Click here to switch to the map view.

The map label for this gene is hbdA [H]

Identifier: 119897319

GI number: 119897319

Start: 1105799

End: 1106650

Strand: Direct

Name: hbdA [H]

Synonym: azo1028

Alternate gene names: 119897319

Gene position: 1105799-1106650 (Clockwise)

Preceding gene: 119897318

Following gene: 119897322

Centisome position: 25.27

GC content: 60.45

Gene sequence:

>852_bases
ATGAGCATCAAGAAAGTAGGTGTAGTGGGTGCCGGCACGATGGGCAACGGTATCGTCCAGGCTTTCGCGGTCGCGGGCTT
CGACGTGGTCATGACCGATATTGCCGACGCTGCGCTGCAGAGGGGTGTGCAGACGATCTCGGGCAGTTTCGATCGTTTGA
TCAAGAAGGAGAAAATGACCTGCGACGAGAAGGCTGCGGCGCTTGGTCGAGTCAAGACGTCGACCGATCTGGACGCGATG
GCGGATGTTGATCTGGTGATCGAGGCCGCCACCGAGAATCTCGATCTGAAGCTGAAAATCTTCGCCCAGCTCGATTCGGT
CGTGAAGGCCGACGCAATCGTCGCCAGCAATACGTCTTCGATCTCCATCACCAAGTTGGCGGCCGCGATGAAGCGCCCCG
AGCAGTTTGTCGGCATGCACTTCTTCAACCCGGTTCCGATGATGGCGCTGGTTGAACTGATCCGGGGCTTGCAGACCTCG
GATGCTACCTACGCCGCGGTTGAAGCCGCAGCCAAGGCGGTGGGCAAGACGCCCGTGCAAGTGCGCAACAGCCCGGGCTT
TGTGGTCAACCGACTGCTGTGCCCGATGATCAACGAGGCGATTTTCGCCCTCGGCGAGGGGCTGGCCACCGCCGCGGAGA
TCGACGAGGCGATGAAGCTGGGTTGCAACCATCCCATCGGTCCGCTGGCGTTGTGCGACCTGATCGGTCTCGACGTCGAA
CTGGCGGTGATGCAGGTGCTGTTCGAAGGATTCAAGGATCCCAAGTACCGGCCGGCGCCCTTGCTGGTTGAAATGGTTGA
AGCGGGCCGCCTCGGTCGGAAAGTGGGTAAGGGCTTCTTCGACTACGCCTGA

Upstream 100 bases:

>100_bases
GTATGGCTAAAAGCGTAGTGATAAGCTACATTTCTTTCCATACGCATCGGTATGGATTGGTTCGTCCGCTGCGTCGATCA
AGAAAGGAGAAGACAGCACA

Downstream 100 bases:

>100_bases
GGCGCCTCGCCTAAATTAGGCGCTACAGAAAATACAAAAGCCACCCCGGGGTGGCTTTTGTTTTGTGCTGTCGGGACTAT
CCGCGCCTCATTGCATCGAA

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MSIKKVGVVGAGTMGNGIVQAFAVAGFDVVMTDIADAALQRGVQTISGSFDRLIKKEKMTCDEKAAALGRVKTSTDLDAM
ADVDLVIEAATENLDLKLKIFAQLDSVVKADAIVASNTSSISITKLAAAMKRPEQFVGMHFFNPVPMMALVELIRGLQTS
DATYAAVEAAAKAVGKTPVQVRNSPGFVVNRLLCPMINEAIFALGEGLATAAEIDEAMKLGCNHPIGPLALCDLIGLDVE
LAVMQVLFEGFKDPKYRPAPLLVEMVEAGRLGRKVGKGFFDYA

Sequences:

>Translated_283_residues
MSIKKVGVVGAGTMGNGIVQAFAVAGFDVVMTDIADAALQRGVQTISGSFDRLIKKEKMTCDEKAAALGRVKTSTDLDAM
ADVDLVIEAATENLDLKLKIFAQLDSVVKADAIVASNTSSISITKLAAAMKRPEQFVGMHFFNPVPMMALVELIRGLQTS
DATYAAVEAAAKAVGKTPVQVRNSPGFVVNRLLCPMINEAIFALGEGLATAAEIDEAMKLGCNHPIGPLALCDLIGLDVE
LAVMQVLFEGFKDPKYRPAPLLVEMVEAGRLGRKVGKGFFDYA
>Mature_282_residues
SIKKVGVVGAGTMGNGIVQAFAVAGFDVVMTDIADAALQRGVQTISGSFDRLIKKEKMTCDEKAAALGRVKTSTDLDAMA
DVDLVIEAATENLDLKLKIFAQLDSVVKADAIVASNTSSISITKLAAAMKRPEQFVGMHFFNPVPMMALVELIRGLQTSD
ATYAAVEAAAKAVGKTPVQVRNSPGFVVNRLLCPMINEAIFALGEGLATAAEIDEAMKLGCNHPIGPLALCDLIGLDVEL
AVMQVLFEGFKDPKYRPAPLLVEMVEAGRLGRKVGKGFFDYA

