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The map label for this gene is mdtA [H]

Identifier: 119897137

GI number: 119897137

Start: 908683

End: 909771

Strand: Direct

Name: mdtA [H]

Synonym: azo0846

Alternate gene names: 119897137

Gene position: 908683-909771 (Clockwise)

Preceding gene: 119897136

Following gene: 119897138

Centisome position: 20.76

GC content: 73.19

Gene sequence:

>1089_bases
ATGAACCCGCGCTCCGTTCTGGCGCCGCTCGCCGCGTTGCTGCTGGTGGCCTGCTCCGAGGCGCCGCCCCCGCCGGCCGC
GCCGCGTGTGGTGCTGGTGCAGCGGCTTGCCGAGCCCGGCGCGGTCGAATCCGCCGAGCTATACACGGGGGAAATCCGGG
CGCGCTACGAAAGTCCGCTTGCGTTCCGCATCGGCGGCAAGCTGGTGGAGCGCAAGGTCGAGGTGGGCAGCGAGGTACGG
CGCGGTCAGGTGCTGGCGCGGCTGGATCCGCGCGACGCGGAGCTGGGGGCTGCCGCCGCGGCGGCCCAGGTGGCGGCGGC
GCGGGCCGATGCCGCGCTGGCAGTGGCGGAATACGAGCGGGCGGTGGGGCTACGCGCGCAGAACTTCATCAGCGGCTCTG
CCCTGGACGCGCGCCGCAGCGCGCGCGAAGCGGCCGAAGCGAAGCTGCGCCAGGCGGAGGCGCAGGCGGCCGCGGCGCGC
AACCAGAGCGGCTACACCGCCTTGGTTGCAGATAGCGACGGCGTCGTCACCGCGCTGGAAGCAGAGGTGGGACAGGTGCT
GGCCGAGGGGCAAGCGGTGATGACGCTGGCGCGGCCGGGCAACCGCGAGCTGCTGGTCCATGTGCCGGAGGGGCGGATGC
GCGAGCTGGTGCCGGGGCGGGAGGCCGAAGTCCGGCTGTGGAGCGCGCCCTTGCAGACTTACCGCGGCCGTGTCCGCGAA
GTCGCGCCGATGGCGGACGCCGCAACCCGCACTTACGCACTGCGGATTGCGCTGCCTGATGCCGGGTTGCCGCTGGGTGC
TACCGCCAGCGCCACTTTCCATACCGACGCTGCTGATTCACGCGTGCTGCCGGCGGCGGCAGTCACGCGCGCGGGCGAAG
GCGCGGTGGTGTGGGTGGTGGACAACGAGGAGCGGGTACGGCCGGTGGCCGTGGAGGTGCTGGCCTACGACGAACGCGGT
GCCACCTTGCGCGGTGGTCCGCCGGCCGGTACGCGCGTGGTGATTGCGGGCGTGCACAAGCTGGTTGAAGGCGAGGCGGT
GCGGGCGGTGGAATCCGGTGCTCCGGTCGCGCTGGATGCGCAGCGATGA

Upstream 100 bases:

>100_bases
GCTGCGCCACCGACATCGAACCGCGCGCCTATGTCGACGCGCATATCGACCTGGTCCTCCACGGGCTGCGCAACGACCCC
GTGCCCGCCGGAGTTGCCCG

Downstream 100 bases:

>100_bases
GCCGGCGCCGCGGCTTCAATATCTCCGCGTGGGGGCTCGCCCATCCCGCGCTGGTGCTCTACTGCCTGATCGCACTGAGC
CTGATCGGCATCCTCGCGTA

Product: membrane fusion protein

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MNPRSVLAPLAALLLVACSEAPPPPAAPRVVLVQRLAEPGAVESAELYTGEIRARYESPLAFRIGGKLVERKVEVGSEVR
RGQVLARLDPRDAELGAAAAAAQVAAARADAALAVAEYERAVGLRAQNFISGSALDARRSAREAAEAKLRQAEAQAAAAR
NQSGYTALVADSDGVVTALEAEVGQVLAEGQAVMTLARPGNRELLVHVPEGRMRELVPGREAEVRLWSAPLQTYRGRVRE
VAPMADAATRTYALRIALPDAGLPLGATASATFHTDAADSRVLPAAAVTRAGEGAVVWVVDNEERVRPVAVEVLAYDERG
ATLRGGPPAGTRVVIAGVHKLVEGEAVRAVESGAPVALDAQR

Sequences:

>Translated_362_residues
MNPRSVLAPLAALLLVACSEAPPPPAAPRVVLVQRLAEPGAVESAELYTGEIRARYESPLAFRIGGKLVERKVEVGSEVR
RGQVLARLDPRDAELGAAAAAAQVAAARADAALAVAEYERAVGLRAQNFISGSALDARRSAREAAEAKLRQAEAQAAAAR
NQSGYTALVADSDGVVTALEAEVGQVLAEGQAVMTLARPGNRELLVHVPEGRMRELVPGREAEVRLWSAPLQTYRGRVRE
VAPMADAATRTYALRIALPDAGLPLGATASATFHTDAADSRVLPAAAVTRAGEGAVVWVVDNEERVRPVAVEVLAYDERG
ATLRGGPPAGTRVVIAGVHKLVEGEAVRAVESGAPVALDAQR
>Mature_362_residues
MNPRSVLAPLAALLLVACSEAPPPPAAPRVVLVQRLAEPGAVESAELYTGEIRARYESPLAFRIGGKLVERKVEVGSEVR
RGQVLARLDPRDAELGAAAAAAQVAAARADAALAVAEYERAVGLRAQNFISGSALDARRSAREAAEAKLRQAEAQAAAAR
NQSGYTALVADSDGVVTALEAEVGQVLAEGQAVMTLARPGNRELLVHVPEGRMRELVPGREAEVRLWSAPLQTYRGRVRE
VAPMADAATRTYALRIALPDAGLPLGATASATFHTDAADSRVLPAAAVTRAGEGAVVWVVDNEERVRPVAVEVLAYDERG
ATLRGGPPAGTRVVIAGVHKLVEGEAVRAVESGAPVALDAQR

Specific function: The mdtABC tripartite complex confers resistance against novobiocin and deoxycholate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=315, Percent_Identity=26.984126984127, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87081796, Length=275, Percent_Identity=25.4545454545455, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081951, Length=199, Percent_Identity=28.1407035175879, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1789929, Length=377, Percent_Identity=25.1989389920424, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 37826; Mature: 37826

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPRSVLAPLAALLLVACSEAPPPPAAPRVVLVQRLAEPGAVESAELYTGEIRARYESPL
CCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCHHEEECCEEECCCCCE
AFRIGGKLVERKVEVGSEVRRGQVLARLDPRDAELGAAAAAAQVAAARADAALAVAEYER
EEECCHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVGLRAQNFISGSALDARRSAREAAEAKLRQAEAQAAAARNQSGYTALVADSDGVVTALE
HHCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEHH
AEVGQVLAEGQAVMTLARPGNRELLVHVPEGRMRELVPGREAEVRLWSAPLQTYRGRVRE
HHHHHHHHCCCEEEEEECCCCCEEEEECCCCHHHHHCCCCCCCEEEEHHHHHHHHHHHHH
VAPMADAATRTYALRIALPDAGLPLGATASATFHTDAADSRVLPAAAVTRAGEGAVVWVV
HHHHHHHCCEEEEEEEEECCCCCCCCCCCCCEEECCCCCCCCCCHHHHHCCCCCEEEEEE
DNEERVRPVAVEVLAYDERGATLRGGPPAGTRVVIAGVHKLVEGEAVRAVESGAPVALDA
CCCCCCCEEEEEEEEECCCCCEECCCCCCCCEEEEEHHHHHHCCHHHHHHHCCCCEEEEC
QR
CC
>Mature Secondary Structure
MNPRSVLAPLAALLLVACSEAPPPPAAPRVVLVQRLAEPGAVESAELYTGEIRARYESPL
CCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCHHEEECCEEECCCCCE
AFRIGGKLVERKVEVGSEVRRGQVLARLDPRDAELGAAAAAAQVAAARADAALAVAEYER
EEECCHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVGLRAQNFISGSALDARRSAREAAEAKLRQAEAQAAAARNQSGYTALVADSDGVVTALE
HHCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEHH
AEVGQVLAEGQAVMTLARPGNRELLVHVPEGRMRELVPGREAEVRLWSAPLQTYRGRVRE
HHHHHHHHCCCEEEEEECCCCCEEEEECCCCHHHHHCCCCCCCEEEEHHHHHHHHHHHHH
VAPMADAATRTYALRIALPDAGLPLGATASATFHTDAADSRVLPAAAVTRAGEGAVVWVV
HHHHHHHCCEEEEEEEEECCCCCCCCCCCCCEEECCCCCCCCCCHHHHHCCCCCEEEEEE
DNEERVRPVAVEVLAYDERGATLRGGPPAGTRVVIAGVHKLVEGEAVRAVESGAPVALDA
CCCCCCCEEEEEEEEECCCCCEECCCCCCCCEEEEEHHHHHHCCHHHHHHHCCCCEEEEC
QR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA