BacMap

Definition	Azoarcus sp. BH72 chromosome, complete genome.
Accession	NC_008702
Length	4,376,040

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The map label for this gene is fabG [C]

Identifier: 119896674

GI number: 119896674

Start: 409658

End: 410446

Strand: Direct

Name: fabG [C]

Synonym: azo0383

Alternate gene names: 119896674

Gene position: 409658-410446 (Clockwise)

Preceding gene: 119896673

Following gene: 119896675

Centisome position: 9.36

GC content: 71.74

Gene sequence:

>789_bases
ATGCTGACGGCCGCCGCCGCAGGGTCTCCACGGGTATTCCTCACCGGCGCCTCCAGCGGGCTCGGTGCCGCGCTTGCGCG
CCACTACGCAGCACGCGGCGCCAGCCTCGGCTTGGTCGCGCGCCGGGCCGATGCGCTCCATGAACTGGTCGCCAGCCTGC
CGGGGCGCCATCTTGCCCTCGTCGCTGACGTCGCCGATCCTGCTGCGCTGCGCTCGGCGGCGACGCGGTTCGAGGCCGCG
TTCGGCGTGCCGGACATCGTCATCGCCAACGCGGGCGTTTCGGTCGGCACGCTGACCGAGTACGCCGAGGACCTCGACGC
CTTCGAGCGCGTGCTGCGCACCAACCTGCTCGGCATGGCGGCCACGTTCCAGCCTTTCGTCGAAGCCATGCGCGCGCGCG
GTCGCGGACGGCTCGCCGGCATCGCTTCGGTGGCCGGCATCCGCGGCCTGCCGGGGGCGGGCGCCTACAGCGCCTCCAAG
GCGGCCGCGATCACCTACCTCGAAAGTCTGCGCGTCGAACTGCACGGCAGCGGCGTCACCGTCACCACCATCGCGCCCGG
CTACGTCGCCACACCGATGACCGCGGTCAATCCGTATCCGATGCCGTTCATGTTGCCGGCGGCGGAGGCTGCGGCCCGCA
TCGCGCGCCATATCGATACCGGACGACGCTATGCGGTGGTGCCATGGCAGATGGCGCTGGTTGCCAAGCTGCTGCGCGTG
CTGCCGGATGCGTTGTTTGACCGCCTGTTCGCGCACGCCGGCCGCAAGCCGCGCGGGCTGCCGCTGTAG

Upstream 100 bases:

>100_bases
AGCCACGAGGCGACGCTGAAGGTGGTGGACGATCTCATCGCCCGCGCCCGCAGCCAGCCGCGCCGCGGTTGATTTCCCGC
AGCGTCAGGACTCCGGCGGC

Downstream 100 bases:

>100_bases
CACGATTCCGCTGCCGCGCACGATGGGTGCGCGGGTTCCTTCGTTTATCATGCGGGCATTTTCCCCGCATGGTGATAGCG
AAGATGGATATGAAAAGCGG

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MLTAAAAGSPRVFLTGASSGLGAALARHYAARGASLGLVARRADALHELVASLPGRHLALVADVADPAALRSAATRFEAA
FGVPDIVIANAGVSVGTLTEYAEDLDAFERVLRTNLLGMAATFQPFVEAMRARGRGRLAGIASVAGIRGLPGAGAYSASK
AAAITYLESLRVELHGSGVTVTTIAPGYVATPMTAVNPYPMPFMLPAAEAAARIARHIDTGRRYAVVPWQMALVAKLLRV
LPDALFDRLFAHAGRKPRGLPL

Sequences:

>Translated_262_residues
MLTAAAAGSPRVFLTGASSGLGAALARHYAARGASLGLVARRADALHELVASLPGRHLALVADVADPAALRSAATRFEAA
FGVPDIVIANAGVSVGTLTEYAEDLDAFERVLRTNLLGMAATFQPFVEAMRARGRGRLAGIASVAGIRGLPGAGAYSASK
AAAITYLESLRVELHGSGVTVTTIAPGYVATPMTAVNPYPMPFMLPAAEAAARIARHIDTGRRYAVVPWQMALVAKLLRV
LPDALFDRLFAHAGRKPRGLPL
>Mature_262_residues
MLTAAAAGSPRVFLTGASSGLGAALARHYAARGASLGLVARRADALHELVASLPGRHLALVADVADPAALRSAATRFEAA
FGVPDIVIANAGVSVGTLTEYAEDLDAFERVLRTNLLGMAATFQPFVEAMRARGRGRLAGIASVAGIRGLPGAGAYSASK
AAAITYLESLRVELHGSGVTVTTIAPGYVATPMTAVNPYPMPFMLPAAEAAARIARHIDTGRRYAVVPWQMALVAKLLRV
LPDALFDRLFAHAGRKPRGLPL

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI20149619, Length=193, Percent_Identity=35.2331606217617, Blast_Score=110, Evalue=9e-25,
Organism=Homo sapiens, GI142976729, Length=243, Percent_Identity=28.3950617283951, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI40254992, Length=179, Percent_Identity=29.608938547486, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI7706318, Length=190, Percent_Identity=31.0526315789474, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI40807363, Length=241, Percent_Identity=29.045643153527, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI157739938, Length=198, Percent_Identity=26.2626262626263, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI15277342, Length=201, Percent_Identity=29.8507462686567, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI31543615, Length=240, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4503817, Length=189, Percent_Identity=31.2169312169312, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI150247226, Length=195, Percent_Identity=30.2564102564103, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI126723750, Length=190, Percent_Identity=28.4210526315789, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI32483357, Length=190, Percent_Identity=26.3157894736842, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI223718074, Length=190, Percent_Identity=34.7368421052632, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI19743808, Length=188, Percent_Identity=28.1914893617021, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI166795268, Length=200, Percent_Identity=30, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787335, Length=182, Percent_Identity=33.5164835164835, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI87082100, Length=186, Percent_Identity=36.5591397849462, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787820, Length=178, Percent_Identity=29.7752808988764, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1786701, Length=263, Percent_Identity=28.1368821292776, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17508895, Length=244, Percent_Identity=29.5081967213115, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17567345, Length=235, Percent_Identity=28.0851063829787, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17564282, Length=243, Percent_Identity=29.2181069958848, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17507613, Length=191, Percent_Identity=29.8429319371728, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI32563809, Length=191, Percent_Identity=29.8429319371728, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562990, Length=189, Percent_Identity=29.1005291005291, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17560150, Length=188, Percent_Identity=28.7234042553192, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=189, Percent_Identity=29.6296296296296, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=251, Percent_Identity=25.4980079681275, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17555706, Length=189, Percent_Identity=26.984126984127, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI193203117, Length=251, Percent_Identity=25.4980079681275, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=189, Percent_Identity=28.042328042328, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=202, Percent_Identity=29.2079207920792, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=195, Percent_Identity=28.2051282051282, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17531453, Length=189, Percent_Identity=28.042328042328, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115534660, Length=191, Percent_Identity=27.7486910994764, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562904, Length=208, Percent_Identity=27.4038461538462, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25147288, Length=216, Percent_Identity=26.8518518518519, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=226, Percent_Identity=25.2212389380531, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=200, Percent_Identity=30.5, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21358495, Length=191, Percent_Identity=32.9842931937173, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21355631, Length=254, Percent_Identity=30.7086614173228, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI116007236, Length=216, Percent_Identity=32.8703703703704, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI23397609, Length=222, Percent_Identity=32.4324324324324, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24644339, Length=193, Percent_Identity=31.6062176165803, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28571526, Length=191, Percent_Identity=32.4607329842932, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21357041, Length=187, Percent_Identity=30.4812834224599, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24641232, Length=197, Percent_Identity=31.4720812182741, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24641388, Length=196, Percent_Identity=34.6938775510204, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28571387, Length=195, Percent_Identity=34.3589743589744, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24581726, Length=205, Percent_Identity=27.8048780487805, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI281364892, Length=247, Percent_Identity=25.5060728744939, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI281364494, Length=193, Percent_Identity=31.6062176165803, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI116007238, Length=224, Percent_Identity=29.9107142857143, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17737361, Length=197, Percent_Identity=30.9644670050761, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24639444, Length=194, Percent_Identity=31.9587628865979, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24648693, Length=206, Percent_Identity=28.6407766990291, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21355889, Length=206, Percent_Identity=28.6407766990291, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI116007234, Length=212, Percent_Identity=31.6037735849057, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24643142, Length=192, Percent_Identity=30.7291666666667, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24649181, Length=253, Percent_Identity=24.1106719367589, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221510726, Length=224, Percent_Identity=29.4642857142857, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 27201; Mature: 27201

Theoretical pI: Translated: 10.84; Mature: 10.84

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTAAAAGSPRVFLTGASSGLGAALARHYAARGASLGLVARRADALHELVASLPGRHLAL
CCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEE
VADVADPAALRSAATRFEAAFGVPDIVIANAGVSVGTLTEYAEDLDAFERVLRTNLLGMA
EECCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ATFQPFVEAMRARGRGRLAGIASVAGIRGLPGAGAYSASKAAAITYLESLRVELHGSGVT
HHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHEECCCCEE
VTTIAPGYVATPMTAVNPYPMPFMLPAAEAAARIARHIDTGRRYAVVPWQMALVAKLLRV
EEEECCCHHCCCCCCCCCCCCCEECHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHH
LPDALFDRLFAHAGRKPRGLPL
HHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MLTAAAAGSPRVFLTGASSGLGAALARHYAARGASLGLVARRADALHELVASLPGRHLAL
CCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEE
VADVADPAALRSAATRFEAAFGVPDIVIANAGVSVGTLTEYAEDLDAFERVLRTNLLGMA
EECCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ATFQPFVEAMRARGRGRLAGIASVAGIRGLPGAGAYSASKAAAITYLESLRVELHGSGVT
HHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHEECCCCEE
VTTIAPGYVATPMTAVNPYPMPFMLPAAEAAARIARHIDTGRRYAVVPWQMALVAKLLRV
EEEECCCHHCCCCCCCCCCCCCEECHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHH
LPDALFDRLFAHAGRKPRGLPL
HHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1730672 [H]