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The map label for this gene is murC

Identifier: 119897176

GI number: 119897176

Start: 947097

End: 948500

Strand: Direct

Name: murC

Synonym: azo0885

Alternate gene names: 119897176

Gene position: 947097-948500 (Clockwise)

Preceding gene: 119897175

Following gene: 119897177

Centisome position: 21.64

GC content: 68.87

Gene sequence:

>1404_bases
ATGAAACATAAAGTCAAACGCATCCACTTTGTAGGTATCGGCGGCGCCGGCATGAGCGGCATCGCCGAGGTGCTGGTCAA
CCTCGGCTACAGCGTCAGCGGCTCGGATCTCGGCGACAGCGCCGCGACCCGCCGCCTGAAGGCGATGGGCGCGAAGGTCG
TGCTCGGCCACGACGCCGCCAACGTCGAAGCAGCCGATGCGCTGGTGGTATCCACCGCGGTGAAGAACGACAACCCGGAG
GTGATCGCGGCGCGTGCCCGTCACATCCCGATCGTGCCGCGCGCGCAGATGCTGGCCGAGTTGATGCGGCTGAAGAGCGG
CATCGCCATCGCCGGCACCCACGGCAAGACGACCACCACCTCGCTGGTGGCCAGCATCCTCGCCGAAGGGGCGATGGACC
CGACCTTCGTGATCGGTGGCCGCCTCAATGCCGCCGGTGCCAATGCGCGCCTGGGCAAGGGCGATTTCCTGGTCGCCGAG
GCGGACGAATCCGACGCCTCCTTCCTGATGCTGAGCCCGGTGATCTCGGTGGTGACCAACATCGACGCCGACCACATGGA
CACCTACGGCCACGATTTCGCCCGCCTCAAGCAGGCCTTCGTGGACTTCCTGCAGCGGCTGCCCTTCTACGGCGTCGCGG
TGCTGTGCGAGGACGATCCGCACGTGCGCTCGATCATGCCGCTGGTGTCCAAGCAGGTGGTGCGCTACGGCCTGTCCGAA
ACCGCCAACATCCGCGCCGAGAACATCCGCGCCGAAGGCGGCCGCATGATCTTCGACGTGTTGCGGGTCAATGGCAGCAC
CACCCGGCTGGCCGACGTCGTGCTCAACCTGCCGGGCCTGCACAACGTGCGCAACGCGCTCGCGGCGATCGCGGTGGCGA
CCGAAGTGCAGGTGCCGGACGAGGCGATCGTCAAGGCGCTGGCCGAGTTCAGCGGGGTCGGCCGCCGCTTCCAGCGCTAC
GGCGAAGTCGCCGCGCCGTCCGGCGGCACGTTCACGTTGATCGACGACTACGGCCACCACCCGGTGGAGATGGAAGCGAC
GCTGGCCGCGGCGCGCGGCGCCTTCCCGGGCCGCCGCCTGGTGCTGGCCTTCCAGCCGCACCGCTACACCCGCACCCGCG
ACTGTTTCGAGGACTTCGTCAAGGTGCTGTCGACGGTGGATGCGCTGCTGCTGGCCGAGGTCTATGCCGCTGGCGAGGCG
CCGATCGTCGCCGCCGACGGCCGCGCGCTGTCGCGAGCGCTGCGGGTGGCAGGCAAGGTGGAACCGGTGTTCGTCGAGGA
CATCGGCGGCATGCCGCAGGCGGTGCTGGAGGCGGTGCGCGACGGCGATGTGGTGATCACGATGGGTGCGGGCAGCATCG
GCGCGGTGCCGGGCAAGCTCGCCAGCAACGAGGAGCAGGCGTGA

Upstream 100 bases:

>100_bases
AACTGTTGCAGATGGCCGAGCACGCCCGCGCGCAGGCGAAGCCGCGCGCGACCGAGGCGGTCGCCCGTGCCTGCGAGGAA
CTGGCGGAGGGACGCAAGGC

Downstream 100 bases:

>100_bases
AGCAGCGGTTTGGAAAAGTGGCGGTGCTGTTCGGCGGCTCTTCCGCCGAGCGCGATGTTTCGCTGATGTCGGGCGCGGCG
GTGCTGGCCGCGCTGCAGGG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MKHKVKRIHFVGIGGAGMSGIAEVLVNLGYSVSGSDLGDSAATRRLKAMGAKVVLGHDAANVEAADALVVSTAVKNDNPE
VIAARARHIPIVPRAQMLAELMRLKSGIAIAGTHGKTTTTSLVASILAEGAMDPTFVIGGRLNAAGANARLGKGDFLVAE
ADESDASFLMLSPVISVVTNIDADHMDTYGHDFARLKQAFVDFLQRLPFYGVAVLCEDDPHVRSIMPLVSKQVVRYGLSE
TANIRAENIRAEGGRMIFDVLRVNGSTTRLADVVLNLPGLHNVRNALAAIAVATEVQVPDEAIVKALAEFSGVGRRFQRY
GEVAAPSGGTFTLIDDYGHHPVEMEATLAAARGAFPGRRLVLAFQPHRYTRTRDCFEDFVKVLSTVDALLLAEVYAAGEA
PIVAADGRALSRALRVAGKVEPVFVEDIGGMPQAVLEAVRDGDVVITMGAGSIGAVPGKLASNEEQA

Sequences:

>Translated_467_residues
MKHKVKRIHFVGIGGAGMSGIAEVLVNLGYSVSGSDLGDSAATRRLKAMGAKVVLGHDAANVEAADALVVSTAVKNDNPE
VIAARARHIPIVPRAQMLAELMRLKSGIAIAGTHGKTTTTSLVASILAEGAMDPTFVIGGRLNAAGANARLGKGDFLVAE
ADESDASFLMLSPVISVVTNIDADHMDTYGHDFARLKQAFVDFLQRLPFYGVAVLCEDDPHVRSIMPLVSKQVVRYGLSE
TANIRAENIRAEGGRMIFDVLRVNGSTTRLADVVLNLPGLHNVRNALAAIAVATEVQVPDEAIVKALAEFSGVGRRFQRY
GEVAAPSGGTFTLIDDYGHHPVEMEATLAAARGAFPGRRLVLAFQPHRYTRTRDCFEDFVKVLSTVDALLLAEVYAAGEA
PIVAADGRALSRALRVAGKVEPVFVEDIGGMPQAVLEAVRDGDVVITMGAGSIGAVPGKLASNEEQA
>Mature_467_residues
MKHKVKRIHFVGIGGAGMSGIAEVLVNLGYSVSGSDLGDSAATRRLKAMGAKVVLGHDAANVEAADALVVSTAVKNDNPE
VIAARARHIPIVPRAQMLAELMRLKSGIAIAGTHGKTTTTSLVASILAEGAMDPTFVIGGRLNAAGANARLGKGDFLVAE
ADESDASFLMLSPVISVVTNIDADHMDTYGHDFARLKQAFVDFLQRLPFYGVAVLCEDDPHVRSIMPLVSKQVVRYGLSE
TANIRAENIRAEGGRMIFDVLRVNGSTTRLADVVLNLPGLHNVRNALAAIAVATEVQVPDEAIVKALAEFSGVGRRFQRY
GEVAAPSGGTFTLIDDYGHHPVEMEATLAAARGAFPGRRLVLAFQPHRYTRTRDCFEDFVKVLSTVDALLLAEVYAAGEA
PIVAADGRALSRALRVAGKVEPVFVEDIGGMPQAVLEAVRDGDVVITMGAGSIGAVPGKLASNEEQA

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=463, Percent_Identity=52.6997840172786, Blast_Score=442, Evalue=1e-125,
Organism=Escherichia coli, GI1790680, Length=469, Percent_Identity=29.2110874200426, Blast_Score=169, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_AZOSB (A1K3U7)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_932389.1
- ProteinModelPortal:   A1K3U7
- SMR:   A1K3U7
- STRING:   A1K3U7
- GeneID:   4609293
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo0885
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- PhylomeDB:   A1K3U7
- ProtClustDB:   PRK00421
- BioCyc:   ASP62928:AZO0885-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 49290; Mature: 49290

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHKVKRIHFVGIGGAGMSGIAEVLVNLGYSVSGSDLGDSAATRRLKAMGAKVVLGHDAA
CCCCEEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCC
NVEAADALVVSTAVKNDNPEVIAARARHIPIVPRAQMLAELMRLKSGIAIAGTHGKTTTT
CCCHHHHEEEEHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCHHH
SLVASILAEGAMDPTFVIGGRLNAAGANARLGKGDFLVAEADESDASFLMLSPVISVVTN
HHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCEEHHHHHHHHHHC
IDADHMDTYGHDFARLKQAFVDFLQRLPFYGVAVLCEDDPHVRSIMPLVSKQVVRYGLSE
CCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCC
TANIRAENIRAEGGRMIFDVLRVNGSTTRLADVVLNLPGLHNVRNALAAIAVATEVQVPD
CCCCCHHHEECCCCCEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCH
EAIVKALAEFSGVGRRFQRYGEVAAPSGGTFTLIDDYGHHPVEMEATLAAARGAFPGRRL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCEEHHHHHHHHHCCCCCCEE
VLAFQPHRYTRTRDCFEDFVKVLSTVDALLLAEVYAAGEAPIVAADGRALSRALRVAGKV
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCC
EPVFVEDIGGMPQAVLEAVRDGDVVITMGAGSIGAVPGKLASNEEQA
CEEEHHHCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKHKVKRIHFVGIGGAGMSGIAEVLVNLGYSVSGSDLGDSAATRRLKAMGAKVVLGHDAA
CCCCEEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCC
NVEAADALVVSTAVKNDNPEVIAARARHIPIVPRAQMLAELMRLKSGIAIAGTHGKTTTT
CCCHHHHEEEEHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCHHH
SLVASILAEGAMDPTFVIGGRLNAAGANARLGKGDFLVAEADESDASFLMLSPVISVVTN
HHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCEEHHHHHHHHHHC
IDADHMDTYGHDFARLKQAFVDFLQRLPFYGVAVLCEDDPHVRSIMPLVSKQVVRYGLSE
CCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCC
TANIRAENIRAEGGRMIFDVLRVNGSTTRLADVVLNLPGLHNVRNALAAIAVATEVQVPD
CCCCCHHHEECCCCCEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCH
EAIVKALAEFSGVGRRFQRYGEVAAPSGGTFTLIDDYGHHPVEMEATLAAARGAFPGRRL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCEEHHHHHHHHHCCCCCCEE
VLAFQPHRYTRTRDCFEDFVKVLSTVDALLLAEVYAAGEAPIVAADGRALSRALRVAGKV
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCC
EPVFVEDIGGMPQAVLEAVRDGDVVITMGAGSIGAVPGKLASNEEQA
CEEEHHHCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA