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The map label for this gene is fadB1 [H]

Identifier: 119896756

GI number: 119896756

Start: 499899

End: 501935

Strand: Direct

Name: fadB1 [H]

Synonym: azo0465

Alternate gene names: 119896756

Gene position: 499899-501935 (Clockwise)

Preceding gene: 119896755

Following gene: 119896757

Centisome position: 11.42

GC content: 73.98

Gene sequence:

>2037_bases
ATGAACGCGGTGGCTGATCTCGCCCGCAGCGACTGGCATCACTGGCGCATCGAGCGCAGCCCGGACGCGATCCTGTGGCT
GTGGCTGGACCGGGCCGGCGCCAGCGCCAACACCCTGTCGGCCGCGGTGCTGGACGAATTCGAGGTGGTGCTGGCGGCGC
TGGAGGCCAACCTGCCGGCGGCGCTCGTCATCGCTTCCGCCAAGCCGGCCGGCTTCGTCGCCGGGGCCGACATCGAGGAG
TTCTCCGCACTGCCGGATCCGCATGCGGCGCGCGCGCTGGTCGAACGCGGCTGGCGCCTGTTCGACCGCCTCGCCGCGCT
GCGCTGCCCGACGCTGGCGCTGATCCGCGGCCACTGCATGGGCGGCGGGCTGGAGCTGGCCCTGGCCTGCCGCTACCGCC
TGGTGGTGGACGAGCCCGCCACCCGGCTCGCGCTGCCGGAGGTAATGCTCGGCATCGTTCCGGCCTGGGGCGGCATGCGC
CGCCTGCCGGCGCTGATCGGTCCGGTGGCCGCGCTCGACATGATGCTCACCGGCCGCAGCCTCGATGCGCGCCGCGCGCG
CCGGATCGGCCTCGCGGACGACTGCGTGCCGCCGCGGGTGATGGAAAACGCCGCCCGCGTGCTGGTCAGCTCGGGCCAGC
GTCCGGCCTTGCCCGGCCTGCTCGCGCGCCTGCTCAACGGGCCGCTGAAGCCGCTTGTCGCGGCGCGCGCGCAGCGCCAG
ACGGCGGCCCGCGTCAGCCGCGCGCACTACCCCGCGCCGTTCGCGATCATCGACATCTGGGCGCGCCACGGCGGTAATGC
GCTGGCCGTGCCGGCGGGCGATCCGGCCTCGCTGGAGACGATCTTCGCCTCGCCCACCGCGCATAACCTGGCGCGCGTGT
TCTTTCTGCGCGAGCGGTTGAAAGGCTTCGGCAAGCAGGCGGCGTTCGCGCCGCGCCAGGTGCACGTGGTGGGCGCCGGC
ATCATGGGCGGCGACATTGCCGCGGTGTGCGCGCTGGCCGGGCTGAGGGTGACGCTGCAGGACCAGGGCGTGGACCGGAT
TGCGCCGGCCATCGCGCGCGCCGCGCGGCTGTTCGAGCGCCGCCTGCGCGGCGACGCGCGCGCGCAGCGGCTGGCGCTGG
ACCGGCTGATCCCCGATCCGCAGGGGCGCGGGGTGGCCGCGGCCGACCTCGTGATCGAGGCGATCAGCGAAAACCTCGAT
GCCAAGCGTGCGCTGTTCGCCGACCTGGAAGCCCGTGCCCGACCGGACGCGCTGCTCGCCACCAACACCTCCAGCCTGCG
GCTGGCCGACATCGCCGCCGGCATGCGCACGCCGGCGCGGCTGGTGGGCATCCATTTTTTCAATCCGGTGGCAAAGATGC
CGCTGGTCGAGGTGGTGAGCGCCGCGGCCACCGCGGCGGAGGATGCGGCGCGCGCGGCCGCCTTCGTCCGCCTGCTCGAC
AAGCTGGCGCTGCCGGTGCGCGATGTGCCCGGCTTCCTGGTCAACGCCGCGCTGGCGCCCTACATGCTGGAAGCGCTGCG
CTGCGTCGAAGAGGGCGTGGCGCCCGCGGTGGTGGATGCGGCGCTGACCCGCTTCGGCATGGCGATGGGCCCGGTGGAAC
TGGTCGACACCGTCGGGCTGGACGTGGCGCTGGCGGCCGGCAAGGCCTTGGCTGCGGGGGCCGAGGTGCCGCCGCAACTG
GCGGCGCGGGTGGCCGAAGGCAAGCTCGGGCGCAAGACGGGCGAGGGCTATTACCGCTGGGCGCCGCAGCCGGGCGGGGA
GGCGCGCATCGTCGGGCGCGCGCCGGTGGAGGCGGTGCCGGAGGGACTGGCCGAGCGCGTGCTCGCCCCGCTGTTGGCGG
CGGTGCGGCACAGCGTGGCCGAAGGCGTGGTGGCCGATGCCGACCTCGCCGACGCGGGGCTCATCTTCGGGGCGGGTTTC
GCACCCTGGACGGGCGGTCCGCTGCATCATGCGCAGGGGCGCGATTTCCGGATTGGCGCCTCTGCTGCAAAGCAGCAAAC
TGGACCGGCTCCTACAACACAACAGGTATCGCGATGA

Upstream 100 bases:

>100_bases
TGCATGTACTGCGGCGCGAGGGCGTGGCCGGCGCGCGCGGCATCGCCAGCCTGTGCGTCGGCGGCGGGCAGGGCGGGGCG
ATGCTGGTGGAGGCAATGGC

Downstream 100 bases:

>100_bases
CCCCTCCTGTCGAGAACATCTCCCTCCCCGACGACAAGTTCCTCACCCTGCGCGTGGTGCCGATGCCCGGCGACCTCAAT
CCTTCCGGCGACGTGTTCGG

Product: enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase; 3-hydroxyacyl-CoA dehydrogenase [H]

Number of amino acids: Translated: 678; Mature: 678

Protein sequence:

>678_residues
MNAVADLARSDWHHWRIERSPDAILWLWLDRAGASANTLSAAVLDEFEVVLAALEANLPAALVIASAKPAGFVAGADIEE
FSALPDPHAARALVERGWRLFDRLAALRCPTLALIRGHCMGGGLELALACRYRLVVDEPATRLALPEVMLGIVPAWGGMR
RLPALIGPVAALDMMLTGRSLDARRARRIGLADDCVPPRVMENAARVLVSSGQRPALPGLLARLLNGPLKPLVAARAQRQ
TAARVSRAHYPAPFAIIDIWARHGGNALAVPAGDPASLETIFASPTAHNLARVFFLRERLKGFGKQAAFAPRQVHVVGAG
IMGGDIAAVCALAGLRVTLQDQGVDRIAPAIARAARLFERRLRGDARAQRLALDRLIPDPQGRGVAAADLVIEAISENLD
AKRALFADLEARARPDALLATNTSSLRLADIAAGMRTPARLVGIHFFNPVAKMPLVEVVSAAATAAEDAARAAAFVRLLD
KLALPVRDVPGFLVNAALAPYMLEALRCVEEGVAPAVVDAALTRFGMAMGPVELVDTVGLDVALAAGKALAAGAEVPPQL
AARVAEGKLGRKTGEGYYRWAPQPGGEARIVGRAPVEAVPEGLAERVLAPLLAAVRHSVAEGVVADADLADAGLIFGAGF
APWTGGPLHHAQGRDFRIGASAAKQQTGPAPTTQQVSR

Sequences:

>Translated_678_residues
MNAVADLARSDWHHWRIERSPDAILWLWLDRAGASANTLSAAVLDEFEVVLAALEANLPAALVIASAKPAGFVAGADIEE
FSALPDPHAARALVERGWRLFDRLAALRCPTLALIRGHCMGGGLELALACRYRLVVDEPATRLALPEVMLGIVPAWGGMR
RLPALIGPVAALDMMLTGRSLDARRARRIGLADDCVPPRVMENAARVLVSSGQRPALPGLLARLLNGPLKPLVAARAQRQ
TAARVSRAHYPAPFAIIDIWARHGGNALAVPAGDPASLETIFASPTAHNLARVFFLRERLKGFGKQAAFAPRQVHVVGAG
IMGGDIAAVCALAGLRVTLQDQGVDRIAPAIARAARLFERRLRGDARAQRLALDRLIPDPQGRGVAAADLVIEAISENLD
AKRALFADLEARARPDALLATNTSSLRLADIAAGMRTPARLVGIHFFNPVAKMPLVEVVSAAATAAEDAARAAAFVRLLD
KLALPVRDVPGFLVNAALAPYMLEALRCVEEGVAPAVVDAALTRFGMAMGPVELVDTVGLDVALAAGKALAAGAEVPPQL
AARVAEGKLGRKTGEGYYRWAPQPGGEARIVGRAPVEAVPEGLAERVLAPLLAAVRHSVAEGVVADADLADAGLIFGAGF
APWTGGPLHHAQGRDFRIGASAAKQQTGPAPTTQQVSR
>Mature_678_residues
MNAVADLARSDWHHWRIERSPDAILWLWLDRAGASANTLSAAVLDEFEVVLAALEANLPAALVIASAKPAGFVAGADIEE
FSALPDPHAARALVERGWRLFDRLAALRCPTLALIRGHCMGGGLELALACRYRLVVDEPATRLALPEVMLGIVPAWGGMR
RLPALIGPVAALDMMLTGRSLDARRARRIGLADDCVPPRVMENAARVLVSSGQRPALPGLLARLLNGPLKPLVAARAQRQ
TAARVSRAHYPAPFAIIDIWARHGGNALAVPAGDPASLETIFASPTAHNLARVFFLRERLKGFGKQAAFAPRQVHVVGAG
IMGGDIAAVCALAGLRVTLQDQGVDRIAPAIARAARLFERRLRGDARAQRLALDRLIPDPQGRGVAAADLVIEAISENLD
AKRALFADLEARARPDALLATNTSSLRLADIAAGMRTPARLVGIHFFNPVAKMPLVEVVSAAATAAEDAARAAAFVRLLD
KLALPVRDVPGFLVNAALAPYMLEALRCVEEGVAPAVVDAALTRFGMAMGPVELVDTVGLDVALAAGKALAAGAEVPPQL
AARVAEGKLGRKTGEGYYRWAPQPGGEARIVGRAPVEAVPEGLAERVLAPLLAAVRHSVAEGVVADADLADAGLIFGAGF
APWTGGPLHHAQGRDFRIGASAAKQQTGPAPTTQQVSR

Specific function: Catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the central section; belongs to the 3-hydroxyacyl- CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI20127408, Length=678, Percent_Identity=30.6784660766962, Blast_Score=286, Evalue=4e-77,
Organism=Homo sapiens, GI68989263, Length=663, Percent_Identity=28.8084464555053, Blast_Score=204, Evalue=3e-52,
Organism=Homo sapiens, GI261878539, Length=579, Percent_Identity=28.6701208981002, Blast_Score=189, Evalue=8e-48,
Organism=Homo sapiens, GI296179429, Length=294, Percent_Identity=36.734693877551, Blast_Score=163, Evalue=6e-40,
Organism=Homo sapiens, GI296179427, Length=311, Percent_Identity=34.0836012861736, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI194097323, Length=167, Percent_Identity=29.3413173652695, Blast_Score=87, Evalue=8e-17,
Organism=Homo sapiens, GI115430219, Length=232, Percent_Identity=29.3103448275862, Blast_Score=80, Evalue=9e-15,
Organism=Homo sapiens, GI157694516, Length=136, Percent_Identity=30.8823529411765, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI213417737, Length=136, Percent_Identity=30.8823529411765, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI157694520, Length=136, Percent_Identity=30.8823529411765, Blast_Score=73, Evalue=8e-13,
Organism=Escherichia coli, GI1788682, Length=664, Percent_Identity=34.9397590361446, Blast_Score=312, Evalue=4e-86,
Organism=Escherichia coli, GI1790281, Length=671, Percent_Identity=31.4456035767511, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI1787661, Length=280, Percent_Identity=43.2142857142857, Blast_Score=172, Evalue=6e-44,
Organism=Escherichia coli, GI1787659, Length=174, Percent_Identity=33.9080459770115, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI221142681, Length=194, Percent_Identity=33.5051546391753, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17508953, Length=684, Percent_Identity=32.1637426900585, Blast_Score=289, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI17508951, Length=684, Percent_Identity=32.1637426900585, Blast_Score=289, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI17558304, Length=691, Percent_Identity=30.5354558610709, Blast_Score=287, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI25144276, Length=614, Percent_Identity=32.7361563517915, Blast_Score=273, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17549919, Length=290, Percent_Identity=40.6896551724138, Blast_Score=182, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17553560, Length=285, Percent_Identity=38.5964912280702, Blast_Score=181, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17563036, Length=296, Percent_Identity=35.8108108108108, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71985923, Length=382, Percent_Identity=27.4869109947644, Blast_Score=155, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI71985930, Length=358, Percent_Identity=27.6536312849162, Blast_Score=152, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17540714, Length=194, Percent_Identity=29.3814432989691, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25145438, Length=235, Percent_Identity=25.1063829787234, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17554946, Length=161, Percent_Identity=25.4658385093168, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24583077, Length=687, Percent_Identity=32.7510917030568, Blast_Score=274, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24583079, Length=687, Percent_Identity=32.7510917030568, Blast_Score=274, Evalue=2e-73,
Organism=Drosophila melanogaster, GI19921000, Length=687, Percent_Identity=32.7510917030568, Blast_Score=274, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24653139, Length=191, Percent_Identity=30.8900523560209, Blast_Score=87, Evalue=5e-17,
Organism=Drosophila melanogaster, GI20129971, Length=191, Percent_Identity=26.7015706806283, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24653477, Length=191, Percent_Identity=26.7015706806283, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI45549573, Length=235, Percent_Identity=26.8085106382979, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24650670, Length=160, Percent_Identity=30.625, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR018376
- InterPro:   IPR012802
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =4.2.1.17; =5.1.2.3; =1.1.1.35 [H]

Molecular weight: Translated: 71271; Mature: 71271

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAVADLARSDWHHWRIERSPDAILWLWLDRAGASANTLSAAVLDEFEVVLAALEANLPA
CCHHHHHHHCCCHHEEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCE
ALVIASAKPAGFVAGADIEEFSALPDPHAARALVERGWRLFDRLAALRCPTLALIRGHCM
EEEEECCCCCCEEECCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
GGGLELALACRYRLVVDEPATRLALPEVMLGIVPAWGGMRRLPALIGPVAALDMMLTGRS
CCCHHEEEEEEEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCC
LDARRARRIGLADDCVPPRVMENAARVLVSSGQRPALPGLLARLLNGPLKPLVAARAQRQ
CCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHH
TAARVSRAHYPAPFAIIDIWARHGGNALAVPAGDPASLETIFASPTAHNLARVFFLRERL
HHHHHHHHCCCCCHHHHHHHHHCCCCEEEECCCCCCCCHHEECCCCHHHHHHHHHHHHHH
KGFGKQAAFAPRQVHVVGAGIMGGDIAAVCALAGLRVTLQDQGVDRIAPAIARAARLFER
HHCCCHHCCCCCEEEEEECCCCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHH
RLRGDARAQRLALDRLIPDPQGRGVAAADLVIEAISENLDAKRALFADLEARARPDALLA
HHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEE
TNTSSLRLADIAAGMRTPARLVGIHFFNPVAKMPLVEVVSAAATAAEDAARAAAFVRLLD
ECCCCEEHHHHHHCCCCCHHHHHHHHHCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLALPVRDVPGFLVNAALAPYMLEALRCVEEGVAPAVVDAALTRFGMAMGPVELVDTVGL
HHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHCCC
DVALAAGKALAAGAEVPPQLAARVAEGKLGRKTGEGYYRWAPQPGGEARIVGRAPVEAVP
HHHHHCCCHHHCCCCCCHHHHHHHHHCCCCCCCCCCCEEECCCCCCCEEEEECCCHHHHH
EGLAERVLAPLLAAVRHSVAEGVVADADLADAGLIFGAGFAPWTGGPLHHAQGRDFRIGA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCEEECC
SAAKQQTGPAPTTQQVSR
HHHHHCCCCCCCHHHCCC
>Mature Secondary Structure
MNAVADLARSDWHHWRIERSPDAILWLWLDRAGASANTLSAAVLDEFEVVLAALEANLPA
CCHHHHHHHCCCHHEEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCE
ALVIASAKPAGFVAGADIEEFSALPDPHAARALVERGWRLFDRLAALRCPTLALIRGHCM
EEEEECCCCCCEEECCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
GGGLELALACRYRLVVDEPATRLALPEVMLGIVPAWGGMRRLPALIGPVAALDMMLTGRS
CCCHHEEEEEEEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCC
LDARRARRIGLADDCVPPRVMENAARVLVSSGQRPALPGLLARLLNGPLKPLVAARAQRQ
CCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHH
TAARVSRAHYPAPFAIIDIWARHGGNALAVPAGDPASLETIFASPTAHNLARVFFLRERL
HHHHHHHHCCCCCHHHHHHHHHCCCCEEEECCCCCCCCHHEECCCCHHHHHHHHHHHHHH
KGFGKQAAFAPRQVHVVGAGIMGGDIAAVCALAGLRVTLQDQGVDRIAPAIARAARLFER
HHCCCHHCCCCCEEEEEECCCCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHH
RLRGDARAQRLALDRLIPDPQGRGVAAADLVIEAISENLDAKRALFADLEARARPDALLA
HHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEE
TNTSSLRLADIAAGMRTPARLVGIHFFNPVAKMPLVEVVSAAATAAEDAARAAAFVRLLD
ECCCCEEHHHHHHCCCCCHHHHHHHHHCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLALPVRDVPGFLVNAALAPYMLEALRCVEEGVAPAVVDAALTRFGMAMGPVELVDTVGL
HHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHCCC
DVALAAGKALAAGAEVPPQLAARVAEGKLGRKTGEGYYRWAPQPGGEARIVGRAPVEAVP
HHHHHCCCHHHCCCCCCHHHHHHHHHCCCCCCCCCCCEEECCCCCCCEEEEECCCHHHHH
EGLAERVLAPLLAAVRHSVAEGVVADADLADAGLIFGAGFAPWTGGPLHHAQGRDFRIGA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCEEECC
SAAKQQTGPAPTTQQVSR
HHHHHCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA