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The map label for this gene is paaH1 [H]

Identifier: 119896592

GI number: 119896592

Start: 325526

End: 327073

Strand: Direct

Name: paaH1 [H]

Synonym: azo0301

Alternate gene names: 119896592

Gene position: 325526-327073 (Clockwise)

Preceding gene: 119896591

Following gene: 119896593

Centisome position: 7.44

GC content: 71.38

Gene sequence:

>1548_bases
GTGACTGCAGCAGACAAGGCGCTCGACAAGCAGGTGAAGGTGCTGGTGATCGGTGCCGGCGCGATGGGCAGCGGCATTGC
CCACGTGGCGGCGCTGGCCGGCCATCCGGTGTATCTGTACGACACCCGCGCGGAAGCGATCGACAAGGGCATCGGCGGCA
TCGCCAAGGATCTCGCCTTCCTGGTCGAAAAGGGCAAGCTCGCCGGCGCGGAGCGCGACGCGGTGCTCGCCCGCATCAGC
GGCATCACCCAGCTGGCCGACGCGAAGGACGCGGGCCTGGCGATCGAAGCCATCGTCGAGAACCTCGACATCAAGCAGAA
GCTCTTCCGCGAACTCGAAGCCCTGCTGGCGGAGGACGCGGTGCTGGCCTCCAACACCTCCTCGCTGTCGATCACCGCGA
TGGGCGCCGCGCTGGCGCGCCCCGAACGCCTGGTCGGGCTGCATTTCTTCAATCCGGCGCCGCGCATGAAGCTGGTCGAG
ATCGTCTCGGGTCTGGCCACGCCGCGCGAACTCGCCGAGCGCATGCACGCCACCGCCAAGGCGTGGGGCAAGGTGCCGGT
GCATGCGAAGTCGACGCCGGGCTTCATCGTCAATCGCGTCGCCCGCCCGTACTACGCCGAGGCCCAGCGCGTGCTGGCCG
AATGCGCTGCCGAGCCGGCTACGCTGGATGCGGCAATGCGCGAAGGTTGCGGCTTCCCGATGGGGCCGTTCGAGCTGATG
GACCTGATCGGCCACGACGTCAATTTCGCCGTCACCAACTCGGTGTTCGACGCCTACTTCGGCGACAAGCGCTTCACGCC
CAGCCTGCTGCAGCAGGAACTGGTTGCCGCCGGCCGGCTGGGCCGCAAGAGCGGCCACGGCTTCTACAGCTACGCCGCGG
GCGCCGCCCGGCCGGCGCCGCAGACCGAGGAGCCGCACGAGGCCGAAGCCGCGATCACCGTGGTCGGCGGGCTGGGGGTG
GCCGCGGCGCTGATCGGCCGCTTCGAGGCCGCCGGCATCGAGGTGCGCCGCACGGCTGGTGCGGGCGGCAGCGACGCCCA
GGGCTGGCTGGAGATCGGCGGCGCCCGCGTGGCGCTGTCCGACGGCCGCACCGCCACCCGCCGCGCGGTGGAAGAGGGCG
TGCCCAACCTGGTGCTGTTCGACCTCTGCCTGGACTACGCCACCACGCCGCGCCTGACGCTGGCGCGCGCCGACCAGTGC
GGCCACGGCGCCTGGGGCGCGGCGGTGGGCACGCTGCAGCGGGCCGGCCTGGCGGTGTCGCGCATCGACGACGTCGCCGG
CCTGGTGGGCCTGCGCACCGTGGCGATGCTGGCCAACGAAGCCGCCGACGCGGTGCTGCAGGGCATCGGCACCGCGGCCG
ACATCGACACCGCGATGCGCTTCGGCACCAACTATCCCAAGGGGCCGCTCGCCTGGGCCGACCAGCTCGGCGTGGCCTTC
GTCGCCCGCGTGCTGGCCAACCTGCGCGAGCACTACGGCGAGGAACGCTACCGCGTGTCGCCGCTGATCCAGCGCAAGAC
CTTCAGTGGAGCCGCATTCCATGAGTGA

Upstream 100 bases:

>100_bases
GCGCGATGCCATGCGGGCCTGCGGCCGCTCGCATGACTACCGCGAAGGCGTGGCCGCCTTCATGGAAAAACGCGCTCCTC
AATTCAAGGGGAATTAAGGC

Downstream 100 bases:

