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The map label for this gene is groEL [H]

Identifier: 119897265

GI number: 119897265

Start: 1045775

End: 1047424

Strand: Direct

Name: groEL [H]

Synonym: azo0974

Alternate gene names: 119897265

Gene position: 1045775-1047424 (Clockwise)

Preceding gene: 119897264

Following gene: 119897266

Centisome position: 23.9

GC content: 63.88

Gene sequence:

>1650_bases
ATGGCTGCTAAAGAAGTCAAGTTTGGCGATTCCGCCCGCGAACGCATGGTTGCCGGCGTCAATGTGCTGGCCAACGCCGT
CAAGGTGACCCTGGGCCCGAAGGGCCGCAACGTGGTGCTCGAGCGCTCGTTCGGCGCCCCCACCGTGACCAAGGACGGCG
TGTCCGTCGCCAAGGAAATCGAACTGAAGGACAAGTTCGAGAACATGGGCGCGCAGATGGTCAAGGAAGTCGCTTCCAAG
ACCTCCGACATCGCCGGTGACGGCACCACCACCGCCACCGTGCTGGCCCAGTCCATCGTCCGCGAAGGCATGAAGTTCGT
CGCCGCCGGCATGAACCCGATGGACCTGAAGCGCGGCATCGACAAGGCTGTCGTCGCCACCATCGAAGAACTGAAGAAGC
TGTCGAAGCCCTGCTCGACCAACAAGGAAATCGCCCAGGTCGGTTCGATCTCCGCCAACTCCGACGCCGACATCGGCGGC
ATCATCGCCCAGGCGATGGAGAAGGTCGGCAAGGAAGGCGTCATCACCGTCGAAGACGGCAAGTCGCTGAACAACGAGCT
GGACGTCGTCGAAGGCATGCAGTTCGACCGCGGCTACCTGTCGCCCTACTTCATCAACAACCCGGACAAGCAGGTTGCCA
TCCTGGAAAACCCGTTCGTCCTGCTGTTCGACAAGAAGATCTCCAACATCCGCGACCTGCTGCCGGTGCTGGAACAAGTC
GCCAAGGCCGGCCGTCCGCTGCTGATCATCGCTGAAGACGTCGACGGCGAAGCGCTCGCCACCCTGGTGGTGAACAACAT
CCGCGGCATCCTCAAGACCTGCGCCGTCAAGGCCCCGGGCTTCGGCGACCGTCGCAAGGCCATGCTCGAAGACATCGCCA
TCCTGACCGGTGGCCAGGTGATCGCCGAAGAAGTCGGCCTGACCCTCGAAAAGGCTACCCTGCAGGACCTCGGCCAGGCC
AAGCGCATCGAGATCGGCAAGGAAAACACCATCATCATCGACGGCGCCGGCGAAGCCTCCCGTATCGAAGCCCGCGTCAA
GCAGATCCGCGTGCAGATCGAGGAAGCGACCTCCGACTACGACCGTGAAAAGCTGCAAGAGCGCGTGGCCAAGCTGGCCG
GCGGCGTTGCGGTGATCAAGGTCGGTGCCGCCACCGAAGTCGAAATGAAGGAAAAGAAGGCCCGCGTGGAAGACGCCCTG
CACGCCACCCGCGCTGCGGTGGAAGAAGGCATCGTCCCCGGGGGCGGTGTTGCGCTGCTGCGTGCCCGCGCCAGCCTGGC
CGGCCTGAAGGGCGACAACCACGACCAGGACGCCGGCATCAAGATCGTGCTGCGCGCGATGGAACAGCCGCTGCGTGAAA
TCGTTGCCAACGCCGGCGACGAGGCTTCCGTGGTGGTGAACAAGGTTGTCGAAGGCTCCGGCAACTTCGGCTACAACGCC
GCTACCGGCGAGTACGGCGACATGGTCGAGATGGGCGTGCTGGATCCGACCAAGGTGACCCGCACCGCGCTGCAGAACGC
TGCTTCCGTCGCCAGCCTGATGCTCACCACCGACTGCATGGTCGGCGAGCTGGCTGAAGACAAGCCCGCCGGCGGCATGC
CGGGCATGGGCGGCATGGGTGGCATGGGCGGCATGGACATGGGTATGTAA

Upstream 100 bases:

>100_bases
AGAGCTGCTCGTCATGCGCGAAGAAGACATCATGGGTGTGGTCGAGGCCTGAGCCTCCCGCCGGTTCTGATTCCCATCCC
CGAATTCAAGGAGTTGAAGA

Downstream 100 bases:

>100_bases
TGCCCCGTCCGGTGGCGGCGGTTGCCGCCACCCGCAGTTCGACGGCCCCGCTTCGGCGGGGCCGTTGTCGTTTACGGCGC
GGCACAGGCGGGCATGGGCG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 549; Mature: 548

Protein sequence:

>549_residues
MAAKEVKFGDSARERMVAGVNVLANAVKVTLGPKGRNVVLERSFGAPTVTKDGVSVAKEIELKDKFENMGAQMVKEVASK
TSDIAGDGTTTATVLAQSIVREGMKFVAAGMNPMDLKRGIDKAVVATIEELKKLSKPCSTNKEIAQVGSISANSDADIGG
IIAQAMEKVGKEGVITVEDGKSLNNELDVVEGMQFDRGYLSPYFINNPDKQVAILENPFVLLFDKKISNIRDLLPVLEQV
AKAGRPLLIIAEDVDGEALATLVVNNIRGILKTCAVKAPGFGDRRKAMLEDIAILTGGQVIAEEVGLTLEKATLQDLGQA
KRIEIGKENTIIIDGAGEASRIEARVKQIRVQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGIVPGGGVALLRARASLAGLKGDNHDQDAGIKIVLRAMEQPLREIVANAGDEASVVVNKVVEGSGNFGYNA
ATGEYGDMVEMGVLDPTKVTRTALQNAASVASLMLTTDCMVGELAEDKPAGGMPGMGGMGGMGGMDMGM

Sequences:

>Translated_549_residues
MAAKEVKFGDSARERMVAGVNVLANAVKVTLGPKGRNVVLERSFGAPTVTKDGVSVAKEIELKDKFENMGAQMVKEVASK
TSDIAGDGTTTATVLAQSIVREGMKFVAAGMNPMDLKRGIDKAVVATIEELKKLSKPCSTNKEIAQVGSISANSDADIGG
IIAQAMEKVGKEGVITVEDGKSLNNELDVVEGMQFDRGYLSPYFINNPDKQVAILENPFVLLFDKKISNIRDLLPVLEQV
AKAGRPLLIIAEDVDGEALATLVVNNIRGILKTCAVKAPGFGDRRKAMLEDIAILTGGQVIAEEVGLTLEKATLQDLGQA
KRIEIGKENTIIIDGAGEASRIEARVKQIRVQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGIVPGGGVALLRARASLAGLKGDNHDQDAGIKIVLRAMEQPLREIVANAGDEASVVVNKVVEGSGNFGYNA
ATGEYGDMVEMGVLDPTKVTRTALQNAASVASLMLTTDCMVGELAEDKPAGGMPGMGGMGGMGGMDMGM
>Mature_548_residues
AAKEVKFGDSARERMVAGVNVLANAVKVTLGPKGRNVVLERSFGAPTVTKDGVSVAKEIELKDKFENMGAQMVKEVASKT
SDIAGDGTTTATVLAQSIVREGMKFVAAGMNPMDLKRGIDKAVVATIEELKKLSKPCSTNKEIAQVGSISANSDADIGGI
IAQAMEKVGKEGVITVEDGKSLNNELDVVEGMQFDRGYLSPYFINNPDKQVAILENPFVLLFDKKISNIRDLLPVLEQVA
KAGRPLLIIAEDVDGEALATLVVNNIRGILKTCAVKAPGFGDRRKAMLEDIAILTGGQVIAEEVGLTLEKATLQDLGQAK
RIEIGKENTIIIDGAGEASRIEARVKQIRVQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALH
ATRAAVEEGIVPGGGVALLRARASLAGLKGDNHDQDAGIKIVLRAMEQPLREIVANAGDEASVVVNKVVEGSGNFGYNAA
TGEYGDMVEMGVLDPTKVTRTALQNAASVASLMLTTDCMVGELAEDKPAGGMPGMGGMGGMGGMDMGM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=527, Percent_Identity=53.5104364326376, Blast_Score=548, Evalue=1e-156,
Organism=Homo sapiens, GI31542947, Length=527, Percent_Identity=53.5104364326376, Blast_Score=548, Evalue=1e-156,
Organism=Homo sapiens, GI24307939, Length=364, Percent_Identity=23.0769230769231, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1790586, Length=530, Percent_Identity=76.0377358490566, Blast_Score=805, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=52.4621212121212, Blast_Score=550, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI193210679, Length=210, Percent_Identity=51.9047619047619, Blast_Score=217, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=54.0076335877863, Blast_Score=556, Evalue=1e-159,
Organism=Saccharomyces cerevisiae, GI6322524, Length=392, Percent_Identity=23.9795918367347, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24641193, Length=526, Percent_Identity=52.4714828897338, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24641191, Length=526, Percent_Identity=52.4714828897338, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI45550936, Length=523, Percent_Identity=50.6692160611855, Blast_Score=533, Evalue=1e-151,
Organism=Drosophila melanogaster, GI45550132, Length=523, Percent_Identity=50.6692160611855, Blast_Score=533, Evalue=1e-151,
Organism=Drosophila melanogaster, GI45550935, Length=523, Percent_Identity=50.6692160611855, Blast_Score=533, Evalue=1e-151,
Organism=Drosophila melanogaster, GI17864606, Length=551, Percent_Identity=44.2831215970962, Blast_Score=470, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24584129, Length=522, Percent_Identity=37.7394636015326, Blast_Score=338, Evalue=8e-93,
Organism=Drosophila melanogaster, GI19921262, Length=522, Percent_Identity=37.7394636015326, Blast_Score=338, Evalue=8e-93,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57886; Mature: 57754

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKEVKFGDSARERMVAGVNVLANAVKVTLGPKGRNVVLERSFGAPTVTKDGVSVAKEI
CCCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHH
ELKDKFENMGAQMVKEVASKTSDIAGDGTTTATVLAQSIVREGMKFVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCH
DKAVVATIEELKKLSKPCSTNKEIAQVGSISANSDADIGGIIAQAMEKVGKEGVITVEDG
HHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECC
KSLNNELDVVEGMQFDRGYLSPYFINNPDKQVAILENPFVLLFDKKISNIRDLLPVLEQV
CCCCCCHHHHHCCCCCCCCCCCEEECCCCCEEEEECCCEEEEECHHHHHHHHHHHHHHHH
AKAGRPLLIIAEDVDGEALATLVVNNIRGILKTCAVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHH
IAEEVGLTLEKATLQDLGQAKRIEIGKENTIIIDGAGEASRIEARVKQIRVQIEEATSDY
HHHHHCCCHHHHHHHHCCCCCEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RARASLAGLKGDNHDQDAGIKIVLRAMEQPLREIVANAGDEASVVVNKVVEGSGNFGYNA
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCC
ATGEYGDMVEMGVLDPTKVTRTALQNAASVASLMLTTDCMVGELAEDKPAGGMPGMGGMG
CCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GMGGMDMGM
CCCCCCCCC
>Mature Secondary Structure 
AAKEVKFGDSARERMVAGVNVLANAVKVTLGPKGRNVVLERSFGAPTVTKDGVSVAKEI
CCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHH
ELKDKFENMGAQMVKEVASKTSDIAGDGTTTATVLAQSIVREGMKFVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCH
DKAVVATIEELKKLSKPCSTNKEIAQVGSISANSDADIGGIIAQAMEKVGKEGVITVEDG
HHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECC
KSLNNELDVVEGMQFDRGYLSPYFINNPDKQVAILENPFVLLFDKKISNIRDLLPVLEQV
CCCCCCHHHHHCCCCCCCCCCCEEECCCCCEEEEECCCEEEEECHHHHHHHHHHHHHHHH
AKAGRPLLIIAEDVDGEALATLVVNNIRGILKTCAVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHH
IAEEVGLTLEKATLQDLGQAKRIEIGKENTIIIDGAGEASRIEARVKQIRVQIEEATSDY
HHHHHCCCHHHHHHHHCCCCCEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RARASLAGLKGDNHDQDAGIKIVLRAMEQPLREIVANAGDEASVVVNKVVEGSGNFGYNA
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCC
ATGEYGDMVEMGVLDPTKVTRTALQNAASVASLMLTTDCMVGELAEDKPAGGMPGMGGMG
CCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GMGGMDMGM
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA