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The map label for this gene is lysR [H]

Identifier: 119896874

GI number: 119896874

Start: 614751

End: 615716

Strand: Direct

Name: lysR [H]

Synonym: azo0583

Alternate gene names: 119896874

Gene position: 614751-615716 (Clockwise)

Preceding gene: 119896871

Following gene: 119896879

Centisome position: 14.05

GC content: 72.46

Gene sequence:

>966_bases
ATGAGCGAACTCAACCTCGAACCCCTCGCCGGCGCTGATCGCGTCGAGCTGCTGCGTACCCTCGTGCGCATCGTCGAAGC
CGGCAGCCTGTCGGCGGCGGCGCAGCAGCTTGGCATCACCCAGCCGACGGTCAGCCGGCGGCTGCAGGCGCTGGAGCGCG
CGCTCGGCCTCAAGCTGCTGCAGCGCTCCACCCACGGCATGAAACTCACGGGCGAGGGCGAGCGCTGCTACGCCCATGCG
CGCGACCTGATCGAGCGCTGGCAGGCGATGGAAACCGACCTGCATGGTGCCCGCGACGAACCGCGCGGCAACCTGCGGGT
GCTGGTGCCGCACGCCTTCGGCCAAGGCCAGCTGATCGCGCCGCTGGTCGATTACTTGCGGCGCTATCCGGAAGTGGCGG
TGGAGTGGCTGCTGCACGACCGCCGCCCGGACTTTCTCGCCGAGGGCATCGACTGCGCGATCCAGGTCGGCGAGGTTGCG
GATCCGGGCGTGGTGGCGGTGCGGCTGGCGGAGGTGCCGCGCATCGTGGTGGCGGCGCCGGGCGCGTGGGGCGAGGGCGC
GCCGCCCGCGGCCCCCGAAGCGCTGGCGGCGATGCCGTGGCTGGCGCTGCGCACCTACTACCGCGATGAGGTGCTGCTGG
TGCGTAGCGGCGACGGTGAGCGCAGCCGCTTCCCGATCCGGCCGCGGCTGAGTACCGACAGCCTGTACGCGCTGCGTACC
GCGGCGCTGACCGGACTGGGCGCCTGCGTGACGTCAGCGTGGGTCGTCGCCGACGATGTCGCGGGGGGCAAGCTGTGCCA
CCTGCTGCCGGAGTGGGAGGCTCCGCCGTTGCCGGTGTATCTGGTCTATCCGCACGCCCGCCACTATCCGGCCAAGCTGC
GGGTGTTCAACGCGATGATGCGCGCCTGCATGCCGGCGCTGGGCGGCATGCGCCCGCCGACGCCGGCTTCCGCCGGCCTC
GGCTGA

Upstream 100 bases:

>100_bases
TCATGGAAAACTCCGGGGTGTGGGGCGACGGATGAATTCTTCCTTTTGACGATGCGGGTTTGTAGTGGCGGGAGATGCAG
GACTGTTATACGTTTGACGC

Downstream 100 bases:

>100_bases
GCCCCCGCTTGGGGGCCTTCTATCTCAGGCCAGCCCGAGGCGCTTGCAGATCTCGGTGGTGAGCGCGGACTGGTTCATGC
TGTAGAAGTGCAGGCCGGGG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MSELNLEPLAGADRVELLRTLVRIVEAGSLSAAAQQLGITQPTVSRRLQALERALGLKLLQRSTHGMKLTGEGERCYAHA
RDLIERWQAMETDLHGARDEPRGNLRVLVPHAFGQGQLIAPLVDYLRRYPEVAVEWLLHDRRPDFLAEGIDCAIQVGEVA
DPGVVAVRLAEVPRIVVAAPGAWGEGAPPAAPEALAAMPWLALRTYYRDEVLLVRSGDGERSRFPIRPRLSTDSLYALRT
AALTGLGACVTSAWVVADDVAGGKLCHLLPEWEAPPLPVYLVYPHARHYPAKLRVFNAMMRACMPALGGMRPPTPASAGL
G

Sequences:

>Translated_321_residues
MSELNLEPLAGADRVELLRTLVRIVEAGSLSAAAQQLGITQPTVSRRLQALERALGLKLLQRSTHGMKLTGEGERCYAHA
RDLIERWQAMETDLHGARDEPRGNLRVLVPHAFGQGQLIAPLVDYLRRYPEVAVEWLLHDRRPDFLAEGIDCAIQVGEVA
DPGVVAVRLAEVPRIVVAAPGAWGEGAPPAAPEALAAMPWLALRTYYRDEVLLVRSGDGERSRFPIRPRLSTDSLYALRT
AALTGLGACVTSAWVVADDVAGGKLCHLLPEWEAPPLPVYLVYPHARHYPAKLRVFNAMMRACMPALGGMRPPTPASAGL
G
>Mature_320_residues
SELNLEPLAGADRVELLRTLVRIVEAGSLSAAAQQLGITQPTVSRRLQALERALGLKLLQRSTHGMKLTGEGERCYAHAR
DLIERWQAMETDLHGARDEPRGNLRVLVPHAFGQGQLIAPLVDYLRRYPEVAVEWLLHDRRPDFLAEGIDCAIQVGEVAD
PGVVAVRLAEVPRIVVAAPGAWGEGAPPAAPEALAAMPWLALRTYYRDEVLLVRSGDGERSRFPIRPRLSTDSLYALRTA
ALTGLGACVTSAWVVADDVAGGKLCHLLPEWEAPPLPVYLVYPHARHYPAKLRVFNAMMRACMPALGGMRPPTPASAGLG

Specific function: Positive regulator required for L-tartrate-dependent anaerobic growth on glycerol. Induces expression of the ttdA-ttdB- ygjE operon [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789440, Length=308, Percent_Identity=32.4675324675325, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1789639, Length=284, Percent_Identity=29.2253521126761, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI145693193, Length=298, Percent_Identity=28.5234899328859, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI87081978, Length=287, Percent_Identity=28.9198606271777, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1786401, Length=288, Percent_Identity=28.4722222222222, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1787128, Length=288, Percent_Identity=22.5694444444444, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1787589, Length=284, Percent_Identity=23.943661971831, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786713, Length=116, Percent_Identity=32.7586206896552, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI157672245, Length=166, Percent_Identity=29.5180722891566, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790783, Length=283, Percent_Identity=22.2614840989399, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789173, Length=173, Percent_Identity=28.9017341040462, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787601, Length=129, Percent_Identity=24.8062015503876, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34925; Mature: 34794

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: PS50931 HTH_LYSR ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELNLEPLAGADRVELLRTLVRIVEAGSLSAAAQQLGITQPTVSRRLQALERALGLKLL
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
QRSTHGMKLTGEGERCYAHARDLIERWQAMETDLHGARDEPRGNLRVLVPHAFGQGQLIA
HHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCHH
PLVDYLRRYPEVAVEWLLHDRRPDFLAEGIDCAIQVGEVADPGVVAVRLAEVPRIVVAAP
HHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEECCCCCCCCEEEEHHHCCEEEEECC
GAWGEGAPPAAPEALAAMPWLALRTYYRDEVLLVRSGDGERSRFPIRPRLSTDSLYALRT
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHH
AALTGLGACVTSAWVVADDVAGGKLCHLLPEWEAPPLPVYLVYPHARHYPAKLRVFNAMM
HHHHHHHHHHHHHHHEECCCCCCCEEEECCCCCCCCCCEEEECCCCCCCCHHHHHHHHHH
RACMPALGGMRPPTPASAGLG
HHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SELNLEPLAGADRVELLRTLVRIVEAGSLSAAAQQLGITQPTVSRRLQALERALGLKLL
CCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
QRSTHGMKLTGEGERCYAHARDLIERWQAMETDLHGARDEPRGNLRVLVPHAFGQGQLIA
HHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCHH
PLVDYLRRYPEVAVEWLLHDRRPDFLAEGIDCAIQVGEVADPGVVAVRLAEVPRIVVAAP
HHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEECCCCCCCCEEEEHHHCCEEEEECC
GAWGEGAPPAAPEALAAMPWLALRTYYRDEVLLVRSGDGERSRFPIRPRLSTDSLYALRT
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHH
AALTGLGACVTSAWVVADDVAGGKLCHLLPEWEAPPLPVYLVYPHARHYPAKLRVFNAMM
HHHHHHHHHHHHHHHEECCCCCCCEEEECCCCCCCCCCEEEECCCCCCCCHHHHHHHHHH
RACMPALGGMRPPTPASAGLG
HHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]