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The map label for this gene is fadA1 [H]

Identifier: 119896755

GI number: 119896755

Start: 498430

End: 499902

Strand: Direct

Name: fadA1 [H]

Synonym: azo0464

Alternate gene names: 119896755

Gene position: 498430-499902 (Clockwise)

Preceding gene: 119896754

Following gene: 119896756

Centisome position: 11.39

GC content: 74.27

Gene sequence:

>1473_bases
ATGAGCACCCGCGCCCGGCCGCCCGAAGCGGGTGCGTCCTCCCTCGGGGAGGATGTCGCGCAGCGACAGGAGGGCGGTGG
CATGAGCACCCGCGCCCGGCCGCCCGAAGCGGGTGCGCCCTCCCTCGGGGAGGATGTCGCGCAGCGACAGGAGGACGGTG
GCGTGAGCATGAATGCGATGCCGGAAGCACGCGACGTGTACATCATCGACGGCGCGCGCACGCCCTTCCTGAAGGCGCGC
AACGCGCCCGGGCCGTTTGCCGCGGCGGATCTCGCCACCGCCGCCGGCAGCGCGCTGCTGCTGCGCCAGTCCTTCGCCCC
CGATGCGCTCGACGAGGTCATCCTCGGCTGCGCCAGTCCGTCGCCGGACGAGGTCAACATCGGCCGCGTGGTGGCCCTGC
GCATGGGCTGCGGGCCCCGGGTGCCCGGCTGGACGGTGATGCGCAACTGCGCCAGCGGCATGCAGGCGCTGGATTCCGCC
TGCGCCAACATCCGCGGCGGCCGCGCCGATCTGGTGCTGGCGGGCGGCGTCGATGCGCTGTCGCGCGCGCCGCTGCTGTT
CTCCGACGCGATGGTGCGCTGGCTCGCCGGCTGGTACGCGGCCAAGGGCGCGGGGCAGAAGCTGGCCGCGCTGCGGCACT
TCCGCCCCGCCTACCTCGCGCCGGTGATCGGCATCGTGCGTGGCCTCACCGACCCCTATGTCGGGCAGATGATGGGCCAG
ACCGCCGAGAACCTCGCCTGGCAGTTCCGCATCAGCCGCGAGGAGATGGACGTCTATGCCGCCGAAAGCCACCGCCGCGC
GATCGCCGCGCACGACGGCGGCCGCTTTGCCGACGAACTGGCGCCGCTGGTGGGGCGCGACGGCACGGTGTACGCGGCCG
ACGACGGCGTGCGGCGCGACTCCACGCCGGCCGCACTCGCGCGGCTCAAACCCTTCTTCGACAAGCGCTACGGCCGCGTC
ACCGCCGGCAACAGCTCGCAGGTCAGCGACGGCGCCGCGTGGCTGCTGCTGGCCTCGGCCGCCGCGGTGGAGCGCCACGG
CCTGCAACCGCTCGGCCGCATCGTCGACAGCGCGTGGGCGGCGCTGCCGCCCGAACACATGGGCCTTGGCCCGGTGCATG
CGGCGATGCCGCTGCTCGCCCGCCATCAACTGGCCACGCGCGACCTCGCCGCGTGGGAGATCAACGAAGCCTTCGCCGCC
CAGCTCATCGCCTGCCTGCGTGCGCTGGACGACGACGGCTATTGCCAGGACCACTTCGGATTGCCCGCGCCCGGCGCGCC
CGACCCGGCCCGCCTCAACGTCGACGGCGGCGCGGTCGCGCTCGGGCATCCGGTGGGCGCGAGCGGCGCGCGCATCGTGC
TGCACCTGCTGCATGTACTGCGGCGCGAGGGCGTGGCCGGCGCGCGCGGCATCGCCAGCCTGTGCGTCGGCGGCGGGCAG
GGCGGGGCGATGCTGGTGGAGGCAATGGCATGA

Upstream 100 bases:

>100_bases
GCGCCGAACTGCGCGACAAGGTGATCCGGGTGGACGACTTCCCCTTCGACCTCGCCGCCGAAACCGGCAGCGAAGCGGCG
CCGAAGATGCGGGTGGTGGC

Downstream 100 bases:

>100_bases
ACGCGGTGGCTGATCTCGCCCGCAGCGACTGGCATCACTGGCGCATCGAGCGCAGCCCGGACGCGATCCTGTGGCTGTGG
CTGGACCGGGCCGGCGCCAG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: 3-oxoadipyl-CoA thiolase [H]

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MSTRARPPEAGASSLGEDVAQRQEGGGMSTRARPPEAGAPSLGEDVAQRQEDGGVSMNAMPEARDVYIIDGARTPFLKAR
NAPGPFAAADLATAAGSALLLRQSFAPDALDEVILGCASPSPDEVNIGRVVALRMGCGPRVPGWTVMRNCASGMQALDSA
CANIRGGRADLVLAGGVDALSRAPLLFSDAMVRWLAGWYAAKGAGQKLAALRHFRPAYLAPVIGIVRGLTDPYVGQMMGQ
TAENLAWQFRISREEMDVYAAESHRRAIAAHDGGRFADELAPLVGRDGTVYAADDGVRRDSTPAALARLKPFFDKRYGRV
TAGNSSQVSDGAAWLLLASAAAVERHGLQPLGRIVDSAWAALPPEHMGLGPVHAAMPLLARHQLATRDLAAWEINEAFAA
QLIACLRALDDDGYCQDHFGLPAPGAPDPARLNVDGGAVALGHPVGASGARIVLHLLHVLRREGVAGARGIASLCVGGGQ
GGAMLVEAMA

Sequences:

>Translated_490_residues
MSTRARPPEAGASSLGEDVAQRQEGGGMSTRARPPEAGAPSLGEDVAQRQEDGGVSMNAMPEARDVYIIDGARTPFLKAR
NAPGPFAAADLATAAGSALLLRQSFAPDALDEVILGCASPSPDEVNIGRVVALRMGCGPRVPGWTVMRNCASGMQALDSA
CANIRGGRADLVLAGGVDALSRAPLLFSDAMVRWLAGWYAAKGAGQKLAALRHFRPAYLAPVIGIVRGLTDPYVGQMMGQ
TAENLAWQFRISREEMDVYAAESHRRAIAAHDGGRFADELAPLVGRDGTVYAADDGVRRDSTPAALARLKPFFDKRYGRV
TAGNSSQVSDGAAWLLLASAAAVERHGLQPLGRIVDSAWAALPPEHMGLGPVHAAMPLLARHQLATRDLAAWEINEAFAA
QLIACLRALDDDGYCQDHFGLPAPGAPDPARLNVDGGAVALGHPVGASGARIVLHLLHVLRREGVAGARGIASLCVGGGQ
GGAMLVEAMA
>Mature_489_residues
STRARPPEAGASSLGEDVAQRQEGGGMSTRARPPEAGAPSLGEDVAQRQEDGGVSMNAMPEARDVYIIDGARTPFLKARN
APGPFAAADLATAAGSALLLRQSFAPDALDEVILGCASPSPDEVNIGRVVALRMGCGPRVPGWTVMRNCASGMQALDSAC
ANIRGGRADLVLAGGVDALSRAPLLFSDAMVRWLAGWYAAKGAGQKLAALRHFRPAYLAPVIGIVRGLTDPYVGQMMGQT
AENLAWQFRISREEMDVYAAESHRRAIAAHDGGRFADELAPLVGRDGTVYAADDGVRRDSTPAALARLKPFFDKRYGRVT
AGNSSQVSDGAAWLLLASAAAVERHGLQPLGRIVDSAWAALPPEHMGLGPVHAAMPLLARHQLATRDLAAWEINEAFAAQ
LIACLRALDDDGYCQDHFGLPAPGAPDPARLNVDGGAVALGHPVGASGARIVLHLLHVLRREGVAGARGIASLCVGGGQG
GAMLVEAMA

Specific function: Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=431, Percent_Identity=37.122969837587, Blast_Score=249, Evalue=5e-66,
Organism=Homo sapiens, GI4504327, Length=432, Percent_Identity=35.4166666666667, Blast_Score=246, Evalue=4e-65,
Organism=Homo sapiens, GI4557237, Length=434, Percent_Identity=32.7188940092166, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI148539872, Length=426, Percent_Identity=34.2723004694836, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI4501853, Length=434, Percent_Identity=33.6405529953917, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI194353979, Length=264, Percent_Identity=30.3030303030303, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI87082165, Length=429, Percent_Identity=37.0629370629371, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1787663, Length=439, Percent_Identity=36.6742596810934, Blast_Score=215, Evalue=6e-57,
Organism=Escherichia coli, GI1788554, Length=428, Percent_Identity=36.214953271028, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI48994986, Length=433, Percent_Identity=35.5658198614319, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1788683, Length=426, Percent_Identity=32.6291079812207, Blast_Score=195, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI133906874, Length=427, Percent_Identity=35.8313817330211, Blast_Score=221, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI17551802, Length=437, Percent_Identity=31.1212814645309, Blast_Score=204, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI17535921, Length=430, Percent_Identity=30.6976744186047, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI25147385, Length=439, Percent_Identity=29.1571753986333, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17535917, Length=439, Percent_Identity=25.7403189066059, Blast_Score=119, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6322031, Length=357, Percent_Identity=33.3333333333333, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6325229, Length=442, Percent_Identity=32.1266968325792, Blast_Score=173, Evalue=5e-44,
Organism=Drosophila melanogaster, GI17137578, Length=428, Percent_Identity=34.5794392523364, Blast_Score=248, Evalue=5e-66,
Organism=Drosophila melanogaster, GI24655093, Length=430, Percent_Identity=36.2790697674419, Blast_Score=232, Evalue=5e-61,
Organism=Drosophila melanogaster, GI17648125, Length=432, Percent_Identity=34.9537037037037, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI24640423, Length=435, Percent_Identity=31.9540229885057, Blast_Score=196, Evalue=4e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012793
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.174 [H]

Molecular weight: Translated: 51064; Mature: 50932

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTRARPPEAGASSLGEDVAQRQEGGGMSTRARPPEAGAPSLGEDVAQRQEDGGVSMNAM
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCC
PEARDVYIIDGARTPFLKARNAPGPFAAADLATAAGSALLLRQSFAPDALDEVILGCASP
CCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHCCCC
SPDEVNIGRVVALRMGCGPRVPGWTVMRNCASGMQALDSACANIRGGRADLVLAGGVDAL
CCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHH
SRAPLLFSDAMVRWLAGWYAAKGAGQKLAALRHFRPAYLAPVIGIVRGLTDPYVGQMMGQ
HCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHH
TAENLAWQFRISREEMDVYAAESHRRAIAAHDGGRFADELAPLVGRDGTVYAADDGVRRD
HHHHCEEEEEECHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCCCEEEECCCCCCCC
STPAALARLKPFFDKRYGRVTAGNSSQVSDGAAWLLLASAAAVERHGLQPLGRIVDSAWA
CCHHHHHHHHHHHHHHCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ALPPEHMGLGPVHAAMPLLARHQLATRDLAAWEINEAFAAQLIACLRALDDDGYCQDHFG
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
LPAPGAPDPARLNVDGGAVALGHPVGASGARIVLHLLHVLRREGVAGARGIASLCVGGGQ
CCCCCCCCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
GGAMLVEAMA
CCCEEEEECC
>Mature Secondary Structure 
STRARPPEAGASSLGEDVAQRQEGGGMSTRARPPEAGAPSLGEDVAQRQEDGGVSMNAM
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCC
PEARDVYIIDGARTPFLKARNAPGPFAAADLATAAGSALLLRQSFAPDALDEVILGCASP
CCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHCCCC
SPDEVNIGRVVALRMGCGPRVPGWTVMRNCASGMQALDSACANIRGGRADLVLAGGVDAL
CCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHH
SRAPLLFSDAMVRWLAGWYAAKGAGQKLAALRHFRPAYLAPVIGIVRGLTDPYVGQMMGQ
HCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHH
TAENLAWQFRISREEMDVYAAESHRRAIAAHDGGRFADELAPLVGRDGTVYAADDGVRRD
HHHHCEEEEEECHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCCCEEEECCCCCCCC
STPAALARLKPFFDKRYGRVTAGNSSQVSDGAAWLLLASAAAVERHGLQPLGRIVDSAWA
CCHHHHHHHHHHHHHHCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ALPPEHMGLGPVHAAMPLLARHQLATRDLAAWEINEAFAAQLIACLRALDDDGYCQDHFG
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
LPAPGAPDPARLNVDGGAVALGHPVGASGARIVLHLLHVLRREGVAGARGIASLCVGGGQ
CCCCCCCCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
GGAMLVEAMA
CCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]