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=288, Percent_Identity=40.2777777777778, Blast_Score=210, Evalue=1e-54,
Organism=Homo sapiens, GI296179427, Length=306, Percent_Identity=38.562091503268, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI20127408, Length=281, Percent_Identity=35.5871886120996, Blast_Score=167, Evalue=9e-42,
Organism=Homo sapiens, GI261878539, Length=291, Percent_Identity=34.3642611683849, Blast_Score=151, Evalue=6e-37,
Organism=Homo sapiens, GI68989263, Length=291, Percent_Identity=34.3642611683849, Blast_Score=151, Evalue=7e-37,
Organism=Homo sapiens, GI115430219, Length=239, Percent_Identity=30.9623430962343, Blast_Score=99, Evalue=4e-21,
Organism=Escherichia coli, GI1787661, Length=283, Percent_Identity=40.6360424028269, Blast_Score=217, Evalue=6e-58,
Organism=Escherichia coli, GI1790281, Length=265, Percent_Identity=38.4905660377359, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1788682, Length=259, Percent_Identity=37.4517374517375, Blast_Score=165, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17553560, Length=287, Percent_Identity=44.9477351916376, Blast_Score=241, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17549919, Length=289, Percent_Identity=40.8304498269896, Blast_Score=223, Evalue=8e-59,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=36.5853658536585, Blast_Score=196, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI25144276, Length=285, Percent_Identity=38.9473684210526, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17508953, Length=285, Percent_Identity=38.9473684210526, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17508951, Length=285, Percent_Identity=38.9473684210526, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17558304, Length=285, Percent_Identity=36.4912280701754, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI71985923, Length=282, Percent_Identity=32.2695035460993, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71985930, Length=285, Percent_Identity=29.8245614035088, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI115533614, Length=214, Percent_Identity=25.7009345794392, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193203623, Length=214, Percent_Identity=25.7009345794392, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19921000, Length=282, Percent_Identity=36.8794326241135, Blast_Score=174, Evalue=9e-44,
Organism=Drosophila melanogaster, GI24583077, Length=282, Percent_Identity=36.8794326241135, Blast_Score=173, Evalue=9e-44,
Organism=Drosophila melanogaster, GI24583079, Length=282, Percent_Identity=36.8794326241135, Blast_Score=173, Evalue=9e-44,
Organism=Drosophila melanogaster, GI20129993, Length=224, Percent_Identity=26.7857142857143, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI45549573, Length=243, Percent_Identity=28.3950617283951, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 29993; Mature: 29862

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKKVGVVGAGTMGNGIVQAFAVAGFDVVMTDIADAALQRGVQTISGSFDRLIKKEKMT
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
CDEKAAALGRVKTSTDLDAMADVDLVIEAATENLDLKLKIFAQLDSVVKADAIVASNTSS
HHHHHHHHHCCCCCCCHHHHHHHHHHEEECCCCCCEEEHHHHHHHHHHHHHHHEECCCCC
ISITKLAAAMKRPEQFVGMHFFNPVPMMALVELIRGLQTSDATYAAVEAAAKAVGKTPVQ
CHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEE
VRNSPGFVVNRLLCPMINEAIFALGEGLATAAEIDEAMKLGCNHPIGPLALCDLIGLDVE
EECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHH
LAVMQVLFEGFKDPKYRPAPLLVEMVEAGRLGRKVGKGFFDYA
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SIKKVGVVGAGTMGNGIVQAFAVAGFDVVMTDIADAALQRGVQTISGSFDRLIKKEKMT
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
CDEKAAALGRVKTSTDLDAMADVDLVIEAATENLDLKLKIFAQLDSVVKADAIVASNTSS
HHHHHHHHHCCCCCCCHHHHHHHHHHEEECCCCCCEEEHHHHHHHHHHHHHHHEECCCCC
ISITKLAAAMKRPEQFVGMHFFNPVPMMALVELIRGLQTSDATYAAVEAAAKAVGKTPVQ
CHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEE
VRNSPGFVVNRLLCPMINEAIFALGEGLATAAEIDEAMKLGCNHPIGPLALCDLIGLDVE
EECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHH
LAVMQVLFEGFKDPKYRPAPLLVEMVEAGRLGRKVGKGFFDYA
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA