRMPNNMAHIDLG
READAVLVAPASADFIARIAGGRADDLLTTLCLARDCPLLVAPAMNRQMWEHPATQRNVGQAVADGVTMLGPAAGDQACG
ETGMGRMEEPEALLEGLEAFFVAKTLAGRRVVLTAGPTFEAIDPVRGITNSSSGKMGYALARACAQAGAEVVLVSGPVAL
PVPRGVRRVDVRSALEMRGAVLDALPGTDVFIAVAAVADYRPAQTAEHKIKKSGDTLHLSLTPNPDILAEVAARPDAPFC
VGFAAESRDLDAYAEGKRRNKRLPLLVGNLVGDGLGGDDNLVVLYDDRGKHPLPRAPKTELARQIVDHLAALLPPSNSR
>Mature_398_residues
TSLQGKRIVLGVTGGVAAYKAAELVRLLGKAGVDVHVVLTEAGARFVGAVTFQALSGNPVWSDLWDPRMPNNMAHIDLGR
EADAVLVAPASADFIARIAGGRADDLLTTLCLARDCPLLVAPAMNRQMWEHPATQRNVGQAVADGVTMLGPAAGDQACGE
TGMGRMEEPEALLEGLEAFFVAKTLAGRRVVLTAGPTFEAIDPVRGITNSSSGKMGYALARACAQAGAEVVLVSGPVALP
VPRGVRRVDVRSALEMRGAVLDALPGTDVFIAVAAVADYRPAQTAEHKIKKSGDTLHLSLTPNPDILAEVAARPDAPFCV
GFAAESRDLDAYAEGKRRNKRLPLLVGNLVGDGLGGDDNLVVLYDDRGKHPLPRAPKTELARQIVDHLAALLPPSNSR

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=167, Percent_Identity=40.1197604790419, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI87082301, Length=405, Percent_Identity=46.9135802469136, Blast_Score=319, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI17560194, Length=174, Percent_Identity=33.9080459770115, Blast_Score=79, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6322762, Length=189, Percent_Identity=29.1005291005291, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24657262, Length=187, Percent_Identity=29.9465240641711, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 41883; Mature: 41751

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLQGKRIVLGVTGGVAAYKAAELVRLLGKAGVDVHVVLTEAGARFVGAVTFQALSGNP
CCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEEEEEECCCC
VWSDLWDPRMPNNMAHIDLGREADAVLVAPASADFIARIAGGRADDLLTTLCLARDCPLL
CHHHCCCCCCCCCCEEEECCCCCCEEEEECCCHHHHHHHCCCCHHHHHHHHHHHCCCCEE
VAPAMNRQMWEHPATQRNVGQAVADGVTMLGPAAGDQACGETGMGRMEEPEALLEGLEAF
EECHHHHHHHHCCCHHHHHHHHHHCCHHEECCCCCCHHCCCCCCCCCCCHHHHHHHHHHH
FVAKTLAGRRVVLTAGPTFEAIDPVRGITNSSSGKMGYALARACAQAGAEVVLVSGPVAL
HHHHHHCCCEEEEEECCCCHHCCHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCEEE
PVPRGVRRVDVRSALEMRGAVLDALPGTDVFIAVAAVADYRPAQTAEHKIKKSGDTLHLS
CCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEE
LTPNPDILAEVAARPDAPFCVGFAAESRDLDAYAEGKRRNKRLPLLVGNLVGDGLGGDDN
ECCCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCEEEEHHHCCCCCCCCC
LVVLYDDRGKHPLPRAPKTELARQIVDHLAALLPPSNSR
EEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TSLQGKRIVLGVTGGVAAYKAAELVRLLGKAGVDVHVVLTEAGARFVGAVTFQALSGNP
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEEEEEECCCC
VWSDLWDPRMPNNMAHIDLGREADAVLVAPASADFIARIAGGRADDLLTTLCLARDCPLL
CHHHCCCCCCCCCCEEEECCCCCCEEEEECCCHHHHHHHCCCCHHHHHHHHHHHCCCCEE
VAPAMNRQMWEHPATQRNVGQAVADGVTMLGPAAGDQACGETGMGRMEEPEALLEGLEAF
EECHHHHHHHHCCCHHHHHHHHHHCCHHEECCCCCCHHCCCCCCCCCCCHHHHHHHHHHH
FVAKTLAGRRVVLTAGPTFEAIDPVRGITNSSSGKMGYALARACAQAGAEVVLVSGPVAL
HHHHHHCCCEEEEEECCCCHHCCHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCEEE
PVPRGVRRVDVRSALEMRGAVLDALPGTDVFIAVAAVADYRPAQTAEHKIKKSGDTLHLS
CCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEE
LTPNPDILAEVAARPDAPFCVGFAAESRDLDAYAEGKRRNKRLPLLVGNLVGDGLGGDDN
ECCCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCEEEEHHHCCCCCCCCC
LVVLYDDRGKHPLPRAPKTELARQIVDHLAALLPPSNSR
EEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]