>100_bases
AGCCGCCTACCGTGACGTCACTGCCGGCCTCGATCCGCAAGCCCTGGCCGAAAAGGTGCGCGACGGCATGTTCGAACGCG
ACCAGGCCGCGCGCAGCCTG

Product: 3-hydroxy-acyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 515; Mature: 514

Protein sequence:

>515_residues
MTAADKALDKQVKVLVIGAGAMGSGIAHVAALAGHPVYLYDTRAEAIDKGIGGIAKDLAFLVEKGKLAGAERDAVLARIS
GITQLADAKDAGLAIEAIVENLDIKQKLFRELEALLAEDAVLASNTSSLSITAMGAALARPERLVGLHFFNPAPRMKLVE
IVSGLATPRELAERMHATAKAWGKVPVHAKSTPGFIVNRVARPYYAEAQRVLAECAAEPATLDAAMREGCGFPMGPFELM
DLIGHDVNFAVTNSVFDAYFGDKRFTPSLLQQELVAAGRLGRKSGHGFYSYAAGAARPAPQTEEPHEAEAAITVVGGLGV
AAALIGRFEAAGIEVRRTAGAGGSDAQGWLEIGGARVALSDGRTATRRAVEEGVPNLVLFDLCLDYATTPRLTLARADQC
GHGAWGAAVGTLQRAGLAVSRIDDVAGLVGLRTVAMLANEAADAVLQGIGTAADIDTAMRFGTNYPKGPLAWADQLGVAF
VARVLANLREHYGEERYRVSPLIQRKTFSGAAFHE

Sequences:

>Translated_515_residues
MTAADKALDKQVKVLVIGAGAMGSGIAHVAALAGHPVYLYDTRAEAIDKGIGGIAKDLAFLVEKGKLAGAERDAVLARIS
GITQLADAKDAGLAIEAIVENLDIKQKLFRELEALLAEDAVLASNTSSLSITAMGAALARPERLVGLHFFNPAPRMKLVE
IVSGLATPRELAERMHATAKAWGKVPVHAKSTPGFIVNRVARPYYAEAQRVLAECAAEPATLDAAMREGCGFPMGPFELM
DLIGHDVNFAVTNSVFDAYFGDKRFTPSLLQQELVAAGRLGRKSGHGFYSYAAGAARPAPQTEEPHEAEAAITVVGGLGV
AAALIGRFEAAGIEVRRTAGAGGSDAQGWLEIGGARVALSDGRTATRRAVEEGVPNLVLFDLCLDYATTPRLTLARADQC
GHGAWGAAVGTLQRAGLAVSRIDDVAGLVGLRTVAMLANEAADAVLQGIGTAADIDTAMRFGTNYPKGPLAWADQLGVAF
VARVLANLREHYGEERYRVSPLIQRKTFSGAAFHE
>Mature_514_residues
TAADKALDKQVKVLVIGAGAMGSGIAHVAALAGHPVYLYDTRAEAIDKGIGGIAKDLAFLVEKGKLAGAERDAVLARISG
ITQLADAKDAGLAIEAIVENLDIKQKLFRELEALLAEDAVLASNTSSLSITAMGAALARPERLVGLHFFNPAPRMKLVEI
VSGLATPRELAERMHATAKAWGKVPVHAKSTPGFIVNRVARPYYAEAQRVLAECAAEPATLDAAMREGCGFPMGPFELMD
LIGHDVNFAVTNSVFDAYFGDKRFTPSLLQQELVAAGRLGRKSGHGFYSYAAGAARPAPQTEEPHEAEAAITVVGGLGVA
AALIGRFEAAGIEVRRTAGAGGSDAQGWLEIGGARVALSDGRTATRRAVEEGVPNLVLFDLCLDYATTPRLTLARADQCG
HGAWGAAVGTLQRAGLAVSRIDDVAGLVGLRTVAMLANEAADAVLQGIGTAADIDTAMRFGTNYPKGPLAWADQLGVAFV
ARVLANLREHYGEERYRVSPLIQRKTFSGAAFHE

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=285, Percent_Identity=42.1052631578947, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI296179427, Length=302, Percent_Identity=40.0662251655629, Blast_Score=199, Evalue=6e-51,
Organism=Homo sapiens, GI20127408, Length=295, Percent_Identity=36.6101694915254, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI68989263, Length=288, Percent_Identity=30.5555555555556, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI261878539, Length=288, Percent_Identity=30.9027777777778, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI115430219, Length=235, Percent_Identity=31.063829787234, Blast_Score=116, Evalue=6e-26,
Organism=Escherichia coli, GI1787661, Length=501, Percent_Identity=45.5089820359281, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1788682, Length=274, Percent_Identity=35.4014598540146, Blast_Score=158, Evalue=8e-40,
Organism=Escherichia coli, GI1790281, Length=284, Percent_Identity=34.1549295774648, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17549919, Length=290, Percent_Identity=43.448275862069, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17563036, Length=288, Percent_Identity=40.9722222222222, Blast_Score=205, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17553560, Length=296, Percent_Identity=38.8513513513513, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI25144276, Length=288, Percent_Identity=34.0277777777778, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17508953, Length=288, Percent_Identity=34.0277777777778, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17508951, Length=288, Percent_Identity=34.0277777777778, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17558304, Length=284, Percent_Identity=33.0985915492958, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71985930, Length=291, Percent_Identity=26.8041237113402, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71985923, Length=292, Percent_Identity=26.7123287671233, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI193203623, Length=196, Percent_Identity=26.530612244898, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115533614, Length=196, Percent_Identity=26.530612244898, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583077, Length=278, Percent_Identity=35.9712230215827, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24583079, Length=278, Percent_Identity=35.9712230215827, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI19921000, Length=278, Percent_Identity=35.9712230215827, Blast_Score=170, Evalue=3e-42,
Organism=Drosophila melanogaster, GI45549573, Length=236, Percent_Identity=30.0847457627119, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI20129993, Length=223, Percent_Identity=29.1479820627803, Blast_Score=82, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR011967
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 54097; Mature: 53966

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAADKALDKQVKVLVIGAGAMGSGIAHVAALAGHPVYLYDTRAEAIDKGIGGIAKDLAF
CCCHHHHHCCCEEEEEEECCCCCCHHHHHHHHCCCCEEEEECHHHHHHHHCCHHHHHHHH
LVEKGKLAGAERDAVLARISGITQLADAKDAGLAIEAIVENLDIKQKLFRELEALLAEDA
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCH
VLASNTSSLSITAMGAALARPERLVGLHFFNPAPRMKLVEIVSGLATPRELAERMHATAK
HEECCCCCEEEEEHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
AWGKVPVHAKSTPGFIVNRVARPYYAEAQRVLAECAAEPATLDAAMREGCGFPMGPFELM
HHCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHH
DLIGHDVNFAVTNSVFDAYFGDKRFTPSLLQQELVAAGRLGRKSGHGFYSYAAGAARPAP
HHHCCCCCEEEHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCC
QTEEPHEAEAAITVVGGLGVAAALIGRFEAAGIEVRRTAGAGGSDAQGWLEIGGARVALS
CCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHEECCEEEEEC
DGRTATRRAVEEGVPNLVLFDLCLDYATTPRLTLARADQCGHGAWGAAVGTLQRAGLAVS
CCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCHHH
RIDDVAGLVGLRTVAMLANEAADAVLQGIGTAADIDTAMRFGTNYPKGPLAWADQLGVAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
VARVLANLREHYGEERYRVSPLIQRKTFSGAAFHE
HHHHHHHHHHHHCCCCEECCHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TAADKALDKQVKVLVIGAGAMGSGIAHVAALAGHPVYLYDTRAEAIDKGIGGIAKDLAF
CCHHHHHCCCEEEEEEECCCCCCHHHHHHHHCCCCEEEEECHHHHHHHHCCHHHHHHHH
LVEKGKLAGAERDAVLARISGITQLADAKDAGLAIEAIVENLDIKQKLFRELEALLAEDA
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCH
VLASNTSSLSITAMGAALARPERLVGLHFFNPAPRMKLVEIVSGLATPRELAERMHATAK
HEECCCCCEEEEEHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
AWGKVPVHAKSTPGFIVNRVARPYYAEAQRVLAECAAEPATLDAAMREGCGFPMGPFELM
HHCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHH
DLIGHDVNFAVTNSVFDAYFGDKRFTPSLLQQELVAAGRLGRKSGHGFYSYAAGAARPAP
HHHCCCCCEEEHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCC
QTEEPHEAEAAITVVGGLGVAAALIGRFEAAGIEVRRTAGAGGSDAQGWLEIGGARVALS
CCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHEECCEEEEEC
DGRTATRRAVEEGVPNLVLFDLCLDYATTPRLTLARADQCGHGAWGAAVGTLQRAGLAVS
CCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCHHH
RIDDVAGLVGLRTVAMLANEAADAVLQGIGTAADIDTAMRFGTNYPKGPLAWADQLGVAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
VARVLANLREHYGEERYRVSPLIQRKTFSGAAFHE
HHHHHHHHHHHHCCCCEECCHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]