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The map label for this gene is acyH [H]

Identifier: 119896878

GI number: 119896878

Start: 617790

End: 619199

Strand: Reverse

Name: acyH [H]

Synonym: azo0587

Alternate gene names: 119896878

Gene position: 619199-617790 (Counterclockwise)

Preceding gene: 119896880

Following gene: 119896877

Centisome position: 14.15

GC content: 64.4

Gene sequence:

>1410_bases
ATGAACACTGTGGCTGACATCAAGGATTACGTGATTGCCGACCTGTCGCTCGCCGACTGGGGACGCAAGGAAATCCGCAT
CGCCGAAACCGAAATGCCGGGCCTGATGGCGATCCGCGAGGAATACGCCGCCCGCCAGCCCTTGAAGGGCGCGCGCATCA
CCGGCTCGCTGCACATGACCATCCAGACCGCGGTGCTGATCGAGACGCTAACCGCGCTCGGCGCCGAAGTGCGCTGGGCC
TCGTGCAACATCTTCTCCACCCAGGACCACGCCGCCGCCGCCATCGCCGCTTCGGGCGTGCCGGTGTTCGCGGTCAAGGG
TGAATCGCTGGAAGACTACTGGGACTACACCCACCGCATCTTCGAATGGAAGGACGGCGGCTACAGCAACATGATCCTCG
ACGACGGCGGCGATGCCACCCTGCTGCTGCACCTGGGCGCCCGCGCCGAGCAGGACATCGCGGTGCTGGACAAGCCGGAC
AGCGAGGAAGCGACCGTGCTGTTCGCCAGCATCAAGGCCAAGCTCAAGACCGACCCGACCTGGTACTCCACCCGCCTCGC
GCAGATCAAGGGCGTCACCGAAGAGACCACCACCGGCGTCCACCGCCTGTACCAGATGCACGCCAAGGGCGAACTCAAGT
TCCCGGCGATCAACGTCAACGATTCGGTCACCAAGTCCAAGTTCGACAACCTCTACGGCTGCCGTGAATCCCTGGTGGAT
GGCATCAAGCGCGCCACCGACGTGATGATCGCCGGCAAGATCGGCGTGGTGCTCGGCTACGGCGACGTGGGCAAGGGCTG
CGCCCAGTCGCTGCGCGGCCTCGGCGCCACCGTGTGGGTTACCGAAATCGACCCGATCTGCGCGCTGCAGGCGGCGATGG
AAGGCTTCCGCGTGGTCACCATGGAAGACGCCGCTGCGCTGGGCGACATCTTCGTCACCACCACCGGCAACGTCGGCGTG
ATCACCCACGAGCACATGAAGGCGATGAAGAACAACGCCATCGTCTGCAACATCGGCCACTTCGACTCCGAGATCGAAGT
CGCCAGCCTGCGCCAGTACGAGTGGGAGAACATCAAGCCCCAGGTCGACCACATCATCTTCCCGGACGGCAAGCGCATCA
TCCTGCTGGCCGAAGGCCGCCTGGTGAACCTGGGCTGCGCCACCGGCCATCCGAGCTTCGTGATGAGCAACTCCTTCGCC
AACCAGACCCTGGCGCAGATCGAGCTGTTCACCAAGACCGGCGACTACCCGGTCGGCGTGTACGTGCTGCCCAAGCAACT
GGACGAGATGGTCGCCCGCCTGCACCTGAAGAAGATCGGGGCGAATCTCACCGTGCTGAGCCAGGCCCAGGCCGACTACA
TCGGCGTGCCGGTCGAAGGCCCGTACAAGCCCAACCACTACCGCTACTGA

Upstream 100 bases:

>100_bases
CTTCAGAACTGCGCTCACCTAATAACCCGTGCCGGGCACGGGGTGACGAGGTGAGATCACCGTTGCACCCCCTCCCGGCC
ACACGTTCAAGGATTACGAC

Downstream 100 bases:

>100_bases
TCGCGGCGGCGGGCGGCCTGCGGGCTGCCCGCCTTGTCAGGACTAGGCCGGTTTCCTGCAAGGATGTCCGGTTGTTTTCG
CGAAGGCGGCGAAATGAGCA

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MNTVADIKDYVIADLSLADWGRKEIRIAETEMPGLMAIREEYAARQPLKGARITGSLHMTIQTAVLIETLTALGAEVRWA
SCNIFSTQDHAAAAIAASGVPVFAVKGESLEDYWDYTHRIFEWKDGGYSNMILDDGGDATLLLHLGARAEQDIAVLDKPD
SEEATVLFASIKAKLKTDPTWYSTRLAQIKGVTEETTTGVHRLYQMHAKGELKFPAINVNDSVTKSKFDNLYGCRESLVD
GIKRATDVMIAGKIGVVLGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGFRVVTMEDAAALGDIFVTTTGNVGV
ITHEHMKAMKNNAIVCNIGHFDSEIEVASLRQYEWENIKPQVDHIIFPDGKRIILLAEGRLVNLGCATGHPSFVMSNSFA
NQTLAQIELFTKTGDYPVGVYVLPKQLDEMVARLHLKKIGANLTVLSQAQADYIGVPVEGPYKPNHYRY

Sequences:

>Translated_469_residues
MNTVADIKDYVIADLSLADWGRKEIRIAETEMPGLMAIREEYAARQPLKGARITGSLHMTIQTAVLIETLTALGAEVRWA
SCNIFSTQDHAAAAIAASGVPVFAVKGESLEDYWDYTHRIFEWKDGGYSNMILDDGGDATLLLHLGARAEQDIAVLDKPD
SEEATVLFASIKAKLKTDPTWYSTRLAQIKGVTEETTTGVHRLYQMHAKGELKFPAINVNDSVTKSKFDNLYGCRESLVD
GIKRATDVMIAGKIGVVLGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGFRVVTMEDAAALGDIFVTTTGNVGV
ITHEHMKAMKNNAIVCNIGHFDSEIEVASLRQYEWENIKPQVDHIIFPDGKRIILLAEGRLVNLGCATGHPSFVMSNSFA
NQTLAQIELFTKTGDYPVGVYVLPKQLDEMVARLHLKKIGANLTVLSQAQADYIGVPVEGPYKPNHYRY
>Mature_469_residues
MNTVADIKDYVIADLSLADWGRKEIRIAETEMPGLMAIREEYAARQPLKGARITGSLHMTIQTAVLIETLTALGAEVRWA
SCNIFSTQDHAAAAIAASGVPVFAVKGESLEDYWDYTHRIFEWKDGGYSNMILDDGGDATLLLHLGARAEQDIAVLDKPD
SEEATVLFASIKAKLKTDPTWYSTRLAQIKGVTEETTTGVHRLYQMHAKGELKFPAINVNDSVTKSKFDNLYGCRESLVD
GIKRATDVMIAGKIGVVLGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGFRVVTMEDAAALGDIFVTTTGNVGV
ITHEHMKAMKNNAIVCNIGHFDSEIEVASLRQYEWENIKPQVDHIIFPDGKRIILLAEGRLVNLGCATGHPSFVMSNSFA
NQTLAQIELFTKTGDYPVGVYVLPKQLDEMVARLHLKKIGANLTVLSQAQADYIGVPVEGPYKPNHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=468, Percent_Identity=60.8974358974359, Blast_Score=548, Evalue=1e-156,
Organism=Homo sapiens, GI239937451, Length=440, Percent_Identity=61.5909090909091, Blast_Score=521, Evalue=1e-148,
Organism=Homo sapiens, GI24308043, Length=464, Percent_Identity=51.2931034482759, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI195539337, Length=464, Percent_Identity=51.2931034482759, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI298286489, Length=464, Percent_Identity=51.2931034482759, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI195539349, Length=464, Percent_Identity=51.2931034482759, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI21361647, Length=464, Percent_Identity=50.2155172413793, Blast_Score=451, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17506425, Length=465, Percent_Identity=61.9354838709677, Blast_Score=552, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6320882, Length=482, Percent_Identity=60.5809128630705, Blast_Score=544, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24642172, Length=462, Percent_Identity=61.4718614718615, Blast_Score=540, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24656245, Length=453, Percent_Identity=52.9801324503311, Blast_Score=466, Evalue=1e-131,
Organism=Drosophila melanogaster, GI45553387, Length=463, Percent_Identity=50.5399568034557, Blast_Score=443, Evalue=1e-124,
Organism=Drosophila melanogaster, GI45553385, Length=462, Percent_Identity=50.4329004329004, Blast_Score=441, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 51337; Mature: 51337

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTVADIKDYVIADLSLADWGRKEIRIAETEMPGLMAIREEYAARQPLKGARITGSLHMT
CCCHHHHHHHHEEECCHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEEEEE
IQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAIAASGVPVFAVKGESLEDYWDYTHRI
EHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHEEEECCCEEEEEECCCHHHHHHHHHEE
FEWKDGGYSNMILDDGGDATLLLHLGARAEQDIAVLDKPDSEEATVLFASIKAKLKTDPT
EEECCCCCCEEEEECCCCEEEEEEECCCCCCCEEEECCCCCCCCEEEEEEEEEECCCCCC
WYSTRLAQIKGVTEETTTGVHRLYQMHAKGELKFPAINVNDSVTKSKFDNLYGCRESLVD
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEECCEECCCCCHHHHHHHHHHHHHHHHHH
GIKRATDVMIAGKIGVVLGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGFRVVT
HHHHHHEEEEEECEEEEEECCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCEEEE
MEDAAALGDIFVTTTGNVGVITHEHMKAMKNNAIVCNIGHFDSEIEVASLRQYEWENIKP
ECCCCCCCCEEEEECCCEEEEEHHHHHHHHCCEEEEEECCCCCCEEHHHHHHCCCCCCCC
QVDHIIFPDGKRIILLAEGRLVNLGCATGHPSFVMSNSFANQTLAQIELFTKTGDYPVGV
CCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHCCEEEEEEEEECCCCEEEE
YVLPKQLDEMVARLHLKKIGANLTVLSQAQADYIGVPVEGPYKPNHYRY
EECHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MNTVADIKDYVIADLSLADWGRKEIRIAETEMPGLMAIREEYAARQPLKGARITGSLHMT
CCCHHHHHHHHEEECCHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEEEEE
IQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAIAASGVPVFAVKGESLEDYWDYTHRI
EHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHEEEECCCEEEEEECCCHHHHHHHHHEE
FEWKDGGYSNMILDDGGDATLLLHLGARAEQDIAVLDKPDSEEATVLFASIKAKLKTDPT
EEECCCCCCEEEEECCCCEEEEEEECCCCCCCEEEECCCCCCCCEEEEEEEEEECCCCCC
WYSTRLAQIKGVTEETTTGVHRLYQMHAKGELKFPAINVNDSVTKSKFDNLYGCRESLVD
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEECCEECCCCCHHHHHHHHHHHHHHHHHH
GIKRATDVMIAGKIGVVLGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGFRVVT
HHHHHHEEEEEECEEEEEECCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCEEEE
MEDAAALGDIFVTTTGNVGVITHEHMKAMKNNAIVCNIGHFDSEIEVASLRQYEWENIKP
ECCCCCCCCEEEEECCCEEEEEHHHHHHHHCCEEEEEECCCCCCEEHHHHHHCCCCCCCC
QVDHIIFPDGKRIILLAEGRLVNLGCATGHPSFVMSNSFANQTLAQIELFTKTGDYPVGV
CCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHCCEEEEEEEEECCCCEEEE
YVLPKQLDEMVARLHLKKIGANLTVLSQAQADYIGVPVEGPYKPNHYRY
EECHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA