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The map label for this gene is dctR [H]

Identifier: 119897208

GI number: 119897208

Start: 982714

End: 983319

Strand: Reverse

Name: dctR [H]

Synonym: azo0917

Alternate gene names: 119897208

Gene position: 983319-982714 (Counterclockwise)

Preceding gene: 119897209

Following gene: 119897204

Centisome position: 22.47

GC content: 64.36

Gene sequence:

>606_bases
ATGACCCAGGCCTGCGCCCACATCATTGACGACGACGAAGCCATCCGCGACGCGCTGCAATGGTTGTTCAAGACGCGCTC
GGTGAACTGCCGGGCCTGGAGCAGCGGCGAGGCTTTTCTGGGGGCATGGCGCCCCGAATGGCGCGGCTGCATCGTGCTCG
ATATCCGCATGGACGGGATGAGCGGGCTCGAATGCTTCGACGCACTGATCGAGCGCGGCTGCCAGTTGCCGGTCATCTTC
ATCACGGGCCATGGCGACGTGCCGATGGCGGTTGGCGCGCTGAAGAAGGGCGCGTTCGACTTCATCGAGAAGCCGTTCAA
CGACAACCAGCTTGTGGACCTGGTCGAAAAGGCGATCCAGCGCGACGCCGAGCGTCAGCGCGTGGCGGCCGACCGTGAAA
CCGTAGCCGCCCGGCTCGCCACGCTGACCGCACGCGAGCGCGAGGTGATGGACCTCATCCTCGAAGGCAAATTCAACAAG
GTCATCGCCGACGACCTGCAGATCTCGATGCGCACCGTCGAAGCCCACCGCTCGCGGGTATTCGACAAGATGGAAGTGCG
CTCAGCGGTCGAACTGGCCCAGATGCTGACCCTGCTGCGCAGCTGA

Upstream 100 bases:

>100_bases
CTGCCGCTCGATCGCCGAGCTGCACCACGGCCGCCTCGGTTTTGAGCCAGCTCCCGACGGCGGTACCATCTTCACCCTCA
CGCTCCCGGTGGACTCCTGA

Downstream 100 bases:

>100_bases
CGCCGGCACCCACGCCGGCACCACGCCCTGCTCCCCCTCCGCGCACTGGAACTGCGCGGCGATGCCAATACCGCCGATCC
AGGCCGGCTCGCCCGCCACC

Product: two-component response regulator

Products: NADP; 2 glutathione [C]

Alternate protein names: NA

Number of amino acids: Translated: 201; Mature: 200

Protein sequence:

>201_residues
MTQACAHIIDDDEAIRDALQWLFKTRSVNCRAWSSGEAFLGAWRPEWRGCIVLDIRMDGMSGLECFDALIERGCQLPVIF
ITGHGDVPMAVGALKKGAFDFIEKPFNDNQLVDLVEKAIQRDAERQRVAADRETVAARLATLTAREREVMDLILEGKFNK
VIADDLQISMRTVEAHRSRVFDKMEVRSAVELAQMLTLLRS

Sequences:

>Translated_201_residues
MTQACAHIIDDDEAIRDALQWLFKTRSVNCRAWSSGEAFLGAWRPEWRGCIVLDIRMDGMSGLECFDALIERGCQLPVIF
ITGHGDVPMAVGALKKGAFDFIEKPFNDNQLVDLVEKAIQRDAERQRVAADRETVAARLATLTAREREVMDLILEGKFNK
VIADDLQISMRTVEAHRSRVFDKMEVRSAVELAQMLTLLRS
>Mature_200_residues
TQACAHIIDDDEAIRDALQWLFKTRSVNCRAWSSGEAFLGAWRPEWRGCIVLDIRMDGMSGLECFDALIERGCQLPVIFI
TGHGDVPMAVGALKKGAFDFIEKPFNDNQLVDLVEKAIQRDAERQRVAADRETVAARLATLTAREREVMDLILEGKFNKV
IADDLQISMRTVEAHRSRVFDKMEVRSAVELAQMLTLLRS

Specific function: Member of the two-component regulatory system dctS/dctR involved in the transport of C4-dicarboxylates. DctR functions as a transcriptional repressor of genes for C4-dicarboxylate transport [H]

COG id: COG4566

COG function: function code T; Response regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790299, Length=127, Percent_Identity=35.4330708661417, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788222, Length=198, Percent_Identity=22.7272727272727, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1788550, Length=121, Percent_Identity=28.099173553719, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788905, Length=125, Percent_Identity=28.8, Blast_Score=65, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 22696; Mature: 22565

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQACAHIIDDDEAIRDALQWLFKTRSVNCRAWSSGEAFLGAWRPEWRGCIVLDIRMDGM
CCCHHHHHCCCHHHHHHHHHHHHHHCCCCCEEECCCCCEEECCCCCCCCEEEEEEEECCC
SGLECFDALIERGCQLPVIFITGHGDVPMAVGALKKGAFDFIEKPFNDNQLVDLVEKAIQ
CHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
RDAERQRVAADRETVAARLATLTAREREVMDLILEGKFNKVIADDLQISMRTVEAHRSRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
FDKMEVRSAVELAQMLTLLRS
HHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQACAHIIDDDEAIRDALQWLFKTRSVNCRAWSSGEAFLGAWRPEWRGCIVLDIRMDGM
CCHHHHHCCCHHHHHHHHHHHHHHCCCCCEEECCCCCEEECCCCCCCCEEEEEEEECCC
SGLECFDALIERGCQLPVIFITGHGDVPMAVGALKKGAFDFIEKPFNDNQLVDLVEKAIQ
CHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
RDAERQRVAADRETVAARLATLTAREREVMDLILEGKFNKVIADDLQISMRTVEAHRSRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
FDKMEVRSAVELAQMLTLLRS
HHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADPH2; oxidized glutathione [C]

Specific reaction: NADPH2 + oxidized glutathione = NADP + 2 glutathione [C]

General reaction: Oxidoreductases; Acting on NADH or NADPH; With a disulfide as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8455557 [H]